Predicting overfishing and extinction threats in multispecies fisheries.

abstract：:Micrometeorites with diameter approximately 100-200 microm dominate the flux of extraterrestrial matter on Earth. The vast majority of micrometeorites are chemically, mineralogically, and isotopically related to carbonaceous chondrites, which amount to only 2.5% of meteorite falls. Here, we report the discovery of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gounelle M,Chaussidon M,Morbidelli A,Barrat JA,Engrand C,Zolensky ME,McKeegan KD

更新日期：2009-04-28 00:00:00

abstract：:Chronic inflammation results in increased nitrogen monoxide (.NO) formation and the accumulation of nitrite (NO(2-)). Neutrophils stimulated by various inflammatory mediators release myeloperoxidase to produce the cytotoxic agent hypochlorous acid (HOCl). Exposure of chondrocytic SW1353 cells to HOCl resulted in a con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whiteman M,Hooper DC,Scott GS,Koprowski H,Halliwell B

更新日期：2002-09-17 00:00:00

abstract：:Administration of gamma-glutamylcysteinylglycyl monomethyl (or monoethyl) ester to mice leads to substantial increases in the levels of glutathione in the liver and kidney. Mice depleted of glutathione by treatment with buthionine sulfoximine, a potent inhibitor of gamma-glutamylcysteine synthetase, exhibited about a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puri RN,Meister A

更新日期：1983-09-01 00:00:00

abstract：:Inward rectifying potassium (Kir) channels participate in regulating potassium concentration (K(+)) in the central nervous system (CNS), including in the retina. We explored the contribution of Kir channels to retinal function by delivering Kir antibodies (Kir-Abs) into the rat eye in vivo to interrupt channel activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raz-Prag D,Grimes WN,Fariss RN,Vijayasarathy C,Campos MM,Bush RA,Diamond JS,Sieving PA

更新日期：2010-07-13 00:00:00

abstract：:Quinacrine's ability to reduce levels of pathogenic prion protein (PrP(Sc)) in mouse cells infected with experimentally adapted prions led to several unsuccessful clinical studies in patients with prion diseases, a 10-y investment to understand its mechanism of action, and the production of related compounds with expe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bian J,Kang HE,Telling GC

更新日期：2014-04-22 00:00:00

abstract：:Migrations allow animals to track seasonal changes in resources, find mates, and avoid harsh climates, but these regular, long-distance movements also have implications for parasite dynamics and animal health. Migratory animals have been dubbed "superspreaders" of infection, but migration can also reduce parasite burd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peacock SJ,Krkošek M,Lewis MA,Molnár PK

更新日期：2020-05-19 00:00:00

abstract：:This perspective addresses recent advances in lipid transport across the Gram-negative inner and outer membranes. While we include a summary of previously existing literature regarding this topic, we focus on the maintenance of lipid asymmetry (Mla) pathway. Discovered in 2009 by the Silhavy group [J. C. Malinverni, T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Powers MJ,Trent MS

更新日期：2019-08-27 00:00:00

abstract：:Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work demands (muscle plasticity). Calcineurin, a calcium/calmodulin-dependent, serine-threonine protein phosphatase, has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberg P,Hawkins A,Stiber J,Shelton JM,Hutcheson K,Bassel-Duby R,Shin DM,Yan Z,Williams RS

更新日期：2004-06-22 00:00:00

abstract：:We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical need for a noninvasive tool to assess atherosclerosis from a molecular and cellular standpoint. Macrophages play a central role in atherosclerosis and are assoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbekian V,Lipinski MJ,Briley-Saebo KC,Amirbekian S,Aguinaldo JG,Weinreb DB,Vucic E,Frias JC,Hyafil F,Mani V,Fisher EA,Fayad ZA

更新日期：2007-01-16 00:00:00

abstract：:Plants can sense the direction of gravity and change the growth orientation of their organs. The molecular mechanisms of gravity sensing and signal transduction during gravitropism are not well known. We have isolated several shoot gravitropism (sgr) mutants of Arabidopsis. The sgr3-1 mutant exhibits a reduced gravitr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yano D,Sato M,Saito C,Sato MH,Morita MT,Tasaka M

更新日期：2003-07-08 00:00:00

abstract：:Many urological studies rely on models of animals, such as rats and pigs, but their relation to the human urinary system is poorly understood. Here, we elucidate the hydrodynamics of urination across five orders of magnitude in body mass. Using high-speed videography and flow-rate measurement obtained at Zoo Atlanta, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang PJ,Pham J,Choo J,Hu DL

更新日期：2014-08-19 00:00:00

abstract：:Topical application of phorbol myristate acetate (PMA) elicits intense local inflammation that facilitates outgrowth of premalignant lesions in skin after carcinogen exposure. The inflammatory response to PMA treatment activates immune stimulatory mechanisms. However, we show here that PMA exposure also induces plasma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muller AJ,Sharma MD,Chandler PR,Duhadaway JB,Everhart ME,Johnson BA 3rd,Kahler DJ,Pihkala J,Soler AP,Munn DH,Prendergast GC,Mellor AL

更新日期：2008-11-04 00:00:00

abstract：:Ehrlich and Raven formally introduced the concept of stepwise coevolution using butterfly and angiosperm interactions in an attempt to account for the impressive biological diversity of these groups. However, many biologists currently envision butterflies evolving 50 to 30 million years (Myr) after the major angiosper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wheat CW,Vogel H,Wittstock U,Braby MF,Underwood D,Mitchell-Olds T

更新日期：2007-12-18 00:00:00

abstract：:p53 is the most frequently mutated gene in human cancers and mutant p53 has a gain of function (GOF) that promotes tumor progression and therapeutic resistance. One of the major GOF activities of mutant p53 is to suppress 2 other p53 family proteins, p63 and p73. However, the molecular basis is not fully understood. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,Sun W,Kong X,Zhang Y,Yang HJ,Ren C,Jiang Y,Chen M,Chen X

更新日期：2019-11-26 00:00:00

abstract：:The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tyson JJ

更新日期：1991-08-15 00:00:00

abstract：:Volume changes associated with protein folding reactions contain valuable information about the folding mechanism and the nature of the transition state. However, meaningful interpretation of such data requires that overall volume changes be deconvoluted into individual contributions from different structural componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neumaier S,Büttner M,Bachmann A,Kiefhaber T

更新日期：2013-12-24 00:00:00

abstract：:The influenza virus hemagglutinin polypeptides, HA1 and HA2, have been purified by gel filtration in the presence of sodium dodecyl sulfate from a vaccine preparation of the recombinant strain Heq1N2. Use of this technique for purification of the hemagglutinin polypeptides eliminated the need for proteolytic agents fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bucher DJ,Li SS,Kehoe JM,Kilbourne ED

更新日期：1976-01-01 00:00:00

abstract：:We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of LSC, we identified 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majeti R,Becker MW,Tian Q,Lee TL,Yan X,Liu R,Chiang JH,Hood L,Clarke MF,Weissman IL

更新日期：2009-03-03 00:00:00

abstract：:Adipose tissue dysfunction is causally implicated in the impaired metabolic homeostasis associated with obesity; however, detailed mechanisms underlying dysregulated adipocyte functions in obesity remain to be elucidated. Here we searched for genes that provide a previously unknown mechanism in adipocyte metabolic fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wardhana DA,Ikeda K,Barinda AJ,Nugroho DB,Qurania KR,Yagi K,Miyata K,Oike Y,Hirata KI,Emoto N

更新日期：2018-02-13 00:00:00

abstract：:Mechanisms leading to down-regulation of activated microglia and astrocytes are poorly understood, in spite of the potentially detrimental role of activated glia in neurodegeneration. Prostaglandins, produced both by neurons and glia, may serve as mediators of glial and neuronal functions. We examined the influence of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrova TV,Akama KT,Van Eldik LJ

更新日期：1999-04-13 00:00:00

abstract：:The rate of change of climate codetermines the global warming impacts on natural and socioeconomic systems and their capabilities to adapt. Establishing past rates of climate change from temperature proxy data remains difficult given their limited spatiotemporal resolution. In contrast, past greenhouse gas radiative f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joos F,Spahni R

更新日期：2008-02-05 00:00:00

abstract：:Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after nonselective growth. Rifampicin-resistant (Rif(r)) isolates were stable, suggesting that they had arisen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sánchez-Romero MA,Casadesús J

更新日期：2014-01-07 00:00:00

abstract：:An electrophoretic karyotype of Aspergillus nidulans has been obtained using contour-clamped homogeneous electric field gel electrophoresis. Six chromosomal bands were separated, with two of the bands migrating as doublets. Using the Schizosaccharomyces pombe and Saccharomyces cerevisiae chromosomes as size standards,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brody H,Carbon J

更新日期：1989-08-01 00:00:00

abstract：:We have screened about 1.4 million colonies of Escherichia coli K-12 for their ability to grow on nutrient agar at 30 degrees and 41 degrees. Among the 2266 temperature-sensitive mutants found, 110 were defective in DNA synthesis but not in protein synthesis at 41 degrees. Three of these dna mutations mapped at two pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sevastopoulos CG,Wehr CT,Glaser DA

更新日期：1977-08-01 00:00:00

abstract：:Cardioviruses comprise a genus of picornaviruses that cause severe illnesses in rodents, but little is known about the prevalence, diversity, or spectrum of disease of such agents among humans. A single cardiovirus isolate, Saffold virus, was cultured in 1981 in stool from an infant with fever. Here, we describe the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiu CY,Greninger AL,Kanada K,Kwok T,Fischer KF,Runckel C,Louie JK,Glaser CA,Yagi S,Schnurr DP,Haggerty TD,Parsonnet J,Ganem D,DeRisi JL

更新日期：2008-09-16 00:00:00

abstract：:Few mechanisms are known that explain how transcription factors can adjust phenotypic outputs to accommodate differing environments. In Saccharomyces cerevisiae, the decision to mate or invade relies on environmental cues that converge on a shared transcription factor, Ste12. Specificity toward invasion occurs via Ste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorrity MW,Cuperus JT,Carlisle JA,Fields S,Queitsch C

更新日期：2018-08-21 00:00:00

abstract：:The 1,25-dihydroxyvitamin D3 [1,25-(OH)2vitamin D3] analog KH1060 exerts very potent effects on cell proliferation and cell differentiation via the vitamin D receptor (VDR). However, the activities of KH1060 are not associated with an increased affinity for the VDR. We now show that increased stabilization of the VDR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van den Bemd GC,Pols HA,Birkenhäger JC,van Leeuwen JP

更新日期：1996-10-01 00:00:00

abstract：:The fusiform face area (FFA) is a region of human cortex that responds selectively to faces, but whether it supports a more general function relevant for perceptual expertise is debated. Although both faces and objects of expertise engage many brain areas, the FFA remains the focus of the strongest modular claims and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGugin RW,Gatenby JC,Gore JC,Gauthier I

更新日期：2012-10-16 00:00:00

abstract：:Light-grown, wild type Euglena gracilis contains two aminoacyl-tRNA synthetases for both phenylalanine and isoleucine. Only one of the two synthetases for each amino acid is found in isolated chloroplasts, as are the light-induced phenylalanine and isoleucine tRNAs. In each case the light-induced chloroplast tRNAs can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reger BJ,Fairfield SA,Epler JL,Barnett WE

更新日期：1970-11-01 00:00:00

abstract：:Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we report that activatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR

更新日期：2020-03-17 00:00:00