Dysregulated gene expression networks in human acute myelogenous leukemia stem cells.

abstract：:Progress in ecosystem service science has been rapid, and there is now a healthy appetite among key public and private sector decision makers for this science. However, changing policy and management is a long-term project, one that raises a number of specific practical challenges. One impediment to broad adoption of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polasky S,Tallis H,Reyers B

更新日期：2015-06-16 00:00:00

abstract：:A method for assessing genomic similarity based on relative abundances of short oligonucleotides in large DNA samples is introduced. The method requires neither homologous sequences nor prior sequence alignments. The analysis centers on (i) dinucleotide (and tri- and tetra-) relative abundance extremes in genomic sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karlin S,Ladunga I

更新日期：1994-12-20 00:00:00

abstract：:We studied the abundance and structure of globin mRNAs present in K562 cells both before and after induction of hemoglobin synthesis by hemin. In vitro translation of poly(A)+ RNA from K562 cells generated protein products corresponding to alpha, A gamma-, G gamma-, epsilon-, and zeta-globin mRNAs. Individual globin m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dean A,Ley TJ,Humphries RK,Fordis M,Schechter AN

更新日期：1983-09-01 00:00:00

abstract：:Protein 4.1R (4.1R) is a multifunctional component of the red cell membrane. It forms a ternary complex with actin and spectrin, which defines the nodal junctions of the membrane-skeletal network, and its attachment to the transmembrane protein glycophorin C creates a bridge between the protein network and the membran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salomao M,Zhang X,Yang Y,Lee S,Hartwig JH,Chasis JA,Mohandas N,An X

更新日期：2008-06-10 00:00:00

abstract：:In vitro recombination of cloned H-2 genes resulted in two allogeneically novel mouse transplantation antigens in which the C2 domains of H-2Ld and H-2Dd were exchanged. These genes were introduced into mouse L cells by DNA-mediated gene transfer. We have used these transformed fibroblast lines, expressing recombinant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozato K,Evans GA,Shykind B,Margulies DH,Seidman JG

更新日期：1983-04-01 00:00:00

abstract：:Molecular hybridization with (125)I-labeled citrus exocortis viroid RNA has been used to survey nucleic acid preparations from Gynura aurantiaca for viroid complementary molecules. A differential hybridization effect was detected between nucleic acid extracts from healthy and infected tissue in which significant RNase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grill LK,Semancik JS

更新日期：1978-02-01 00:00:00

abstract：:Picomole amounts of oligodeoxynucleotides [polydeoxyadenylic acids, (dA)40-60] were baseline resolved and analyzed in less than 8 min by high-performance capillary electrophoresis with polyacrylamide gels. In addition, fast analysis of a crude 70-mer oligodeoxynucleotide and a slab gel-purified 99-mer oligodeoxynucleo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen AS,Najarian DR,Paulus A,Guttman A,Smith JA,Karger BL

更新日期：1988-12-01 00:00:00

abstract：:Interest in cell-associated collagens led others to isolate A and B collagen chains, also known as type V collagen, from many tissues, but only after pepsin cleavage. Soluble precursors of these chains are synthesized in vitro by crop, a chicken embryo muscle tissue, and are converted by at least two processing steps ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumamoto CA,Fessler JH

更新日期：1980-11-01 00:00:00

abstract：:The primary structure of about half of the protein chain of yeast alcohol dehydrogenase has been determined and compared with the amino-acid sequences of other dehydrogenases. The enzyme is found to be distantly related to horse-liver alcohol dehydrogenase, although these two proteins have different quaternary structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jörnvall H

更新日期：1973-08-01 00:00:00

abstract：:A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2) gene has recently been identified as associated with insulin resistance in humans. To understand the cellular and molecular mechanisms by which alterations in Nat2 activity might cause insulin resistance, we examined murine ortholog N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Camporez JP,Wang Y,Faarkrog K,Chukijrungroat N,Petersen KF,Shulman GI

更新日期：2017-12-26 00:00:00

abstract：:Persisting (P) cells (murine cells that resemble mast cells and grow continuously in vitro for prolonged periods in the presence of a specific growth factor) did not express detectable levels of Ia antigens (murine class II major histocompatibility antigens) when their growth was supported by partially purified P cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong GH,Clark-Lewis I,McKimm-Breschkin JL,Schrader JW

更新日期：1982-11-01 00:00:00

abstract：:Natural-abundance (13)C nuclear magnetic resonance spectra of ten common nucleotides in neutral, aqueous solutions have been determined and interpreted. The spectra of two of these substances were also determined in acidic solutions, and several of the carbon chemical shifts were found to depend markedly on pH. Within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorman DE,Roberts JD

更新日期：1970-01-01 00:00:00

abstract：:The F-box protein Skp2 (S-phase kinase-associated protein 2) positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. We show here that Skp2 expression correlates directly with grade of malignancy and inversely with p27 levels in human ly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Latres E,Chiarle R,Schulman BA,Pavletich NP,Pellicer A,Inghirami G,Pagano M

更新日期：2001-02-27 00:00:00

abstract：:Rhinoviruses (RVs) are the major causes of common colds in humans. They have a nonenveloped, icosahedral capsid surrounding a positive-strand RNA genome. Here we report that the antigen-binding (Fab) fragment of a neutralizing antibody (C5) can trigger genome release from RV-B14 to form emptied particles and neutraliz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong Y,Liu Y,Jiang W,Smith TJ,Xu Z,Rossmann MG

更新日期：2017-07-25 00:00:00

abstract：:2(S)-dihydroxypropanesulfonate (DHPS) is a microbial degradation product of 6-deoxy-6-sulfo-d-glucopyranose (sulfoquinovose), a component of plant sulfolipid with an estimated annual production of 1010 tons. DHPS is also at millimolar levels in highly abundant marine phytoplankton. Its degradation and sulfur recycling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Wei Y,Lin L,Teng L,Yin J,Lu Q,Chen J,Zheng Y,Li Y,Xu R,Zhai W,Liu Y,Liu Y,Cao P,Ang EL,Zhao H,Yuchi Z,Zhang Y

更新日期：2020-07-07 00:00:00

abstract：:Dihydroisohistrionicotoxin inhibits acetylcholine receptor-dependent 22Na+ uptake of cultured chick muscle cells with a KI of 0.2 micrometer. The inhibition is noncompetitive with respect to agonists. The toxin enhances desensitization of the receptor by agonists which is accompanied by a 10-fold increase in receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burgermeister W,Catterall WA,Witkop B

更新日期：1977-12-01 00:00:00

abstract：:Whether the regulatory protein of an inducible operon for a catabolic pathway is a positive or a negative element in the control of expression is correlated with the frequent or infrequent presence, respectively, of the system's substrate in the natural environment. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Savageau MA

更新日期：1974-06-01 00:00:00

abstract：:A single dose of N-methyl-N-nitrosourea given to sexually immature female Buf/N rats produces a high incidence of mammary adenocarcinomas. A large percentage of these tumors contain the Ha-ras oncogene, activated by a G----A transition at the second nucleotide of codon 12. Copenhagen rats, on the other hand, are compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu SJ,Archer MC

更新日期：1992-02-01 00:00:00

abstract：:The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in wome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazat L,Lafont S,Berr C,Debuire B,Tessier JF,Dartigues JF,Baulieu EE

更新日期：2001-07-03 00:00:00

abstract：:SIRT6 (sirtuin 6) is a member of sirtuin family of deacetylases involved in diverse processes including genome stability, metabolic homeostasis, and tumorigenesis. However, the role of SIRT6 deacetylase activity in its tumor-suppressor functions is not well understood. Here we report that SIRT6 binds to and deacetylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhardwaj A,Das S

更新日期：2016-02-02 00:00:00

abstract：:The F-box represents a protein motif originally identified as a conserved amino-terminal domain within the Neurospora crassa negative regulator sulfur controller-2. Recently, F-boxes have been found within a number of cell cycle regulatory proteins, where they mediate ubiquitin-driven proteolytic events required for m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Paietta JV

更新日期：1998-03-03 00:00:00

abstract：:Previously, we reported that bilateral excitotoxic lesions of the basolateral nucleus of the amygdala (BLA) block the enhancing effects of posttraining systemic or intrahippocampal glucocorticoid administration on memory for inhibitory avoidance training. The present study further examined the basis of this permissive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roozendaal B,Nguyen BT,Power AE,McGaugh JL

更新日期：1999-09-28 00:00:00

abstract：:Most of the cell-surface molecules involved in T-cell immune responses are N-linked glycoproteins. We have investigated the effects of inhibitors of glycoprotein processing on specific T-cell functions, with the dual aims of examining the functional role of carbohydrate and of testing the usefulness of such compounds ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall KA,Pierce JD,Elbein AD

更新日期：1988-08-01 00:00:00

abstract：:Seed plants vary tremendously in size and morphology; however, variation and covariation in plant traits may be governed, at least in part, by universal biophysical laws and biological constants. Metabolic scaling theory (MST) posits that whole-organismal metabolism and growth rate are under stabilizing selection that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasseur F,Exposito-Alonso M,Ayala-Garay OJ,Wang G,Enquist BJ,Vile D,Violle C,Weigel D

更新日期：2018-03-27 00:00:00

abstract：:Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we developed a dual-lu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan CT,Reeves RE,Geller R,Yaghoubi SS,Hoehne A,Solow-Cordero DE,Chiosis G,Massoud TF,Paulmurugan R,Gambhir SS

更新日期：2012-09-11 00:00:00

abstract：:Hypomagnesemia affects insulin resistance and is a risk factor for diabetes mellitus type 2 (DM2) and gestational diabetes mellitus (GDM). Two single nucleotide polymorphisms (SNPs) in the epithelial magnesium channel TRPM6 (V(1393)I, K(1584)E) were predicted to confer susceptibility for DM2. Here, we show using patch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nair AV,Hocher B,Verkaart S,van Zeeland F,Pfab T,Slowinski T,Chen YP,Schlingmann KP,Schaller A,Gallati S,Bindels RJ,Konrad M,Hoenderop JG

更新日期：2012-07-10 00:00:00

abstract：:The regional chromosomal location of the human gene for plasminogen activator inhibitor type 1 (PAI1) was determined by three independent methods of gene mapping. PAI1 was localized first to 7cen-q32 and then to 7q21.3-q22 by Southern blot hybridization analysis of a panel of human and mouse somatic cell hybrids with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klinger KW,Winqvist R,Riccio A,Andreasen PA,Sartorio R,Nielsen LS,Stuart N,Stanislovitis P,Watkins P,Douglas R

更新日期：1987-12-01 00:00:00

abstract：:Simian virus 40 (SV40)-transformed hamster cells were relatively resistant to the lytic effect of activated macrophages from animals with chronic intracellular infections. Conversely, SV40-transformed mouse and rat cells and adenovirus 2-transformed hamster cells were highly susceptible to destruction by tumoricidal a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JL,Hibbs JB Jr,Lewis AM Jr

更新日期：1980-11-01 00:00:00

abstract：:Perilipin coats the lipid droplets of adipocytes and is thought to have a role in regulating triacylglycerol hydrolysis. To study the role of perilipin in vivo, we have created a perilipin knockout mouse. Perilipin null (peri(-/-)) and wild-type (peri(+/+)) mice consume equal amounts of food, but the adipose tissue ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tansey JT,Sztalryd C,Gruia-Gray J,Roush DL,Zee JV,Gavrilova O,Reitman ML,Deng CX,Li C,Kimmel AR,Londos C

更新日期：2001-05-22 00:00:00

abstract：:Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge Y,Dong Z,Bagot RC,Howland JG,Phillips AG,Wong TP,Wang YT

更新日期：2010-09-21 00:00:00