Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation.

abstract：:The heptadecapeptide orphanin FQ (OFQ) is a recently discovered neuropeptide that exhibits structural features reminiscent of the opioid peptides and that is an endogenous ligand to a G protein-coupled receptor sequentially related to the opioid receptors. We have cloned both the human and rat cDNAs encoding the OFQ p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nothacker HP,Reinscheid RK,Mansour A,Henningsen RA,Ardati A,Monsma FJ Jr,Watson SJ,Civelli O

更新日期：1996-08-06 00:00:00

abstract：:The endosymbiont Wolbachia is common among insects and known for the reproductive manipulations it exerts on hosts as well as inhibition of virus replication in their hosts. Recently, we showed that Wolbachia uses host microRNAs to manipulate host gene expression for its efficient maintenance in the dengue mosquito ve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang G,Hussain M,O'Neill SL,Asgari S

更新日期：2013-06-18 00:00:00

abstract：:Many studies have demonstrated that the primary visual cortex contains multiple functional maps of visual properties (e.g., ocular dominance, orientation preference, and spatial-frequency preference), but as yet no consistent picture has emerged as to how these maps are related to one another. Three divergent, prior o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirovich L,Uglesich R

更新日期：2004-11-30 00:00:00

abstract：:Brefeldin A, a fungal metabolite that inhibits membrane transport, induces the mono(ADP-ribosyl)ation of two cytosolic proteins of 38 and 50 kDa as judged by SDS/PAGE. The 38-kDa substrate has been previously identified as glyceraldehyde-3-phosphate dehydrogenase (GAPDH). We report that the 50-kDa BFA-induced ADP-ribo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Girolamo M,Silletta MG,De Matteis MA,Braca A,Colanzi A,Pawlak D,Rasenick MM,Luini A,Corda D

更新日期：1995-07-18 00:00:00

abstract：:Glc3Man9GlcNAc2 is the preferred substrate of the oligosaccharyltransferase of N-linked glycosylation of proteins, but nonglucosylated oligosaccharides can be transferred to proteins in Saccharomyces cerevisiae. Mutations affecting the addition of the three terminal glucose residues lead to accumulation of Man9GlcNAc2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagljar I,te Heesen S,Aebi M

更新日期：1994-06-21 00:00:00

abstract：:Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force. Biochemical and biophysic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cochrane SA,Findlay B,Bakhtiary A,Acedo JZ,Rodriguez-Lopez EM,Mercier P,Vederas JC

更新日期：2016-10-11 00:00:00

abstract：:We have determined the packing efficiency at the protein-water interface by calculating the volumes of atoms on the protein surface and nearby water molecules in 22 crystal structures. We find that an atom on the protein surface occupies, on average, a volume approximately 7% larger than an atom of equivalent chemical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerstein M,Chothia C

更新日期：1996-09-17 00:00:00

abstract：:Cedar virus (CedV) is a bat-borne henipavirus related to Nipah virus (NiV) and Hendra virus (HeV), zoonotic agents of fatal human disease. CedV receptor-binding protein (G) shares only ∼30% sequence identity with those of NiV and HeV, although they can all use ephrin-B2 as an entry receptor. We demonstrate that CedV a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laing ED,Navaratnarajah CK,Cheliout Da Silva S,Petzing SR,Xu Y,Sterling SL,Marsh GA,Wang LF,Amaya M,Nikolov DB,Cattaneo R,Broder CC,Xu K

更新日期：2019-10-08 00:00:00

abstract：:Resonance Raman and optical absorption spectra of ligand-free (deoxy) myoglobin and CO-bound myoglobin (MbCO) at pH 2.6 have been measured by using continuous-flow/rapid-mixing techniques. The spectra of deoxy myoglobin at low pH within 6 ms of the pH drop demonstrate that the iron-histidine bond has been ruptured but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han S,Rousseau DL,Giacometti G,Brunori M

更新日期：1990-01-01 00:00:00

abstract：:Ferroelectricity and antiferroelectricity are widely seen in various types of condensed matter and are of technological significance not only due to their electrical switchability but also due to intriguing cross-coupling effects such as electro-mechanical and electro-caloric effects. The control of the two types of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takae K,Tanaka H

更新日期：2018-10-02 00:00:00

abstract：:Muscle contraction and relaxation is regulated by transient elevations of myoplasmic Ca(2+). Ca(2+) is released from stores in the lumen of the sarco(endo)plasmic reticulum (SER) to initiate formation of the Ca(2+) transient by activation of a class of Ca(2+) release channels referred to as ryanodine receptors (RyRs) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amador FJ,Liu S,Ishiyama N,Plevin MJ,Wilson A,MacLennan DH,Ikura M

更新日期：2009-07-07 00:00:00

abstract：:In the United States, blood donors are being screened for infection with human T cell lymphotropic viruses I and II (HTLV-I/II) by serologic means, which detect antibodies to the structural proteins of these viruses. Because patients with mycosis fungoides (MF) usually do not have such antibodies even though their cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zucker-Franklin D,Pancake BA,Marmor M,Legler PM

更新日期：1997-06-10 00:00:00

abstract：:Promoter-proximal stalling, a general phenomenon observed during the expression of many RNA polymerase II transcribed genes, is dependent on transcription factor IIH (TFIIH). Reactions lacking TFIIH initiated transcription, but the transcription complex encountered a block to elongation proximal to the promoter. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar KP,Akoulitchev S,Reinberg D

更新日期：1998-08-18 00:00:00

abstract：:Efforts to delineate the advent of many enzymes essential to protein translation are often limited by the fact that the modern genetic code evolved before divergence of the tree of life. Glutaminyl-tRNA synthetase (GlnRS) is one noteworthy exception to the universality of the translation apparatus. In eukaryotes and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skouloubris S,Ribas de Pouplana L,De Reuse H,Hendrickson TL

更新日期：2003-09-30 00:00:00

abstract：:A modified differential screening procedure was applied to analyze cDNA libraries of cloned helper T lymphocytes (Th) and cytolytic T lymphocytes (CTL). Negative and positive differential screening and RNA blot analysis were used to identify cDNA clones that were expressed preferentially in Th or CTL. Seven clones cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon BS,Kim GS,Prystowsky MB,Lancki DW,Sabath DE,Pan JL,Weissman SM

更新日期：1987-05-01 00:00:00

abstract：:Tropical forests hold most of Earth's biodiversity. Their continued loss through deforestation and agriculture is the main threat to species globally, more than disease, invasive species, and climate change. However, not all tropical forests have the same ability to sustain biodiversity. Those that have been disturbed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hedges SB,Cohen WB,Timyan J,Yang Z

更新日期：2018-11-13 00:00:00

abstract：:While the physical dimensions of climate change are now routinely assessed through multimodel intercomparisons, projected impacts on the global ocean ecosystem generally rely on individual models with a specific set of assumptions. To address these single-model limitations, we present standardized ensemble projections...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotze HK,Tittensor DP,Bryndum-Buchholz A,Eddy TD,Cheung WWL,Galbraith ED,Barange M,Barrier N,Bianchi D,Blanchard JL,Bopp L,Büchner M,Bulman CM,Carozza DA,Christensen V,Coll M,Dunne JP,Fulton EA,Jennings S,Jones MC,

更新日期：2019-06-25 00:00:00

abstract：:We analyzed the relationship of genetic factors determining the expression of endogenous type-C RNA tumor viruses and other host-gene markers to tumorigenesis. A hybridization experiment was performed with mice of strains AKR/J and C57L, the first filial (F(1)) generation hybrids, the second filial (F(2)) generation h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meier H,Taylor BA,Cherry M,Buebner RJ

更新日期：1973-05-01 00:00:00

abstract：:The lamB protein, the receptor for phage lambda, was purified from the outer membrane of Escherichia coli K-12 by extraction with Triton X-100 and EDTA, chromatography on DEAE-Sephacel in Triton X-100, exchange of Triton for cholate by gel filtration, and chromatography on Sephacryl S-200 in cholate, NaCl, and EDTA. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luckey M,Nikaido H

更新日期：1980-01-01 00:00:00

abstract：:In t(15;17) acute promyelocytic leukemia, all-trans retinoic acid (RA) induces leukemic cell maturation in vitro and remission in acute promyelocytic leukemia patients, but in vivo treatments invariably lead to relapse with resistance to RA. NB4, a maturation-inducible cell line, and NB4-RAr sublines (R1 and R2) displ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruchaud S,Duprez E,Gendron MC,Houge G,Genieser HG,Jastorff B,Doskeland SO,Lanotte M

更新日期：1994-08-30 00:00:00

abstract：:The virB operon of the Agrobacterium tume-faciens pTiA6NC plasmid likely plays a role in directing T-DNA transfer events at the bacterial membrane, as determined previously by mutagenesis and cellular fractionation studies and by DNA sequence analysis of the approximately 12-kilobase-pair operon. The DNA sequence anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christie PJ,Ward JE Jr,Gordon MP,Nester EW

更新日期：1989-12-01 00:00:00

abstract：:Much of the success of Plasmodium falciparum in establishing persistent infections is attributed to immune evasion through antigenic variation. This process involves periodically exchanging variants of the major surface antigen PfEMP1, a protein also responsible for parasite cytoadherence. PfEMP1 is encoded by genes o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ralph SA,Scheidig-Benatar C,Scherf A

更新日期：2005-04-12 00:00:00

abstract：:Dimerization of human immunodeficiency virus type 1 protease (HIV-1 PR) monomers is an essential prerequisite for viral proteolytic activity and the subsequent generation of infectious virus particles. Disruption of the dimer interface inhibits this activity as does formation of heterodimers between wild-type and defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McPhee F,Good AC,Kuntz ID,Craik CS

更新日期：1996-10-15 00:00:00

abstract：:The Raf family includes three members, of which B-Raf is frequently mutated in melanoma and other tumors. We show that Raf-1 and A-Raf require Hsp90 for stability, whereas B-Raf does not. In contrast, mutated, activated B-Raf binds to an Hsp90-cdc37 complex, which is required for its stability and function. Exposure o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grbovic OM,Basso AD,Sawai A,Ye Q,Friedlander P,Solit D,Rosen N

更新日期：2006-01-03 00:00:00

abstract：:Many groups of insects are specialists in exploiting sensory cues to locate food resources or conspecifics. To achieve orientation, bees and ants analyze the polarization pattern of the sky, male moths orient along the females' odor plume, and cicadas, grasshoppers, and crickets use acoustic signals to locate singing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulet JF,Hedwig B

更新日期：2005-10-25 00:00:00

abstract：:Proteins can bind target molecules through either induced fit or conformational selection pathways. In the conformational selection model, a protein samples a scarcely populated high-energy state that resembles a target-bound conformation. In enzymatic catalysis, such high-energy states have been identified as crucial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovermann M,Grundström C,Sauer-Eriksson AE,Sauer UH,Wolf-Watz M

更新日期：2017-06-13 00:00:00

abstract：:The trilaminate vascular architecture provides biochemical regulation and mechanical integrity. Yet regulatory control can be regained after injury without recapitulating tertiary structure. Tissue-engineered (TE) endothelium controls repair even when placed in the perivascular space of injured vessels. It remains unc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zani BG,Kojima K,Vacanti CA,Edelman ER

更新日期：2008-05-13 00:00:00

abstract：:The mechanisms that regulate the ubiquitin (Ub)-proteasome system's own components, although critically important, are largely unknown. Ub, a principal component of the system, must be maintained at adequate levels to support cellular homeostasis under basal and stressed conditions. It was suggested that Ub is degrade...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shabek N,Herman-Bachinsky Y,Ciechanover A

更新日期：2009-07-21 00:00:00

abstract：:Using a genome-wide approach, we asked how many transporter genes contribute to symbiotic phosphate uptake and analyzed their evolutionary conservation. Considering the sequenced rice genome at hand, only the Oryza sativa phosphate transporter (OsPT) gene OsPT11 was specifically induced during the arbuscular mycorrhiz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paszkowski U,Kroken S,Roux C,Briggs SP

更新日期：2002-10-01 00:00:00

abstract：:In mantle cell lymphoma (MCL), the translocation t(11;14) is considered the cytogenetic hallmark of the disease. Recently, however, deletion of the chromosomal region 11q22-q23 has been identified as a frequent event in this type of cancer, indicating the existence of a pathogenically relevant tumor suppressor gene in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaffner C,Idler I,Stilgenbauer S,Döhner H,Lichter P

更新日期：2000-03-14 00:00:00