Adaptive diversification of growth allometry in the plant Arabidopsis thaliana.

abstract：:A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance--wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis. Although efforts to explain this have focused on f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vatner DF,Majumdar SK,Kumashiro N,Petersen MC,Rahimi Y,Gattu AK,Bears M,Camporez JP,Cline GW,Jurczak MJ,Samuel VT,Shulman GI

更新日期：2015-01-27 00:00:00

abstract：:Profilin1, a ubiquitously expressed actin-binding protein, plays a critical role in cell migration through actin cytoskeletal regulation. Given the traditional view of profilin1 as a promigratory molecule, it is difficult to reconcile observations that profilin1 is down-regulated in various invasive adenocarcinomas an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bae YH,Ding Z,Das T,Wells A,Gertler F,Roy P

更新日期：2010-12-14 00:00:00

abstract：:Physical biochemical techniques are used to establish the structure, subunit stoichiometry, and assembly pathway of the primosome complex of the bacteriophage T4 DNA replication system. Analytical ultracentrifugation and fluorescence anisotropy methods show that the functional T4 primosome consists of six gp41 helicas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jose D,Weitzel SE,Jing D,von Hippel PH

更新日期：2012-08-21 00:00:00

abstract：:The development of cardiac hypertrophy is mediated, in part, by increase in NADPH oxidase activity and myocardial oxidative stress. The Rho GTPase, Rac, regulates NADPH oxidase activity through interaction with gp91(phox) and p67(phox) (in which "phox" is phagocyte oxidase). However, it is not known which Rac isoform ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Satoh M,Ogita H,Takeshita K,Mukai Y,Kwiatkowski DJ,Liao JK

更新日期：2006-05-09 00:00:00

abstract：:Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear. Here, we report the structural features and functional behavior of a phosphomimetic cyto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerra-Castellano A,Díaz-Quintana A,Pérez-Mejías G,Elena-Real CA,González-Arzola K,García-Mauriño SM,De la Rosa MA,Díaz-Moreno I

更新日期：2018-07-31 00:00:00

abstract：:This note presents the derivation of generalized Ambartsumian-Chandrasekhar X and Y functions for stationary transfer in a plane-parallel slab. An algebraic formula relating these functions to the usual reflection function is also presented, together with the appropriate generalization of the Chandrasekhar H-equations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casti J

更新日期：1975-03-01 00:00:00

abstract：:We have postulated that the toxic neuropathies associated with neurofilament-filled axonal swellings have a common pathogenesis, the covalent crosslinking of neurofilaments during anterograde transport. The newly described gamma-diketone, 3,4-dimethyl-2,5-hexanedione (DMHD), is a more potent analogue of the toxic meta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graham DG,Szakál-Quin G,Priest JW,Anthony DC

更新日期：1984-08-01 00:00:00

abstract：:A new ribonuclease, RNase BN, has been identified and partially purified from a strain of Escherichia coli lacking RNase II and RNase D by using the artificial tRNA precursor tRNA-C-[14C]U as substrate. This enzyme is present in E. coli B but absent from the tRNA processing mutant strain BN which is unable to process ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asha PK,Blouin RT,Zaniewski R,Deutscher MP

更新日期：1983-06-01 00:00:00

abstract：:We have isolated a cold-sensitive mutant of Saccharomyces cerevisiae in which there is a deficit of 60S ribosomal subunits. Cold sensitivity and the assembly defect are recessive and cosegregate, defining a single essential gene that we designated DRS1 (deficiency of ribosomal subunits). The wild-type DRS1 gene was cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ripmaster TL,Vaughn GP,Woolford JL Jr

更新日期：1992-12-01 00:00:00

abstract：:Depolarization of isolated nerve terminals (synaptosomes) has been shown to stimulate neurotransmitter release and to increase the phosphorylation state of a number of proteins, including synapsin I, in a Ca2+-dependent manner. Synapsin I, a prominent nerve terminal phosphoprotein, interacts with the cytoplasmic surfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sihra TS,Wang JK,Gorelick FS,Greengard P

更新日期：1989-10-01 00:00:00

abstract：:The interaction of homogeneous preparations of mouse submandibular gland nerve growth factor (NGF) with the classical complement pathway was studied. NGF was found to be capable of carrying out the enzyme activities of the first component (C1-) of the classical complement pathway (i.e., the cleavage of zymogen C4 and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyle MD,Young M

更新日期：1982-04-01 00:00:00

abstract：:A volcanic catastrophe even more devastating than the famous anno Domini 79 Pompeii eruption occurred during the Old Bronze Age at Vesuvius. The 3780-yr-B.P. Avellino plinian eruption produced an early violent pumice fallout and a late pyroclastic surge sequence that covered the volcano surroundings as far as 25 km aw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mastrolorenzo G,Petrone P,Pappalardo L,Sheridan MF

更新日期：2006-03-21 00:00:00

abstract：:Escherichia coli peptide chain release factors are proteins that direct the termination of translation in response to specific peptide chain termination codons. The mechanisms of codon recognition and peptidyl-tRNA hydrolysis are unknown. We have characterized the genes encoding release factor 1 (RF-1) and release fac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Craigen WJ,Cook RG,Tate WP,Caskey CT

更新日期：1985-06-01 00:00:00

abstract：:A pentapeptide open reading frame equipped with a canonical ribosome-binding site is present in the Escherichia coli 23S rRNA. Overexpression of 23S rRNA fragments containing the mini-gene renders cells resistant to the ribosome-inhibiting antibiotic erythromycin. Mutations that change either the initiator or stop cod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tenson T,DeBlasio A,Mankin A

更新日期：1996-05-28 00:00:00

abstract：:Scattering of light from dielectric particles whose size is on the order of an optical wavelength underlies a plethora of visual phenomena in nature and is a foundation for optical coatings and paints. Tailoring the internal nanoscale geometry of such "photonic particles" allows tuning their optical scattering charact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao G,Kaufman JJ,Shabahang S,Rezvani Naraghi R,Sukhov SV,Joannopoulos JD,Fink Y,Dogariu A,Abouraddy AF

更新日期：2016-06-21 00:00:00

abstract：:Purified human platelet-derived growth factor (PDGF) induces an increase in amino acid uptake via system A in quiescent human diploid fibroblasts. Cells must be exposed to PDGF for 45 min to obtain maximum transport stimulation. Transport stimulation requires protein synthesis. Transient exposure to PDGF, alone, in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AJ 3rd,Geyer RP,Antoniades HN

更新日期：1982-05-01 00:00:00

abstract：:A cyclophilin (CyP) purified to homogeneity from the polycentric anaerobic rumen fungus Orpinomyces sp. strain PC-2 had a molecular mass of 20.5 kDa and a pI of 8.1. The protein catalyzed the isomerization of the prolyl peptide bond of N-succinyl-Ala-Ala-(cis,trans)-Pro-Phe p-nitroanilide with a kcat/Km value of 9.3 x...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen H,Li XL,Ljungdahl LG

更新日期：1995-03-28 00:00:00

abstract：:Some dinosaurs reached masses that were approximately 8 times those of the largest, ecologically equivalent terrestrial mammals. The factors most responsible for setting the maximal body size of vertebrates are resource quality and quantity, as modified by the mobility of the consumer, and the vertebrate's rate of ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNab BK

更新日期：2009-07-21 00:00:00

abstract：:Depression, the most prevalent mental illness, is underdiagnosed and undertreated, highlighting the need to extend the scope of current screening methods. Here, we use language from Facebook posts of consenting individuals to predict depression recorded in electronic medical records. We accessed the history of Faceboo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eichstaedt JC,Smith RJ,Merchant RM,Ungar LH,Crutchley P,Preoţiuc-Pietro D,Asch DA,Schwartz HA

更新日期：2018-10-30 00:00:00

abstract：:Left ventricular remodeling that occurs after myocardial infarction (MI) and pressure overload is generally accepted as a determinant of the clinical course of heart failure. The molecular mechanism of this process, however, remains to be elucidated. Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi O,Higuchi Y,Hirotani S,Kashiwase K,Nakayama H,Hikoso S,Takeda T,Watanabe T,Asahi M,Taniike M,Matsumura Y,Tsujimoto I,Hongo K,Kusakari Y,Kurihara S,Nishida K,Ichijo H,Hori M,Otsu K

更新日期：2003-12-23 00:00:00

abstract：:For an excitable cell to function properly, a precise number of ion channel proteins need to be trafficked to distinct locations on the cell surface membrane, through a network and anchoring activity of cytoskeletal proteins. Not surprisingly, mutations in anchoring proteins have profound effects on membrane excitabil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rafizadeh S,Zhang Z,Woltz RL,Kim HJ,Myers RE,Lu L,Tuteja D,Singapuri A,Bigdeli AA,Harchache SB,Knowlton AA,Yarov-Yarovoy V,Yamoah EN,Chiamvimonvat N

更新日期：2014-07-08 00:00:00

abstract：:In cat retina, antisera directed against tyrosine hydroxylase (tyrosine 3-monooxygenase; EC 1.14.16.2) labeled three morphologically distinct classes of neurons; amacrine cells, displaced amacrine cells, and interplexiform cells. These three cell populations differed not only in their morphologies but also in their nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oyster CW,Takahashi ES,Cilluffo M,Brecha NC

更新日期：1985-09-01 00:00:00

abstract：:We used cryo-electron tomography in conjunction with single-particle averaging techniques to study the structures of frozen-hydrated envelope glycoprotein (Env) complexes on intact Moloney murine leukemia retrovirus particles. Cryo-electron tomography allows 3D imaging of viruses in toto at a resolution sufficient to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Förster F,Medalia O,Zauberman N,Baumeister W,Fass D

更新日期：2005-03-29 00:00:00

abstract：:A key energy-saving adaptation to chronic hypoxia that enables cardiomyocytes to withstand severe ischemic insults is hibernation, i.e., a reversible arrest of contractile function. Whereas hibernating cardiomyocytes represent the critical reserve of dysfunctional cells that can be potentially rescued, a lack of a sui...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： May D,Gilon D,Djonov V,Itin A,Lazarus A,Gordon O,Rosenberger C,Keshet E

更新日期：2008-01-08 00:00:00

abstract：:Across the Upper Missouri River Basin, the recent drought of 2000 to 2010, known as the "turn-of-the-century drought," was likely more severe than any in the instrumental record including the Dust Bowl drought. However, until now, adequate proxy records needed to better understand this event with regard to long-term v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin JT,Pederson GT,Woodhouse CA,Cook ER,McCabe GJ,Anchukaitis KJ,Wise EK,Erger PJ,Dolan L,McGuire M,Gangopadhyay S,Chase KJ,Littell JS,Gray ST,St George S,Friedman JM,Sauchyn DJ,St-Jacques JM,King J

更新日期：2020-05-26 00:00:00

abstract：:The mammalian form of the protozoan parasite Leishmania mexicana contains high activity of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb). Homozygous null mutants for lmcpb have been produced by targeted gene disruption. All life-cycle stages of the mutant can be cultured in vitro, demonst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mottram JC,Souza AE,Hutchison JE,Carter R,Frame MJ,Coombs GH

更新日期：1996-06-11 00:00:00

abstract：:The rapid induction of type I IFN is a central event of the innate defense against viral infections and is tightly regulated by a number of cellular molecules. Viral components induce strong type I IFN responses through the activation of toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as an RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arimoto K,Funami K,Saeki Y,Tanaka K,Okawa K,Takeuchi O,Akira S,Murakami Y,Shimotohno K

更新日期：2010-09-07 00:00:00

abstract：:A mouse cDNA clone has been isolated that contains the complete coding region of a protein highly homologous to the delta subunit of the Torpedo acetylcholine receptor (AcChoR). The cDNA library was constructed in the vector lambda 10 from membrane-associated poly(A)+ RNA from BC3H-1 mouse cells. Surprisingly, the del...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaPolla RJ,Mayne KM,Davidson N

更新日期：1984-12-01 00:00:00

abstract：:Single-molecule methods have given experimental access to the mechanical properties of single protein molecules. So far, access has been limited to mostly one spatial direction of force application. Here, we report single-molecule experiments that explore the mechanical properties of a folded protein structure in prec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietz H,Berkemeier F,Bertz M,Rief M

更新日期：2006-08-22 00:00:00

abstract：:The generation of diverse neuronal types and subtypes from multipotent progenitors during development is crucial for assembling functional neural circuits in the adult central nervous system. During mouse retinogenesis, early retinal progenitors give rise to several cell types, including ganglion, amacrine, horizontal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo H,Jin K,Xie Z,Qiu F,Li S,Zou M,Cai L,Hozumi K,Shima DT,Xiang M

更新日期：2012-02-28 00:00:00