Modeling the cell division cycle: cdc2 and cyclin interactions.

abstract：:The chief impediment to the precise biochemical identification of transfer factor and its mechanism of action has been the lack of a reproducible in vitro assay. We now report on a method by which dialysates containing transfer factor of proven in vivo potency can convert nonimmune lymphocytes to immune responsiveness...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ascher MS,Schneider WJ,Valentine FT,Lawrence HS

更新日期：1974-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that requires preexisiting epithelial injury to cause acute infections. We report that P. aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T (ExoT)-dependent manner. ExoT is a bifunctional type III secretion system effector protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shafikhani SH,Engel J

更新日期：2006-10-17 00:00:00

abstract：:The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as a REV-ERBα-interacting protein. By shielding cytoplasmic OGT from proteasoma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berthier A,Vinod M,Porez G,Steenackers A,Alexandre J,Yamakawa N,Gheeraert C,Ploton M,Maréchal X,Dubois-Chevalier J,Hovasse A,Schaeffer-Reiss C,Cianférani S,Rolando C,Bray F,Duez H,Eeckhoute J,Lefebvre T,Staels B,Lef

更新日期：2018-11-20 00:00:00

abstract：:Biological diversity reflects an underlying molecular diversity. The molecules found in nature may be regarded as solutions to challenges that have been confronted and overcome during molecular evolution. As our understanding of these solutions deepens, the efficiency with which we can discover and/or design new treat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caporale LH

更新日期：1995-01-03 00:00:00

abstract：:A system for studying Z-DNA formation in the Escherichia coli chromosome was developed. Prior investigations in recombinant plasmids showed that alternating (Pur-Pyr) sequences can adopt a left-handed Z-DNA conformation both in vitro and in vivo. We constructed mobile, transposon-based cassettes carrying cloned (Pur-P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lukomski S,Wells RD

更新日期：1994-10-11 00:00:00

abstract：:Viruses are obligatory intracellular parasites that suffer strong evolutionary pressure from the host immune system. Rapidly evolving viral genomes can adapt to this pressure by acquiring genes that counteract host defense mechanisms. For example, many vertebrate DNA viruses have hijacked cellular genes encoding cytok...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamiable O,Kellenberger C,Kemp C,Troxler L,Pelte N,Boutros M,Marques JT,Daeffler L,Hoffmann JA,Roussel A,Imler JL

更新日期：2016-01-19 00:00:00

abstract：:Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kessler RJ,Vande Zande H,Tyson CA,Blondin GA,Fairfield J,Glasser P,Green DE

更新日期：1977-06-01 00:00:00

abstract：:Statistically significant declines in chronic disability prevalence rates were observed in the elderly United States population between the 1982 and 1989 National Long Term Care Surveys (NLTCS). The 1994 NLTCS was used to investigate whether disability rate declines continued to 1994. The 1982, 1984, 1989, and 1994 NL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manton KG,Corder L,Stallard E

更新日期：1997-03-18 00:00:00

abstract：:Rhythmic, spontaneously pulsating cardiac cells cultured from newborn rats are immediately stimulated to beat faster by addition of a number of tubulin-binding agents but not by their non-tubulin-binding analogues. The tubulin-binding agents tested include vinblastine, vincristine, navelbine, two analogs of vinblastin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampidis TJ,Kolonias D,Savaraj N,Rubin RW

更新日期：1992-02-15 00:00:00

abstract：:O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associated with neurodegenerative diseases such as α-synuclein, amyloid precursor protein, and tau. Deletion of the O-GlcNAc transferase (ogt) gene responsible for the modification causes early postnata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang AC,Jensen EH,Rexach JE,Vinters HV,Hsieh-Wilson LC

更新日期：2016-12-27 00:00:00

abstract：:The neuropeptide galanin is expressed developmentally in the dorsal root ganglion (DRG) and is rapidly up-regulated 120-fold after peripheral nerve section in the adult. Here we report that adult mice carrying a loss-of-function mutation in the galanin gene have a 13% reduction in the number of cells in the DRG associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes FE,Mahoney S,King VR,Bacon A,Kerr NC,Pachnis V,Curtis R,Priestley JV,Wynick D

更新日期：2000-10-10 00:00:00

abstract：:Most higher eukaryotic tubulins are separated into alpha- and beta-tubulin when electrophoresed in NaDodSO4- denaturing gels, while many lower eukaryotic tubulins are poorly resolved under these conditions, which include a stacking gel (pH 6.80) and a separating gel (pH 8.80). By lowering the pH of the separating gel ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suprenant KA,Hays E,LeCluyse E,Dentler WL

更新日期：1985-10-01 00:00:00

abstract：:In humans, spontaneous movements are often preceded by early brain signals. One such signal is the readiness potential (RP) that gradually arises within the last second preceding a movement. An important question is whether people are able to cancel movements after the elicitation of such RPs, and if so until which po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultze-Kraft M,Birman D,Rusconi M,Allefeld C,Görgen K,Dähne S,Blankertz B,Haynes JD

更新日期：2016-01-26 00:00:00

abstract：:Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however, the mechanism through which epigenetic regulation modulates intestinal epithelial integrity remains largely undefined. Here we show that EZH2, the catalytic subunit of polycomb repressive complex (PRC2), is indispensable for m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Peng J,Sun T,Li N,Zhang L,Ren J,Yuan H,Kan S,Pan Q,Li X,Ding Y,Jiang M,Cong X,Tan M,Ma Y,Fu D,Cai S,Xiao Y,Wang X,Qin J

更新日期：2017-05-09 00:00:00

abstract：:Titania, which exhibits superwetting under light illumination, has been widely used as an ideal material for environmental solution such as self-cleaning, water-air purification, and antifogging. There have been various studies to understand such superhydrophilic conversion. The origin of superwetting has not been cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee K,Kim Q,An S,An J,Kim J,Kim B,Jhe W

更新日期：2014-04-22 00:00:00

abstract：:Triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1) deficiency is a recessive disorder that results in hemolytic anemia and neuromuscular dysfunction. To determine the molecular basis of this disorder, a TPI allele from two unrelated patients homozygous for TPI deficiency was com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daar IO,Artymiuk PJ,Phillips DC,Maquat LE

更新日期：1986-10-01 00:00:00

abstract：:Modern protein crystal structures are based nearly exclusively on X-ray data collected at cryogenic temperatures (generally 100 K). The cooling process is thought to introduce little bias in the functional interpretation of structural results, because cryogenic temperatures minimally perturb the overall protein backbo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraser JS,van den Bedem H,Samelson AJ,Lang PT,Holton JM,Echols N,Alber T

更新日期：2011-09-27 00:00:00

abstract：:As the rate and magnitude of climate change accelerate, understanding the consequences becomes increasingly important. Species distribution models (SDMs) based on current ecological niche constraints are used to project future species distributions. These models contain assumptions that add to the uncertainty in model...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiens JA,Stralberg D,Jongsomjit D,Howell CA,Snyder MA

更新日期：2009-11-17 00:00:00

abstract：:In rod photoreceptors, several phototransduction components display light-dependent translocation between cellular compartments. Notably, the G protein transducin translocates from rod outer segments to inner segments/spherules in bright light, but the functional consequences of translocation remain unclear. We genera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majumder A,Pahlberg J,Boyd KK,Kerov V,Kolandaivelu S,Ramamurthy V,Sampath AP,Artemyev NO

更新日期：2013-07-23 00:00:00

abstract：:Using a water-based prebiotic model of sugar synthesis involving glycolaldehyde self-condensation, we demonstrate that homochiral L-dipeptide catalysts lead to the stereospecific syntheses of tetroses. The asymmetric effect is largest for erythrose, which may reach a D-enantiomeric excess of >80% with L-Val-L-Val cata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber AL,Pizzarello S

更新日期：2006-08-22 00:00:00

abstract：:Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories requires de novo protein synthesis. However, inhibition of protein synthesis might disrupt other neural functions to interfere with memory formation. Intraamygda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canal CE,Chang Q,Gold PE

更新日期：2007-07-24 00:00:00

abstract：:Container-shaped molecules provide structured environments that impart geometric bounds on the motions and conformations of smaller molecular occupants. Moreover, they provide "solvation" that is constrained in time and space. When inwardly directed functional groups are present, they can interact chemically with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purse BW,Rebek J Jr

更新日期：2005-08-02 00:00:00

abstract：:VEGF and angiopoietin-1 (Ang1) are two major angiogenic factors being investigated for the treatment of myocardial infarction (MI). Targeting VEGF and Ang1 expression in the ischemic myocardium can increase their local therapeutic effects and reduce possible adverse effects. Adeno-associated viral vectors (AAVs) expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao Z,Chen B,Tan X,Zhao Y,Wang L,Zhu T,Cao K,Yang Z,Kan YW,Su H

更新日期：2011-02-01 00:00:00

abstract：:Memory stretches over a lifetime. In controlled laboratory settings, the hippocampus and other medial temporal lobe brain structures have been shown to represent space and time on the scale of meters and seconds. It remains unclear whether the hippocampus also represents space and time over the longer scales necessary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nielson DM,Smith TA,Sreekumar V,Dennis S,Sederberg PB

更新日期：2015-09-01 00:00:00

abstract：:Many empirical studies throughout the social and biomedical sciences focus only on very narrow outcomes such as income, or a single specific disease state, or a measure of positive affect. Human well-being or flourishing, however, consists in a much broader range of states and outcomes, certainly including mental and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： VanderWeele TJ

更新日期：2017-08-01 00:00:00

abstract：:High magnetic fields have revealed a surprisingly small Fermi surface in underdoped cuprates, possibly resulting from Fermi-surface reconstruction due to an order parameter that breaks translational symmetry of the crystal lattice. A crucial issue concerns the doping extent of such a state and its relationship to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan MK,McDonald RD,Ramshaw BJ,Betts JB,Shekhter A,Bauer ED,Harrison N

更新日期：2020-05-05 00:00:00

abstract：:We recently found that many residues in enzyme active sites can be computationally predicted by the optimization of scoring functions based on substrate binding affinity, subject to constraints on the geometry of catalytic residues and protein stability. Here, we explore the generality of this surprising observation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakrabarti R,Klibanov AM,Friesner RA

更新日期：2005-08-23 00:00:00

abstract：:In this paper I review the ways in which the glassy state is obtained both in nature and in materials science and highlight a "new twist"--the recent recognition of polymorphism within the glassy state. The formation of glass by continuous cooling (viscous slowdown) is then examined, the strong/fragile liquids classif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angell CA

更新日期：1995-07-18 00:00:00

abstract：:Electron micrographs of replicating lambda DNA molecules, during the period of progeny-particle DNA formation, show single-tailed circular structures. The tails are, predominantly, shorter than one viral genome. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiger JA Jr,Sinsheimer RL

更新日期：1971-01-01 00:00:00

abstract：:Microprocessor [Drosha-DGCR8 (DiGeorge syndrome critical region gene 8) complex] processing of primary microRNA (pri-miRNA) is the critical first step in miRNA biogenesis, but how the Drosha cleavage site is determined has been unclear. Previous models proposed that the Drosha-DGCR8 complex measures either ~22 nt from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma H,Wu Y,Choi JG,Wu H

更新日期：2013-12-17 00:00:00