Uncouplers and the molecular mechanism of uncoupling in mitochondria.

Abstract:

:Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The molecular mechanism of uncoupling sheds strong light on the mechanism of coupling.

authors

Kessler RJ,Vande Zande H,Tyson CA,Blondin GA,Fairfield J,Glasser P,Green DE

doi

10.1073/pnas.74.6.2241

keywords:

subject

Has Abstract

pub_date

1977-06-01 00:00:00

pages

2241-5

issue

6

eissn

0027-8424

issn

1091-6490

journal_volume

74

pub_type

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