Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.

abstract：:Functionally differentiated chicken macrophages were derived by in vitro differentiation of embryonic yolk sac cells and were characterized by several macrophage-specific cell markers. Uniform, infected, virus-producing cultures were obtained after exposure of these macrophages to avian myoblastosis virus (AMV), avian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durban EM,Boettiger D

更新日期：1981-06-01 00:00:00

abstract：:The recent cloning of a second member of the nerve growth factor family, brain-derived neurotrophic factor (BDNF), has prompted investigation into the cells that express this factor's mRNA and protein. In the present study, antibodies raised against unique peptide sequences within the porcine BDNF protein detect BDNF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wetmore C,Cao YH,Pettersson RF,Olson L

更新日期：1991-11-01 00:00:00

abstract：:Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor, important to vessel devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellstrom A,Perruzzi C,Ju M,Engstrom E,Hard AL,Liu JL,Albertsson-Wikland K,Carlsson B,Niklasson A,Sjodell L,LeRoith D,Senger DR,Smith LE

更新日期：2001-05-08 00:00:00

abstract：:The abelian sandpile is a cellular automaton which serves as the archetypical model to study self-organized criticality, a phenomenon occurring in various biological, physical, and social processes. Its recurrent configurations form an abelian group, whose identity is a fractal composed of self-similar patches. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lang M,Shkolnikov M

更新日期：2019-02-19 00:00:00

abstract：:beta-catenin has functions as both an adhesion and a signaling molecule. Disruption of these functions through mutations of the beta-catenin gene (CTNNB1) may be important in the development of colorectal tumors. We examined the entire coding sequence of beta-catenin by reverse transcriptase-PCR (RT-PCR) and direct se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ilyas M,Tomlinson IP,Rowan A,Pignatelli M,Bodmer WF

更新日期：1997-09-16 00:00:00

abstract：:Unlike normal cells, malignant rat and two simian virus 40-transformed human cell lines can neither grow nor survive in B12-and folate-supplemented media in which methionine is replaced by homocysteine. Yet three lines of evidence indicate that the malignant and transformed cells synthesize large amounts of methionine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman RM,Erbe RW

更新日期：1976-05-01 00:00:00

abstract：:Initiation of bovine papillomavirus (BPV) DNA synthesis in vivo and in vitro depends on the interaction of the viral initiator protein E1 with the replication origin (ori+ DNA). The viral E2 protein assists this interaction, resulting in a cooperative assembly of both proteins on the replication origin. Using gel mobi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lusky M,Hurwitz J,Seo YS

更新日期：1994-09-13 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of abundant desmoplastic stroma primarily composed of cancer-associated fibroblasts (CAFs). It is generally accepted that CAFs stimulate tumor progression and might be implicated in drug resistance and immunosuppression. Here, we have compared th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Djurec M,Graña O,Lee A,Troulé K,Espinet E,Cabras L,Navas C,Blasco MT,Martín-Díaz L,Burdiel M,Li J,Liu Z,Vallespinós M,Sanchez-Bueno F,Sprick MR,Trumpp A,Sainz B Jr,Al-Shahrour F,Rabadan R,Guerra C,Barbacid M

更新日期：2018-02-06 00:00:00

abstract：:The biological function of the soluble form of the amyloid beta-protein (ABP) was examined by assaying its interaction with neuronal receptors expressed in Xenopus oocytes. ABP weakly activated tachykinin receptors, but in the presence of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4- propionate-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura H,Schubert D

更新日期：1993-08-15 00:00:00

abstract：:Vitamin A signals play critical roles during embryonic development. In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor alpha (RXRalpha), as the systemic mutation of this receptor results in thinning of the myocardium and embryonic lethality. However, the molecular and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merki E,Zamora M,Raya A,Kawakami Y,Wang J,Zhang X,Burch J,Kubalak SW,Kaliman P,Izpisua Belmonte JC,Chien KR,Ruiz-Lozano P

更新日期：2005-12-20 00:00:00

abstract：:The avian predentary is a small skeletal structure located rostral to the paired dentaries found only in Mesozoic ornithuromorphs. The evolution and function of this enigmatic element is unknown. Skeletal tissues forming the predentary and the lower jaws in the basal ornithuromorph Yanornis martini are identified usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailleul AM,Li Z,O'Connor J,Zhou Z

更新日期：2019-12-03 00:00:00

abstract：:On April 20, 2010, the Deepwater Horizon (DWH) blowout occurred, releasing more oil than any accidental spill in history. Oil release continued for 87 d and much of the oil and gas remained in, or returned to, the deep sea. A coral community significantly impacted by the spill was discovered in late 2010 at 1,370 m de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisher CR,Hsing PY,Kaiser CL,Yoerger DR,Roberts HH,Shedd WW,Cordes EE,Shank TM,Berlet SP,Saunders MG,Larcom EA,Brooks JM

更新日期：2014-08-12 00:00:00

abstract：:An essential step in the pathogenesis of human papillomavirus (HPV)-associated cancers is the dysregulated expression of the viral oncogenes. The papillomavirus E2 protein can silence the long control region (LCR) promoter that controls viral E6 and E7 oncogene expression. The mechanisms by which E2 represses oncogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith JA,White EA,Sowa ME,Powell ML,Ottinger M,Harper JW,Howley PM

更新日期：2010-02-23 00:00:00

abstract：:Two functional domains in the primary structure of basic fibroblast growth factor (FGF) have been identified on the basis of their ability to interact with the FGF receptor, bind radiolabeled heparin, and modulate the cellular response to FGF. Peptides derived from these two functional domains can act as partial agoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Schubert D,Ling N,Guillemin R

更新日期：1988-04-01 00:00:00

abstract：:The receptor-like tyrosine kinase (Ryk), a Wnt receptor, is important for cell fate determination during corticogenesis. During neuronal differentiation, the Ryk intracellular domain (ICD) is cleaved. Cleavage of Ryk and nuclear translocation of Ryk-ICD are required for neuronal differentiation. However, the mechanism...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang WH,Choi SH,Moon BS,Cai M,Lyu J,Bai J,Gao F,Hajjali I,Zhao Z,Campbell DB,Weiner LP,Lu W

更新日期：2017-12-12 00:00:00

abstract：:Certain cognitive functions differ in men and women, although the anatomical and functional substrates underlying these differences remain unknown. Because neocortical activity is directly related with higher brain function, numerous studies have focused on the cerebral cortex when searching for possible structural co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alonso-Nanclares L,Gonzalez-Soriano J,Rodriguez JR,DeFelipe J

更新日期：2008-09-23 00:00:00

abstract：:Relatively little is known about the biochemical mechanisms through which the Epstein-Barr virus latent infection integral membrane protein 1 (LMP1) transmembrane domains cause constitutive LMP1 aggregation and continuous cytoplasmic C terminus-mediated signal transduction. We now evaluate the role of the three consec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Luftig M,Soni V,Kieff E

更新日期：2004-01-06 00:00:00

abstract：:Retrograde axonal transport plays an important role in the maintenance of neuronal functions, but the mechanism is poorly defined partly because the constituents of the retrograde transport system and their interactions have yet to be elucidated. Of special interest is how dynein/dynactin motor proteins interact with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu JJ,Ding J,Wu C,Bhagavatula P,Cui B,Chu S,Mobley WC,Yang Y

更新日期：2007-02-13 00:00:00

abstract：:Peroxisome proliferators cause rapid and coordinated transcriptional activation of genes encoding peroxisomal beta-oxidation system enzymes by activating peroxisome proliferator-activated receptor (PPAR) isoform(s). Since the thyroid hormone (T3; 3,3',5-triiodothyronine) receptor (TR), another member of the nuclear ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu R,Madison LD,Lin Y,Kopp P,Rao MS,Jameson JL,Reddy JK

更新日期：1995-12-05 00:00:00

abstract：:Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion within the huntingtin gene that encodes a polymorphic glutamine tract at the amino terminus of the huntingtin protein. HD is one of nine polyglutamine expansion diseases. The clinical threshold of polyglutamine expansion for HD is near 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caron NS,Desmond CR,Xia J,Truant R

更新日期：2013-09-03 00:00:00

abstract：:Germinal centers (GCs) are specialized microenvironments in secondary lymphoid organs where high-affinity antibody-producing B cells are selected based on B-cell antigen receptor (BCR) signal strength. BCR signaling required for normal GC selection is uncertain. We have found that protein kinase N1 (PKN1, also known a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Sakakibara-Yada K,Nishimura T,Morita K,Tada S,Mosialos G,Kieff E,Kikutani H

更新日期：2012-12-18 00:00:00

abstract：:Pheromone biosynthesis-activating neuropeptide (PBAN) regulates sex pheromone biosynthesis in female Helicoverpa (Heliothis) zea. Two oligonucleotide probes representing two overlapping amino acid regions of PBAN were used to screen 2.5 x 10(5) recombinant plaques, and a positive recombinant clone was isolated. Sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MT,Vakharia VN,Henry J,Kempe TG,Raina AK

更新日期：1992-01-01 00:00:00

abstract：:Atomic level characterization of proteins and other macromolecules in the living cell is challenging. Recent advances in NMR instrumentation and methods, however, have enabled in-cell studies with prospects for multidimensional spectral characterization of individual macromolecular components. We present NMR data on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustus AM,Reardon PN,Spicer LD

更新日期：2009-03-31 00:00:00

abstract：:In the absence of lasers approaching trapped ion clock transitions in sharpness we propose to replace the 12.49 m laser field exciting the D3/2-D5/2 transition of the single Ba+ ion A in D3/2 with the near-field of a close by identical ion B in the excited D5/2 state. We tune the frequency of the near-field by the dif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dehmelt H,Zhao X,Yu N,Nagourney W

更新日期：1996-07-09 00:00:00

abstract：:The molecular weight of the major glycoprotein from the human erythrocyte membrane is 29,000, of which 55% is carbohydrate and 45% is protein. The binding of sodium dodecyl sulfate to this glycoprotein is anomalous when compared to water soluble proteins and leads to migration rates in sodium dodecyl sulfate-polyacryl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grefrath SP,Reynolds JA

更新日期：1974-10-01 00:00:00

abstract：:The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of Saccharomyces cerevisiae short Mgm1 (s-Mgm1) in complex with GDP. It revealed an N-terminal GTPase (G) do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan L,Qi Y,Ricketson D,Li L,Subramanian K,Zhao J,Yu C,Wu L,Sarsam R,Wong M,Lou Z,Rao Z,Nunnari J,Hu J

更新日期：2020-02-25 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family has recently expanded by the identification and cloning of three additional members, namely VEGF-B, VEGF-C, and VEGF-D. In this study we demonstrate that VEGF-B binds selectively to VEGF receptor-1/Flt-1. This binding can be blocked by excess VEGF, indicating that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olofsson B,Korpelainen E,Pepper MS,Mandriota SJ,Aase K,Kumar V,Gunji Y,Jeltsch MM,Shibuya M,Alitalo K,Eriksson U

更新日期：1998-09-29 00:00:00

abstract：:The ion transport properties of the rough endoplasmic reticulum (RER) from liver have been defined by using measurements of active and potential gradient-driven transport. The Ca2+ pump is shown to be electrogenic, and both ATP and potential difference is able to drive vanadate-inhibitable Ca2+ uptake into the RER. AT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muallem S,Schoeffield M,Pandol S,Sachs G

更新日期：1985-07-01 00:00:00

abstract：:Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have shown that WNK4 modulates the activity of the renal Na(+)Cl(-) cotransporter, NCC. Because the renal consequences of WNK4 carrying pseudoa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castañeda-Bueno M,Cervantes-Pérez LG,Vázquez N,Uribe N,Kantesaria S,Morla L,Bobadilla NA,Doucet A,Alessi DR,Gamba G

更新日期：2012-05-15 00:00:00

abstract：:Non-protein-coding RNA genes play an important role in various biological processes. How new RNA genes originated and whether this process is controlled by similar evolutionary mechanisms for the origin of protein-coding genes remains unclear. A young chimeric RNA gene that we term sphinx (spx) provides the first insi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Brunet FG,Nevo E,Long M

更新日期：2002-04-02 00:00:00