Abstract:
:B-1a cells reside in both the peritoneal cavity and the spleen. LPS stimulates splenic B-1a to differentiate to plasma cells producing natural IgM specific for microbial and self antigens. However, there are conflicting views as to whether the B-1a cells divide before this differentiation occurs, and hence how the resident B-1a population is maintained in the spleen. Studies here resolve this dispute in favor of both sides: we show that (some or all) B-1a cells resident in the spleen respond to LPS by differentiating to plasma cells immediately, without dividing; however, we also show that additional B-1a cells immigrate into the spleen after LPS stimulation and divide at least once before differentiating. Importantly, the studies we presently describe reveal the complex cell migration and differentiation events that collectively underlie the rapid production of natural antibodies in response to in vivo LPS stimulation. Thus, the studies present a different view of the roles that B-1a cells play in the early phases of the innate immune response.
journal_name
Proc Natl Acad Sci U S Aauthors
Yang Y,Tung JW,Ghosn EE,Herzenberg LA,Herzenberg LAdoi
10.1073/pnas.0700001104subject
Has Abstractpub_date
2007-03-13 00:00:00pages
4542-6issue
11eissn
0027-8424issn
1091-6490pii
0700001104journal_volume
104pub_type
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