The oldest modern therian mammal from Europe and its bearing on stem marsupial paleobiogeography.

abstract：:The specific ornithine decarboxylase inhibitor alpha-difluoromethylornithine, when given to adult rats in vivo for 5 wk, resulted in a decrease in peripheral blood cell elements in normal rats and a marked suppression of marrow recovery in rats with chemotherapy-induced marrow hypoplasia. In normal rats, alpha-difluor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luk GD,Sharkis SJ,Abeloff MD,McCann PP,Sjoerdsma A,Baylin SB

更新日期：1983-08-01 00:00:00

abstract：:Melittin messenger RNA from queen bee venom glands has been translated in a cell-free system from wheat germ. A product larger than promelittin is formed which has the carboxy-terminal sequence-Gln-Gln-GlyCOOH. Melittin and promelittin from venom glands terminate in -Gln-GlnCONH2. The possible role of the extra glycin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suchanek G,Kreil G

更新日期：1977-03-01 00:00:00

abstract：:Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant viruses that had acquired the characteristic 184-Ile mutation in their RT in addition to the NNRTI-specific mutations. Conve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balzarini J,Pelemans H,Karlsson A,De ClercQ E,Kleim JP

更新日期：1996-11-12 00:00:00

abstract：:The sequence of spontaneous Epstein-Barr virus activation was studied in P3HR-1 carrier cells and in P3HR-1(BrdU) cells made resistant to 5-bromodeoxyuridine. Virus activation was initiated during the normal cell cycle, and recruitment of additional virus-activated cells was prevented by the DNA inhibitors, 1-beta-D-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampar B,Derge JG,Martos LM,Tagamets MA,Burroughs MA

更新日期：1972-09-01 00:00:00

abstract：:Mutations in superoxide dismutase 1 (SOD1) cause familial ALS. Mutant SOD1 preferentially associates with the cytoplasmic face of mitochondria from spinal cords of rats and mice expressing SOD1 mutations. Two-dimensional gels and multidimensional liquid chromatography, in combination with tandem mass spectrometry, rev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Q,Vande Velde C,Israelson A,Xie J,Bailey AO,Dong MQ,Chun SJ,Roy T,Winer L,Yates JR,Capaldi RA,Cleveland DW,Miller TM

更新日期：2010-12-07 00:00:00

abstract：:A mitochondrial ribosome with an approximate sedimentation coefficient of 60 S has been isolated from the ovary of the South African clawed toad, Xenopus laevis. This ribosome is active in a submitochondrial protein-synthesizing system. It contains two species of RNA, designated as "21S" and 13S RNA, which have sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson RF,Dawid IB

更新日期：1970-05-01 00:00:00

abstract：:The genomic RNA of the avian influenza A virus, fowl plague, was fractionated into eight species by electrophoresis in polyacrylamide-agarose gels containing 6 M urea. The separated 32P-labeled RNA species were characterized by digestion with RNase T1 and fractionation of the resulting oligonucleotides by two-dimensio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGeoch D,Fellner P,Newton C

更新日期：1976-09-01 00:00:00

abstract：:The techniques of electrophoresis were used in a search for evidence of mutation affecting protein structure, the indicators being hemoglobin and a set of serum proteins and erythrocyte enzymes. Among 94,796 locus tests on Amerindians from Central and South America, there was no evidence for mutation. Among 105,649 lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neel JV,Mohrenweiser HW,Meisler MH

更新日期：1980-10-01 00:00:00

abstract：:The neu gene is distantly related to the erbB gene and encodes a cell surface protein that appears to function as a growth factor receptor. To study the mechanisms that caused the conversion of the normal neu gene to an oncogenic allele, we have isolated molecular clones of the neu oncogene as well as a clone of the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hung MC,Schechter AL,Chevray PY,Stern DF,Weinberg RA

更新日期：1986-01-01 00:00:00

abstract：:C1q-like genes (C1ql1-C1ql4) encode small, secreted proteins that are expressed in differential patterns in the brain but whose receptors and functions remain unknown. BAI3 protein, in contrast, is a member of the cell-adhesion class of G protein-coupled receptors that are expressed at high levels in the brain but who...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolliger MF,Martinelli DC,Südhof TC

更新日期：2011-02-08 00:00:00

abstract：:We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates. This delivery system has been found to be very effective for both the internalization and the expression of genetic material in cells that have many transferrin rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Cotten M,Foisner R,Birnstiel ML

更新日期：1991-05-15 00:00:00

abstract：:Despite its theoretical prominence and sound principles, integrated pest management (IPM) continues to suffer from anemic adoption rates in developing countries. To shed light on the reasons, we surveyed the opinions of a large and diverse pool of IPM professionals and practitioners from 96 countries by using structur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parsa S,Morse S,Bonifacio A,Chancellor TC,Condori B,Crespo-Pérez V,Hobbs SL,Kroschel J,Ba MN,Rebaudo F,Sherwood SG,Vanek SJ,Faye E,Herrera MA,Dangles O

更新日期：2014-03-11 00:00:00

abstract：:The mechanisms for plant growth restriction during stress conditions remains unclear. Here, we demonstrate that a phytochrome-interacting factor-like protein, OsPIL1/OsPIL13, acts as a key regulator of reduced internode elongation in rice under drought conditions. The level of OsPIL1 mRNA in rice seedlings grown under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Todaka D,Nakashima K,Maruyama K,Kidokoro S,Osakabe Y,Ito Y,Matsukura S,Fujita Y,Yoshiwara K,Ohme-Takagi M,Kojima M,Sakakibara H,Shinozaki K,Yamaguchi-Shinozaki K

更新日期：2012-09-25 00:00:00

abstract：:Developmental constraint is indicated when one finds that similar genetic mechanisms are responsible for independent origins of the same derived phenotype. We studied three independent origins of rosette flowering within the mustard family and attempted to evaluate the extent to which the same mechanisms were involved...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoon HS,Baum DA

更新日期：2004-04-27 00:00:00

abstract：:Liver fibrosis interferes with normal liver function and facilitates hepatocellular carcinoma (HCC) development, representing a major threat to human health. Here, we present a comprehensive perspective of microRNA (miRNA) function on targeting the fibrotic microenvironment. Starting from a murine HCC model, we identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winkler I,Bitter C,Winkler S,Weichenhan D,Thavamani A,Hengstler JG,Borkham-Kamphorst E,Kohlbacher O,Plass C,Geffers R,Weiskirchen R,Nordheim A

更新日期：2020-01-07 00:00:00

abstract：:Ninety kilobase pairs (kb) of DNA have been isolated from the 3B region of the X chromosome of Drosophila melanogaster. Previous cytogenetic analyses have placed a gene required for rhythmic behavior (per) in this chromosomal interval. Physical characterization of a series of chromosomal rearrangements altering per lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bargiello TA,Young MW

更新日期：1984-04-01 00:00:00

abstract：:E2F is a heterodimeric transcription factor that regulates the expression of genes at the G1/S boundary and is composed of two related but distinct families of proteins, E2F and DP. E2F/DP heterodimers form complexes with the retinoblastoma (Rb) protein, the Rb-related proteins p107 and p130, and cyclins/cdks in a cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KT,Higgins PD,Milla MM,Phillips RS,Horowitz JM

更新日期：1996-07-23 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are IP(3)-gated Ca(2+) channels that are located on intracellular Ca(2+) stores. We previously identified an IP(3)R binding protein, termed IP(3)R binding protein released with IP(3) (IRBIT). Because IRBIT is released from IP(3)R by physiological concentrations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shirakabe K,Priori G,Yamada H,Ando H,Horita S,Fujita T,Fujimoto I,Mizutani A,Seki G,Mikoshiba K

更新日期：2006-06-20 00:00:00

abstract：:A "projection function," P(x,z), is defined as the partial integral of the molecular electron density, rho(x,y,z), over the region -infinity < y < +infinity. The projection provides a three-dimensional representation of molecular electron distributions. Chemically useful information can be discerned from graphical dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streitwieser A,Collins JB,McKelvey JM,Grier D,Sender J,Toczko AG

更新日期：1979-06-01 00:00:00

abstract：:The development of Drosophila organ discs can be arrested by culturing them in adult male flies. These aged discs lose some of their differentiation competence and form incomplete imaginal structures. The more advanced the aging, the greater the loss of competence. Discs made to differentiate prematurely show deficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweizer P,Bodenstein D

更新日期：1975-11-01 00:00:00

abstract：:Lithium-sulfur batteries (Li-S batteries) have attracted intense interest because of their high specific capacity and low cost, although they are still hindered by severe capacity loss upon cycling caused by the soluble lithium polysulfide intermediates. Although many structure innovations at the material and device l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu W,Jiang J,Yang KR,Mi Y,Kumaravadivel P,Zhong Y,Fan Q,Weng Z,Wu Z,Cha JJ,Zhou H,Batista VS,Brudvig GW,Wang H

更新日期：2017-04-04 00:00:00

abstract：:CCAAT/enhancer binding protein (C/EBP) epsilon is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of hematopoietic origin. The human C/EBPepsilon gene is transcribed by two alternative promoters, Palpha and Pbeta. A combination of differential splicing and al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamanaka R,Kim GD,Radomska HS,Lekstrom-Himes J,Smith LT,Antonson P,Tenen DG,Xanthopoulos KG

更新日期：1997-06-10 00:00:00

abstract：:It had long been thought, but never demonstrated, that imino acids are formed in the reactions catalyzed by D- and L-amino acid oxidases (EC 1.4.3.3 and 1.4.3.2). The formation of imino acids is now shown directly by allowing the amino acid oxidase reaction to proceed in the presence of NaBH(4), when the imino acid is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hafner EW,Wellner D

更新日期：1971-05-01 00:00:00

abstract：:Adjacent paraffin sections of rat hypothalami fixed in Bouin's fluid were treated either with buffer or with luteinizing hormone-releasing hormone (LHRH) before immunocytochemical staining with anti-LHRH. Upon buffer pretreatment, pituitary gonadotrophs were unstained and hypothalamic fibers were stained. Upon LHRH pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternberger LA,Greenwald JL,Hock D,Elger K,Forssmann WG

更新日期：1981-08-01 00:00:00

abstract：:The cytokine IFN-γ is a critical regulator of immune system development and function. Almost all leukocytes express the receptor for IFN-γ, yet each cell type elicits a different response to this cytokine. Cell type-specific effects of IFN-γ make it difficult to predict the outcomes of the systemic IFN-γ blockade and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krummel MF,Mahale JN,Uhl LFK,Hardison EA,Mujal AM,Mazet JM,Weber RJ,Gartner ZJ,Gérard A

更新日期：2018-11-06 00:00:00

abstract：:Biomass burning drives changes in greenhouse gases, climate-forcing aerosols, and global atmospheric chemistry. There is controversy about the magnitude and timing of changes in biomass burning emissions on millennial time scales from preindustrial to present and about the relative importance of climate change and hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicewonger MR,Aydin M,Prather MJ,Saltzman ES

更新日期：2018-12-04 00:00:00

abstract：:Agrobacterium tumefaciens is the causal agent of crown gall disease. The bacterium is capable of transferring a segment of single-stranded DNA (ssDNA) into recipient cells during the transformation process, and it has been widely used as a genetic modification tool for plants and nonplant organisms. Transferred DNA (T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Yang Q,Peng L,Tu H,Lee LY,Gelvin SB,Pan SQ

更新日期：2020-10-20 00:00:00

abstract：:To investigate the role of an anchoring pocket in allele-specific peptide presentation by a major histocompatibility complex class I molecule, we "transplanted" a B pocket from HLA-A*0201 into HLA-B*2705 by site-directed mutagenesis. The resulting protein, designated B27.A2B, binds a different set of endogenous peptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colbert RA,Rowland-Jones SL,McMichael AJ,Frelinger JA

更新日期：1993-07-15 00:00:00

abstract：:Overexpression of the receptor tyrosine kinase (RTK) erbB2 (also designated neu or HER2) was implicated in causing a variety of human cancers, including mammary and ovarian carcinomas. Ligand-induced receptor dimerization is critical for stimulation of the intrinsic protein tyrosine kinase (PTK) of RTKs. It was theref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleishman SJ,Schlessinger J,Ben-Tal N

更新日期：2002-12-10 00:00:00

abstract：:Identifying the drivers and processes that determine globally the geographic range size of species is crucial to understanding the geographic distribution of biodiversity and further predicting the response of species to current global changes. However, these drivers and processes are still poorly understood, and no e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvajal-Quintero J,Villalobos F,Oberdorff T,Grenouillet G,Brosse S,Hugueny B,Jézéquel C,Tedesco PA

更新日期：2019-07-02 00:00:00