Aging and its relation to cell growth and differentiation in Drosophila imaginal discs: developmental response to growth restricting conditions.

abstract：:The recent discovery of small molecules targeting the cytochrome bc 1 :aa 3 in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalia NP,Hasenoehrl EJ,Ab Rahman NB,Koh VH,Ang MLT,Sajorda DR,Hards K,Grüber G,Alonso S,Cook GM,Berney M,Pethe K

更新日期：2017-07-11 00:00:00

abstract：:The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesis, translational repression, starvation responses, and ribosome turnover. In the opportunistic pathogen Staphylococcus aureus and most other bacteria, hibernation-promoting factor (HPF) ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu A,Yap MN

更新日期：2017-09-26 00:00:00

abstract：:SapB is a morphogenetic peptide that is important for aerial mycelium formation by the filamentous bacterium Streptomyces coelicolor. Production of SapB commences during aerial mycelium formation and depends on most of the genes known to be required for the morphogenesis of aerial hyphae. Furthermore, the application ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodani S,Hudson ME,Durrant MC,Buttner MJ,Nodwell JR,Willey JM

更新日期：2004-08-03 00:00:00

abstract：:Telomerase is an RNA-directed DNA polymerase, composed of RNA and protein subunits, that replicates the telomere ends of linear eukaryotic chromosomes. Using a genetic strategy described here, we identify the product of the EST2 gene, Est2p, as a subunit of telomerase in the yeast Saccharomyces cerevisiae. Est2p is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Counter CM,Meyerson M,Eaton EN,Weinberg RA

更新日期：1997-08-19 00:00:00

abstract：:MicroRNAs are predicted to regulate approximately 30% of all human genes by targeting sequences in their 3' UTR. Polymorphisms in 3' UTR of several genes have been reported to affect gene expression, but the mechanism is not fully understood. Here, we demonstrate that 829C-->T, a naturally occurring SNP, near the miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mishra PJ,Humeniuk R,Mishra PJ,Longo-Sorbello GS,Banerjee D,Bertino JR

更新日期：2007-08-14 00:00:00

abstract：:An increasing amount of investment has been devoted to protecting and restoring ecosystem services worldwide. The efficiency of conservation investments, including payments for ecosystem services (PES), has been found to be affected by biological, political, economic, demographic, and social factors, but little is kno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Lupi F,He G,Liu J

更新日期：2009-07-14 00:00:00

abstract：:The developmental loss of neurons in sympathetic, sensory, and some parasympathetic ganglia in familial dysautonomia suggests an inherited defect in the action of beta-nerve growth factor (beta-NGF). The role of this growth factor in dysautonomia has been difficult to resolve as there is no known source of authentic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breakefield XO,Orloff G,Castiglione C,Coussens L,Axelrod FB,Ullrich A

更新日期：1984-07-01 00:00:00

abstract：:Although the function of silicon (Si) in plant physiology has long been debated, its beneficial effects on plant resistance against abiotic and biotic stresses, including insect herbivory, have been well documented. In addition, the jasmonate (JA) signaling pathway plays a crucial role in mediating antiherbivore defen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye M,Song Y,Long J,Wang R,Baerson SR,Pan Z,Zhu-Salzman K,Xie J,Cai K,Luo S,Zeng R

更新日期：2013-09-17 00:00:00

abstract：:Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about the evolution of these important chromatin regulators. Here we focus on Polycomb Repressive Compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gahan JM,Rentzsch F,Schnitzler CE

更新日期：2020-09-15 00:00:00

abstract：:The circadian clock is a global regulatory mechanism that controls the expression of 50 to 80% of transcripts in mammals. Some of the genes controlled by the circadian clock are oncogenes or tumor suppressors. Among these Myc has been the focus of several studies which have investigated the effect of clock genes and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Selby CP,Yang Y,Lindsey-Boltz LA,Cao X,Eynullazada K,Sancar A

更新日期：2020-09-01 00:00:00

abstract：:Time-resolved optical measurements encompassing the femtoseconds to seconds time scales have been used to investigate Rhodobacter capsulatus reaction centers (RCs) in which the histidine residue at position 200 on the M polypeptide has been changed to a leucine by site-directed mutagenesis. The HisM200----Leu RC, whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirmaier C,Holten D,Bylina EJ,Youvan DC

更新日期：1988-10-01 00:00:00

abstract：:The deduced amino acid sequence of two members of the signal transducers and activators of transcription (STAT) family from the mouse are described. Comparison with the deduced protein sequence of the two previously described genes (Stat91 and Stat113), discovered because of their activation as transcription factors a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong Z,Wen Z,Darnell JE Jr

更新日期：1994-05-24 00:00:00

abstract：:While cells within tissues generate and sense 3D states of strain, the current understanding of the mechanics of fibrous extracellular matrices (ECMs) stems mainly from uniaxial, biaxial, and shear tests. Here, we demonstrate that the multiaxial deformations of fiber networks in 3D cannot be inferred solely based on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ban E,Wang H,Franklin JM,Liphardt JT,Janmey PA,Shenoy VB

更新日期：2019-04-02 00:00:00

abstract：:An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti, was en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise de Valdez MR,Nimmo D,Betz J,Gong HF,James AA,Alphey L,Black WC 4th

更新日期：2011-03-22 00:00:00

abstract：:We have developed a method for conjugating low density lipoproteins (LDL) with colloidal gold. Conjugation, complete after 1 min, occurs by electrostatic adsorption of the LDL to the negatively charged gold particle. Each conjugate consists of approximately eight biologically active LDL molecules clustered around a ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Handley DA,Arbeeny CM,Witte LD,Chien S

更新日期：1981-01-01 00:00:00

abstract：:We have devised a general strategy for gene mapping based upon the direct amplification of a target sequence within a single microdissected Giemsa-banded chromosomal segment using the polymerase chain reaction. The usefulness of this approach was demonstrated by mapping a cloned human brain sodium channel (alpha subun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han JA,Lu CM,Brown GB,Rado TA

更新日期：1991-01-15 00:00:00

abstract：:The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epidermal growth facto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin JP,Karakas B,Weiss MB,Abukhdeir AM,Lauring J,Garay JP,Cosgrove D,Tamaki A,Konishi H,Konishi Y,Mohseni M,Wang G,Rosen DM,Denmeade SR,Higgins MJ,Vitolo MI,Bachman KE,Park BH

更新日期：2009-02-24 00:00:00

abstract：:Biological diversity reflects an underlying molecular diversity. The molecules found in nature may be regarded as solutions to challenges that have been confronted and overcome during molecular evolution. As our understanding of these solutions deepens, the efficiency with which we can discover and/or design new treat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caporale LH

更新日期：1995-01-03 00:00:00

abstract：:Tata Element Modulatory Factor (TMF/ARA160) is a multifunctional Golgi-associated protein, which accumulates in colonic enterocytes and goblet cells. Mice lacking TMF/ARA160 (TMF(-/-)) produce thick and uniform colonic mucus that resists adherent bacterial colonization and diminishes susceptibility of these mice to in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bel S,Elkis Y,Elifantz H,Koren O,Ben-Hamo R,Lerer-Goldshtein T,Rahimi R,Ben Horin S,Nyska A,Shpungin S,Nir U

更新日期：2014-04-01 00:00:00

abstract：:Experimental intramolecular vibrational dephasing transients for several large organic molecules are reanalyzed. Fits to the experimental data, as well as full numerical quantum calculations with a factorized potential surface for all active degrees of freedom of fluorene indicate that power law decays, not exponentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gruebele M

更新日期：1998-05-26 00:00:00

abstract：:The alphavbeta3 integrins are linked to human bleeding disorders, and pathogenic hantaviruses regulate the function of alphavbeta3 integrins and cause acute vascular diseases. alphavbeta3 integrins are present in either extended (active) or dramatically bent (inactive) structures, and interconversion of alphavbeta3 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raymond T,Gorbunova E,Gavrilovskaya IN,Mackow ER

更新日期：2005-01-25 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) is a membrane-associated member of the immunoglobulin superfamily capable of both homophilic and heterophilic binding. To investigate the significance of this binding, a gene targeting strategy in embryonic stem (ES) cells was used to replace the membrane-associated forms of NC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rabinowitz JE,Rutishauser U,Magnuson T

更新日期：1996-06-25 00:00:00

abstract：:The region of human chromosome 22q11 is prone to rearrangements. The resulting chromosomal abnormalities are involved in Velo-cardio-facial and DiGeorge syndromes (VCFS and DGS) (deletions), "cat eye" syndrome (duplications), and certain types of tumors (translocations). As a prelude to the development of mouse models...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puech A,Saint-Jore B,Funke B,Gilbert DJ,Sirotkin H,Copeland NG,Jenkins NA,Kucherlapati R,Morrow B,Skoultchi AI

更新日期：1997-12-23 00:00:00

abstract：:The 5'-terminal triphosphate of the 35S RNA isolated from Rous sarcoma virus is blocked by 7-methylguanosine in 5' linkage with the penultimate nucleoside which is methylated in the 2'-O-ribose position, a type of endgroup found in all animal mRNAs investigated during the past year. The specific nuclease-resistant ter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keith J,Fraenkel-Conrat H

更新日期：1975-09-01 00:00:00

abstract：:An electrophoretic karyotype of Aspergillus nidulans has been obtained using contour-clamped homogeneous electric field gel electrophoresis. Six chromosomal bands were separated, with two of the bands migrating as doublets. Using the Schizosaccharomyces pombe and Saccharomyces cerevisiae chromosomes as size standards,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brody H,Carbon J

更新日期：1989-08-01 00:00:00

abstract：:Many processes in science and engineering develop multiscale temporal and spatial patterns, with complex underlying dynamics and time-dependent external forcings. Because of the importance in understanding and predicting these phenomena, extracting the salient modes of variability empirically from incomplete observati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giannakis D,Majda AJ

更新日期：2012-02-14 00:00:00

abstract：:Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowak MA,Komarova NL,Sengupta A,Jallepalli PV,Shih IeM,Vogelstein B,Lengauer C

更新日期：2002-12-10 00:00:00

abstract：:The stress inoculation hypothesis presupposes that brief intermittent stress exposure early in life induces the development of subsequent stress resistance in human and nonhuman primates. Rodent studies, however, suggest a role for maternal care rather than stress exposure per se (i.e., the maternal mediation hypothes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker KJ,Buckmaster CL,Sundlass K,Schatzberg AF,Lyons DM

更新日期：2006-02-21 00:00:00

abstract：:Silicon, with its great abundance and mature infrastructure, is a foundational material for a range of applications, such as electronics, sensors, solar cells, batteries, and thermoelectrics. These applications rely on the purification of Si to different levels. Recently, it has been shown that nanosized silicon can o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zong L,Zhu B,Lu Z,Tan Y,Jin Y,Liu N,Hu Y,Gu S,Zhu J,Cui Y

更新日期：2015-11-03 00:00:00

abstract：:The majority of outer membrane proteins (OMPs) from gram-negative bacteria and many of mitochondria and chloroplasts are β-barrels. Insertion and assembly of these proteins are catalyzed by the Omp85 protein family in a seemingly conserved process. All members of this family exhibit a characteristic N-terminal polypep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommer MS,Daum B,Gross LE,Weis BL,Mirus O,Abram L,Maier UG,Kühlbrandt W,Schleiff E

更新日期：2011-08-16 00:00:00