Identification of the 5' end of Rous sarcoma virus RNA.

Abstract:

:The 5'-terminal triphosphate of the 35S RNA isolated from Rous sarcoma virus is blocked by 7-methylguanosine in 5' linkage with the penultimate nucleoside which is methylated in the 2'-O-ribose position, a type of endgroup found in all animal mRNAs investigated during the past year. The specific nuclease-resistant terminal fragment of RSV RNA has the structure 7mG5'ppp5'GmpCp-. This finding supports the belief that RNA of Rous sarcoma virus represents a (+) strand messenger which may be directly translated upon infection.

authors

Keith J,Fraenkel-Conrat H

doi

10.1073/pnas.72.9.3347

subject

Has Abstract

pub_date

1975-09-01 00:00:00

pages

3347-50

issue

9

eissn

0027-8424

issn

1091-6490

journal_volume

72

pub_type

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