Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.

abstract：:Choroideremia is an X-linked hereditary retinal degeneration resulting from mutations in the Rab escort protein-1 (REP1). The Rep1 protein facilitates posttranslational modification of Rab proteins, which regulate intracellular trafficking in the retinal pigment epithelium (RPE) and photoreceptors and are likely invol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krock BL,Bilotta J,Perkins BD

更新日期：2007-03-13 00:00:00

abstract：:Myosin-binding protein C (MyBP-C) is an accessory protein of striated muscle thick filaments and a modulator of cardiac muscle contraction. Defects in the cardiac isoform, cMyBP-C, cause heart disease. cMyBP-C includes 11 Ig- and fibronectin-like domains and a cMyBP-C-specific motif. In vitro studies show that in addi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mun JY,Previs MJ,Yu HY,Gulick J,Tobacman LS,Beck Previs S,Robbins J,Warshaw DM,Craig R

更新日期：2014-02-11 00:00:00

abstract：:Blindsight is a phenomenon in which human patients with damage to striate cortex deny any visual sensation in the resultant visual field defect but can nonetheless detect and localize stimuli when persuaded to guess. Although monkeys with striate lesions have also been shown to exhibit some residual vision, it is not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Rodman HR,Repp AB,Gross CG

更新日期：1995-08-29 00:00:00

abstract：:Phosphatidylinositol 3-kinases (PI 3-kinases) have been implicated in membrane trafficking in the secretory and endocytic pathways of yeast and mammalian cells, but the molecular mechanisms by which these lipid kinases operate are not known. Here we identify a protein of 170 kDa that is rapidly released from cell memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patki V,Virbasius J,Lane WS,Toh BH,Shpetner HS,Corvera S

更新日期：1997-07-08 00:00:00

abstract：:Not having enough of what one needs has long been shown to have detrimental consequences for decision making. Recent work suggests that the experience of insufficient resources can create a "scarcity" mindset; increasing attention toward the scarce resource itself, but at the cost of attention for unrelated aspects. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huijsmans I,Ma I,Micheli L,Civai C,Stallen M,Sanfey AG

更新日期：2019-06-11 00:00:00

abstract：:We investigated the effects of beta-estradiol on the locomotor behavior of female mice in a radial maze. Data comprising the total distance traveled during each arm entry were obtained from video records of six consecutive daily recording sessions. Distributions of these data were bimodal for both ovariectomized contr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coop AD,Stavarache MA,Pfaff DW,Reeke GN

更新日期：2006-10-17 00:00:00

abstract：:The structure of DNA toroids made of individual DNA molecules of various lengths (3,000 to 55,000 bp) was studied, by using partially filled bacteriophage capsids in conjunction with cryoelectron microscopy. The tetravalent cation spermine was diffused through the capsid to condense the DNA under conditions that were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leforestier A,Livolant F

更新日期：2009-06-09 00:00:00

abstract：:Three-dimensional topological insulators (3D TIs) represent states of quantum matters in which surface states are protected by time-reversal symmetry and an inversion occurs between bulk conduction and valence bands. However, the bulk-band inversion, which is intimately tied to the topologically nontrivial nature of 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ZG,Chen RY,Zhong RD,Schneeloch J,Zhang C,Huang Y,Qu F,Yu R,Li Q,Gu GD,Wang NL

更新日期：2017-01-31 00:00:00

abstract：:The physiological significance of multiple G-protein-coupled receptor subtypes, such as the beta-adrenergic receptors (beta ARs), remains obscure, since in many cases several subtypes activate the same effector and utilize the same physiological agonists. We inspected the deduced amino acid sequences of the beta AR su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liggett SB,Freedman NJ,Schwinn DA,Lefkowitz RJ

更新日期：1993-04-15 00:00:00

abstract：:Three classes of heterogeneous nuclear RNA (HnRNA) alpha, beta, and gamma, with different chemical and physical properties, can be identified in the early sea urchin embryo by hybridization with poly(U). The relative amounts of these classes vary as a function of embryonic development. It is demonstrated here that the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dubroff LM

更新日期：1977-06-01 00:00:00

abstract：:Inactivation of the retinoblastoma gene (RB gene) is associated with the development of several human malignancies including retinoblastomas, some osteo- and soft tissue sarcomas, small cell lung cancer, and possibly breast and bladder cancers. To our knowledge, this gene has not been evaluated in human germ-cell mali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strohmeyer T,Reissmann P,Cordon-Cardo C,Hartmann M,Ackermann R,Slamon D

更新日期：1991-08-01 00:00:00

abstract：:Professional antigen-presenting dendritic cells (DCs) are critical in regulating T cell immune responses at both systemic and mucosal sites. Many Lactobacillus species are normal members of the human gut microflora and most are regarded as safe when administered as probiotics. Because DCs can naturally or therapeutica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohamadzadeh M,Olson S,Kalina WV,Ruthel G,Demmin GL,Warfield KL,Bavari S,Klaenhammer TR

更新日期：2005-02-22 00:00:00

abstract：:Phytochromes (phy) are red/far-red-absorbing photoreceptors that regulate the adaption of plant growth and development to changes in ambient light conditions. The nuclear transport of the phytochromes upon light activation is regarded as a key step in phytochrome signaling. Although nuclear import of phyA is regulated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeiffer A,Nagel MK,Popp C,Wüst F,Bindics J,Viczián A,Hiltbrunner A,Nagy F,Kunkel T,Schäfer E

更新日期：2012-04-10 00:00:00

abstract：:The circular dichroism data on 17 adenine nucleosides show that the 260- and 207-mmu absorption systems of the adenine chromophore each contain at least two electronic transitions. The CD maxima are commonly found at around 260, 220, and 200 mmu, and occasionally at 240 mmu. Solvent studies suggest that these CD bands...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Robins MJ,Robins RK,Eyring H

更新日期：1969-01-01 00:00:00

abstract：:We identify a gene, organ boundary1 (OBO1), by its unique pattern of enhancer- driven GFP expression at the boundaries between the apical meristems and lateral organs in Arabidopsis embryos, seedlings, and mature plants. OBO1 also is expressed at the root apical meristem and in distinct cell files surrounding this are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho E,Zambryski PC

更新日期：2011-02-01 00:00:00

abstract：:Compulsive behavior is a debilitating clinical feature of many forms of neuropsychiatric disease, including Tourette syndrome, obsessive-compulsive spectrum disorders, eating disorders, and autism. Although several studies link striatal dysfunction to compulsivity, the pathophysiology remains poorly understood. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu P,Grueter BA,Britt JK,McDaniel L,Huntington PJ,Hodge R,Tran S,Mason BL,Lee C,Vong L,Lowell BB,Malenka RC,Lutter M,Pieper AA

更新日期：2013-06-25 00:00:00

abstract：:Integrating sulfanyl substituents into copper-bonded phenoxyls significantly alters their optical and redox properties and provides insight into the influence of cysteine modification of the tyrosine cofactor in the enzyme galactose oxidase. The model complexes [1(SR2)](+) are class II mixed-valent Cu(II)-phenoxyl-phe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma P,Pratt RC,Storr T,Wasinger EC,Stack TD

更新日期：2011-11-15 00:00:00

abstract：:The replication initiator proteins encoded by the pT181 and related plasmids have sequence-specific DNA binding and topoisomerase activities. These proteins create a site-specific nick in one strand of the DNA at the origin of replication that serves as a primer for the initiation of replication. To define the regions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dempsey LA,Birch P,Khan SA

更新日期：1992-04-01 00:00:00

abstract：:The ability of lysosomes to move within the cytoplasm is important for many cellular functions. This ability is particularly critical in neurons, which comprise vast, highly differentiated domains such as the axon and dendrites. The mechanisms that control lysosome movement in these domains, however, remain poorly und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS

更新日期：2017-04-04 00:00:00

abstract：:A glycoprotein, termed amphiregulin (AR), inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells. It has been purified to apparent homogeneity from serum-free conditioned medium of MCF-7 human breast carcinoma cells that had been trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shoyab M,McDonald VL,Bradley JG,Todaro GJ

更新日期：1988-09-01 00:00:00

abstract：:Recommended Daily Allowances (US RDA) of the Food and Drug Administration for ascorbic acid are higher than Recommended Dietary Allowances (set by the Food and Nutrition Board) for adults. There is a 6-fold margin between the requirement to prevent scurvy and the US RDA. The high requirement reported for the rhesus mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jukes TH

更新日期：1975-10-01 00:00:00

abstract：:Many and diverse modifications of the myosin subfragment 1 (S-1) increase (modulate) its ATPase activity, including interaction of this particle with actin; a recent addition to these modifications is the extensive lysine modification of S-1 that seems prerequisite to crystallizing it for structure analysis. In this s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bivin DB,Ue K,Khoroshev M,Morales M

更新日期：1994-08-30 00:00:00

abstract：:We have examined whether dissociation of the histone octamer is required for elongation of RNA transcripts through arrays of nucleosome cores in vitro. Control or dimethyl suberimidate-crosslinked histone octamers were reconstituted onto supercoiled, closed circular pT207-18 DNA, which contains tandemly repeated 207-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill TE,Smith JG,Bradbury EM

更新日期：1993-07-01 00:00:00

abstract：:Since at least the 1920s, it has been reported that common chimpanzees (Pan troglodytes) differ from humans in being capable of exceptional feats of "super strength," both in the wild and in captive environments. A mix of anecdotal and more controlled studies provides some support for this view; however, a critical re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill MC,Umberger BR,Holowka NB,Larson SG,Reiser PJ

更新日期：2017-07-11 00:00:00

abstract：:Asymmetric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been investigated. High enantioselectivity (89-93% enantiomeric excess) has been attained for this challenging class of alkenes. Mechanistic studies show that substituents on the ketone catalyst can have electronic influ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickey M,Goeddel D,Crane Z,Shi Y

更新日期：2004-04-20 00:00:00

abstract：:Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kessler RJ,Vande Zande H,Tyson CA,Blondin GA,Fairfield J,Glasser P,Green DE

更新日期：1977-06-01 00:00:00

abstract：:Biological carbon fixation is limited by the supply of Fe in vast regions of the global ocean. Dissolved Fe in seawater is primarily sourced from continental mineral dust, submarine hydrothermalism, and sediment dissolution along continental margins. However, the relative contributions of these three sources to the Fe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horner TJ,Williams HM,Hein JR,Saito MA,Burton KW,Halliday AN,Nielsen SG

更新日期：2015-02-03 00:00:00

abstract：:Newly formed hepatic granulomas around Schistosoma mansoni eggs become progressively smaller during the chronic (greater than or equal to 15 weeks after infection) phase of the disease. This reduction in granuloma size, termed "modulation," is known to be caused in part by a T lymphocyte that can adoptively transfer m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green WF,Colley DG

更新日期：1981-02-01 00:00:00

abstract：:A technique involving 5-bromodeoxyuridine, 33258 Hoechst, and fluorescence microscopy has been used to analyze replication kinetics in cells from embryonic and adult mice bearing the Cattanach [T(X;7)ICt] translocation in a balanced or an unbalanced form. In balanced 9- and 13-day female embryos, the translocated X wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Disteche CM,Eicher EM,Latt SA

更新日期：1979-10-01 00:00:00

abstract：:There is significant variation in the reported magnitude and even the sign of [Formula: see text] shifts in thin polymer films with nominally the same chemistry, film thickness, and supporting substrate. The implicit assumption is that methods used to estimate [Formula: see text] in bulk materials are relevant for inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang W,Douglas JF,Starr FW

更新日期：2018-05-29 00:00:00