Abstract:
:Fetal exposure to environmental insults increases the susceptibility to late-onset neuropsychiatric disorders. Alcohol is listed as one of such prenatal environmental risk factors and known to exert devastating teratogenetic effects on the developing brain, leading to complex neurological and psychiatric symptoms observed in fetal alcohol spectrum disorder (FASD). Here, we performed a coordinated transcriptome analysis of human and mouse fetal cerebral cortices exposed to ethanol in vitro and in vivo, respectively. Up- and down-regulated genes conserved in the human and mouse models and the biological annotation of their expression profiles included many genes/terms related to neural development, such as cell proliferation, neuronal migration and differentiation, providing a reliable connection between the two species. Our data indicate that use of the combined rodent and human model systems provides an effective strategy to reveal and analyze gene expression changes inflicted by various physical and chemical environmental exposures during prenatal development. It also can potentially provide insight into the pathogenesis of environmentally caused brain disorders in humans.
journal_name
Proc Natl Acad Sci U S Aauthors
Hashimoto-Torii K,Kawasawa YI,Kuhn A,Rakic Pdoi
10.1073/pnas.1100903108subject
Has Abstractpub_date
2011-03-08 00:00:00pages
4212-7issue
10eissn
0027-8424issn
1091-6490pii
1100903108journal_volume
108pub_type
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