Genes encoding major light-harvesting polypeptides are clustered on the genome of the cyanobacterium Fremyella diplosiphon.

abstract：:Estradiol-17beta administration to young (10- to 12-week-old) rabbits to produce the "estrogen-dominated" uterus increased the uterine contractile response to both oxytocin and methacholine in vitro. In "progesterone-dominated" uteri, obtained from rabbits that received progesterone for 4 days after estrogen pretreatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nissenson R,Fluoret G,Hechter O

更新日期：1978-04-01 00:00:00

abstract：:When a local mechanical perturbation is applied to the surface of a thin film of a mechanically interlocked molecule (a rotaxane), the molecules self-organize into periodic arrays of discrete dots or lines. The dimensionality of the nanostructures depends on whether the mechanical stimulus acts along a 1D line or over...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biscarini F,Cavallini M,Kshirsagar R,Bottari G,Leigh DA,León S,Zerbetto F

更新日期：2006-11-21 00:00:00

abstract：:Primary--i.e., nonsyndromal-postlingual deafness is inherited as an autosomal dominant phenotype in a large kindred in Costa Rica. Genetically susceptible individuals begin to lose hearing at low frequencies at about age 10 years, after language and speaking are learned. Deafness inevitably progresses by age 30 years ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leon PE,Raventos H,Lynch E,Morrow J,King MC

更新日期：1992-06-01 00:00:00

abstract：:Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro kinetic assays on PBMCs in 195 MS patients and 60 matched controls and quantified the phosphorylation of 17 kinases using xMAP assays. Phosphoprotein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotelnikova E,Kiani NA,Messinis D,Pertsovskaya I,Pliaka V,Bernardo-Faura M,Rinas M,Vila G,Zubizarreta I,Pulido-Valdeolivas I,Sakellaropoulos T,Faigle W,Silberberg G,Masso M,Stridh P,Behrens J,Olsson T,Martin R,Paul F

更新日期：2019-05-07 00:00:00

abstract：:Recent evidence suggests that tumor necrosis factor alpha (TNFalpha) signaling in vascular cells can have antiatherogenic consequences, but the mechanisms are poorly understood. TNFalpha is released by free cholesterol-loaded apoptotic macrophages, and the clearance of these cells by phagocytic macrophages may help to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerbod-Giannone MC,Li Y,Holleboom A,Han S,Hsu LC,Tabas I,Tall AR

更新日期：2006-02-28 00:00:00

abstract：:The evolution of insect resistance to pesticides poses a continuing threat to agriculture and human health. While much is known about the proximate molecular and biochemical mechanisms that confer resistance, far less is known about the regulation of the specific genes/gene families involved, particularly by trans-act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang X,Deng S,Wei X,Yang J,Zhao Q,Yin C,Du T,Guo Z,Xia J,Yang Z,Xie W,Wang S,Wu Q,Yang F,Zhou X,Nauen R,Bass C,Zhang Y

更新日期：2020-05-12 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that transmit diverse extracellular signals across a membrane. Herpesvirus genomes encode multiple GPCRs implicated in viral pathogenesis. Kaposi sarcoma-associated herpesvirus GPCR (kGPCR) activates proliferative pathways and, when expressed in endo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Lu X,Zhu L,Shen Y,Chengedza S,Feng H,Wang L,Jung JU,Gutkind JS,Feng P

更新日期：2013-07-02 00:00:00

abstract：:We examined the effect of the inhibition of initiation of DNA replication on the membrane association of the chromosomal origin of replication of Bacillus subtilis and the Staphylococcus aureus-Bacillus pumilus chimeric plasmid pSL103, using temperature-sensitive mutants of B. subtilis that have specifically affected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winston S,Sueoka N

更新日期：1980-05-01 00:00:00

abstract：:The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult mammalian brain, we have built a gene expression-based brain map. We measured gene expression patterns for 24 neural ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zapala MA,Hovatta I,Ellison JA,Wodicka L,Del Rio JA,Tennant R,Tynan W,Broide RS,Helton R,Stoveken BS,Winrow C,Lockhart DJ,Reilly JF,Young WG,Bloom FE,Lockhart DJ,Barlow C

更新日期：2005-07-19 00:00:00

abstract：:The present studies were conducted to determine whether prostaglandin F2 alpha (PGF2 alpha) stimulates the production of "second messengers" derived from inositol phospholipid hydrolysis and increases intracellular free Ca2+ ([Ca2+]i) in isolated bovine luteal cells. PGF2 alpha provoked rapid (10 sec) and sustained (u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JS,Weakland LL,Weiland DA,Farese RV,West LA

更新日期：1987-06-01 00:00:00

abstract：:The multifunctional DNA-binding protein (DBP) encoded by human adenovirus binds RNA. The association of purified DBP with RNA in vitro was demonstrated by using either a gel filtration or a filter binding assay. This association is sensitive to ionic strength and exhibits no apparent sequence specificity. DBP also int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleghon VG,Klessig DF

更新日期：1986-12-01 00:00:00

abstract：:Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes in relation to heroin abuse and gene expression in the human striatum and the relevance of genetic dopamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikoshkov A,Drakenberg K,Wang X,Horvath MC,Keller E,Hurd YL

更新日期：2008-01-15 00:00:00

abstract：:In recent years, the field of psychology has begun to conduct replication tests on a large scale. Here, we show that "replicator degrees of freedom" make it far too easy to obtain and publish false-negative replication results, even while appearing to adhere to strict methodological standards. Specifically, using data...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryan CJ,Yeager DS,O'Brien JM

更新日期：2019-12-17 00:00:00

abstract：:In binocular rivalry, a subject views two incongruent stimuli through each eye but consciously perceives only one stimulus at a time, with a switch in perceptual dominance every few seconds. To investigate the neural correlates of perceptual dominance in humans, seven subjects were recorded with a 148-channel magnetoe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tononi G,Srinivasan R,Russell DP,Edelman GM

更新日期：1998-03-17 00:00:00

abstract：:Two objects with homologous landmarks are said to be of the same shape if the configuration of landmarks of one object can be exactly matched with that of the other by translation, rotation/reflection, and scaling. In an earlier paper, the authors proposed statistical analysis of shape by considering logarithmic diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao CR,Suryawanshi S

更新日期：1998-04-14 00:00:00

abstract：:Preference behaviors are often established during early life, but the underlying neural circuit mechanisms remain unknown. Adapting a unique nesting behavior assay, we confirmed a "critical period" for developing music preference in C57BL/6 mice. Early music exposure between postnatal days 15 and 24 reversed their inn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang EJ,Lin EW,Hensch TK

更新日期：2012-10-16 00:00:00

abstract：:A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25-OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haussler MR,Boyce DW,Littledike ET,Rasmussen H

更新日期：1971-01-01 00:00:00

abstract：:Predicting climate change impact on ecosystem structure and services is one of the most important challenges in ecology. Until now, plant species response to climate change has been described at the level of fixed plant functional types, an approach limited by its inflexibility as there is much interspecific functiona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soudzilovskaia NA,Elumeeva TG,Onipchenko VG,Shidakov II,Salpagarova FS,Khubiev AB,Tekeev DK,Cornelissen JH

更新日期：2013-11-05 00:00:00

abstract：:An equation for the bond angles OC-M-CO for tetracarbonyl groups in which the transition metal atom M is enneacovalent, derived from the simple theory of hybrid sp(3)d(5) bond orbitals, is tested by comparison of the calculated values of the angles with the experimental values reported for many compounds containing M(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1978-02-01 00:00:00

abstract：:We have measured the opioid receptor reserve in the guinea pig ileum myenteric plexus by means of the site-directed alkylating agent, beta-chlornaltrexamine. Treatment of the tissue with low (less than 10 nM) concentrations of beta-chlornaltrexamine caused a parallel shift of the log concentration-response curves for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chavkin C,Goldstein A

更新日期：1984-11-01 00:00:00

abstract：:Earlier studies have shown that the DNA of herpes simplex virus 1 consists of two covalently linked components, L and S, each flanked by inverted repeats. The two components can invert, and viral DNA extracted from infected cells or virions consists of equimolar concentrations of four populations differing solely in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poffenberger KL,Tabares E,Roizman B

更新日期：1983-05-01 00:00:00

abstract：:We have studied ten phenotypically similar patients with complete androgen insensitivity. All of the patients tested had significantly elevated serum luteinizing hormone and plasma androgens within or above the normal adult male range. On the basis of specific dihydrotestosterone binding by skin fibroblasts, we identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amrhein JA,Meyer WJ 3rd,Jones HW Jr,Migeon CJ

更新日期：1976-03-01 00:00:00

abstract：:T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systematic analysis of T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lever M,Lim HS,Kruger P,Nguyen J,Trendel N,Abu-Shah E,Maini PK,van der Merwe PA,Dushek O

更新日期：2016-10-25 00:00:00

abstract：:Many urological studies rely on models of animals, such as rats and pigs, but their relation to the human urinary system is poorly understood. Here, we elucidate the hydrodynamics of urination across five orders of magnitude in body mass. Using high-speed videography and flow-rate measurement obtained at Zoo Atlanta, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang PJ,Pham J,Choo J,Hu DL

更新日期：2014-08-19 00:00:00

abstract：:There is currently an unmet need for versatile techniques to monitor the assembly and dynamics of ternary complexes in live cells. Here we describe bioluminescence resonance energy transfer with fluorescence enhancement by combined transfer (BRETFect), a high-throughput technique that enables robust spectrometric dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cotnoir-White D,El Ezzy M,Boulay PL,Rozendaal M,Bouvier M,Gagnon E,Mader S

更新日期：2018-03-13 00:00:00

abstract：:The response of forests to climate change depends in part on whether the photosynthetic benefit from increased atmospheric CO2 (∆Ca = future minus historic CO2) compensates for increased physiological stresses from higher temperature (∆T). We predicted the outcome of these competing responses by using optimization the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sperry JS,Venturas MD,Todd HN,Trugman AT,Anderegg WRL,Wang Y,Tai X

更新日期：2019-12-17 00:00:00

abstract：:Saccades are rapid eye movements that orient the visual axis toward objects of interest to allow their processing by the central, high-acuity retina. Our ability to collect visual information efficiently relies on saccadic accuracy, which is limited by a combination of uncertainty in the location of the target and mot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisi M,Solomon JA,Morgan MJ

更新日期：2019-08-06 00:00:00

abstract：:Accurate modification of the 3 billion-base-pair human genome requires tools with exceptional sequence specificity. Here, we describe a general strategy for the design of enzymes that target a single site within the genome. We generated chimeric zinc finger recombinases with cooperative DNA-binding and catalytic speci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordley RM,Gersbach CA,Barbas CF 3rd

更新日期：2009-03-31 00:00:00

abstract：:The structural requirements of E. coli formylmethionine tRNA for aminoacylation have been examined by chemical modification of the tRNA, followed by separation of the modified molecules into active and inactive components. Photooxidation of tRNA(fMet) at 50 degrees in the presence of methylene blue results in modifica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulman LH

更新日期：1972-12-01 00:00:00

abstract：:Employing a cell-free chromatin transcription system that recapitulates progesterone receptor (PR)-mediated transcription in vivo, we have investigated further the coactivator functions of steroid receptor coactivator-1 (SRC-1) in terms of its functional domains as well as cooperation with other coactivators in PR tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Wong J,Tsai SY,Tsai MJ,O'Malley BW

更新日期：2001-10-23 00:00:00