Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway.

abstract：:Lakes are considered the second largest natural source of atmospheric methane (CH4). However, current estimates are still uncertain and do not account for diel variability of CH4 emissions. In this study, we performed high-resolution measurements of CH4 flux from several lakes, using an automated and sensor-based flux...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sieczko AK,Duc NT,Schenk J,Pajala G,Rudberg D,Sawakuchi HO,Bastviken D

更新日期：2020-09-01 00:00:00

abstract：:We demonstrate the use of self-assembly for the integration of freestanding micrometer-scale components, including single-crystal, silicon field-effect transistors (FETs) and diffusion resistors, onto flexible plastic substrates. Preferential self-assembly of multiple microcomponent types onto a common platform is ach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stauth SA,Parviz BA

更新日期：2006-09-19 00:00:00

abstract：:A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and ferti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansing JS,Watkins JC,Hallmark B,Cox MP,Karafet TM,Sudoyo H,Hammer MF

更新日期：2008-08-19 00:00:00

abstract：:Human cDNA clones encoding a structure-specific recognition protein, SSRP1, that binds specifically to DNA modified with cisplatin have been isolated and characterized. The SSRP1 gene maps to human chromosome 11q12. The cDNA clones, obtained by using partial-length cDNAs described previously, predict an 81-kDa protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruhn SL,Pil PM,Essigmann JM,Housman DE,Lippard SJ

更新日期：1992-03-15 00:00:00

abstract：:Syringomycin, a peptide toxin and a virulence factor produced by the bacterial phytopathogen Pseudomonas syringae pv. syringae, stimulated the phosphorylation of several plasma membrane polypeptides of red beet storage tissue. Among these was a 100-kDa polypeptide, which corresponds in size to the proton pump ATPase. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bidwai AP,Takemoto JY

更新日期：1987-10-01 00:00:00

abstract：:Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of Alzheimer's disease. IDE possesses an enclosed catalytic chamber that engulfs and degrades its peptide substrates; however, the molecular mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCord LA,Liang WG,Dowdell E,Kalas V,Hoey RJ,Koide A,Koide S,Tang WJ

更新日期：2013-08-20 00:00:00

abstract：:We report the crystal structure of a translation termination complex formed by the Thermus thermophilus 70S ribosome bound with release factor RF2, in response to a UAA stop codon, solved at 3 A resolution. The backbone of helix alpha5 and the side chain of serine of the conserved SPF motif of RF2 recognize U1 and A2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korostelev A,Asahara H,Lancaster L,Laurberg M,Hirschi A,Zhu J,Trakhanov S,Scott WG,Noller HF

更新日期：2008-12-16 00:00:00

abstract：:Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular (wet) form of advanced AMD and leads to significant vision loss. A gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasegawa E,Inafuku S,Mulki L,Okunuki Y,Yanai R,Smith KE,Kim CB,Klokman G,Bielenberg DR,Puli N,Falck JR,Husain D,Miller JW,Edin ML,Zeldin DC,Lee KSS,Hammock BD,Schunck WH,Connor KM

更新日期：2017-09-05 00:00:00

abstract：:Lignocellulosic plant biomass is an attractive feedstock for the production of sustainable biofuels, but the commercialization of such products is hampered by the high costs of processing this material into fermentable sugars (saccharification). One approach to lowering these costs is to produce crops with cell walls ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marriott PE,Sibout R,Lapierre C,Fangel JU,Willats WG,Hofte H,Gómez LD,McQueen-Mason SJ

更新日期：2014-10-07 00:00:00

abstract：:Vascular flow through tissues is regulated via a number of homeostatic mechanisms. Localized control of tissue blood flow, or autoregulation, is a key factor in regulating tissue perfusion and oxygenation. We show here that the net balance between two hypoxia-inducible factor (HIF) transcription factor isoforms, HIF-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowburn AS,Takeda N,Boutin AT,Kim JW,Sterling JC,Nakasaki M,Southwood M,Goldrath AW,Jamora C,Nizet V,Chilvers ER,Johnson RS

更新日期：2013-10-22 00:00:00

abstract：:Escherichia coli is a model laboratory bacterium, a species that is widely distributed in the environment, as well as a mutualist and pathogen in its human hosts. As such, E. coli represents an attractive organism to study how environment impacts microbial genome structure and function. Uropathogenic E. coli (UPEC) mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen SL,Hung CS,Xu J,Reigstad CS,Magrini V,Sabo A,Blasiar D,Bieri T,Meyer RR,Ozersky P,Armstrong JR,Fulton RS,Latreille JP,Spieth J,Hooton TM,Mardis ER,Hultgren SJ,Gordon JI

更新日期：2006-04-11 00:00:00

abstract：:Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for anticoagulants due t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao L,Wu M,Xiao C,Yang L,Zhou L,Gao N,Li Z,Chen J,Chen J,Liu J,Qin H,Zhao J

更新日期：2015-07-07 00:00:00

abstract：:Ancient DNA (aDNA) analysis provides a powerful means of investigating human migration, social organization, and a plethora of other crucial questions about humanity's past. Recently, specialists have suggested that the ideal research design involving aDNA would include multiple independent lines of evidence. In this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bongers JL,Nakatsuka N,O'Shea C,Harper TK,Tantaleán H,Stanish C,Fehren-Schmitz L

更新日期：2020-08-04 00:00:00

abstract：:In the normal development of retinotectal connections, the site in the tectum at which an optic fiber synapses is related to the position of its ganglion-cell body in the retina. How and when the ganglion cells acquire information about their positions is unknown, but the positional information that each ganglion cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-10-01 00:00:00

abstract：:Prostate carcinoma is the second leading cause of death from malignancy in men in the United States. Prostate cancer cells express type I insulin-like growth factor receptor (IGF-IR) and prostate cancer selectively metastazises to bone, which is an environment rich in insulin-like growth factors (IGFs), thereby suppor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burfeind P,Chernicky CL,Rininsland F,Ilan J,Ilan J

更新日期：1996-07-09 00:00:00

abstract：:During natural fertilization, mammalian spermatozoa must pass through the zona pellucida before reaching the plasma membrane of the oocyte. It is assumed that this step involves partial lysis of the zona by sperm acrosomal enzymes, but there has been no unequivocal evidence to support this view. Here we present eviden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirose M,Honda A,Fulka H,Tamura-Nakano M,Matoba S,Tomishima T,Mochida K,Hasegawa A,Nagashima K,Inoue K,Ohtsuka M,Baba T,Yanagimachi R,Ogura A

更新日期：2020-02-04 00:00:00

abstract：:Somatostatin (somatotropin release-inhibiting factor; SRIF) is a tetradecapeptide present in brain, pancreas, gastrointestinal tract, and thyroid that inhibits the secretion or action of several hormones in these tissues. We observed that the toad urinary bladder contains concentrations of endogenous somatostatin (8.0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forrest JN Jr,Reichlin S,Goodman DB

更新日期：1980-08-01 00:00:00

abstract：:We report the cloning and characterization of a cancer-associated cell membrane glycoprotein recognized by mAb NCC-3G10. The antibody showed strong reactivity to a wide variety of cancer cells, but only to a limited number of normal cells including lymphocytes, endothelial cells, and basal cells of stratified squamous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ino Y,Gotoh M,Sakamoto M,Tsukagoshi K,Hirohashi S

更新日期：2002-01-08 00:00:00

abstract：:Cancer is a genetic disease caused by genomic instability. In many cancers, this instability is manifested by chromosomal reconfigurations and karyotypic complexity. These features are particular hallmarks of the epithelial cancers that are some of the malignancies most resistant to long term control by current chemot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roschke AV,Lababidi S,Tonon G,Gehlhaus KS,Bussey K,Weinstein JN,Kirsch IR

更新日期：2005-02-22 00:00:00

abstract：:RNA-binding motif protein 4 (RBM4) plays a regulatory role in alternative splicing of precursor mRNA. We show here that cell stress such as arsenite exposure induces phosphorylation of RBM4 at serine 309 and also drives its cytoplasmic accumulation and targeting to stress granule via the MKK(3/6)-p38 signaling pathway...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin JC,Hsu M,Tarn WY

更新日期：2007-02-13 00:00:00

abstract：:Atherosclerosis is a complex disease resulting from the interaction of multiple genes. We have used the Ldlr knockout mouse model in an interspecific genetic cross to map atherosclerosis susceptibility loci. A total of 174 (MOLF/Ei x B6.129S7-Ldlr(tm1Her)) x C57BL/6J-Ldlr(tm1Her) backcross mice, homozygous for the Ldl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welch CL,Bretschger S,Latib N,Bezouevski M,Guo Y,Pleskac N,Liang CP,Barlow C,Dansky H,Breslow JL,Tall AR

更新日期：2001-07-03 00:00:00

abstract：:Many discoveries in cell biology rely on making specific proteins visible within their native cellular environment. There are various genetically encoded tags, such as fluorescent proteins, developed for fluorescence microscopy (FM). However, there are almost no genetically encoded tags that enable cellular proteins t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doh JK,White JD,Zane HK,Chang YH,López CS,Enns CA,Beatty KE

更新日期：2018-12-18 00:00:00

abstract：:Embryonal rhabdomyosarcoma (ERMS) is a common pediatric malignancy of muscle, with relapse being the major clinical challenge. Self-renewing tumor-propagating cells (TPCs) drive cancer relapse and are confined to a molecularly definable subset of ERMS cells. To identify drugs that suppress ERMS self-renewal and induce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen EY,DeRan MT,Ignatius MS,Grandinetti KB,Clagg R,McCarthy KM,Lobbardi RM,Brockmann J,Keller C,Wu X,Langenau DM

更新日期：2014-04-08 00:00:00

abstract：:A particularly promising approach to deconstructing and fractionating lignocellulosic biomass to produce green renewable fuels and high-value chemicals pretreats the biomass with organic solvents in aqueous solution. Here, neutron scattering and molecular-dynamics simulations reveal the temperature-dependent morpholog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pingali SV,Smith MD,Liu SH,Rawal TB,Pu Y,Shah R,Evans BR,Urban VS,Davison BH,Cai CM,Ragauskas AJ,O'Neill HM,Smith JC,Petridis L

更新日期：2020-07-21 00:00:00

abstract：:Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamase A,Muraguchi T,Naka K,Tanaka S,Kinoshita M,Hoshii T,Ohmura M,Shugo H,Ooshio T,Nakada M,Sawamoto K,Onodera M,Matsumoto K,Oshima M,Asano M,Saya H,Okano H,Suda T,Hamada J,Hirao A

更新日期：2009-10-06 00:00:00

abstract：:Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of structural remodelin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czéh B,Michaelis T,Watanabe T,Frahm J,de Biurrun G,van Kampen M,Bartolomucci A,Fuchs E

更新日期：2001-10-23 00:00:00

abstract：:Phenylglyoxal is an arginine-specific reagent that inactivates creatine kinase (CK). Previous results suggest that modification of the dimeric enzyme at a single arginine residue per subunit causes complete inactivation accompanied by the loss of nucleotide binding; the actual site of modification was not identified. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood TD,Guan Z,Borders CL Jr,Chen LH,Kenyon GL,McLafferty FW

更新日期：1998-03-31 00:00:00

abstract：:The ovaries of the mosquito Aedes aegypti cultured in vitro secrete material that behaves like ecdysone in a radioimmunoassay. The material was identified as alpha-ecdysone by high-resolution liquid and gas-liquid chromatography. Secretion reached a maximum 16 hr after a blood meal as shown by bioassay and direct dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagedorn HH,O'Connor JD,Fuchs MS,Sage B,Schlaeger DA,Bohm MK

更新日期：1975-08-01 00:00:00

abstract：:Cognitive studies of memory processes demonstrate that memory for stimuli is a function of how they are encoded; stimuli processed semantically are better remembered than those processed in a perceptual or shallow fashion. This study investigates the neural correlates of this cognitive phenomenon. Twelve subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kapur S,Craik FI,Tulving E,Wilson AA,Houle S,Brown GM

更新日期：1994-03-15 00:00:00

abstract：:A human collagenase inhibitor (CI) of Mr 28,500 has been extensively characterized in skin fibroblasts and identified in a variety of connective tissues. Because human alveolar macrophages synthesize and secrete both a collagenase and CI that are immunologically and functionally identical to their counterparts in fibr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Shavit Z,Teitelbaum SL,Stricklin GP,Eisen AZ,Kahn AJ,Welgus HG

更新日期：1985-08-01 00:00:00