Liquid behavior of cross-linked actin bundles.

abstract：:We recently showed that the mammalian genome encodes >1,000 large intergenic noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene expression patterns have implicated these lincRNAs in diverse biological processes, including cell-cycle regulation, immune surveillance, and embryonic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khalil AM,Guttman M,Huarte M,Garber M,Raj A,Rivea Morales D,Thomas K,Presser A,Bernstein BE,van Oudenaarden A,Regev A,Lander ES,Rinn JL

更新日期：2009-07-14 00:00:00

abstract：:Phosphatase PP2A expression levels are positively correlated to the clinical severity of systemic lupus erythematosus (SLE) and IL17A cytokine overproduction, indicating a potential role of PP2A in controlling TH17 differentiation and inflammation. By generating a mouse strain with ablation of the catalytic subunit α ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Q,Jin X,Zheng M,Rohila D,Fu G,Wen Z,Lou J,Wu S,Sloan R,Wang L,Hu H,Gao X,Lu L

更新日期：2019-01-15 00:00:00

abstract：:Perhydrohistrionicotoxin, at concentrations of 10(-12)-10(-7) M, depressed the current generated by iontophoretic application of acetylcholine to endplate regions of soleus and extensor digitorum longus muscles of rats. However, no changes in the amplitude or time course of spontaneous miniature endplate potentials or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albuquerque EX,Gage PW

更新日期：1978-03-01 00:00:00

abstract：:We have previously identified and purified a cell surface glycoprotein from retina and brain, called neural cell adhesion molecule or N-CAM, that appears to be involved in neural cell--cell adhesion, the fasciculation of neurites, and the formation of normal tissue patterns in the retina. The present studies reveal th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rutishauser U,Hoffman S,Edelman GM

更新日期：1982-01-01 00:00:00

abstract：:Viruses modulate biochemical cellular pathways to permit infection. A recently described mechanism mediates selective protein interactions between acidic domain readers and unacetylated, lysine-rich regions, opposite of bromodomain function. Kaposi´s sarcoma (KS)-associated herpesvirus (KSHV) is tightly linked with KS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juillard F,de Miranda MP,Li S,Franco A,Seixas AF,Liu B,Álvarez ÁL,Tan M,Szymula A,Kaye KM,Simas JP

更新日期：2020-09-08 00:00:00

abstract：:We describe a technique for transferring electrophoretically separated bands of RNA from an agarose gel to paper strips. The RNA is coupled covalently to diazobenzyloxymethyl groups on the paper. After transfer and appropriate treatment of the paper to destroy remaining diazo groups, specific RNA bands can be detected...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alwine JC,Kemp DJ,Stark GR

更新日期：1977-12-01 00:00:00

abstract：:The geographical structure of a population distributed continuously and homogeneously along an infinite linear habitat is explored. The analysis is restricted to a single locus in the absence of selection, and every mutant is assumed to be new to the population. An explicit formula is derived for the probability that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagylaki T

更新日期：1974-08-01 00:00:00

abstract：:High magnetic fields have revealed a surprisingly small Fermi surface in underdoped cuprates, possibly resulting from Fermi-surface reconstruction due to an order parameter that breaks translational symmetry of the crystal lattice. A crucial issue concerns the doping extent of such a state and its relationship to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan MK,McDonald RD,Ramshaw BJ,Betts JB,Shekhter A,Bauer ED,Harrison N

更新日期：2020-05-05 00:00:00

abstract：:Damage to the protooncogene MYC has been implicated in the genesis of diverse human tumors, but the tumorigenic potential of the isolated gene has been disputed. Here we report the use of a retroviral vector to test the potency of human MYC for neoplastic transformation in avian cells. We found that sustained and abun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsay GM,Moscovici G,Moscovici C,Bishop JM

更新日期：1990-03-01 00:00:00

abstract：:Increasing concentrations of estradiol (E2) ranging from 0.01 to 10 nM were found to inhibit partially but significantly the lactogenic effect of ovine prolactin (oPRL) on alpha-lactalbumin production in primate mammary tissues maintained in organ culture for 9 days. E2 at 10 nM inhibited by 38% (mean) PRL-stimulated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinberg DL,Todd J,Babitsky G

更新日期：1983-07-01 00:00:00

abstract：:Small, single-module proteins that fold in a single cooperative step may be paradigms for understanding early events in protein-folding pathways generally. Recent experimental studies of the 64-residue chymotrypsin inhibitor 2 (CI2) support a nucleation mechanism for folding, as do some computer stimulations. CI2 has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fersht AR

更新日期：1995-11-21 00:00:00

abstract：:Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextroamphetamine and methylphenidate are effective for increasing arousal and inducing reanimation, or active emergence from general anesthesia. DA neurons in the ventral tegmental area (VTA) are involved in reward processing, motivation, emoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor NE,Van Dort CJ,Kenny JD,Pei J,Guidera JA,Vlasov KY,Lee JT,Boyden ES,Brown EN,Solt K

更新日期：2016-11-08 00:00:00

abstract：:Circadian rhythms in metazoan eukaryotes are controlled by an endogenous molecular clock. It functions in many locations, including subsets of brain neurons (clock neurons) within the central nervous system. Although the molecular clock relies on transcription/translation feedback loops, posttranscriptional regulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Rosbash M

更新日期：2016-05-24 00:00:00

abstract：:Fall migratory monarch butterflies, tested for their directional responses to magnetic cues under three conditions, amagnetic, normal, and reversed magnetic fields, showed three distinct patterns. In the absence of a magnetic field, monarchs lacked directionality as a group. In the normal magnetic field, monarchs orie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etheredge JA,Perez SM,Taylor OR,Jander R

更新日期：1999-11-23 00:00:00

abstract：:Although aminoacyl-tRNA synthetases (ARSs) are essential for protein synthesis, they also function as regulators and signaling molecules in diverse biological processes. Here, we screened 11 different human ARSs to identify the enzyme that is secreted as a signaling molecule. Among them, we found that lysyl-tRNA synth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SG,Kim HJ,Min YH,Choi EC,Shin YK,Park BJ,Lee SW,Kim S

更新日期：2005-05-03 00:00:00

abstract：:Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seybold BA,Stanco A,Cho KK,Potter GB,Kim C,Sohal VS,Rubenstein JL,Schreiner CE

更新日期：2012-08-21 00:00:00

abstract：:A strain of Escherichia coli, selected on the basis of its resistance to colicin N, reveals distinct structural and functional alterations in unspecific OmpF porin. A single mutation [Gly-119-->Asp (G119D)] was identified in the internal loop L3 that contributes critically to the formation of the construction inside t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeanteur D,Schirmer T,Fourel D,Simonet V,Rummel G,Widmer C,Rosenbusch JP,Pattus F,Pagès JM

更新日期：1994-10-25 00:00:00

abstract：:Lymphangiogenesis is an important process that contributes to the spread of cancer. Here we show that insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) induce lymphangiogenesis in vivo. In a mouse cornea assay, IGF-1 and IGF-2 induce lymphangiogenesis as detected with LYVE-1, a specific marker for lymphatic endothel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Björndahl M,Cao R,Nissen LJ,Clasper S,Johnson LA,Xue Y,Zhou Z,Jackson D,Hansen AJ,Cao Y

更新日期：2005-10-25 00:00:00

abstract：:Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) is an eight-carbon sugar mostly confined to Gram-negative bacteria. It is often involved in attaching surface polysaccharides to their lipid anchors. α-Kdo provides a bridge between lipid A and the core oligosaccharide in all bacterial LPSs, whereas an oligosaccharide of β-Kdo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ovchinnikova OG,Mallette E,Koizumi A,Lowary TL,Kimber MS,Whitfield C

更新日期：2016-05-31 00:00:00

abstract：:The allocation of carbon and nitrogen resources to the synthesis of plant proteins, carbohydrates, and lipids is complex and under the control of many genes; much remains to be understood about this process. QQS (Qua-Quine Starch; At3g30720), an orphan gene unique to Arabidopsis thaliana, regulates metabolic processes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Zheng W,Zhu Y,Ye H,Tang B,Arendsee ZW,Jones D,Li R,Ortiz D,Zhao X,Du C,Nettleton D,Scott MP,Salas-Fernandez MG,Yin Y,Wurtele ES

更新日期：2015-11-24 00:00:00

abstract：:Assessing temporal variability in extreme rainfall events before the historical era is complicated by the sparsity of long-term "direct" storm proxies. Here we present a 2,200-y-long, accurate, and precisely dated record of cave flooding events from the northwest Australian tropics that we interpret, based on an integ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denniston RF,Villarini G,Gonzales AN,Wyrwoll KH,Polyak VJ,Ummenhofer CC,Lachniet MS,Wanamaker AD Jr,Humphreys WF,Woods D,Cugley J

更新日期：2015-04-14 00:00:00

abstract：:The lymphoma-inducing potential of Ig heavy-chain enhancer- and promoter-regulated Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) was evaluated in three transgenic FVB mouse lineages. EBNA1 was expressed at a higher level in transgenic B220(+) splenocytes than in EBV-infected lymphoblastoid cell lines. EBNA1 was a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang MS,Lu H,Yasui T,Sharpe A,Warren H,Cahir-McFarland E,Bronson R,Hung SC,Kieff E

更新日期：2005-01-18 00:00:00

abstract：:Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armache JP,Jarasch A,Anger AM,Villa E,Becker T,Bhushan S,Jossinet F,Habeck M,Dindar G,Franckenberg S,Marquez V,Mielke T,Thomm M,Berninghausen O,Beatrix B,Söding J,Westhof E,Wilson DN,Beckmann R

更新日期：2010-11-16 00:00:00

abstract：:Fossil glycoproteins of the soluble organic matrix are present in an 80-million-year-old mollusk shell from the Late Cretaceous Period. Discrete molecular weight components, as determined by gel electrophoresis, are preserved. The fossil organic matrix was compared with the organic matrix of a living representative sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiner S,Lowenstam HA,Hood L

更新日期：1976-08-01 00:00:00

abstract：:Compressional waves that sample the lowermost mantle west of Central America show a rapid change in travel times of up to 4 s over a sampling distance of 300 km and a change in waveforms. The differential travel times of the PKP waves (which traverse Earth's core) correlate remarkably well with predictions for S-wave ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun X,Song X,Zheng S,Helmberger DV

更新日期：2007-01-02 00:00:00

abstract：:A molecular assembly based on derivatized polystyrene is described, which mimics both the light-harvesting and energy-conversion steps of photosynthesis. The system is unique in that the two key parts of a photosynthetic system are incorporated in a functional assembly constructed from polypyridine complexes of Ru(II)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sykora M,Maxwell KA,DeSimone JM,Meyer TJ

更新日期：2000-07-05 00:00:00

abstract：:3-(4'-Benzoylphenyl)propionyl[3H] Phe-tRNA bound to the peptidyl site of the ribosome is photo-crosslinked exclusively to 23S RNA on irradiation at 320 nm. The site of reaction has been identified both by hybridization and primer-extension experiments as uridine-2584 and uridine-2585, located within the central loop o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barta A,Steiner G,Brosius J,Noller HF,Kuechler E

更新日期：1984-06-01 00:00:00

abstract：:Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+)-sensor synaptotagmin. The N-terminal domain of complexin is importa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Y,Choi UB,Zhang Y,Zhao M,Pfuetzner RA,Wang AL,Diao J,Brunger AT

更新日期：2016-08-09 00:00:00

abstract：:Understanding mammalian spermatozoan development and the events surrounding fertilization has grown slowly, in part because of uncertainty about the number and identity of the cellular components involved. Determination of those transcripts expressed specifically by germ cells should provide an inclusive list of proba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultz N,Hamra FK,Garbers DL

更新日期：2003-10-14 00:00:00

abstract：:It has often been suggested that the frequently observed Watson-Crick base-pair compensatory substitutions in RNA helical structures occur mainly through a slightly deleterious G.U intermediate state. We have scored base substitutions in a set of 82 related Drosophila species for the D1 and D2 variable domains of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousset F,Pélandakis M,Solignac M

更新日期：1991-11-15 00:00:00