Isolation and partial nucleotide sequence of the laccase gene from Neurospora crassa: amino acid sequence homology of the protein to human ceruloplasmin.

abstract：:Activated macrophages are described as classically activated or M1 type and alternatively activated or M2 type, depending on their response to proinflammatory stimuli and the expression of genetic markers including iNOS, arginase1, Ym1, and Fizz1. Here we report that Akt kinases differentially contribute to macrophage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arranz A,Doxaki C,Vergadi E,Martinez de la Torre Y,Vaporidi K,Lagoudaki ED,Ieronymaki E,Androulidaki A,Venihaki M,Margioris AN,Stathopoulos EN,Tsichlis PN,Tsatsanis C

更新日期：2012-06-12 00:00:00

abstract：:Hairs, feathers, and scales normally exhibit precise orientations with respect to the body axes. In Frizzled6 (Fz6)(-/-) mice, the global orientation of hair follicles is disrupted, leading to waves, whorls, and tufts, each comprising many hundreds of hairs. By analyzing the orientation of developing hair follicles, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Badea T,Nathans J

更新日期：2006-12-26 00:00:00

abstract：:In a recent article, Hunter uses the late George Varley and George Gradwell's long-term data on the winter moth (Operophtera brumata) and green tortrix (Tortrix viridana) populations to propose a method of quantifying the relative importance of top-down effects (because of natural enemies) and bottom-up effects (becau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hassell MP,Crawley MJ,Godfray HC,Lawton JH

更新日期：1998-09-01 00:00:00

abstract：:The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood. Using Ubc13 conditional knockout mice, we show that somatic deletion of the Ubc13 gene cau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Yamamoto M,Akira S,Sun SC

更新日期：2009-12-08 00:00:00

abstract：:Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by progressive ectopic mineralization of the skin, eyes, and arteries, for which no effective treatment exists. PXE is caused by inactivating mutations in the gene encoding ATP-binding cassette sub-family C member 6 (ABCC6), an ATP-dependen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansen RS,Küçükosmanoglu A,de Haas M,Sapthu S,Otero JA,Hegman IE,Bergen AA,Gorgels TG,Borst P,van de Wetering K

更新日期：2013-12-10 00:00:00

abstract：:CSB/ERCC6 belongs to an orphan subfamily of SWI2/SNF2-related chromatin remodelers and plays crucial roles in gene expression, DNA damage repair, and the maintenance of genome integrity. The molecular basis of chromatin remodeling by Cockayne syndrome B protein (CSB) is not well understood. Here we investigate the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Xu J,Limbo O,Fei J,Kassavetis GA,Chong J,Kadonaga JT,Russell P,Li B,Wang D

更新日期：2019-03-26 00:00:00

abstract：:Trial electron density functions have some conceptual and computational advantages over wave functions. The properties of some simple density functions for H(+) (2) and H(2) are examined. It appears that for a diatomic molecule a good density function would be given by rho = N(A(2) + B(2)), in which A and B are short ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearson RG,Palke WE

更新日期：1980-04-01 00:00:00

abstract：:Mechanism of photo-induced electron transfer and the subsequent hole transfer in DNA has been studied extensively, but so far we are not aware of any reliable report of the observation of the long-distance hole-transfer process. In this article, we demonstrate the results of direct observation for the long-distance ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takada T,Kawai K,Fujitsuka M,Majima T

更新日期：2004-09-28 00:00:00

abstract：:The influence of the rare initiation triplet AUU on mRNA translation was investigated by comparing the activity of two pairs of model mRNAs that differ in the length of Shine-Dalgarno and spacer sequences. Irrespective of the initiation triplet (AUG or AUU), all mRNAs had similar template activity in vitro, but transl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Teana A,Pon CL,Gualerzi CO

更新日期：1993-05-01 00:00:00

abstract：:In vivo phage display identifies peptides that selectively home to the vasculature of individual organs, tissues, and tumors. Here we report the identification of a cyclic nonapeptide, CPGPEGAGC, which homes to normal breast tissue with a 100-fold selectivity over nontargeted phage. The homing of the phage is inhibite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essler M,Ruoslahti E

更新日期：2002-02-19 00:00:00

abstract：:During brain maturation, the occurrence of the extracellular matrix (ECM) terminates juvenile plasticity by mediating structural stability. Interestingly, enzymatic removal of the ECM restores juvenile forms of plasticity, as for instance demonstrated by topographical reconnectivity in sensory pathways. However, to wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Happel MF,Niekisch H,Castiblanco Rivera LL,Ohl FW,Deliano M,Frischknecht R

更新日期：2014-02-18 00:00:00

abstract：:Starting with assignments of proton nuclear magnetic resonance previously made for oxytocin in deuterated dimethylsulfoxide at 220 MHz, we have assigned resonances for the mammalian antidiuretic hormone, lysine vasopressin. The results demonstrate that spectral assignments of neurohypophyseal hormones and their congen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Glickson JD,Schwartz IL,Havran RT,Meienhofer J,Urry DW

更新日期：1972-07-01 00:00:00

abstract：:Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component of CSF, acts in part by promoting the Rsk-mediated phosphorylation of the APC inhibitor Emi2/Erp1....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu JQ,Hansen DV,Guo Y,Wang MZ,Tang W,Freel CD,Tung JJ,Jackson PK,Kornbluth S

更新日期：2007-10-16 00:00:00

abstract：:Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two cells types are not u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murugaiyan G,Mittal A,Weiner HL

更新日期：2010-06-22 00:00:00

abstract：:Intact squid axons were injected with aequorin and bathed in 3 mM Ca seawater (a concentration close to that of squid blood). Sodium and potassium currents were pharmacologically blocked and repetitive voltage-clamp pulses of a duration of 1.5 ms were applied (to simulate the duration of an action potential) at amplit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mullins LJ,Requena J,Whittembury J

更新日期：1985-03-01 00:00:00

abstract：:Helodermin is a vasoactive intestinal peptide-like peptide in the salivary gland venom of the lizard Heloderma suspectum. Helodermin-like immunofluorescence was observed in the parafollicular (C) cells in several mammals and in the C cell homologues of the chicken ultimobranchial gland. Thus, helodermin-like peptides ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grunditz T,Persson P,Håkanson R,Absood A,Böttcher G,Rerup C,Sundler F

更新日期：1989-02-01 00:00:00

abstract：:Malignant B lymphocytes from several patients with chronic lymphocytic leukemia (CLL) were examined for reactivity with murine monoclonal antibody 17.109. This antibody, prepared against the rheumatoid factor (RF) paraprotein Sie, recognizes a crossreactive idiotype on 48% of human IgM RF paraproteins, but does not re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kipps TJ,Fong S,Tomhave E,Chen PP,Goldfien RD,Carson DA

更新日期：1987-05-01 00:00:00

abstract：:On the basis of earlier energy computations, the various single peptide units in proteins were designated as helix-making or helix-breaking.(1) With the use of these designations, empirical rules for distinguishing between alpha-helical and non-alpha-helical regions of proteins have been formulated. These rules includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotelchuck D,Scheraga HA

更新日期：1969-01-01 00:00:00

abstract：:We describe a strategy to "revive" putatively pathogenic T cells from frozen specimens of human inflammatory target organs. To distinguish pathogenic from irrelevant bystander T cells, we focused on cells that were (i) clonally expanded and (ii) in direct morphological contact with a target cell. Using CDR3 spectratyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seitz S,Schneider CK,Malotka J,Nong X,Engel AG,Wekerle H,Hohlfeld R,Dornmair K

更新日期：2006-08-08 00:00:00

abstract：:Nucleosomes in eukaryotes act as platforms for the dynamic integration of epigenetic information. Posttranslational modifications are reversibly added or removed and core histones exchanged for paralogous variants, in concert with changing demands on transcription and genome accessibility. Histones are also common in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stevens KM,Swadling JB,Hocher A,Bang C,Gribaldo S,Schmitz RA,Warnecke T

更新日期：2020-12-29 00:00:00

abstract：:Parkin functions as a multipurpose E3 ubiquitin ligase, and Parkin loss of function is associated with both sporadic and familial Parkinson's disease (PD). We report that the Bin/Amphiphysin/Rvs (BAR) domain of protein interacting with PRKCA1 (PICK1) bound to the really interesting new gene 1 (RING1) domain of Parkin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He J,Xia M,Yeung PKK,Li J,Li Z,Chung KK,Chung SK,Xia J

更新日期：2018-07-24 00:00:00

abstract：:There has been an increasing interest in cyanobacteria because these photosynthetic organisms convert solar energy into biomass and because of their potential for the production of biofuels. However, the exploitation of cyanobacteria for bioengineering requires knowledge of their transcriptional organization. Using di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitschke J,Georg J,Scholz I,Sharma CM,Dienst D,Bantscheff J,Voss B,Steglich C,Wilde A,Vogel J,Hess WR

更新日期：2011-02-01 00:00:00

abstract：:We have studied the effect of the cholinergic agonist carbachol on the spontaneous release of glutamate in cultured rat hippocampal cells. Spontaneous excitatory postsynaptic currents (sEPSCs) through glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type channels were recorded by means of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bouron A,Reuter H

更新日期：1997-10-28 00:00:00

abstract：:We have isolated a gene from Escherichia coli homologous to the gene encoding the Mr 83,000 Drosophila heat shock protein (hsp83). In E. coli the protein homologous to hsp83 is a heat shock protein called C62.5. The predicted amino acid sequence of C62.5 is 41% and 42% identical to the Drosophila and human hsp83 prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bardwell JC,Craig EA

更新日期：1987-08-01 00:00:00

abstract：:The mouse skeletal muscle acetylcholine receptor is regulated, at least in part, by transcriptional mechanisms. As a first step toward defining the cis- and trans-acting factors involved in acetylcholine receptor transcriptional regulation, we examined mouse muscle and fibroblast cells for the presence of DNase I-hype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowder CM,Merlie JP

更新日期：1986-11-01 00:00:00

abstract：:Marine viruses constitute a major ecological and evolutionary driving force in the marine ecosystems. However, their dispersal mechanisms remain underexplored. Here we follow the dynamics of Emiliania huxleyi viruses (EhV) that infect the ubiquitous, bloom-forming phytoplankton E. huxleyi and show that EhV are emitted...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharoni S,Trainic M,Schatz D,Lehahn Y,Flores MJ,Bidle KD,Ben-Dor S,Rudich Y,Koren I,Vardi A

更新日期：2015-05-26 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) glutamate receptor-mediated increases in intracellular calcium are thought to play a critical role in synaptic plasticity. The mechanisms by which changes in cytoplasmic calcium transmit the glutamate signal to the nucleus, which is ultimately important for long-lasting neuronal responses, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun HY,Gonzalez-Zulueta M,Dawson VL,Dawson TM

更新日期：1998-05-12 00:00:00

abstract：:Osteonectin is a prominent noncollagenous protein of developing bone. A 2150-base-pair cDNA coding for osteonectin, isolated from a bovine bone cell lambda gt11 expression library, was sequenced and identified by comparison with protein sequence data. The nucleotide sequence predicts that osteonectin contains 304 amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolander ME,Young MF,Fisher LW,Yamada Y,Termine JD

更新日期：1988-05-01 00:00:00

abstract：:Glands of the uterus are essential for pregnancy establishment. Forkhead box A2 (FOXA2) is expressed specifically in the glands of the uterus and a critical regulator of glandular epithelium (GE) differentiation, development, and function. Mice with a conditional deletion of FOXA2 in the adult uterus, created using th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dhakal P,Kelleher AM,Behura SK,Spencer TE

更新日期：2020-09-22 00:00:00

abstract：:Maintaining a fleet of buses to transport students to school is a major expense for school districts. To reduce costs by reusing buses between schools, many districts spread start times across the morning. However, assigning each school a time involves estimating the impact on transportation costs and reconciling addi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bertsimas D,Delarue A,Martin S

更新日期：2019-03-26 00:00:00