Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1.

abstract：:The sex pheromone biosynthetic pathways of lepidopterans require the concerted actions of multiple gene products. A number of pheromone gland (PG)-specific genes have been cloned in recent years and, whereas in vitro characterizations have indicated functions consistent with roles in pheromone production, there have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohnishi A,Hull JJ,Matsumoto S

更新日期：2006-03-21 00:00:00

abstract：:A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presente A,Boyles RS,Serway CN,de Belle JS,Andres AJ

更新日期：2004-02-10 00:00:00

abstract：:PIK3R2 encodes a ubiquitous regulatory subunit (p85β) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and migration. We found that p85β expression is elevated in breast and colon carcinomas and that its increased expression correlates with PI3K p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cortés I,Sánchez-Ruíz J,Zuluaga S,Calvanese V,Marqués M,Hernández C,Rivera T,Kremer L,González-García A,Carrera AC

更新日期：2012-07-10 00:00:00

abstract：:The Cdc7p protein kinase is essential for the G1/S transition and initiation of DNA replication during the cell division cycle in Saccharomyces cerevisiae. Cdc7p appears to be an evolutionarily conserved protein, since a homolog Hsk1 has been isolated from Schizosaccharomyces pombe. Here, we report the isolation of a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang W,Hunter T

更新日期：1997-12-23 00:00:00

abstract：:The oxygenation of the atmosphere ∼2.45-2.32 billion years ago (Ga) is one of the most significant geological events to have affected Earth's redox history. Our understanding of the timing and processes surrounding this key transition is largely dependent on the development of redox-sensitive proxies, many of which re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi Fru E,Rodríguez NP,Partin CA,Lalonde SV,Andersson P,Weiss DJ,El Albani A,Rodushkin I,Konhauser KO

更新日期：2016-05-03 00:00:00

abstract：:Alzheimer's disease (AD), characterized by cognitive decline, has emerged as a disease of synaptic failure. The present study reveals an unanticipated role of erythropoietin-producing hepatocellular A4 (EphA4) in mediating hippocampal synaptic dysfunctions in AD and demonstrates that blockade of the ligand-binding dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu AK,Hung KW,Huang H,Gu S,Shen Y,Cheng EY,Ip FC,Huang X,Fu WY,Ip NY

更新日期：2014-07-08 00:00:00

abstract：:Like protein enzymes, RNA enzymes (ribozymes) provide specific binding sites for their substrates. We now show that equilibrium dissociation constants for complexes between the Tetrahymena ribozyme and its RNA substrates and products can be directly measured by electrophoresis in polyacrylamide gels containing divalen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyle AM,McSwiggen JA,Cech TR

更新日期：1990-11-01 00:00:00

abstract：:We demonstrate the use of self-assembly for the integration of freestanding micrometer-scale components, including single-crystal, silicon field-effect transistors (FETs) and diffusion resistors, onto flexible plastic substrates. Preferential self-assembly of multiple microcomponent types onto a common platform is ach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stauth SA,Parviz BA

更新日期：2006-09-19 00:00:00

abstract：:Contractile forces are essential for many developmental processes involving cell shape change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the major component of the contractile machinery, have shown that active contractility occurs above a threshold motor concentration and within a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Wolynes PG

更新日期：2012-04-24 00:00:00

abstract：:Antibiotic resistance in bacteria has emerged as a global challenge over the past 90 years, compromising our ability to effectively treat infections. There has been a dramatic increase in antibiotic resistance-associated determinants in bacterial populations, driven by the mobility and infectious nature of such determ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klemm EJ,Wong VK,Dougan G

更新日期：2018-12-18 00:00:00

abstract：:How did human cooperation evolve? Recent evidence shows that many people are willing to engage in altruistic punishment, voluntarily paying a cost to punish noncooperators. Although this behavior helps to explain how cooperation can persist, it creates an important puzzle. If altruistic punishment provides benefits to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH

更新日期：2005-05-10 00:00:00

abstract：:Over the past years, family 18 chitinases have been validated as potential targets for the design of drugs against human pathogens that contain or interact with chitin during their normal life cycles. Thus far, only one potent chitinase inhibitor has been described in detail, the pseudotrisaccharide allosamidin. Recen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houston DR,Shiomi K,Arai N,Omura S,Peter MG,Turberg A,Synstad B,Eijsink VG,van Aalten DM

更新日期：2002-07-09 00:00:00

abstract：:Variation of chloroplast DNA and nuclear ribosomal DNA (DNA encoding ribosomal RNA) was studied for five species of white oak native to the eastern United States. Although these species differ in many morphological characters and have different (though overlapping) geographical ranges and ecological tolerances, they a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whittemore AT,Schaal BA

更新日期：1991-03-15 00:00:00

abstract：:This article presents an agent-based computational model of civil violence. Two variants of the civil violence model are presented. In the first a central authority seeks to suppress decentralized rebellion. In the second a central authority seeks to suppress communal violence between two warring ethnic groups. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein JM

更新日期：2002-05-14 00:00:00

abstract：:To some extent, the genetic theory of adaptive evolution in bacteria is a simple extension of that developed for sexually reproducing eukaryotes. In other, fundamental ways, the process of adaptive evolution in bacteria is quantitatively and qualitatively different from that of organisms for which recombination is an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin BR,Bergstrom CT

更新日期：2000-06-20 00:00:00

abstract：:The current spread of multidrug-resistant malaria demands rapid vaccine development against the major pathogen Plasmodium falciparum. The high quantities of protein required for a worldwide vaccination campaign select recombinant DNA technology as a practical approach for large-scale antigen production. We describe th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herrera S,Herrera MA,Perlaza BL,Burki Y,Caspers P,Döbeli H,Rotmann D,Certa U

更新日期：1990-05-01 00:00:00

abstract：:A series of small peptides corresponding to the amino termini of the fibrin alpha- and beta-chains has been synthesized. The peptides glycyl-L-prolyl-L-arginyl-L-proline and glycyl-L-prolyl-L-arginylsarcosine are potent inhibitors of fibrin polymerization. Moreover, these peptides have a natural stability stemming fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laudano AP,Doolittle RF

更新日期：1978-07-01 00:00:00

abstract：:A 1-hr exposure of bovine lenses in organ culture to H2O2 concentrations in the range found in the aqueous fluid of patients with cataracts inhibits 86Rb+ influx. At 1 mM H2O2, complete inhibition was observed and further investigated. Membrane permeability is slightly decreased. Although lactate concentrations increa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garner WH,Garner MH,Spector A

更新日期：1983-04-01 00:00:00

abstract：:Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rittschof CC,Bukhari SA,Sloofman LG,Troy JM,Caetano-Anollés D,Cash-Ahmed A,Kent M,Lu X,Sanogo YO,Weisner PA,Zhang H,Bell AM,Ma J,Sinha S,Robinson GE,Stubbs L

更新日期：2014-12-16 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85alpha regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although PI3K enzymatic a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taniguchi CM,Tran TT,Kondo T,Luo J,Ueki K,Cantley LC,Kahn CR

更新日期：2006-08-08 00:00:00

abstract：:Integrins contain two structurally homologous but distantly related domains: an I-like domain that is present in all beta-subunits and an I domain that is present in some alpha-subunits. Atomic resolution and mutagenesis studies of alpha I domains demonstrate a C-terminal, axial displacement of the alpha7-helix that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang W,Shimaoka M,Chen J,Springer TA

更新日期：2004-02-24 00:00:00

abstract：:High-volume hydraulic fracturing (HVHF) has revolutionized the oil and gas industry worldwide but has been accompanied by highly controversial incidents of reported water contamination. For example, groundwater contamination by stray natural gas and spillage of brine and other gas drilling-related fluids is known to o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llewellyn GT,Dorman F,Westland JL,Yoxtheimer D,Grieve P,Sowers T,Humston-Fulmer E,Brantley SL

更新日期：2015-05-19 00:00:00

abstract：:The basis for the 200-fold difference in affinity between two hybridoma antibodies specific for the hapten p-azophenylarsonate (Ars) that have diversified by somatic hypermutation was examined. Oligonucleotide-directed mutagenesis was used to sequentially convert the nucleotide sequence of the lower-affinity antibody ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharon J

更新日期：1990-06-01 00:00:00

abstract：:Reducing monosaccharides and oligosaccharides, after reductive amination, were separated and detected as their 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde (CBQCA) derivatives by capillary electrophoresis/laser-induced fluorescence. Under optimized conditions, the minimum detectable quantities for monosaccharide sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu JP,Shirota O,Wiesler D,Novotny M

更新日期：1991-03-15 00:00:00

abstract：:Human settlement of Polynesia was a major event in world prehistory. Despite the vastness of the distances covered, research suggests that prehistoric Polynesian populations maintained spheres of continuing interaction for at least some period of time in some regions. A low level of genetic variation in ancestral Poly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matisoo-Smith E,Roberts RM,Irwin GJ,Allen JS,Penny D,Lambert DM

更新日期：1998-12-08 00:00:00

abstract：:The existence of immunoregulatory genes conferring dominant resistance to autoimmunity is well documented. In an effort to better understand the nature and mechanisms of action of these genes, we utilized the murine model of autoimmune orchitis as a prototype. When the orchitis-resistant strain DBA/2J is crossed with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meeker ND,Hickey WF,Korngold R,Hansen WK,Sudweeks JD,Wardell BB,Griffith JS,Teuscher C

更新日期：1995-06-06 00:00:00

abstract：:We have isolated CaKRE9, a gene from Candida albicans, that is a functional homologue of the Saccharomyces cerevisiae KRE9 gene involved in beta-1,6-glucan synthesis. Disruption of the CaKRE9 gene in C. albicans shows that CaKre9p is required for the synthesis or assembly of this fungal polymer. Homozygous null disrup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lussier M,Sdicu AM,Shahinian S,Bussey H

更新日期：1998-08-18 00:00:00

abstract：:Complex three-dimensional biophotonic nanostructures produce the vivid structural colors of many butterfly wing scales, but their exact nanoscale organization is uncertain. We used small angle X-ray scattering (SAXS) on single scales to characterize the 3D photonic nanostructures of five butterfly species from two fam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saranathan V,Osuji CO,Mochrie SG,Noh H,Narayanan S,Sandy A,Dufresne ER,Prum RO

更新日期：2010-06-29 00:00:00

abstract：:Rod-shaped "ghosts" that are free of murein have been isolated from E. coli. The shape of these "ghosts" is maintained by a unit membrane soluble in sodium dodecyl sulfate. Ghosts consist of about 20-30% phospholipid (almost exclusively phosphatidylethanolamine) and 50-60% protein; a large fraction of the remaining ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henning U,Rehn K,Hoehn B

更新日期：1973-07-01 00:00:00

abstract：:The detrimental effects of elevated intensities of mid-UV radiation (UVB), a result of stratospheric ozone depletion during the austral spring, on the primary producers of the Antarctic marine ecosystem have been well documented. Here we report that natural populations of Antarctic zooplankton also sustain significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malloy KD,Holman MA,Mitchell D,Detrich HW 3rd

更新日期：1997-02-18 00:00:00