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Neuromolecular responses to social challenge: common mechanisms across mouse, stickleback fish, and honey bee.

Abstract：

:Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly conserved genes and networks that may be modified by lineage-specific mutations. However, the existence of deeply conserved mechanisms for social behaviors has not yet been demonstrated. We used a comparative genomics approach to determine whether shared neuromolecular mechanisms could underlie behavioral response to territory intrusion across species spanning a broad phylogenetic range: house mouse (Mus musculus), stickleback fish (Gasterosteus aculeatus), and honey bee (Apis mellifera). Territory intrusion modulated similar brain functional processes in each species, including those associated with hormone-mediated signal transduction and neurodevelopment. Changes in chromosome organization and energy metabolism appear to be core, conserved processes involved in the response to territory intrusion. We also found that several homologous transcription factors that are typically associated with neural development were modulated across all three species, suggesting that shared neuronal effects may involve transcriptional cascades of evolutionarily conserved genes. Furthermore, immunohistochemical analyses of a subset of these transcription factors in mouse again implicated modulation of energy metabolism in the behavioral response. These results provide support for conserved genetic "toolkits" that are used in independent evolutions of the response to social challenge in diverse taxa.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Rittschof CC,Bukhari SA,Sloofman LG,Troy JM,Caetano-Anollés D,Cash-Ahmed A,Kent M,Lu X,Sanogo YO,Weisner PA,Zhang H,Bell AM,Ma J,Sinha S,Robinson GE,Stubbs L

doi

10.1073/pnas.1420369111

subject

Has Abstract

pub_date

2014-12-16 00:00:00

pages

17929-34

issue

eissn

0027-8424

issn

1091-6490

pii

1420369111

journal_volume

111

pub_type

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Neuromolecular responses to social challenge: common mechanisms across mouse, stickleback fish, and honey bee.