Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.

abstract：:The emergence of antibiotic resistance among nosocomial pathogens has reemphasized the need for effective infection control strategies. The spread of resistant pathogens within hospital settings proceeds along various routes of transmission and is characterized by large fluctuations in prevalence, which are typical fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pelupessy I,Bonten MJ,Diekmann O

更新日期：2002-04-16 00:00:00

abstract：:Mutations in Cu, Zn superoxide dismutase (SOD1) cause the neurodegenerative disease familial amyotrophic lateral sclerosis from an as-yet-unidentified toxic property(ies). Analysis in Saccharomyces cerevisiae of a broad range of human familial amyotrophic lateral sclerosis-linked SOD1 mutants (A4V, G37R, G41D, H46R, H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corson LB,Strain JJ,Culotta VC,Cleveland DW

更新日期：1998-05-26 00:00:00

abstract：:Mechanical injury to the adult mammalian spinal cord results in permanent loss of structural integrity at the lesion site and of the brain-controlled function distal to the lesion. Some of these consequences were permanently averted by altering the cellular constituents at the lesion site with x-irradiation delivered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalderon N,Fuks Z

更新日期：1996-10-01 00:00:00

abstract：:Artificial two-dimensional biological habitats were prepared from porous polymer layers and inoculated with the fungus Penicillium roqueforti to provide a living material. Such composites of classical industrial ingredients and living microorganisms can provide a novel form of functional or smart materials with capabi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber LC,Koehler FM,Grass RN,Stark WJ

更新日期：2012-01-03 00:00:00

abstract：:The proteolytic processing of human amyloid precursor protein (APP) into shorter aggregating amyloid β (Aβ)-peptides, e.g., Aβ1-42, is considered a critical step in the pathogenesis of Alzheimer's disease (AD). Although APP is a well-known membrane glycoprotein carrying both N- and O-glycans, nothing is known about th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halim A,Brinkmalm G,Rüetschi U,Westman-Brinkmalm A,Portelius E,Zetterberg H,Blennow K,Larson G,Nilsson J

更新日期：2011-07-19 00:00:00

abstract：:Experimental exclusion of the Andean flamingo (Phoenicoparrus andinus) from shallow water areas of a salt lake in the Bolivian Andes caused large increases in the biomass of microorganisms inhabiting the surface sediments, especially a large diatom (Surirella wetzeli), amebas, ciliates, and nematodes. This is a conser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurlbert SH,Chang CC

更新日期：1983-08-01 00:00:00

abstract：:Unfolded RNase A is known to contain an equilibrium mixture of two forms, a slow-folding form (U(1)) and a fast-folding form (U(2)). If U(1) is produced after unfolding by the slow cis-trans isomerization of proline residues about X-Pro imide bonds, then the formation of U(1) should be catalyzed by strong acids. There...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmid FX,Baldwin RL

更新日期：1978-10-01 00:00:00

abstract：:The oxygenation of the atmosphere ∼2.45-2.32 billion years ago (Ga) is one of the most significant geological events to have affected Earth's redox history. Our understanding of the timing and processes surrounding this key transition is largely dependent on the development of redox-sensitive proxies, many of which re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi Fru E,Rodríguez NP,Partin CA,Lalonde SV,Andersson P,Weiss DJ,El Albani A,Rodushkin I,Konhauser KO

更新日期：2016-05-03 00:00:00

abstract：:Bright, photostable, and nontoxic fluorescent contrast agents are critical for biological imaging. "Self-healing" dyes, in which triplet states are intramolecularly quenched, enable fluorescence imaging by increasing fluorophore brightness and longevity, while simultaneously reducing the generation of reactive oxygen ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pati AK,El Bakouri O,Jockusch S,Zhou Z,Altman RB,Fitzgerald GA,Asher WB,Terry DS,Borgia A,Holsey MD,Batchelder JE,Abeywickrama C,Huddle B,Rufa D,Javitch JA,Ottosson H,Blanchard SC

更新日期：2020-09-29 00:00:00

abstract：:Collectivistic cultures have been characterized as having harmonious, cooperative ingroup relationships. However, we find evidence that people in collectivistic cultures are more vigilant toward ingroup members, mindful of their possible unethical intentions. Study 1 found that Chinese participants were more vigilant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu SS,Morris MW,Talhelm T,Yang Q

更新日期：2019-07-16 00:00:00

abstract：:Cytoplasmic membrane vesicles prepared from Escherichia coli containing multiple copies of the lac y gene were frozen in liquid nitrogen before or after generation of a proton electrochemical gradient (interior negative and alkaline) and irradiated with a high-energy electron beam at -135 degrees C. Subsequently, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldkorn T,Rimon G,Kempner ES,Kaback HR

更新日期：1984-02-01 00:00:00

abstract：:Because synaptic vesicle exocytosis is a nano-mechanical process, it should be influenced by the mechanical properties of the cell membrane to which the vesicle fuses. By dissolving surfactants at various concentrations in the neuronal membrane, we have perturbed mechanical properties of the membrane and have found th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Y,Stevens CF

更新日期：2008-11-18 00:00:00

abstract：:Cyanogen bromide fragments were isolated from the heavy chains of three human IgG myeloma proteins of the V(H)III subgroup, sequenced by an automated method, and localized to the variable region. Inspection of these sequences, together with corresponding stretches from both human and animal proteins (studied in other ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kehoe JM,Capra JD

更新日期：1971-09-01 00:00:00

abstract：:A Poincaré resolution is given for the supersymmetric ring of brackets over a signed alphabet. As a consequence, a resolution is found for the ring of coordinates of the Grassmanian variety in projective space over any infinite field. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anick D,Rota GC

更新日期：1991-09-15 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease in the tropics and subtropics with high morbidity and mortality. The facultative intracellular bacterium induces host cell fusion through its type VI secretion system 5 (T6SS5) as an important part of its pathogenesis in mammalian h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ku JWK,Chen Y,Lim BJW,Gasser S,Crasta KC,Gan YH

更新日期：2020-07-07 00:00:00

abstract：:Angiogenesis restores blood flow to healing tissues, a process that is inhibited by high doses of glucocorticoids. However, the role of endogenous glucocorticoids and the potential for antiglucocorticoid therapy to enhance angiogenesis is unknown. Using in vitro and in vivo models of angiogenesis in mice, we examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Small GR,Hadoke PW,Sharif I,Dover AR,Armour D,Kenyon CJ,Gray GA,Walker BR

更新日期：2005-08-23 00:00:00

abstract：:Although the function of silicon (Si) in plant physiology has long been debated, its beneficial effects on plant resistance against abiotic and biotic stresses, including insect herbivory, have been well documented. In addition, the jasmonate (JA) signaling pathway plays a crucial role in mediating antiherbivore defen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye M,Song Y,Long J,Wang R,Baerson SR,Pan Z,Zhu-Salzman K,Xie J,Cai K,Luo S,Zeng R

更新日期：2013-09-17 00:00:00

abstract：:We have previously identified a cellular transcription factor, ATF, which is involved in the expression of multiple adenovirus E1a-inducible genes. Here we show that ATF also binds to regulatory elements in cellular cAMP-inducible promoters. In these cellular promoters, ATF binds to a consensus sequence that has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin YS,Green MR

更新日期：1988-05-01 00:00:00

abstract：:High social status reduces stress responses in numerous species, but the stress-buffering effect of status may dissipate or even reverse during times of hierarchical instability. In an experimental test of this hypothesis, 118 participants (57.3% female) were randomly assigned to a high- or low-status position in a st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knight EL,Mehta PH

更新日期：2017-01-03 00:00:00

abstract：:For centuries, traditional agricultural systems have contributed to food and livelihood security throughout the world. Recognizing the ecological legacy in the traditional agricultural systems may help us develop novel sustainable agriculture. We examine how rice-fish coculture (RF), which has been designated a "globa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie J,Hu L,Tang J,Wu X,Li N,Yuan Y,Yang H,Zhang J,Luo S,Chen X

更新日期：2011-12-13 00:00:00

abstract：:Mutations in fibroblast growth factor receptor 2 (FGFR2) and its ligand, FGF10, are known to cause lacrimo-auriculo-dento-digital (LADD) syndrome. Multiple gain-of-function mutations in FGF receptors have been implicated in a variety of severe skeletal disorders and in many cancers. We aimed to elucidate the mechanism...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lew ED,Bae JH,Rohmann E,Wollnik B,Schlessinger J

更新日期：2007-12-11 00:00:00

abstract：:Progesterone is involved in the development and progression of breast cancers, and progesterone receptors (PR) are important markers of hormone dependence and disease prognosis. We have used a human PR cDNA probe, genomic DNA blotting of a series of Chinese hamster-human cell hybrids, and in situ hybridization to map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Law ML,Kao FT,Wei Q,Hartz JA,Greene GL,Zarucki-Schulz T,Conneely OM,Jones C,Puck TT,O'Malley BW

更新日期：1987-05-01 00:00:00

abstract：:Human hepatitis B virus genome encodes a protein, termed HBx, that is widely recognized as a transcriptional transactivator. While HBx does not directly bind cis-acting transcriptional control elements, it has been shown to associate with cellular proteins that bind DNA. Because HBx transactivated a large number of vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qadri I,Conaway JW,Conaway RC,Schaack J,Siddiqui A

更新日期：1996-10-01 00:00:00

abstract：:Following over 3 decades of gradual but uneven increases in sea ice coverage, the yearly average Antarctic sea ice extents reached a record high of 12.8 × 106 km2 in 2014, followed by a decline so precipitous that they reached their lowest value in the 40-y 1979-2018 satellite multichannel passive-microwave record, 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkinson CL

更新日期：2019-07-16 00:00:00

abstract：:Activation of the MEK/ERK/Elk-signaling cascade is a mechanism for relaying mitogenic and stress stimuli for gene activation. MEK1 is the proximate kinase for activation of ERK1/2, and nuclear targeting of ERK1/2 is obligatory for Elk1 transcriptional activity. Human biliverdin reductase (hBVR) is a recently described...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner-Marmarosh N,Miralem T,Gibbs PE,Maines MD

更新日期：2008-05-13 00:00:00

abstract：:HIV type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 as coreceptors for entry into target cells. Here we show that the HIV-1 envelope gp120 (Env) activates multiple ionic signaling responses in primary human macrophages, which are important targets for HIV-1 in vivo. Env from both CCR5-dependent JRFL (R5) an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu QH,Williams DA,McManus C,Baribaud F,Doms RW,Schols D,De Clercq E,Kotlikoff MI,Collman RG,Freedman BD

更新日期：2000-04-25 00:00:00

abstract：:Complete inactivation of the human retinoblastoma gene (RB) is believed to be an essential step in tumorigenesis of several different cancers. To provide a framework for understanding inactivation mechanisms, the structure of RB was delineated. The RB transcript is encoded in 27 exons dispersed over about 200 kilobase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong FD,Huang HJ,To H,Young LJ,Oro A,Bookstein R,Lee EY,Lee WH

更新日期：1989-07-01 00:00:00

abstract：:Cellular regulation by certain growth factor receptors and protooncogene products involves tyrosine kinase activity with the resultant tyrosine phosphorylation of protein substrates. In the present report we describe the distribution of phosphotyrosine-containing material detected by immunocytochemistry (ICC) in the r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moss AM,Unger JW,Moxley RT,Livingston JN

更新日期：1990-06-01 00:00:00

abstract：:A stable free-radical polymeric derivative of prostaglandin B1 (PGBx) has been synthesized that exhibits regenerative effects on oxidative phosphorylation in aged mitochondria. The molecular weights of the most active preparations fall between 2000 and 2600. PGBx is characterized by a single-line electron spin resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polis BD,Polis E,Kwong S

更新日期：1979-04-01 00:00:00

abstract：:Calcicludine (CaC) is a 60-amino acid polypeptide from the venom of Dendroaspis angusticeps. It is structurally homologous to the Kunitz-type protease inhibitor, to dendrotoxins, which block K+ channels, and to the protease inhibitor domain of the amyloid beta protein that accumulates in Alzheimer disease. Voltage-cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweitz H,Heurteaux C,Bois P,Moinier D,Romey G,Lazdunski M

更新日期：1994-02-01 00:00:00