The interaction of histone IV with nucleoside triphosphates.

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common extranodal lymphoid cell neoplasia; it frequently follows chronic bacteria-induced inflammation in various tissues. MALT lymphomas are characterized genetically by the t(11;18)(q21;q21) translocation, which yields chimeric transcripts encoding struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoffel A,Chaurushiya M,Singh B,Levine AJ

更新日期：2004-06-15 00:00:00

abstract：:Recent research links diet-induced obesity (DIO) with impaired immunity, although the underlying mechanisms remain unclear. We find that the induction of inducible NO synthase (iNOS) and cytokines is suppressed in mice with DIO and in bone marrow macrophages (BMMPhi) from mice with DIO exposed to an oral pathogen, Por...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Q,Leeman SE,Amar S

更新日期：2009-06-30 00:00:00

abstract：:The kinetics and order of rearrangements in the gene complex encoding T-cell-receptor beta chains were studied by Southern blot hybridization in a collection of hybridomas derived from fetal thymocytes at various stages of ontogeny (day 14 to day 17). Our results show a steady increase in the frequency of rearranged b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Born W,Yagüe J,Palmer E,Kappler J,Marrack P

更新日期：1985-05-01 00:00:00

abstract：:The with-no-lysine (K) (WNK) signaling pathway to STE20/SPS1-related proline- and alanine-rich kinase (SPAK) and oxidative stress-responsive 1 (OSR1) kinase is an important mediator of cell volume and ion transport. SPAK and OSR1 associate with upstream kinases WNK 1-4, substrates, and other proteins through their C-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor CA 4th,An SW,Kankanamalage SG,Stippec S,Earnest S,Trivedi AT,Yang JZ,Mirzaei H,Huang CL,Cobb MH

更新日期：2018-04-10 00:00:00

abstract：:The nucleotide and predicted amino acid sequences of two variant cDNAs [rat brain thyroid hormone receptor (rTR alpha) vI and vII], isolated from a rat brain cDNA library by using the Pst I fragment of v-erbA, showed virtual identity with the rat brain thyroid hormone receptor (rTR alpha) [Thompson, C. C., Weinberger,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsuhashi T,Tennyson GE,Nikodem VM

更新日期：1988-08-01 00:00:00

abstract：:cDNA clones corresponding to the polypeptide that has been shown to be an endogenous diazepam binding inhibitor and may act as a physiological ligand for the benzodiazepine/beta-carboline receptor have been isolated from bacteriophage lambda recombinant libraries from rat hypothalamus, total brain, and liver. The clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mocchetti I,Einstein R,Brosius J

更新日期：1986-10-01 00:00:00

abstract：:Plants constantly undergo external mechanical loads such as wind or touch and respond to these stimuli by acclimating their growth processes. A fascinating feature of this mechanical-induced growth response is that it can occur rapidly and at long distance from the initial site of stimulation, suggesting the existence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Louf JF,Guéna G,Badel E,Forterre Y

更新日期：2017-10-17 00:00:00

abstract：:The proteasome regulates cellular processes as diverse as cell cycle progression and NF-kappaB activation. In this study, we show that the potent antitumor natural product epoxomicin specifically targets the proteasome. Utilizing biotinylated-epoxomicin as a molecular probe, we demonstrate that epoxomicin covalently b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng L,Mohan R,Kwok BH,Elofsson M,Sin N,Crews CM

更新日期：1999-08-31 00:00:00

abstract：:Many urological studies rely on models of animals, such as rats and pigs, but their relation to the human urinary system is poorly understood. Here, we elucidate the hydrodynamics of urination across five orders of magnitude in body mass. Using high-speed videography and flow-rate measurement obtained at Zoo Atlanta, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang PJ,Pham J,Choo J,Hu DL

更新日期：2014-08-19 00:00:00

abstract：:The benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols (4-, 5-, 7-, 8-, 9-, and 10-hydroxybenzo[a]pyrene) have been tested for mutagenic and cytotoxic activity in bacteria and in a mammalian cell culture system. Benzo[a]pyrene 4,5-oxide (K-region) was highly mutagenic in two histidine-depende...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Goode RL,Chang RL,Levin W,Conney AH,Yagi H,Dansette PM,Jerina DM

更新日期：1975-08-01 00:00:00

abstract：:The production of the staphylococcal exotoxin toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus has been associated with essentially all cases of menstruation-associated toxic shock syndrome (TSS). In this work, we show that the human vaginal isolate Lactobacillus reuteri RC-14 produces small signaling mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Wang W,Xu SX,Magarvey NA,McCormick JK

更新日期：2011-02-22 00:00:00

abstract：:Tissue factor (TF) plays an important role in hemostasis, inflammation, angiogenesis, and the pathophysiology of atherosclerosis and cancer. In this article we uncover a mechanism in which protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the interact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hackeng TM,Seré KM,Tans G,Rosing J

更新日期：2006-02-28 00:00:00

abstract：:Several lines of evidence suggest that the serotonin (5-hydroxytryptamine, 5-HT) regulates cardiovascular functions during embryogenesis and adulthood. 5-HT binds to numerous cognate receptors to initiate its biological effects. However, none of the 5-HT receptor disruptions in mice have yet resulted in embryonic defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nebigil CG,Choi DS,Dierich A,Hickel P,Le Meur M,Messaddeq N,Launay JM,Maroteaux L

更新日期：2000-08-15 00:00:00

abstract：:Tolerance and resistance provide hosts with two distinct defense strategies against parasitism. In resistance the hosts "fight" the parasite directly, whereas in tolerance the hosts fight the disease by ameliorating the damage that infection causes. There is increasing recognition that the two mechanisms may exhibit v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Best A,White A,Boots M

更新日期：2008-12-30 00:00:00

abstract：:Rhizobia colonize their legume hosts by different modes of entry while initiating symbiotic nitrogen fixation. Most legumes are invaded via growing root hairs by the root hair-curl mechanism, which involves epidermal cell responses. However, invasion of a number of tropical legumes happens through fissures at lateral ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goormachtig S,Capoen W,James EK,Holsters M

更新日期：2004-04-20 00:00:00

abstract：:Antigen-specific activation of T lymphocytes, via stimulation of the T-cell antigen receptor (TCR) complex, is marked by a rapid and sustained increase in the concentration of cytoplasmic free Ca2+ ([Ca2+]i). It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR stimulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaraman T,Ondriasová E,Ondrias K,Harnick DJ,Marks AR

更新日期：1995-06-20 00:00:00

abstract：:The biological activity of the transcription factor NF-kappaB is differentially controlled by three IkappaB proteins, Ikappa Balpha, Ikappa Bbeta, and Ikappa Bepsilon. We have examined the molecular basis for the differential inhibitory strengths of IkappaB proteins by constructing hybrid IkappaBs and found that the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simeonidis S,Stauber D,Chen G,Hendrickson WA,Thanos D

更新日期：1999-01-05 00:00:00

abstract：:In eukaryotes, ubiquitination is an important posttranslational process achieved through a cascade of ubiquitin-activating (E1), conjugating (E2), and ligase (E3) enzymes. Many pathogenic bacteria deliver virulence factors into the host cell that function as E3 ligases. How these bacterial "Trojan horses" integrate in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin DY,Diao J,Chen J

更新日期：2012-02-07 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate (cAMP) and guanosine 3':5'-cyclic monophosphate (cGMP) were localized in cells of rat kidney cortex by an immunocytochemical technique before and after perfusion with parathyroid hormone (PTH). In control tissues the cAMP antiserum detected approximately the same intensity of fluor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dousa TP,Barnes LD,Ong SH,Steiner AL

更新日期：1977-08-01 00:00:00

abstract：:Two brefeldin A (BFA)-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors, 200-kDa BIG1 and 190-kDa BIG2, were copurified from bovine brain cytosol associated with >670-kDa macromolecular complexes. When observed by immunofluorescence in HeLa S3 and HepG2 cells, endogenous BIG1 and coexpressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaji R,Adamik R,Takeda K,Togawa A,Pacheco-Rodriguez G,Ferrans VJ,Moss J,Vaughan M

更新日期：2000-03-14 00:00:00

abstract：:Loss-of-function mutations in the regulatory gene areA of Aspergillus nidulans prevent the utilization of a wide variety of nitrogen sources. The phenotypes of nit-2 mutants of Neurospora crassa suggest that this gene may be analogous to the areA gene. Transformation has been used to introduce a plasmid containing the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MA,Hynes MJ

更新日期：1987-06-01 00:00:00

abstract：:Selenophosphate, an activated form of selenium that can serve as a selenium donor, is generated by the selD gene product, selenophosphate synthetase (SPS). Selenophosphate is required by several bacteria and by mammals for the specific synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. Although...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogasawara Y,Lacourciere GM,Ishii K,Stadtman TC

更新日期：2005-01-25 00:00:00

abstract：:The Escherichia coli flagellar motor senses the intracellular concentration of the response regulator CheY-P and responds by varying the bias between its counterclockwise (CCW) and clockwise (CW) rotational states. The response is ultrasensitive with a large Hill coefficient (approximately 10). Recently, the detailed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tu Y

更新日期：2008-08-19 00:00:00

abstract：:The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)+ intestinal stem cell (ISC) survival through NOD2 activation upon an otherwise lethal oxid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levy A,Stedman A,Deutsch E,Donnadieu F,Virgin HW,Sansonetti PJ,Nigro G

更新日期：2020-01-28 00:00:00

abstract：:To study the similarity between a putative cloned mammalian release factor (RF) and tryptophanyl-tRNA synthetase (TRS), a recombinant rabbit RF fusion protein was expressed from prokaryotic expression vectors. Purified fractions of the fusion proteins were tested for TRS and RF activities. Addition of the fusion prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Timchenko L,Caskey CT

更新日期：1994-03-29 00:00:00

abstract：:Effects of previous strength training can be long-lived, even after prolonged subsequent inactivity, and retraining is facilitated by a previous training episode. Traditionally, such "muscle memory" has been attributed to neural factors in the absence of any identified local memory mechanism in the muscle tissue. We h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruusgaard JC,Johansen IB,Egner IM,Rana ZA,Gundersen K

更新日期：2010-08-24 00:00:00

abstract：:Recent studies have shown that phytoliths are softer than dental enamel but still act as abrasive agents. Thus, phytolith content should be reflected in dental wear. Because native phytoliths show lower indentation hardness than phytoliths extracted by dry ashing, we propose that the hydration state of plant tissue wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winkler DE,Schulz-Kornas E,Kaiser TM,De Cuyper A,Clauss M,Tütken T

更新日期：2019-01-22 00:00:00

abstract：:Cytochrome P450 enzymes are monooxygenases that contain a functional heme b group linked to a conserved cysteine with a thiolate bond. In the native state, the central iron atom is hexacoordinated with a covalently bound water molecule. The exclusion of solvent molecules from the active site is essential for efficient...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oprea TI,Hummer G,Garcia AE

更新日期：1997-03-18 00:00:00

abstract：:RNA polymerase pausing represents an important mechanism of transcriptional regulation. In this study, we use a single-molecule transcription assay to investigate the effect of template base-pair composition on pausing by RNA polymerase II and the evolutionarily distinct mitochondrial polymerase Rpo41. For both enzyme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamft B,Bintu L,Ishibashi T,Bustamante C

更新日期：2012-06-05 00:00:00

abstract：:Humans walk and run over a wide range of speeds with remarkable efficiency. For steady locomotion, moving at different speeds requires the muscle-tendon units of the leg to modulate the amount of mechanical power the limb absorbs and outputs in each step. How individual muscles adapt their behavior to modulate limb po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farris DJ,Sawicki GS

更新日期：2012-01-17 00:00:00