The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling.

abstract：:We have found that 1 of 20 human tumors transplanted and passaged in nude mice was associated with a massive induction of endogenous murine leukemia virus (MuLV). Separation and growth of these viruses on various substrates indicated that both ecotropic and xenotropic MuLV were present in the induced mixture. Tryptic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautsch JW,Knowles AF,Jensen FC,Kaplan NO

更新日期：1980-04-01 00:00:00

abstract：:Plasma growth hormone (GH) profiles are sexually differentiated in many species and regulate the sex-dependence of peripubescent growth rates and liver function, including steroid hydroxylase cytochrome P450 expression, by mechanisms that are poorly understood. By use of an external pump to deliver to hypophysectomize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waxman DJ,Pampori NA,Ram PA,Agrawal AK,Shapiro BH

更新日期：1991-08-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA) is a type 2 integral membrane glycoprotein that serves as an attractive target for cancer immunotherapy by virtue of its abundant and restricted expression on the surface of prostate carcinomas and the neovasculature of most other solid tumors. However, relatively little is kn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schülke N,Varlamova OA,Donovan GP,Ma D,Gardner JP,Morrissey DM,Arrigale RR,Zhan C,Chodera AJ,Surowitz KG,Maddon PJ,Heston WD,Olson WC

更新日期：2003-10-28 00:00:00

abstract：:Previous studies implicate the hypothalamic ventromedial nucleus (VMN) in glycemic control. Here, we report that selective inhibition of the subset of VMN neurons that express the transcription factor steroidogenic-factor 1 (VMN(SF1) neurons) blocks recovery from insulin-induced hypoglycemia whereas, conversely, activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meek TH,Nelson JT,Matsen ME,Dorfman MD,Guyenet SJ,Damian V,Allison MB,Scarlett JM,Nguyen HT,Thaler JP,Olson DP,Myers MG Jr,Schwartz MW,Morton GJ

更新日期：2016-04-05 00:00:00

abstract：:The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo formation of ONOO- has been demonstrated in shock and inflammation. Herein we provide evidence that cytotoxicity in cells exposed to ONOO- is mediated by DNA strand breakage and the subseque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szabó C,Zingarelli B,O'Connor M,Salzman AL

更新日期：1996-03-05 00:00:00

abstract：:The importance of receptor binding in the potent immunogenicity of Escherichia coli heat-labile enterotoxin B subunit (EtxB) was tested by comparing its immunogical properties with those of a receptor binding mutant, EtxB(G33D). Subcutaneous immunization of EtxB(G33D) resulted in 160-fold reduction in antibody titer c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nashar TO,Webb HM,Eaglestone S,Williams NA,Hirst TR

更新日期：1996-01-09 00:00:00

abstract：:Early conformational events during folding of acyl-CoA binding protein (ACBP), an 86-residue alpha-helical protein, were explored by using a continuous-flow mixing apparatus with a dead time of 70 micros to measure changes in intrinsic tryptophan fluorescence and tryptophan-dansyl fluorescence energy transfer. Althoug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teilum K,Maki K,Kragelund BB,Poulsen FM,Roder H

更新日期：2002-07-23 00:00:00

abstract：:T-cell-derived soluble factors that inhibit both X4 and R5 HIV are recognized as important in controlling HIV. Whereas three β chemokines, regulated-on-activation normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1α, and MIP-1β, account for the suppression of R5 HIV by blockade of HI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cocchi F,DeVico AL,Lu W,Popovic M,Latinovic O,Sajadi MM,Redfield RR,Lafferty MK,Galli M,Garzino-Demo A,Gallo RC

更新日期：2012-04-03 00:00:00

abstract：:During endoplasmic reticulum-associated degradation, the multifunctional AAA ATPase p97 is part of a protein degradation complex. p97 associates via its N-terminal domain with various cofactors to recruit ubiquitinated substrates. It also interacts with alternative substrate-processing cofactors, such as Ufd2, Ufd3, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao G,Zhou X,Wang L,Li G,Schindelin H,Lennarz WJ

更新日期：2007-05-22 00:00:00

abstract：:Gamma-Glutamyl transpeptidase, which consists of two nonidentical subunits, is rapidly inactivated with respect to its transpeptidase and hydrolase activities by the gamma-glutamyl analogs 6-diazo-5-oxo-L-norleucine and L-azaserine. Inactivation, which is prevented by gamma-glutamyl substrates (but not by acceptor sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1977-03-01 00:00:00

abstract：:The precipitation and assembly of calcium carbonate skeletons by stony corals is a precisely controlled process regulated by the secretion of an ECM. Recently, it has been reported that the proteome of the skeletal organic matrix (SOM) contains a group of coral acid-rich proteins as well as an assemblage of adhesion a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mass T,Drake JL,Peters EC,Jiang W,Falkowski PG

更新日期：2014-09-02 00:00:00

abstract：:Interleukin 2 (IL-2) is a potent growth factor for T lymphocytes, playing a crucial role in the immune response. In view of the considerable evidence that the immunoregulatory cytokines (or lymphokines) also play a role in the growth and differentiation of cells in the central nervous system (CNS), we examined the ope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okamoto Y,Minamoto S,Shimizu K,Mogami H,Taniguchi T

更新日期：1990-09-01 00:00:00

abstract：:By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evidence supporting this notion is based on several findings: (i) a high...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van der Ploeg LH,Martin WJ,Howard AD,Nargund RP,Austin CP,Guan X,Drisko J,Cashen D,Sebhat I,Patchett AA,Figueroa DJ,DiLella AG,Connolly BM,Weinberg DH,Tan CP,Palyha OC,Pong SS,MacNeil T,Rosenblum C,Vongs A,Tang R

更新日期：2002-08-20 00:00:00

abstract：:The question was addressed whether the risk of cancer of an individual in a heterogeneous population can be predicted on the basis of measurable biochemical and biological variables postulated to be associated with the process of chemical carcinogenesis. Using the skin tumor model with outbred male NMRI mice, the late...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer WH,Lutz WK

更新日期：1995-06-20 00:00:00

abstract：:Phenotypic capacitance refers to the ability of a genome to accumulate mutations that are conditionally hidden and only reveal phenotype-altering effects after certain environmental or genetic changes. Capacitance has important implications for the evolution of novel forms and functions, but experimentally studied mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayden EJ,Bendixsen DP,Wagner A

更新日期：2015-10-06 00:00:00

abstract：:The Dbf4Cdc7 kinase acts at the level of individual origins to promote the initiation of DNA replication. We demonstrate through both immunoprecipitation and two-hybrid assays that a domain comprising the first 296 aa of Dbf4p interacts with Orc2p and Orc3p subunits of the origin recognition complex (ORC). Given that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duncker BP,Shimada K,Tsai-Pflugfelder M,Pasero P,Gasser SM

更新日期：2002-12-10 00:00:00

abstract：:Animals are typically colonized by diverse bacterial symbionts, many of which are commensal and, in numerous cases, even essential for their host's proper development and growth. In exchange, the host must supply a sufficient array and quantity of nutrients to support the proliferation and persistence of its microbial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graf J,Ruby EG

更新日期：1998-02-17 00:00:00

abstract：:Nine subjects were studied by high-speed magnetic resonance imaging while performing language-based tasks. Subjects were asked either to repeat or to generate verbs associated with nouns read by an experimenter while magnetic resonance images were obtained of the left inferior frontal lobe. The echo-planar imaging seq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCarthy G,Blamire AM,Rothman DL,Gruetter R,Shulman RG

更新日期：1993-06-01 00:00:00

abstract：:Rat liver glutamine synthetase (s(20,w) 15.0 S; MW about 352,000) resembles ovine brain glutamine synthetase in that it (a) has 8 subunits, (b) acts on both L- and D-glutamate and certain glutamate analogs (e.g., beta-glutamate, cis-cycloglutamate, and alpha-methyl-L-glutamate), and (c) is irreversibly inhibited by L-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1971-04-01 00:00:00

abstract：:We show that a drop of liquid a few hundred microns in diameter placed under a solid, elastic, thin film (∼10 μm thick) causes it to bulge by tens of microns. The deformed shape is governed by equilibrium of tensions exerted by the various interfaces and the solid film, a form of Neumann's triangle. Unlike Young's equ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadermann N,Hui CY,Jagota A

更新日期：2013-06-25 00:00:00

abstract：:Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary MM tumors. These ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shou Y,Martelli ML,Gabrea A,Qi Y,Brents LA,Roschke A,Dewald G,Kirsch IR,Bergsagel PL,Kuehl WM

更新日期：2000-01-04 00:00:00

abstract：:Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and is a validated targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Kadam RU,Lee CD,Woehl JL,Wu NC,Zhu X,Kitamura S,Wilson IA,Wolan DW

更新日期：2020-08-04 00:00:00

abstract：:Reactive oxygen species, the by-products of oxidative energy metabolism, are considered a main proximate cause of aging. Accordingly, overexpression of the enzyme Cu-Zn superoxide dismutase 1 (SOD1) can lengthen lifespan of Drosophila melanogaster in the laboratory. However, the role of SOD1 as a main determinant of l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker JD,Parker KM,Sohal BH,Sohal RS,Keller L

更新日期：2004-03-09 00:00:00

abstract：:The stability and integrity of mRNAs encoding neurotransmitter receptors and voltage-activated channels in the postmortem rat brain was investigated by isolating poly(A)+ mRNA, injecting it into Xenopus oocytes, and then examining the expression of functional neurotransmitter receptors and voltage-activated channels i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ragsdale DS,Miledi R

更新日期：1991-03-01 00:00:00

abstract：:Multidrug resistance in Gram-negative bacteria, to which multidrug efflux pumps such as the AcrB transporter makes a major contribution, is becoming a major public health problem. Unfortunately only a few compounds have been cocrystallized with AcrB, and thus computational approaches are essential in elucidating the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vargiu AV,Nikaido H

更新日期：2012-12-11 00:00:00

abstract：:In spite of the diversity of possible biological forms observed in nature, a limited range of morphospace is frequently occupied for a given trait. Several mechanisms have been proposed to explain this bias in the distribution of phenotypes including selection, drift, and developmental constraints. Despite extensive w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malagón JN,Ahuja A,Sivapatham G,Hung J,Lee J,Muñoz-Gómez SA,Atallah J,Singh RS,Larsen E

更新日期：2014-09-30 00:00:00

abstract：:Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is initiated by transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawaguchi T,Tanigawa A,Naganuma T,Ohkawa Y,Souquere S,Pierron G,Hirose T

更新日期：2015-04-07 00:00:00

abstract：:Treatment of cultured Hodgkin disease (HD) cells with neuraminidase results in decreased reactivity of monoclonal antibody VIM-D5 with its antigen, the X hapten, a fucosyl-N-acetyllactosamine. The other feature characteristic of HD cells is the expression of high levels of ectosialyltransferase activity. We present ev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paietta E,Stockert RJ,Morell AG,Diehl V,Wiernik PH

更新日期：1986-05-01 00:00:00

abstract：:HU, the major DNA binding protein of Escherichia coli, exists in solution as a heterodimer composed of two highly homologous subunits: HU1, encoded by hupB; HU2, encoded by hupA. The purification of the HU protein from hupA- or hupB- bacteria showed that the hupB mutant strains synthesize normal amounts of the HU2 sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnefoy E,Almeida A,Rouviere-Yaniv J

更新日期：1989-10-01 00:00:00

abstract：:Rapid development of genetic variability may contribute to the pathogenicity of lentiviruses as it may allow escape from immune surveillance and/or from suppression of virus replication. Although apathogenic in African green monkeys, simian immunodeficiency virus isolated from African green monkeys is shown to display...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baier M,Dittmar MT,Cichutek K,Kurth R

更新日期：1991-09-15 00:00:00