Decreased expression of Cu-Zn superoxide dismutase 1 in ants with extreme lifespan.

abstract：:Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in Arabidopsis during leaf aging. The most evident characteristic of these time-dependent networks w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HJ,Park JH,Kim J,Kim JJ,Hong S,Kim J,Kim JH,Woo HR,Hyeon C,Lim PO,Nam HG,Hwang D

更新日期：2018-05-22 00:00:00

abstract：:Mutations in the iPLA2-VIA/PLA2G6 gene are responsible for PARK14-linked Parkinson's disease (PD) with α-synucleinopathy. However, it is unclear how iPLA2-VIA mutations lead to α-synuclein (α-Syn) aggregation and dopaminergic (DA) neurodegeneration. Here, we report that iPLA2-VIA-deficient Drosophila exhibits defects ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mori A,Hatano T,Inoshita T,Shiba-Fukushima K,Koinuma T,Meng H,Kubo SI,Spratt S,Cui C,Yamashita C,Miki Y,Yamamoto K,Hirabayashi T,Murakami M,Takahashi Y,Shindou H,Nonaka T,Hasegawa M,Okuzumi A,Imai Y,Hattori N

更新日期：2019-10-08 00:00:00

abstract：:Double immunofluorescent labeling experiments for lysosomes and either microtubules or vimentin intermediate filaments in cultured well-spread fibroblasts show a remarkable degree of superposition of the lysosomes and the microtubules. Under two different sets of conditions where the microtubules and intermediate fila...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collot M,Louvard D,Singer SJ

更新日期：1984-02-01 00:00:00

abstract：:BSC-1 cells, epithelial cells of African green monkey kidney origin, show pronounced density-dependent regulation of growth in cell culture. Growth of the cells is rapid to a density of approximately 1.5 x 10(5) cells/per cm(2) in Dulbecco-modified Eagle's medium supplemented with 10% calf serum. Above this "saturatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holley RW,Armour R,Baldwin JH

更新日期：1978-01-01 00:00:00

abstract：:Activity-dependent means of altering calcium (Ca(2)(+)) influx are assumed to be of great physiological consequence, although definitive tests of this assumption have only begun to emerge. Facilitation and inactivation offer two opposing, activity-dependent means of altering Ca(2+) influx via cardiac Ca(v)1.2 calcium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blaich A,Welling A,Fischer S,Wegener JW,Köstner K,Hofmann F,Moosmang S

更新日期：2010-06-01 00:00:00

abstract：:The first step in the replication of the adenovirus genome is the covalent attachment of the 5'-terminal nucleotide, dCMP, to the virus-encoded terminal protein precursor (pTP). This reaction can be observed in vitro and has been previously shown to be dependent upon either viral DNA or linearized plasmid DNA containi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Challberg MD,Rawlins DR

更新日期：1984-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) plays an important role in peroxisome biogenesis; some peroxisomal membrane proteins are inserted into the ER and trafficked to peroxisomes in vesicles. These vesicles could also provide the phospholipids required for the growth of peroxisomal membranes, because peroxisomes lack phosphol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raychaudhuri S,Prinz WA

更新日期：2008-10-14 00:00:00

abstract：:This paper presents some calculated results on the vibrational structuring of the magnetic circular dichroism of the benzene (1)A(1g)"(1)B(2u) transition. The good agreement between the experimental and calculated relative intensities of the B-bands (positive magnetic circular dichroism bands) indicates that these ban...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shieh DJ,Lin SH,Eyring H

更新日期：1972-08-01 00:00:00

abstract：:Which network structures favor the rapid spread of new ideas, behaviors, or technologies? This question has been studied extensively using epidemic models. Here we consider a complementary point of view and consider scenarios where the individuals' behavior is the result of a strategic choice among competing alternati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montanari A,Saberi A

更新日期：2010-11-23 00:00:00

abstract：:Sequence comparisons of genomes or expressed sequence tags (ESTs) from related organisms provide insight into functional conservation and diversification. We compare the sequences of ESTs from the male accessory gland of Drosophila simulans to their orthologs in its close relative Drosophila melanogaster, and demonstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson WJ,Clark AG,Waldrip-Dail HM,Wolfner MF,Aquadro CF

更新日期：2001-06-19 00:00:00

abstract：:Despite substantial size variations, proportions of the developing body plan are maintained with a remarkable precision. Little is known about the mechanisms that ensure this adaptation (scaling) of pattern with size. Most models of patterning by morphogen gradients do not support scaling. In contrast, we show that sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Zvi D,Barkai N

更新日期：2010-04-13 00:00:00

abstract：:B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zang X,Loke P,Kim J,Murphy K,Waitz R,Allison JP

更新日期：2003-09-02 00:00:00

abstract：:The formation of nerve-muscle junctions in monolayer cultures of embryonic muscle and spinal cord cells is described. Muscle-forming cells (myoblasts) from leg muscles of 12-day chick embryos were separated with trypsin and cultured on a collagen substrate for two days. Suspensions of ventral spinal cord cells from si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimada Y,Fischman DA,Moscona AA

更新日期：1969-03-01 00:00:00

abstract：:NKp46 is a cell surface receptor expressed on natural killer (NK) cells, on a minute subset of T cells, and on a population of innate lymphoid cells that produce IL-22 and express the transcription factor retinoid-related orphan receptor (ROR)-γt, referred to as NK cell receptor (NKR)(+)ROR-γt(+) cells. Here we descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narni-Mancinelli E,Chaix J,Fenis A,Kerdiles YM,Yessaad N,Reynders A,Gregoire C,Luche H,Ugolini S,Tomasello E,Walzer T,Vivier E

更新日期：2011-11-08 00:00:00

abstract：:Folding mechanisms of proteins incorporated within supramolecular assemblies, including viruses, are little understood and may differ fundamentally from folding mechanisms of small globular proteins. We describe a novel Raman dynamic probe of hydrogen-isotope exchange to investigate directly these protein folding/asse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuma R,Prevelige PE Jr,Thomas GJ Jr

更新日期：1998-08-18 00:00:00

abstract：:Differences between early and late passage cell cultures on the organelle and macromolecular levels have been attributed to cellular "aging". However, concern has been expressed over whether changes in diploid cell populations after serial passage in vitro accurately reflect human cellular aging in vivo. Studies were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider EL,Mitsui Y

更新日期：1976-10-01 00:00:00

abstract：:The apparent detection of an exoplanet orbiting Fomalhaut was announced in 2008. However, subsequent observations of Fomalhaut b raised questions about its status: Unlike other exoplanets, it is bright in the optical and nondetected in the infrared, and its orbit appears to cross the debris ring around the star withou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gáspár A,Rieke GH

更新日期：2020-05-05 00:00:00

abstract：:Although the function of silicon (Si) in plant physiology has long been debated, its beneficial effects on plant resistance against abiotic and biotic stresses, including insect herbivory, have been well documented. In addition, the jasmonate (JA) signaling pathway plays a crucial role in mediating antiherbivore defen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye M,Song Y,Long J,Wang R,Baerson SR,Pan Z,Zhu-Salzman K,Xie J,Cai K,Luo S,Zeng R

更新日期：2013-09-17 00:00:00

abstract：:Based on the DNA sequence of the symbiotic plasmid of Rhizobium strain NGR234, we predicted potential rearrangements generated by homologous recombination. All predicted rearrangements were identified experimentally by using a PCR-based methodology. Thus, the predicted and the actual dynamic maps of the replicon coinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores M,Mavingui P,Perret X,Broughton WJ,Romero D,Hernández G,Dávila G,Palacios R

更新日期：2000-08-01 00:00:00

abstract：:Genomic imprinting results in the differential expression of genes, depending on which allele is inherited from the mother and which from the father. The effects of such differential gene expression are reflected in phenotypic differences between the reciprocal heterozygotes (Aa vs. aA). Although many imprinted genes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheverud JM,Hager R,Roseman C,Fawcett G,Wang B,Wolf JB

更新日期：2008-03-18 00:00:00

abstract：:Excited states of proteins may play important roles in function, yet are difficult to study spectroscopically because of their sparse population. High hydrostatic pressure increases the equilibrium population of excited states, enabling their characterization [Akasaka K (2003) Biochemistry 42:10875-85]. High-pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerch MT,Horwitz J,McCoy J,Hubbell WL

更新日期：2013-12-03 00:00:00

abstract：:Language and analytic processing are currently thought to be represented in the left hemisphere, whereas spatial and holistic processing would involve primarily the right hemisphere in man. An experimental paradigm for engaging the nonlanguage hemisphere (generally the right) is described. This involves active touch e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desmedt JE

更新日期：1977-09-01 00:00:00

abstract：:The role of protein farnesylation in lamin A biogenesis and the pathogenesis of progeria has been studied in considerable detail, but the importance of farnesylation for the B-type lamins, lamin B1 and lamin B2, has received little attention. Lamins B1 and B2 are expressed in nearly every cell type from the earliest s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung HJ,Nobumori C,Goulbourne CN,Tu Y,Lee JM,Tatar A,Wu D,Yoshinaga Y,de Jong PJ,Coffinier C,Fong LG,Young SG

更新日期：2013-05-21 00:00:00

abstract：:The DNA damage response is an essential process for the survival of living cells. In a subset of stress-responsive genes in humans, Elongin controls transcription in response to multiple stimuli, such as DNA damage, oxidative stress, and heat shock. Yeast Elongin (Ela1-Elc1), along with Def1, is known to facilitate ub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damodaren N,Van Eeuwen T,Zamel J,Lin-Shiao E,Kalisman N,Murakami K

更新日期：2017-12-12 00:00:00

abstract：:High molecular weight RNA (35S) isolated from avian myeloblastosis virus directs the cell-free synthesis of two prominent polypeptides of 180,000 and 76,000 molecular weight. The latter polypeptide has previously been identified as the precursor to the group-specific antigens of the virus ("gag" proteins) [Vogt, V. M....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paterson BM,Marciani DJ,Papas TS

更新日期：1977-11-01 00:00:00

abstract：:Coincidence cloning allows the isolation of sequences held in common by two genomic DNA populations. Human DNA from two human-hamster hybrid cell lines was amplified by Alu-repeat primers (Alu PCR) and the products originating from the shared human chromosomal region were cloned. To achieve this, human sequences were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aslanidis C,de Jong PJ

更新日期：1991-08-01 00:00:00

abstract：:Senescent cell antigen (SCA), an aging antigen, is a protein that appears on old cells and marks them for removal by the immune system in mammals. It is derived from band 3, a ubiquitous membrane transport protein found in diverse cell types and tissues. We have used synthetic peptides to identify aging antigenic site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM,Marchalonis JJ,Hughes J,Watanabe K,Schluter SF

更新日期：1990-08-01 00:00:00

abstract：:Two endocytic receptors, the low density lipoprotein (LDL) receptor (LDLR) and the LDLR-related protein (LRP), are thought to act in concert in the hepatic uptake of partially metabolized dietary lipoproteins, the chylomicron remnants. We have evaluated the role of these two receptors in the hepatic metabolism of chyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herz J,Qiu SQ,Oesterle A,DeSilva HV,Shafi S,Havel RJ

更新日期：1995-05-09 00:00:00

abstract：:One of sleep's putative functions is mediation of adaptation to waking experiences. Chronic stress is a common waking experience; however, which specific aspect of sleep is most responsive, and how sleep changes relate to behavioral disturbances and molecular correlates remain unknown. We quantified sleep, physical, e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nollet M,Hicks H,McCarthy AP,Wu H,Möller-Levet CS,Laing EE,Malki K,Lawless N,Wafford KA,Dijk DJ,Winsky-Sommerer R

更新日期：2019-02-12 00:00:00

abstract：:Sulfonated gallium(III) corroles are intensely fluorescent macrocyclic compounds that spontaneously assemble with carrier proteins to undergo cell entry. We report in vivo imaging and therapeutic efficacy of a tumor-targeted corrole noncovalently assembled with a heregulin-modified protein directed at the human epider...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agadjanian H,Ma J,Rentsendorj A,Valluripalli V,Hwang JY,Mahammed A,Farkas DL,Gray HB,Gross Z,Medina-Kauwe LK

更新日期：2009-04-14 00:00:00