Abstract:
:B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-cycle progression, proliferation, and cytokine production of both CD4+ and CD8+ T cells. B7x binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in downregulation of tissue-specific autoimmunity and antitumor responses.
journal_name
Proc Natl Acad Sci U S Aauthors
Zang X,Loke P,Kim J,Murphy K,Waitz R,Allison JPdoi
10.1073/pnas.1434299100keywords:
subject
Has Abstractpub_date
2003-09-02 00:00:00pages
10388-92issue
18eissn
0027-8424issn
1091-6490pii
1434299100journal_volume
100pub_type
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