Three-dimensional structure of a protein from scorpion venom: a new structural class of neurotoxins.

abstract：:Using brain transcriptomic profiles from 853 individual honey bees exhibiting 48 distinct behavioral phenotypes in naturalistic contexts, we report that behavior-specific neurogenomic states can be inferred from the coordinated action of transcription factors (TFs) and their predicted target genes. Unsupervised hierar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chandrasekaran S,Ament SA,Eddy JA,Rodriguez-Zas SL,Schatz BR,Price ND,Robinson GE

更新日期：2011-11-01 00:00:00

abstract：:The sense of body ownership represents a fundamental aspect of our self-awareness, but is disrupted in many neurological, psychiatric, and psychological conditions that are also characterized by disruption of skin temperature regulation, sometimes in a single limb. We hypothesized that skin temperature in a specific l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moseley GL,Olthof N,Venema A,Don S,Wijers M,Gallace A,Spence C

更新日期：2008-09-02 00:00:00

abstract：:Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhisa T,Rajewsky K

更新日期：1985-06-01 00:00:00

abstract：:In an autoshaping experiment, food-deprived pigeons pecked rapidly at a moving dot that preceded the delivery of food. When the moving dot and food were no longer correlated, the rate of pecking dropped nearly to zero. When, subsequently, no food was given, pecking reappeared at a high rate (nearly 200 pecks per min f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein R,Skinner BF

更新日期：1980-10-01 00:00:00

abstract：:Bacterial mutants have been isolated, called groN, that block phage development by interference with the action of the product of the phage N gene. lambdatrp phages, which depend on the N product for the synthesis of tryptophan enzymes, do not make these enzymes in groN bacteria. Two type of phage mutants have been is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Georgopoulos CP

更新日期：1971-12-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been implicated in a variety of physiological and pathological processes, including cancer. In prostate cancer, prostate cancer gene expression marker 1 (PCGEM1) is an androgen-induced prostate-specific lncRNA whose overexpression is highly associated with prostate tumors. PCGEM1's t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hung CL,Wang LY,Yu YL,Chen HW,Srivastava S,Petrovics G,Kung HJ

更新日期：2014-12-30 00:00:00

abstract：:Signal peptides of membrane proteins are cleaved by endoplasmic reticulum-resident signal peptidase, and thus, are not present on mature membrane proteins. Here, we report that, contrary to the paradigm, the signal peptide of ruminant CD18, the beta-subunit of beta(2)-integrins, is not cleaved. Intriguingly, the intac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shanthalingam S,Srikumaran S

更新日期：2009-09-08 00:00:00

abstract：:We have used DNase I as a probe to examine the chromatin structure of mouse immunoglobulin kappa light chain genes in rearranged and unrearranged chromosomes--i.e., in nuclei from myeloma cells and from brain and liver cells. Tissue-specific DNase I-hypersensitive sites are observed 0.7 and 1.7 kilobases upstream from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung SY,Folsom V,Wooley J

更新日期：1983-05-01 00:00:00

abstract：:Replication of the murine leukemia viruses is strongly suppressed in mouse embryonic stem (ES) cells. Proviral DNAs are formed normally but are then silenced by a large complex bound to DNA by the ES cell-specific zinc-finger protein ZFP809. We show here that ZFP809 expression is not regulated by transcription but rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Goff SP

更新日期：2017-02-07 00:00:00

abstract：:GB virus B (GBV-B), which infects tamarins, is the virus most closely related to hepatitis C virus (HCV). HCV has a protein (p7) that is believed to form an ion channel. It is critical for viability. In vitro studies suggest that GBV-B has an analogous but larger protein (p13). We found that substitutions of the -1 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takikawa S,Engle RE,Emerson SU,Purcell RH,St Claire M,Bukh J

更新日期：2006-02-28 00:00:00

abstract：:Cytochrome ba3 from Thermus thermophilus reacts slowly with excess HCN at pH 7.4 to create a form of the enzyme in which CuA, cytochrome b, and CuB remain oxidized, while cytochrome a3 is reduced by one electron, presumably with the formation of cyanogen. We have examined this form of the enzyme by UV-visible, resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Surerus KK,Oertling WA,Fan C,Gurbiel RJ,Einarsdóttir O,Antholine WE,Dyer RB,Hoffman BM,Woodruff WH,Fee JA

更新日期：1992-04-15 00:00:00

abstract：:The structure of Sindbis virus was determined by electron cryomicroscopy. The virion contains two icosahedral shells of viral-encoded proteins separated by a membrane bilayer of cellular origin. The three-dimensional structure of the ice-embedded intact Sindbis virus, reconstructed from electron images, unambiguously ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paredes AM,Brown DT,Rothnagel R,Chiu W,Schoepp RJ,Johnston RE,Prasad BV

更新日期：1993-10-01 00:00:00

abstract：:Peripheral nerve injury induces a robust proregenerative program that drives axon regeneration. While many regeneration-associated genes are known, the mechanisms by which injury activates them are less well-understood. To identify such mechanisms, we performed a loss-of-function pharmacological screen in cultured adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karney-Grobe S,Russo A,Frey E,Milbrandt J,DiAntonio A

更新日期：2018-10-16 00:00:00

abstract：:Alpha-actinin-4 is a widely expressed protein that employs an actin-binding site with two calponin homology domains to crosslink actin filaments (F-actin) in a Ca(2+)-sensitive manner in vitro. An inherited, late-onset form of kidney failure is caused by point mutations in the alpha-actinin-4 actin-binding domain. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weins A,Schlondorff JS,Nakamura F,Denker BM,Hartwig JH,Stossel TP,Pollak MR

更新日期：2007-10-09 00:00:00

abstract：:The impossibility theorems that abound in the theory of social choice show that there can be no satisfactory method for electing and ranking in the context of the traditional, 700-year-old model. A more realistic model, whose antecedents may be traced to Laplace and Galton, leads to a new theory that avoids all imposs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balinski M,Laraki R

更新日期：2007-05-22 00:00:00

abstract：:Double-stranded RNA (dsRNA) recently has been shown to give rise to genetic interference in Caenorhabditis elegans and also is likely to be the basis for phenotypic cosuppression in plants in certain instances. While constructing a plasmid vector for transfection of trypanosome cells, we serendipitously discovered tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ngô H,Tschudi C,Gull K,Ullu E

更新日期：1998-12-08 00:00:00

abstract：:A deficit in early clearance of Pseudomonas aeruginosa (P. aeruginosa) is crucial in nosocomial pneumonia and in chronic lung infections. Few studies have addressed the role of Toll-like receptors (TLRs), which are early pathogen associated molecular pattern receptors, in pathogen uptake and clearance by alveolar macr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Descamps D,Le Gars M,Balloy V,Barbier D,Maschalidi S,Tohme M,Chignard M,Ramphal R,Manoury B,Sallenave JM

更新日期：2012-01-31 00:00:00

abstract：:A central question in protein-DNA recognition is the origin of the specificity that permits binding to the correct site in the presence of excess, nonspecific DNA. In the P22 Arc repressor, the Phe-10 side chain is part of the hydrophobic core of the free protein but rotates out to pack against the sugar-phosphate bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schildbach JF,Karzai AW,Raumann BE,Sauer RT

更新日期：1999-02-02 00:00:00

abstract：:A major function of innate immune receptors is to recognize pathogen-associated molecular patterns and then evoke immune responses appropriate to the nature of the invading pathogen(s). Because innate immune cells express various types of these receptors, distinct combinations of signaling pathways are activated in re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negishi H,Matsuki K,Endo N,Sarashina H,Miki S,Matsuda A,Fukazawa K,Taguchi-Atarashi N,Ikushima H,Yanai H,Nishio J,Honda K,Fujioka Y,Ohba Y,Noda T,Taniguchi S,Nishida E,Zhang Y,Chi H,Flavell RA,Taniguchi T

更新日期：2013-12-03 00:00:00

abstract：:Multiple drug resistance of tumor cells is a common problem in cancer therapy. We have demonstrated that membrane vesicles from highly multidrug-resistant human KB carcinoma cell lines exhibit increased specific and saturable binding of vinblastine. To identify the molecules that bind vinblastine, membrane vesicles fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornwell MM,Safa AR,Felsted RL,Gottesman MM,Pastan I

更新日期：1986-06-01 00:00:00

abstract：:The helical ribosome structures of Mycoplasma gallisepticum have been analyzed by optical diffraction and the rotational symmetry technique. The helix repeat (510 A) is composed of 10 ribosomes in 3 turns. The rotational studies show some ribosome fine structure. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maniloff J

更新日期：1971-01-01 00:00:00

abstract：:Ultrastructural immunocytochemical studies of the expression of major histocompatibility complex class I antigens in the placentas of inbred rats were performed using placentas derived from natural matings and from embryo transfers into females made pseudopregnant by mechanical stimulation. The studies utilized the WF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanbour-Shakir A,Zhang X,Rouleau A,Armstrong DT,Kunz HW,Macpherson TA,Gill TJ 3rd

更新日期：1990-01-01 00:00:00

abstract：:Learning to read requires the acquisition of an efficient visual procedure for quickly recognizing fine print. Thus, reading practice could induce a perceptual learning effect in early vision. Using functional magnetic resonance imaging (fMRI) in literate and illiterate adults, we previously demonstrated an impact of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pegado F,Comerlato E,Ventura F,Jobert A,Nakamura K,Buiatti M,Ventura P,Dehaene-Lambertz G,Kolinsky R,Morais J,Braga LW,Cohen L,Dehaene S

更新日期：2014-12-09 00:00:00

abstract：:Human activities increasingly take place in online environments, providing novel opportunities for relating individual behaviors to population-level outcomes. In this paper, we introduce a simple generative model for the collective behavior of millions of social networking site users who are deciding between different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleeson JP,Cellai D,Onnela JP,Porter MA,Reed-Tsochas F

更新日期：2014-07-22 00:00:00

abstract：:As chips further shrink toward smaller scales, fabrication processes based on the self-assembly of individual particles into patterns or structures are often sought. One of the most popular techniques for two-dimensional assembly (self-assembled monolayers) is based on capillary forces acting on particles placed at a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aubry N,Singh P,Janjua M,Nudurupati S

更新日期：2008-03-11 00:00:00

abstract：:In a genetic screen of available T-DNA-mutagenized Arabidopsis populations for loci potentially involved in phytochrome (phy) signaling, we identified a mutant that displayed reduced seedling deetiolation under continuous red light, but little if any change in responsiveness to continuous far-red light. This behavior ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huq E,Tepperman JM,Quail PH

更新日期：2000-08-15 00:00:00

abstract：:We study static and dynamical properties that distinguish 2D crystals constrained to lie on a curved substrate from their flat-space counterparts. A generic mechanism of dislocation unbinding in the presence of varying Gaussian curvature is presented in the context of a model surface amenable to full analytical treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vitelli V,Lucks JB,Nelson DR

更新日期：2006-08-15 00:00:00

abstract：:A photolyzable derivative of dipeptidyl-tRNA, p-azido-N-tBoc-Phe-[3H]Phe-tRNA, bound reversibly to 70S ribosomes in the presence of poly(U), becomes, when irradiated, covalently attached to components of the 50S ribosomal subunit. Most of the reaction occurs within the 23S RNA, while ribosomal proteins are only weakly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sonenberg N,Wilchek M,Zamir A

更新日期：1975-11-01 00:00:00

abstract：:Bacterial intracellular symbiosis (endosymbiosis) is widespread in nature and impacts many biological processes. In holometabolous symbiotic insects, metamorphosis entails a complete and abrupt internal reorganization that creates a constraint for endosymbiont transmission from larvae to adults. To assess how endosymb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maire J,Parisot N,Galvao Ferrarini M,Vallier A,Gillet B,Hughes S,Balmand S,Vincent-Monégat C,Zaidman-Rémy A,Heddi A

更新日期：2020-08-11 00:00:00

abstract：:Subcortical structures play a critical role in brain function. However, options for assessing electrophysiological activity in these structures are limited. Electromagnetic fields generated by neuronal activity in subcortical structures can be recorded noninvasively, using magnetoencephalography (MEG) and electroencep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krishnaswamy P,Obregon-Henao G,Ahveninen J,Khan S,Babadi B,Iglesias JE,Hämäläinen MS,Purdon PL

更新日期：2017-11-28 00:00:00