Sparsity enables estimation of both subcortical and cortical activity from MEG and EEG.

abstract：:The developmental loss of neurons in sympathetic, sensory, and some parasympathetic ganglia in familial dysautonomia suggests an inherited defect in the action of beta-nerve growth factor (beta-NGF). The role of this growth factor in dysautonomia has been difficult to resolve as there is no known source of authentic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breakefield XO,Orloff G,Castiglione C,Coussens L,Axelrod FB,Ullrich A

更新日期：1984-07-01 00:00:00

abstract：:We modeled the behavior of recessive mutations with deleterious effects to either the sporophyte or the gametophyte, or both, in polysomic tetraploid populations by allowing for varying levels of double reduction, mutation, and self-fertilization. Double reduction causes a decrease of the equilibrium frequencies of de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butruille DV,Boiteux LS

更新日期：2000-06-06 00:00:00

abstract：:Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no reliable test for PI3K pathway activation exists for human tumors. Taking advantage of the observation that loss of PTEN, the negative ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saal LH,Johansson P,Holm K,Gruvberger-Saal SK,She QB,Maurer M,Koujak S,Ferrando AA,Malmström P,Memeo L,Isola J,Bendahl PO,Rosen N,Hibshoosh H,Ringnér M,Borg A,Parsons R

更新日期：2007-05-01 00:00:00

abstract：:Human genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the demic diffusion of agriculture from the Near East, and gene flow from Africa. Using SNP data from 2,099 individuals in 43 populations, we show that estimates o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Botigué LR,Henn BM,Gravel S,Maples BK,Gignoux CR,Corona E,Atzmon G,Burns E,Ostrer H,Flores C,Bertranpetit J,Comas D,Bustamante CD

更新日期：2013-07-16 00:00:00

abstract：:Angiogenesis restores blood flow to healing tissues, a process that is inhibited by high doses of glucocorticoids. However, the role of endogenous glucocorticoids and the potential for antiglucocorticoid therapy to enhance angiogenesis is unknown. Using in vitro and in vivo models of angiogenesis in mice, we examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Small GR,Hadoke PW,Sharif I,Dover AR,Armour D,Kenyon CJ,Gray GA,Walker BR

更新日期：2005-08-23 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. The extinction of fear, however, is labile and a number of factors, including stress, cause extinguished fear to relapse. Here we show that fear relapse in rats limits single-unit activi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustino TF,Fitzgerald PJ,Ressler RL,Maren S

更新日期：2019-04-23 00:00:00

abstract：:The P23T mutant of human gammaD-crystallin (HGD) is associated with cataract. We have previously investigated the solution properties of this mutant, as well as those of the closely related P23V and P23S mutants, and shown that although mutations at site 23 of HGD do not produce a significant structural change in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McManus JJ,Lomakin A,Ogun O,Pande A,Basan M,Pande J,Benedek GB

更新日期：2007-10-23 00:00:00

abstract：:Effects of previous strength training can be long-lived, even after prolonged subsequent inactivity, and retraining is facilitated by a previous training episode. Traditionally, such "muscle memory" has been attributed to neural factors in the absence of any identified local memory mechanism in the muscle tissue. We h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruusgaard JC,Johansen IB,Egner IM,Rana ZA,Gundersen K

更新日期：2010-08-24 00:00:00

abstract：:The likelihood with which an action potential elicits neurotransmitter release, the release probability (p(r)), is an important component of synaptic strength. Regulatory mechanisms controlling several steps of synaptic vesicle (SV) exocytosis may affect p(r), yet their relative importance in determining p(r) and elic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matz J,Gilyan A,Kolar A,McCarvill T,Krueger SR

更新日期：2010-05-11 00:00:00

abstract：:Fluorescence of quinacrine in the presence of different polynucleotides was studied to attempt to identify the specific nucleotides responsible for the fluorescence of stained chromosome preparations. A marked enhancement of fluorescence was seen in the presence of bihelical polynucleotides, such as poly(dA-dT), poly(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weisblum B,De Haseth PL

更新日期：1972-03-01 00:00:00

abstract：:A human collagenase inhibitor (CI) of Mr 28,500 has been extensively characterized in skin fibroblasts and identified in a variety of connective tissues. Because human alveolar macrophages synthesize and secrete both a collagenase and CI that are immunologically and functionally identical to their counterparts in fibr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Shavit Z,Teitelbaum SL,Stricklin GP,Eisen AZ,Kahn AJ,Welgus HG

更新日期：1985-08-01 00:00:00

abstract：:The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role in the replication and maintenance of latent viral episomal DNA. In addition, N-terminally truncated cytoplasmic isoforms of LANA, resul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang G,Chan B,Samarina N,Abere B,Weidner-Glunde M,Buch A,Pich A,Brinkmann MM,Schulz TF

更新日期：2016-02-23 00:00:00

abstract：:The mammalian form of the protozoan parasite Leishmania mexicana contains high activity of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb). Homozygous null mutants for lmcpb have been produced by targeted gene disruption. All life-cycle stages of the mutant can be cultured in vitro, demonst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mottram JC,Souza AE,Hutchison JE,Carter R,Frame MJ,Coombs GH

更新日期：1996-06-11 00:00:00

abstract：:Much of our understanding of atmospheric secondary organic aerosol (SOA) formation from volatile organic compounds derives from laboratory chamber measurements, including mass yield and elemental composition. These measurements alone are insufficient to identify the chemical mechanisms of SOA production. We present he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang X,McVay RC,Huang DD,Dalleska NF,Aumont B,Flagan RC,Seinfeld JH

更新日期：2015-11-17 00:00:00

abstract：:Variation in the masticatory behavior of hunter-gatherer and agricultural populations is hypothesized to be one of the major forces affecting the form of the human mandible. However, this has yet to be analyzed at a global level. Here, the relationship between global mandibular shape variation and subsistence economy ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Cramon-Taubadel N

更新日期：2011-12-06 00:00:00

abstract：:Chick-limb mesodermal cells have been maintained in tissue culture under conditions that permit development of muscle and cartilage. 3-Acetylpyridine, a nicotinamide-antagonized muscle teratogen, potentiates chondrogenic expression in cell cultures, as evidenced by histological and biochemical criteria, including the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caplan AI,Stoolmiller AC

更新日期：1973-06-01 00:00:00

abstract：:The U1 small nuclear ribonucleoprotein particle U1C protein has a zinc finger-like structure (C2H2 motif) at its N terminus, which is conserved from yeast to humans. Mutations of amino acid L13 within this domain rescue the essential function of the helicase protein Prp28p. Prp28p has been implicated in unwinding the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du H,Tardiff DF,Moore MJ,Rosbash M

更新日期：2004-10-12 00:00:00

abstract：:For length and area, a central fact is that the value of the length of a curve or the area of a surface, as given by the Lebesgue theory, is at least as great as that given by the classical formula, whenever the latter has meaning. This is now found not to be valid in higher dimensions. We give an example of a continu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goffman C

更新日期：1969-05-01 00:00:00

abstract：:The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) is important for the initiation of allergic airway inflammation through a dendritic cell-mediated T helper 2 response. To identify the factors that control TSLP expression, we examined the ability of inflammatory mediators to regulate TSLP production ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee HC,Ziegler SF

更新日期：2007-01-16 00:00:00

abstract：:A descriptive medium for the presentation of protein structure has been developed and used to evaluate the structure of the active site of bovine trypsin (EC 3.4.21.4). This technique, involving advanced computer graphics technology, permits the facile display of a representation of the molecular surface of proteins o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldmann RJ,Bing DH,Furie BC,Furie B

更新日期：1978-11-01 00:00:00

abstract：:Molecular genetic analyses of the young pseudogenes of the immunoglobulin C epsilon genes were carried out to obtain qualitative evidence for the phylogenetic branching pattern of hominoid primates. We found that Old World monkeys had two C epsilon genes, one of which was processed. Among the hominoids examined only t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueda S,Takenaka O,Honjo T

更新日期：1985-06-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsilioni I,Pantazopoulos H,Conti P,Leeman SE,Theoharides TC

更新日期：2020-07-14 00:00:00

abstract：:During Drosophila development, nuclear and cell divisions are coordinated in response to developmental signals. In yeast and mammalian cells, signals that control cell division regulate the activity of cyclin-dependent kinases (Cdks) through proteins such as cyclins that interact with the Cdks. Here we describe two Dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finley RL Jr,Thomas BJ,Zipursky SL,Brent R

更新日期：1996-04-02 00:00:00

abstract：:During excitation-contraction (e-c) coupling of striated muscle, depolarization of the surface membrane is converted into Ca2+ release from internal stores. This process occurs at intracellular junctions characterized by a specialized composition and structural organization of membrane proteins. The coordinated arrang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flucher BE,Franzini-Armstrong C

更新日期：1996-07-23 00:00:00

abstract：:The consumption of garlic is inversely correlated with the progression of cardiovascular disease, although the responsible mechanisms remain unclear. Here we show that human RBCs convert garlic-derived organic polysulfides into hydrogen sulfide (H(2)S), an endogenous cardioprotective vascular cell signaling molecule. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benavides GA,Squadrito GL,Mills RW,Patel HD,Isbell TS,Patel RP,Darley-Usmar VM,Doeller JE,Kraus DW

更新日期：2007-11-13 00:00:00

abstract：:Plant litter decomposition is a critical step in the formation of soil organic matter, the mineralization of organic nutrients, and the carbon balance in terrestrial ecosystems. Biotic decomposition in mesic ecosystems is generally negatively correlated with the concentration of lignin, a group of complex aromatic pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austin AT,Ballaré CL

更新日期：2010-03-09 00:00:00

abstract：:The repair of DNA double-strand breaks (DSBs) requires open, flexible chromatin domains. The NuA4-Tip60 complex creates these flexible chromatin structures by exchanging histone H2A.Z onto nucleosomes and promoting acetylation of histone H4. Here, we demonstrate that the accumulation of H2A.Z on nucleosomes at DSBs is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gursoy-Yuzugullu O,Ayrapetov MK,Price BD

更新日期：2015-06-16 00:00:00

abstract：:Untargeted metabolomics of environmental samples routinely detects thousands of small molecules, the vast majority of which cannot be identified. Meta-mass shift chemical (MeMSChem) profiling was developed to identify mass differences between related molecules using molecular networks. This approach illuminates metabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartmann AC,Petras D,Quinn RA,Protsyuk I,Archer FI,Ransome E,Williams GJ,Bailey BA,Vermeij MJA,Alexandrov T,Dorrestein PC,Rohwer FL

更新日期：2017-10-31 00:00:00

abstract：:Rhesus monkeys were immunized by multiple inoculations with purified, disrupted, noninfectious simian immunodeficiency virus (SIV) in adjuvant. Immunized monkeys developed anti-SIV antibodies detectable by whole-virus ELISA and by immunoblot reactivity; these antibodies had weak neutralizing activity. One week after t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desrosiers RC,Wyand MS,Kodama T,Ringler DJ,Arthur LO,Sehgal PK,Letvin NL,King NW,Daniel MD

更新日期：1989-08-01 00:00:00

abstract：:Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to incorporate and metabolize stearic acid. Unstimulated T and B cells incorporated identical amounts of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buttke TM,Van Cleave S,Steelman L,McCubrey JA

更新日期：1989-08-01 00:00:00