当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Differentiation of a human leukemia cell line and expression of collagenase inhibitor.

Differentiation of a human leukemia cell line and expression of collagenase inhibitor.

Abstract：

:A human collagenase inhibitor (CI) of Mr 28,500 has been extensively characterized in skin fibroblasts and identified in a variety of connective tissues. Because human alveolar macrophages synthesize and secrete both a collagenase and CI that are immunologically and functionally identical to their counterparts in fibroblasts, we studied the production of such proteins by an immature human cell line (HL60) that can be induced to differentiate along monocytic or granulocytic pathways. The cells failed to synthesize collagenase under any culture condition tested. However, upon exposure to 1,25-dihydroxyvitamin D3 or phorbol esters (PMA), both of which promote monocytic differentiation of HL60, these cells synthesized and released CI in a dose-dependent manner. Furthermore, the extent of CI expression was paralleled by the acquisition by such cells of the monocytic marker 63D3, indicating that inhibitor production and differentiation are closely correlated. This CI was immunologically and functionally identical to that produced by human macrophages and human skin fibroblasts. The quantity of CI synthesized by PMA-stimulated cells was 3- to 5-fold greater than produced by human alveolar macrophages, approximately equal to 1 microgram per 10(6) cells per day. In contrast, undifferentiated HL60 cells produced little or no detectable CI (less than or equal to 10-20 ng per 10(6) cells per day). Interestingly, when HL60 cells were stimulated to undergo granulocytic differentiation by dimethyl sulfoxide or retinoic acid, they also produced the "monocytic" CI.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Bar-Shavit Z,Teitelbaum SL,Stricklin GP,Eisen AZ,Kahn AJ,Welgus HG

doi

10.1073/pnas.82.16.5380

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

5380-4

issue

16

eissn

0027-8424

issn

1091-6490

journal_volume

82

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.

    abstract：:Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability. However, the mechanism for regulation of the enzymatic activity of SUV39H1 in cancer cells is not yet well known. In this stu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1216596110

    authors： Wang D,Zhou J,Liu X,Lu D,Shen C,Du Y,Wei FZ,Song B,Lu X,Yu Y,Wang L,Zhao Y,Wang H,Yang Y,Akiyama Y,Zhang H,Zhu WG

    更新日期：2013-04-02 00:00:00

  • Survival without recovery after mass extinctions.

    abstract：:Because many survivors of mass extinctions do not participate in postrecovery diversifications, and therefore fall into a pattern that can be termed "Dead Clade Walking" (DCW), the effects of mass extinctions extend beyond the losses observed during the event itself. Analyses at two taxonomic levels provide a first-or...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.102163299

    authors： Jablonski D

    更新日期：2002-06-11 00:00:00

  • Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.

    abstract：:The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing membranolysis. We find that our previously determined 3D structure of the p53 residues of PNC-27 is...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0909364107

    authors： Sarafraz-Yazdi E,Bowne WB,Adler V,Sookraj KA,Wu V,Shteyler V,Patel H,Oxbury W,Brandt-Rauf P,Zenilman ME,Michl J,Pincus MR

    更新日期：2010-02-02 00:00:00

  • Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.

    abstract：:Prions are composed solely of an alternatively folded isoform of the prion protein (PrP), designated PrP(Sc). N-terminally truncated PrP(Sc), denoted PrP 27-30, retains infectivity and polymerizes into rods with the ultrastructural and tinctorial properties of amyloid. We report here that some polyoxometalates (POMs) ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0812770106

    authors： Wille H,Shanmugam M,Murugesu M,Ollesch J,Stubbs G,Long JR,Safar JG,Prusiner SB

    更新日期：2009-03-10 00:00:00

  • Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells.

    abstract：:Fibroblast growth factor 1 (FGF-1) is a potent angiogenic and neurotrophic factor whose structure lacks a classical signal sequence for secretion. Although the initiation of these biological activities involves the interaction between FGF-1 and cell surface receptors, the mechanism responsible for the regulation of FG...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.22.10691

    authors： Jackson A,Friedman S,Zhan X,Engleka KA,Forough R,Maciag T

    更新日期：1992-11-15 00:00:00

  • MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1-IRF3 signaling axis.

    abstract：:The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA- and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is known to trigger the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1615287113

    authors： Seo M,Lee SO,Kim JH,Hong Y,Kim S,Kim Y,Min DH,Kong YY,Shin J,Ahn K

    更新日期：2016-12-13 00:00:00

  • Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore.

    abstract：:The flux of solvent water coupled to the transit of ions through protein pores is considerable. The effect of this electroosmotic solvent flow on the binding of a neutral molecule [beta-cyclodextrin (betaCD)] to sites within the staphylococcal alpha-hemolysin pore was investigated. Mutant alpha-hemolysin pores were us...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2531778100

    authors： Gu LQ,Cheley S,Bayley H

    更新日期：2003-12-23 00:00:00

  • Lyophilization-induced reversible changes in the secondary structure of proteins.

    abstract：:Changes in the secondary structure of some dozen different proteins upon lyophilization of their aqueous solutions have been investigated by means of Fourier-transform infrared spectroscopy in the amide III band region. Dehydration markedly (but reversibly) alters the secondary structure of all the proteins studied, a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.24.10969

    authors： Griebenow K,Klibanov AM

    更新日期：1995-11-21 00:00:00

  • Prostaglandin F2 alpha stimulates phosphatidylinositol 4,5-bisphosphate hydrolysis and mobilizes intracellular Ca2+ in bovine luteal cells.

    abstract：:The present studies were conducted to determine whether prostaglandin F2 alpha (PGF2 alpha) stimulates the production of "second messengers" derived from inositol phospholipid hydrolysis and increases intracellular free Ca2+ ([Ca2+]i) in isolated bovine luteal cells. PGF2 alpha provoked rapid (10 sec) and sustained (u...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.11.3728

    authors： Davis JS,Weakland LL,Weiland DA,Farese RV,West LA

    更新日期：1987-06-01 00:00:00

  • The presumed ginkgophyte Umaltolepis has seed-bearing structures resembling those of Peltaspermales and Umkomasiales.

    abstract：:The origins of the five groups of living seed plants, including the single relictual species Ginkgo biloba, are poorly understood, in large part because of very imperfect knowledge of extinct seed plant diversity. Here we describe well-preserved material from the Early Cretaceous of Mongolia of the previously enigmati...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1621409114

    authors： Herrera F,Shi G,Ichinnorov N,Takahashi M,Bugdaeva EV,Herendeen PS,Crane PR

    更新日期：2017-03-21 00:00:00

  • Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM.

    abstract：:Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the direct characterization of amyloid polymorphism in hydrated and...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1916176117

    authors： Cendrowska U,Silva PJ,Ait-Bouziad N,Müller M,Guven ZP,Vieweg S,Chiki A,Radamaker L,Kumar ST,Fändrich M,Tavanti F,Menziani MC,Alexander-Katz A,Stellacci F,Lashuel HA

    更新日期：2020-03-24 00:00:00

  • Monte Carlo studies of surface chemistry and nonthermal desorption involving interstellar grains.

    abstract：:Although still poorly understood, the chemistry that occurs on the surfaces of interstellar dust particles profoundly affects the growth of molecules in the interstellar medium. The most important surface reaction is the conversion of atomic to molecular hydrogen, which is a precursor for all subsequent molecular deve...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0601556103

    authors： Herbst E,Cuppen HM

    更新日期：2006-08-15 00:00:00

  • Esterase 6 in Drosophila melanogaster: reproductive function of active and null males at low temperature.

    abstract：:Esterase 6 is a polymorphic carboxylesterase (carboxylic-ester hydrolase, EC 3.1.1.1) localized to the reproductive tract of male Drosophila melanogaster and transferred to females at copulation. The reproductive fitness of males is strongly affected by temperature and the esterase 6 alleles (active versus null) that ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.9.2962

    authors： Gilbert DG,Richmond RC

    更新日期：1982-05-01 00:00:00

  • Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

    abstract：:The localization of endothelin 1 mRNA and endothelin-like immunoreactivity was investigated in samples of neurologically normal nervous system tissue from 10 adults by using in situ hybridization and immunocytochemistry. Tissue sections of spinal cord and dorsal root ganglia were hybridized with an 35S-radiolabeled en...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.19.7634

    authors： Giaid A,Gibson SJ,Ibrahim BN,Legon S,Bloom SR,Yanagisawa M,Masaki T,Varndell IM,Polak JM

    更新日期：1989-10-01 00:00:00

  • nit-2, the major positive-acting nitrogen regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein.

    abstract：:The nit-2 major nitrogen regulatory gene of Neurospora crassa turns on the expression of various unlinked structural genes that specify nitrogen-catabolic enzymes under nitrogen-limitation conditions. The nit-2 gene encodes a protein of 1036 amino acid residues with a single zinc finger and a downstream basic region t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.14.5331

    authors： Fu YH,Marzluf GA

    更新日期：1990-07-01 00:00:00

  • Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.

    abstract：:Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a direct inhibitor of autophagy. Autophagy can either promote or inhibit ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1104361108

    authors： Parkhitko A,Myachina F,Morrison TA,Hindi KM,Auricchio N,Karbowniczek M,Wu JJ,Finkel T,Kwiatkowski DJ,Yu JJ,Henske EP

    更新日期：2011-07-26 00:00:00

  • RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

    abstract：:Rapamycin is a potent immunosuppressant that blocks the G1/S transition in antigen-activated T cells and in yeast. The similar effects of rapamycin in animal cells and yeast suggest that the biochemical steps affected by rapamycin are conserved. Using a two-hybrid system we isolated mammalian clones that interact with...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.26.12574

    authors： Chiu MI,Katz H,Berlin V

    更新日期：1994-12-20 00:00:00

  • Purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from apple fruit.

    abstract：:1-Aminocyclopropane-1-carboxylate (ACC) oxidase catalyzes the oxidation of ACC to ethylene. Following conventional column fractionation, the enzyme was purified 180-fold to near homogeneity with a specific activity of 20 nmol/(mg.min). This purified enzyme preparation migrated as a single protein band with an apparent...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.20.9789

    authors： Dong JG,Fernández-Maculet JC,Yang SF

    更新日期：1992-10-15 00:00:00

  • Stimulation of T cells by antigenic peptide complexed with isolated chains of major histocompatibility complex class II molecules.

    abstract：:Major histocompatibility complex (MHC) class II molecules are heterodimeric glycoproteins with one alpha and one beta polypeptide chain of similar molecular size. In this report, we describe the binding of an acetylated N-terminal peptide of myelin basic protein, [Ala4]MBP-(1-14), to purified individual alpha and beta...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.4.1604

    authors： Nag B,Wada HG,Deshpande SV,Passmore D,Kendrick T,Sharma SD,Clark BR,McConnell HM

    更新日期：1993-02-15 00:00:00

  • Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups.

    abstract：:The functional groups found among the RNA bases and in the phosphoribose backbone represent a limited repertoire from which to construct a ribozyme active site. This work investigates the possibility that simple RNA phosphodiester and hydroxyl functional groups could catalyze amide bond synthesis. Reaction of amine gr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.212527799

    authors： Chamberlin SI,Merino EJ,Weeks KM

    更新日期：2002-11-12 00:00:00

  • Quantifying HIV-1 transmission due to contaminated injections.

    abstract：:Assessments of the importance of different routes of HIV-1 (HIV) transmission are vital for prioritization of control efforts. Lack of consistent direct data and large uncertainty in the risk of HIV transmission from HIV-contaminated injections has made quantifying the proportion of transmission caused by contaminated...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0610435104

    authors： White RG,Ben SC,Kedhar A,Orroth KK,Biraro S,Baggaley RF,Whitworth J,Korenromp EL,Ghani A,Boily MC,Hayes RJ

    更新日期：2007-06-05 00:00:00

  • Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka.

    abstract：:Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display widely differing patterns. These contrasting aspects of chromatophores (i.e., the fixed developmental control within sp...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0401278101

    authors： Fukamachi S,Sugimoto M,Mitani H,Shima A

    更新日期：2004-07-20 00:00:00

  • Matrix-transmitted paratensile signaling enables myofibroblast-fibroblast cross talk in fibrosis expansion.

    abstract：:While the concept of intercellular mechanical communication has been revealed, the mechanistic insights have been poorly evidenced in the context of myofibroblast-fibroblast interaction during fibrosis expansion. Here we report and systematically investigate the mechanical force-mediated myofibroblast-fibroblast cross...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1910650117

    authors： Liu L,Yu H,Zhao H,Wu Z,Long Y,Zhang J,Yan X,You Z,Zhou L,Xia T,Shi Y,Xiao B,Wang Y,Huang C,Du Y

    更新日期：2020-05-19 00:00:00

  • A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N6)-methyltransferase from Thermus aquaticus.

    abstract：:Ab initio and density functional calculations have been carried out to more fully understand the factors controlling the catalytic activity of the Thermus aquaticus DNA methyltransferase (MTaqI) in the N-methylation at the N(6) of an adenine nucleobase. The noncatalyzed reaction was modeled as a methyl transfer from t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.122231499

    authors： Newby ZE,Lau EY,Bruice TC

    更新日期：2002-06-11 00:00:00

  • Recent assembly of the Cerrado, a neotropical plant diversity hotspot, by in situ evolution of adaptations to fire.

    abstract：:The relative importance of local ecological and larger-scale historical processes in causing differences in species richness across the globe remains keenly debated. To gain insight into these questions, we investigated the assembly of plant diversity in the Cerrado in South America, the world's most species-rich trop...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0903410106

    authors： Simon MF,Grether R,de Queiroz LP,Skema C,Pennington RT,Hughes CE

    更新日期：2009-12-01 00:00:00

  • Two DR beta allelic series defined by exon II-specific synthetic oligonucleotide genomic hybridization: a method of HLA typing?

    abstract：:Comparisons of exon II HLA-DR beta sequences have shown that nucleotide variations are principally clustered within the following three regions: V1 (amino acid 8-15), V2 (25-32), and V3 (70-77). V1, V2, and V3-derived 24-mers have been synthesized, the DR beta sequences coming from DR1, DR3, Drw6, DR4, DR5, and DRw53 ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.20.7836

    authors： Le Gall I,Millasseau P,Dausset J,Cohen D

    更新日期：1986-10-01 00:00:00

  • Long-lived states to sustain hyperpolarized magnetization.

    abstract：:Major breakthroughs have recently been reported that can help overcome two inherent drawbacks of NMR: the lack of sensitivity and the limited memory of longitudinal magnetization. Dynamic nuclear polarization (DNP) couples nuclear spins to the large reservoir of electrons, thus making it possible to detect dilute endo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0908123106

    authors： Vasos PR,Comment A,Sarkar R,Ahuja P,Jannin S,Ansermet JP,Konter JA,Hautle P,van den Brandt B,Bodenhausen G

    更新日期：2009-11-03 00:00:00

  • Potent antitumor activity of a urokinase-activated engineered anthrax toxin.

    abstract：:The acquisition of cell-surface urokinase plasminogen activator activity is a hallmark of malignancy. We generated an engineered anthrax toxin that is activated by cell-surface urokinase in vivo and displays limited toxicity to normal tissue but broad and potent tumoricidal activity. Native anthrax toxin protective an...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0236849100

    authors： Liu S,Aaronson H,Mitola DJ,Leppla SH,Bugge TH

    更新日期：2003-01-21 00:00:00

  • Inactivation of ethanol-inducible cytochrome P450 and other microsomal P450 isozymes by trans-4-hydroxy-2-nonenal, a major product of membrane lipid peroxidation.

    abstract：:Of the microsomal P450 cytochromes, the ethanol-inducible isoform, P450 2E1, is believed to be predominant in leading to oxidative damage, including the generation of radical species that contribute to lipid peroxidation, and in the reductive beta-scission of lipid hydroperoxides to give hydrocarbons and aldehydes. In...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.9.3764

    authors： Bestervelt LL,Vaz AD,Coon MJ

    更新日期：1995-04-25 00:00:00

  • Site-specifically modified oligodeoxyribonucleotides as templates for Escherichia coli DNA polymerase I.

    abstract：:Oligodeoxyribonucleotides with site-specific modifications have been used as substrates for Escherichia coli DNA polymerase I holoenzyme and Klenow fragment. Modifications included the bulky guanine-8-aminofluorene adduct and a guanine oxidation product resembling the product of photosensitized DNA oxidation. By a com...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.8.2325

    authors： O'Connor D,Stöhrer G

    更新日期：1985-04-01 00:00:00