Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population.

abstract：:A 10-aa motif in transmembrane helix 1 of diphtheria toxin that is conserved in anthrax edema factor, anthrax lethal factor, and botulinum neurotoxin serotypes A, C, and D was identified by blast, clustal w, and meme computational analysis. Using the diphtheria toxin-related fusion protein toxin DAB(389)IL-2, we demon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratts R,Trujillo C,Bharti A,vanderSpek J,Harrison R,Murphy JR

更新日期：2005-10-25 00:00:00

abstract：:Rat skeletal muscle selenoprotein W cDNA was isolated and sequenced. The isolation strategy involved design of degenerate PCR primers from reverse translation of a partial peptide sequence. A reverse transcription-coupled PCR product from rat muscle mRNA was used to screen a muscle cDNA library prepared from selenium-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vendeland SC,Beilstein MA,Yeh JY,Ream W,Whanger PD

更新日期：1995-09-12 00:00:00

abstract：:The amino acid sequence for chicken smooth muscle myosin light chain kinase (smMLCK) was deduced from a full-length cDNA. This has allowed definition of both the complete sequence of the inactive 64-kDa proteolytic fragment, which contains the pseudosubstrate autoregulatory sequence, and of the active 61-kDa Ca2+/calm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson NJ,Pearson RB,Needleman DS,Hurwitz MY,Kemp BE,Means AR

更新日期：1990-03-01 00:00:00

abstract：:Numerous neuroimaging studies have implicated default mode network (DMN) involvement in both internally driven processes and memory. Nevertheless, it is unclear whether memory operations reflect a particular case of internally driven processing or alternatively involve the DMN in a distinct manner, possibly depending ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shapira-Lichter I,Oren N,Jacob Y,Gruberger M,Hendler T

更新日期：2013-03-26 00:00:00

abstract：:Myosin IC (myo1c), a widely expressed motor protein that links the actin cytoskeleton to cell membranes, has been associated with numerous cellular processes, including insulin-stimulated transport of GLUT4, mechanosensation in sensory hair cells, endocytosis, transcription of DNA in the nucleus, exocytosis, and membr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenberg MJ,Lin T,Goldman YE,Shuman H,Ostap EM

更新日期：2012-09-11 00:00:00

abstract：:The genetic code in a eukaryotic system has been expanded by the engineering of Escherichia coli tyrosyl-tRNA synthetase (TyrRS) with the Y37V and Q195C mutations (37V195C), which specifically recognize 3-iodo-L-tyrosine rather than L-tyrosine. In the present study, we determined the 3-iodo-L-tyrosine- and L-tyrosine-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi T,Sakamoto K,Takimura T,Sekine R,Kelly VP,Kamata K,Nishimura S,Yokoyama S

更新日期：2005-02-01 00:00:00

abstract：:cDNA clones encoding a glutamic acid-rich protein were isolated from a bovine retina cDNA expression library. The cDNA sequence contained an open reading frame of 1770 base pairs encoding a protein of 590 amino acids (64,509 Da) and untranslated regions of 60 and 490 base pairs at the 5' and 3' ends, respectively. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugimoto Y,Yatsunami K,Tsujimoto M,Khorana HG,Ichikawa A

更新日期：1991-04-15 00:00:00

abstract：:The catalytic cysteine of the typical 2-Cys Prx subfamily of peroxiredoxins is occasionally hyperoxidized to cysteine sulfinic acid during the peroxidase catalytic cycle. Sulfinic Prx (Prx-SO2H) is reduced back to the active form of the enzyme by sulfiredoxin. The abundance of Prx-SO2H was recently shown to oscillate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho CS,Yoon HJ,Kim JY,Woo HA,Rhee SG

更新日期：2014-08-19 00:00:00

abstract：:Supercritical fluids are a unique class of nonaqueous media in which biocatalytic reactions can occur. The physical properties of supercritical fluids, which include gas-like diffusivities and liquid-like densities, can be predictably controlled with changing pressure. This paper describes how adjustment of pressure, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamat SV,Iwaskewycz B,Beckman EJ,Russell AJ

更新日期：1993-04-01 00:00:00

abstract：:DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and thermal denaturati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escudé C,Nguyen CH,Kukreti S,Janin Y,Sun JS,Bisagni E,Garestier T,Hélène C

更新日期：1998-03-31 00:00:00

abstract：:To maintain genome stability, cells with damaged DNA must arrest to allow repair of mutations before replication. Although several key components required to elicit this arrest have been discovered, much of the pathway remains elusive. Here we report that pRB acts as a central mediator of the proliferative block induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrington EA,Bruce JL,Harlow E,Dyson N

更新日期：1998-09-29 00:00:00

abstract：:3H-Labeled complementary DNA specific for the envelope glycoprotein (env) gene of avian leukosis-sarcoma viruses was isolated by selective nucleic acid hybridization techniques, and used to analyze the expression of the endogenous provirus. The endogenous provirus in certain cell types termed chicken helper factor pos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayward WS,Hanafusa H

更新日期：1976-07-01 00:00:00

abstract：:By use of the indirect peroxidase-antiperoxidase complex immunocytochemical technique, antibody to purified human renal renin was applied to formalin-fixed paraffin sections of human cadaver brain. Immune reaction products were observed in most nerve cells in all areas of the brain examined; staining was limited to th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slater EE,Defendini R,Zimmerman EA

更新日期：1980-09-01 00:00:00

abstract：:Understanding the transmission ability of newly emerging influenza viruses is central to the development of public health preparedness and prevention strategies. Animals are used to model influenza virus infection and transmission, but the routinely used intranasal inoculation of a liquid virus suspension does not ref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin KM,Belser JA,Wadford DA,Pearce MB,Katz JM,Tumpey TM,Maines TR

更新日期：2011-05-17 00:00:00

abstract：:The role of the mouse tumor necrosis factor (TNF) promoter, 5' untranslated region (UTR), and 3' UTR in TNF gene expression has been examined in three nonmacrophage cell lines (HeLa, NIH 3T3, and L-929). The TNF promoter is not macrophage-specific. On the contrary, it constitutively drives reporter gene expression in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kruys V,Kemmer K,Shakhov A,Jongeneel V,Beutler B

更新日期：1992-01-15 00:00:00

abstract：:The spleen from a patient with adult Gaucher's disease was shown to be deficient in a beta-glucosidase (EC 3.2.1.21) isoenzyme that has optimal activity at pH 4.0-4.3, and is stimulated by 0.02% Triton X-100. A mixture of spleen homogenates from a control and from the patient contained beta-glucosidase activity equiva...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MW,O'Brien JS

更新日期：1971-11-01 00:00:00

abstract：:Etioplasts isolated from barley leaves and purified on a Sephadex G-50 (coarse) column were characterized by electron microscopy and nucleic acid analysis. The majority of etioplasts retained an intact outer envelope, and contamination by other fragments was extremely low. The level of gibberellin-like substances extr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans A,Smith H

更新日期：1976-01-01 00:00:00

abstract：:Chinese hamster-human somatic cell hybrids were analyzed for the expression of human galactose-1-phosphate uridyltransferase (GALT; UDPglucose:alpha-D-galactose-1-phosphate uridyltransferase, EC 2.7.7.12) by electrophoresis and for the presence of human chromosomes cytogenetically with the aid of Q-banding. Three of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohandas T,Sparkes RS,Sparkes MC,Shulkin JD

更新日期：1977-12-01 00:00:00

abstract：:General optimization results from physics indicate that maximum efficiency of a process, in the sense of minimum overall entropy production, is achieved when the rate of entropy production is constant over time, however not in ordinary clock time but on an, in general varying, "eigen time" scale, intrinsic to the syst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andresen B,Shiner JS,Uehlinger DE

更新日期：2002-04-30 00:00:00

abstract：:When a fast-moving drop impacts onto a smooth substrate, splashing will be produced at the edge of the expanding liquid sheet. This ubiquitous phenomenon lacks a fundamental understanding. Combining experiment with model, we illustrate that the ultrathin air film trapped under the expanding liquid front triggers splas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Tan P,Xu L

更新日期：2015-03-17 00:00:00

abstract：:A compound of simple structure, 2,4-dichlorobenzyl thiocyanate (DCBT), is an antimitotic agent with a number of unusual properties. The drug causes an extreme reorganization of microtubules in cells in culture. Most normal microtubules disappear, and remaining tubulin-containing structures appear to be bundled or aggr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abraham I,Dion RL,Chi DM,Gottesman MM,Hamel E

更新日期：1986-09-01 00:00:00

abstract：:When an unusually high frequency of an allele is encountered in a population, "founder effect" is often invoked as an explanation. As usually used, the term implies the disproportionate increase through chance (rather than selection) of an allele contributed to the population by a particular ancestor. While genetic th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson EA,Neel JV

更新日期：1978-03-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the number of polyglutamine-encoding CAG repeats in the gene that encodes the huntingtin (htt) protein. A property of the mutant protein that is intimately involved in the development of the disease is the propensity of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colby DW,Chu Y,Cassady JP,Duennwald M,Zazulak H,Webster JM,Messer A,Lindquist S,Ingram VM,Wittrup KD

更新日期：2004-12-21 00:00:00

abstract：:Proteasome activator PA200 enhances proteasome-mediated cleavage after acidic residues in vitro; however, its role within cells is not known. Here, we show that, in response to ionizing radiation, PA200 forms hybrid proteasomes with 19S caps and 20S core proteasomes that accumulate on chromatin, leading to an increase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blickwedehl J,Agarwal M,Seong C,Pandita RK,Melendy T,Sung P,Pandita TK,Bangia N

更新日期：2008-10-21 00:00:00

abstract：:Previous studies imply that the intracellular domain of Notch1 must translocate to the nucleus for its activity. In this study, we demonstrate that a mNotch1 mutant protein that lacks its extracellular domain but retains its membrane-spanning region becomes proteolytically processed on its intracellular surface and, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopan R,Schroeter EH,Weintraub H,Nye JS

更新日期：1996-02-20 00:00:00

abstract：:The lentiviruses are associated with a wide range of chronic diseases in mammals. These include immunodeficiencies (such as HIV/AIDS in humans), malignancies, and lymphatic and neurological disorders in primates, felids, and a variety of wild and domesticated ungulates. Evolutionary analyses of the genomic sequences o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katzourakis A,Tristem M,Pybus OG,Gifford RJ

更新日期：2007-04-10 00:00:00

abstract：:Receptor-type protein tyrosine phosphatase D (PTPRD) is a neuronal cell-adhesion molecule/synaptic specifier that has been implicated in addiction vulnerability and stimulant reward by human genomewide association and mouse cocaine-conditioned place-preference data. However, there have been no reports of effects of re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uhl GR,Martinez MJ,Paik P,Sulima A,Bi GH,Iyer MR,Gardner E,Rice KC,Xi ZX

更新日期：2018-11-06 00:00:00

abstract：:Niemann-Pick C1 (NPC1) and NPC2 proteins are indispensable for the export of LDL-derived cholesterol from late endosomes. Mutations in these proteins result in Niemann-Pick type C disease, a lysosomal storage disease. Despite recent reports of the NPC1 structure depicting its overall architecture, the function of its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Lu F,Trinh MN,Schmiege P,Seemann J,Wang J,Blobel G

更新日期：2017-08-22 00:00:00

abstract：:Recent studies show that plant organ positioning may be mediated by localized concentrations of the plant hormone auxin. Auxin patterning in the shoot apical meristem is in turn brought about by the subcellular polar distribution of the putative auxin efflux mediator, PIN1. However, the question of what signals determ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jönsson H,Heisler MG,Shapiro BE,Meyerowitz EM,Mjolsness E

更新日期：2006-01-31 00:00:00

abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

更新日期：1995-09-12 00:00:00