Sequence homologies among bacterial and mitochondrial superoxide dismutases.

abstract：:Major histocompatibility complex (MHC) class II molecules are heterodimeric glycoproteins with one alpha and one beta polypeptide chain of similar molecular size. In this report, we describe the binding of an acetylated N-terminal peptide of myelin basic protein, [Ala4]MBP-(1-14), to purified individual alpha and beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nag B,Wada HG,Deshpande SV,Passmore D,Kendrick T,Sharma SD,Clark BR,McConnell HM

更新日期：1993-02-15 00:00:00

abstract：:Bacterial outer membrane porins have a robust beta-barrel structure and therefore show potential for use as stochastic sensors based on single-molecule detection. The monomeric porin OmpG is especially attractive compared with multisubunit proteins because appropriate modifications of the pore can be easily achieved b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen M,Khalid S,Sansom MS,Bayley H

更新日期：2008-04-29 00:00:00

abstract：:The gamma-aminobutyrate-synthesizing enzyme glutamate decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) is a major target of autoantibodies associated with both early and late stages of pancreatic beta-cell destruction and development of type 1 diabetes. We have used five monoclonal anti-islet-cell antibod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter W,Shi Y,Baekkeskov S

更新日期：1993-04-01 00:00:00

abstract：:Ancient DNA (aDNA) analysis provides a powerful means of investigating human migration, social organization, and a plethora of other crucial questions about humanity's past. Recently, specialists have suggested that the ideal research design involving aDNA would include multiple independent lines of evidence. In this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bongers JL,Nakatsuka N,O'Shea C,Harper TK,Tantaleán H,Stanish C,Fehren-Schmitz L

更新日期：2020-08-04 00:00:00

abstract：:The evolution of development has been studied through the lens of gene regulation by examining either closely related species or extremely distant animals of different phyla. In nematodes, detailed cell- and stage-specific expression analyses are focused on the model Caenorhabditis elegans, in part leading to the view...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiffer PH,Polsky AL,Cole AG,Camps JIR,Kroiher M,Silver DH,Grishkevich V,Anavy L,Koutsovoulos G,Hashimshony T,Yanai I

更新日期：2018-04-24 00:00:00

abstract：:The peroxisome biogenesis disorders (PBDs), including Zellweger syndrome (ZS) and neonatal adrenoleukodystrophy (NALD), are autosomal recessive diseases caused by defects in peroxisome assembly, for which at least 10 complementation groups have been reported. We have isolated a human PEX1 cDNA (HsPEX1) by functional c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamura S,Okumoto K,Toyama R,Shimozawa N,Tsukamoto T,Suzuki Y,Osumi T,Kondo N,Fujiki Y

更新日期：1998-04-14 00:00:00

abstract：:We report 10 heterozygous mutations in the human insulin gene in 16 probands with neonatal diabetes. A combination of linkage and a candidate gene approach in a family with four diabetic members led to the identification of the initial INS gene mutation. The mutations are inherited in an autosomal dominant manner in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Støy J,Edghill EL,Flanagan SE,Ye H,Paz VP,Pluzhnikov A,Below JE,Hayes MG,Cox NJ,Lipkind GM,Lipton RB,Greeley SA,Patch AM,Ellard S,Steiner DF,Hattersley AT,Philipson LH,Bell GI,Neonatal Diabetes International Collabora

更新日期：2007-09-18 00:00:00

abstract：:This paper describes experiments in which cytosolic Ca2+ concentrations ([Ca2+]i) and catecholamine release were measured in two populations of chromaffin cells stimulated with a solution enriched in K+ (100 mM). Once depolarized, external Ca2+ or Ba2+ ions were offered to cells either as a single 2.5 mM step or as a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michelena P,García-Pérez LE,Artalejo AR,García AG

更新日期：1993-04-15 00:00:00

abstract：:Introduction of a sequence encoding 147 amino acids from human immunodeficiency virus type I (HIV-1) strain MN glycoprotein gp120 into the RNA genome of the stably attenuated Mengo virus strain vM16 yielded an infectious recombinant virus, vMLN450, which expressed the heterologous HIV-1 sequence along with the normal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altmeyer R,Escriou N,Girard M,Palmenberg A,van der Werf S

更新日期：1994-10-11 00:00:00

abstract：:A protein of 87 kilodaltons (87 kDa) was previously identified as a major specific substrate for protein kinase C in neuronal and other tissues. We have now studied the effect of protein kinase C-catalyzed phosphorylation of this protein on its association with membranes in isolated nerve terminals (synaptosomes) from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JK,Walaas SI,Sihra TS,Aderem A,Greengard P

更新日期：1989-04-01 00:00:00

abstract：:It has long been recognized that the renal proximal tubular epithelium of the hamster is a bona fide estrogen target tissue. The effect of estrogens on the growth of proximal tubule cell explants and dissociated single cells derived from these explant outgrowths has been studied in culture. Renal tubular cells were gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberley TD,Lauchner LJ,Pugh TD,Gonzalez A,Goldfarb S,Li SA,Li JJ

更新日期：1989-03-01 00:00:00

abstract：:Sex differences influence brain morphology and physiology during both development and aging. Here we apply a machine learning algorithm to a multiparametric brain PET imaging dataset acquired in a cohort of 20- to 82-year-old, cognitively normal adults (n = 205) to define their metabolic brain age. We find that throug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goyal MS,Blazey TM,Su Y,Couture LE,Durbin TJ,Bateman RJ,Benzinger TL,Morris JC,Raichle ME,Vlassenko AG

更新日期：2019-02-19 00:00:00

abstract：:The bacterial actin homolog, MreB, forms helical cables within the cell that are required for maintenance of a rod shape. These helical structures are thought to be involved in the spatial organization of cell wall (peptidoglycan) synthesizing complexes of penicillin-binding proteins (PBPs). Here, we examined the role...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Divakaruni AV,Loo RR,Xie Y,Loo JA,Gober JW

更新日期：2005-12-20 00:00:00

abstract：:The history of the development of the Chandra X-Ray Observatory is reviewed from a personal perspective. This review is necessarily biased and limited by space because it attempts to cover a time span approaching five decades. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weisskopf MC

更新日期：2010-04-20 00:00:00

abstract：:A parathyroid hormone-like peptide (PTH-LP) has recently been identified in human tumors associated with the syndrome of humoral hypercalcemia of malignancy. The peptide appears to be encoded by a single-copy gene that gives rise to multiple mRNAs that are heterogeneous at both their 5' and their 3' ends. Alternative ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangin M,Ikeda K,Dreyer BE,Broadus AE

更新日期：1989-04-01 00:00:00

abstract：:Recent single-molecule experiments reveal that mechanical tension on DNA can control both the speed and direction of the DNA polymerase motor. We present a theoretical description of this tension-induced "tuning" and "switching." The internal conformational states of the enzyme motor are represented as nodes, and the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goel A,Astumian RD,Herschbach D

更新日期：2003-08-19 00:00:00

abstract：:Encoding activity in the medial temporal lobe, presumably evoked by the presentation of stimuli (postonset activity), is known to predict subsequent memory. However, several independent lines of research suggest that preonset activity also affects subsequent memory. We investigated the role of preonset and postonset s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urgolites ZJ,Wixted JT,Goldinger SD,Papesh MH,Treiman DM,Squire LR,Steinmetz PN

更新日期：2020-06-16 00:00:00

abstract：:The early detection of pathogens with epidemic potential is of major importance to public health. Most emerging infections result in dead-end "spillover" events in which a pathogen is transmitted from an animal reservoir to a human but is unable to achieve the sustained human-to-human transmission necessary for a full...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geoghegan JL,Senior AM,Di Giallonardo F,Holmes EC

更新日期：2016-04-12 00:00:00

abstract：:Mutations of esterase 3 confer two forms of organophosphate resistance on contemporary Australasian Lucilia cuprina. One form, called diazinon resistance, is slightly more effective against commonly used insecticides and is now more prevalent than the other form, called malathion resistance. We report here that the si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartley CJ,Newcomb RD,Russell RJ,Yong CG,Stevens JR,Yeates DK,La Salle J,Oakeshott JG

更新日期：2006-06-06 00:00:00

abstract：:mTOR is an evolutionarily conserved kinase that plays a critical role in sensing and responding to environmental determinants. Recent studies have shown that fine-tuning of the activity of mTOR complexes contributes to organogenesis and tumorigenesis. Although rapamycin, an allosteric mTOR inhibitor, is an effective i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshii T,Kasada A,Hatakeyama T,Ohtani M,Tadokoro Y,Naka K,Ikenoue T,Ikawa T,Kawamoto H,Fehling HJ,Araki K,Yamamura K,Matsuda S,Hirao A

更新日期：2014-03-11 00:00:00

abstract：:The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo. Incubation of endothelial cells (ECs) with H(2)S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, and capilla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papapetropoulos A,Pyriochou A,Altaany Z,Yang G,Marazioti A,Zhou Z,Jeschke MG,Branski LK,Herndon DN,Wang R,Szabó C

更新日期：2009-12-22 00:00:00

abstract：:Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major U2-dependent spliceosome, and further that the minor spliceosome functions in the cytoplasm. To study the subcellular localization of the snRNA components of both the major and minor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pessa HK,Will CL,Meng X,Schneider C,Watkins NJ,Perälä N,Nymark M,Turunen JJ,Lührmann R,Frilander MJ

更新日期：2008-06-24 00:00:00

abstract：:The multifunctional DNA-binding protein (DBP) encoded by human adenovirus binds RNA. The association of purified DBP with RNA in vitro was demonstrated by using either a gel filtration or a filter binding assay. This association is sensitive to ionic strength and exhibits no apparent sequence specificity. DBP also int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleghon VG,Klessig DF

更新日期：1986-12-01 00:00:00

abstract：:mRNA localization is a complex pathway. Besides mRNA sorting per se, this process includes aspects of regulated translation. It requires protein factors that interact with defined sequences (or sequence motifs) of the transcript, and the protein/RNA complexes are finally guided along the cytoskeleton to their ultimate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohr E,Prakash N,Vieluf K,Fuhrmann C,Buck F,Richter D

更新日期：2001-06-19 00:00:00

abstract：:A mutation that confers resistance to the drug paromomycin is shown to be in the structural gene that codes for the ribosomal RNA in Tetrahymena. This observation was made by exploiting a variant of the ribosomal DNA that distorts amplification of this locus when a new somatic nucleus develops during conjugation. Beca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruns PJ,Katzen AL,Martin L,Blackburn EH

更新日期：1985-05-01 00:00:00

abstract：:Cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine were identified during translocation of single DNA template strands through a modified Mycobacterium smegmatis porin A (M2MspA) nanopore under control of phi29 DNA polymerase. This identification was based on three consecutive ionic current states that correspond...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schreiber J,Wescoe ZL,Abu-Shumays R,Vivian JT,Baatar B,Karplus K,Akeson M

更新日期：2013-11-19 00:00:00

abstract：:The sources of human germline mutations are poorly understood. Part of the difficulty is that mutations occur very rarely, and so direct pedigree-based approaches remain limited in the numbers that they can examine. To address this problem, we consider the spectrum of low-frequency variants in a dataset (Genome Aggreg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agarwal I,Przeworski M

更新日期：2019-09-03 00:00:00

abstract：:The impacts of global climate change on different aspects of humanity's diverse life-support systems are complex and often difficult to predict. To facilitate policy decisions on mitigation and adaptation strategies, it is necessary to understand, quantify, and synthesize these climate-change impacts, taking into acco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piontek F,Müller C,Pugh TA,Clark DB,Deryng D,Elliott J,Colón González Fde J,Flörke M,Folberth C,Franssen W,Frieler K,Friend AD,Gosling SN,Hemming D,Khabarov N,Kim H,Lomas MR,Masaki Y,Mengel M,Morse A,Neumann K,N

更新日期：2014-03-04 00:00:00

abstract：:Increased DNA levels in centrally located endosperm nuclei are shown to be related to endosperm development in Zea mays. Mitotic activity sharply decreases in endosperm cells 10-12 days after pollination. At this time nuclear size and DNA content per nucleus (where C = haploid content) sharply increase until peak leve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kowles RV,Phillips RL

更新日期：1985-10-01 00:00:00

abstract：:Group A Streptococcus (GAS) and other bacterial pathogens are known to interact with integrins as an initial step in a complex pathway of bacterial ingestion by host cells. Efficient GAS invasion depends on the interaction of bound fibronectin (Fn) with integrins and activation of integrin signaling. TGF-beta1 regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang B,Li S,Southern PJ,Cleary PP

更新日期：2006-02-14 00:00:00