Ingroup vigilance in collectivistic cultures.

abstract：:A methionine-rich low complexity (LC) domain is found within a C-terminal region of the TDP43 RNA-binding protein. Self-association of this domain leads to the formation of labile cross-β polymers and liquid-like droplets. Treatment with H2O2 caused phenomena of methionine oxidation and droplet melting that were rever...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Y,Zhou X,Kato M,Liu D,Ghaemmaghami S,Tu BP,McKnight SL

更新日期：2020-11-17 00:00:00

abstract：:Using electron microscopy and fitting of crystal structures, we present the 3D reconstruction of ligand-induced dimers of intact receptor tyrosine kinase, KIT. We observe that KIT protomers form close contacts throughout the entire structure of ligand-bound receptor dimers, and that the dimeric receptors adopt multipl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Opatowsky Y,Lax I,Tomé F,Bleichert F,Unger VM,Schlessinger J

更新日期：2014-02-04 00:00:00

abstract：:Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing loss has indicated a possible role for mitochondrial protein synthesis. To stud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie SN,Akshay S,Kalapala SK,Bruell CM,Shcherbakov D,Böttger EC

更新日期：2008-12-30 00:00:00

abstract：:The rat insulin-like growth factor II gene, encoding a fetal somatomedin, expresses a multitranscript family in embryonic/fetal tissues and in the adult brain and spinal cord. By performing in situ hybridization on tissue sections of adult brain and spinal cord, we have found that these transcripts are not expressed i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stylianopoulou F,Herbert J,Soares MB,Efstratiadis A

更新日期：1988-01-01 00:00:00

abstract：:Dominant mutations in the maize homeobox gene knotted1 (kn1) act nonautonomously during maize leaf development, indicating that Kn1 is involved in the generation or transmission of a developmental signal that passes from the inner layers of the leaf to epidermal cells. We previously found that this nonautonomous activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim JY,Yuan Z,Cilia M,Khalfan-Jagani Z,Jackson D

更新日期：2002-03-19 00:00:00

abstract：:The suppressor of Hairy-wing [su(Hw)] protein exerts a polar effect on gene expression by repressing the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw) binding sequences. The directionality of this effect suggests that the su(Hw) protein specifically int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Georgiev PG,Corces VG

更新日期：1995-05-23 00:00:00

abstract：:Cytokines often deliver simultaneous, yet distinct, cell growth and cell survival signals. The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulate cell growth by inducing protein synthesis components. We purified membrane-based p70S6K as a kinase responsible for site-specific phosphorylation of BAD, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada H,Andersen JS,Mann M,Terada N,Korsmeyer SJ

更新日期：2001-08-14 00:00:00

abstract：:Using an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-κB, and AP-1 factors on a genomic scale. These proinflammatory regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ji Z,He L,Regev A,Struhl K

更新日期：2019-05-07 00:00:00

abstract：:Two F' plasmids isolated independently from a recA- strain of Escherichia coli and containing identical deletion end points and identical associated inverted duplications are described. In these plasmids, DNA of F plasmid from the IS3 element alpha 1 beta 1 up to the transposon gamma delta is duplicated in inverted or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai M,Thompson TL,Deonier RC

更新日期：1984-08-01 00:00:00

abstract：:The amino-terminal 20 amino acids are required for microinjected ribonuclease A (RNase A) to be taken up by lysosomes and degraded at an enhanced rate during serum withdrawal. We used water-soluble carbodiimides to covalently attach the RNase S-peptide (residues 1-20) to [3H]RNase S-protein (residues 21-124) at unspec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backer JM,Dice JF

更新日期：1986-08-01 00:00:00

abstract：:Proalbumins are rare genetic variants of human serum albumin containing a basic propeptide that is not removed during post-transcriptional processing because of a mutation in the site of excision, an Arg-Arg sequence. We have identified the amino acid substitutions in three different types of proalbumins designated Ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Takahashi Y,Putnam FW

更新日期：1987-11-01 00:00:00

abstract：:Induction of transcription of the GAL genes of yeast by galactose is a multistep process: Galactose frees the activator Gal4 of its inhibitor, Gal80, allowing Gal4 to recruit proteins required to transcribe the GAL genes. Here, we show that deletion of components of either the HSP90 or the HSP70 chaperone machinery de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Floer M,Bryant GO,Ptashne M

更新日期：2008-02-26 00:00:00

abstract：:Gaseous molecular ions containing argon and perchlorethylene, Ar(n)(C(2)Cl(4))(m) (+) in which n >/= 1-29 and m >/= 1-4, are produced by electron bombardment of van der Waals clusters formed by expanding an Ar/C(2)Cl(4) mixture through a supersonic nozzle. Previous attempts to observe such ions in a high-pressure mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buelow SJ,Worsnop DR,Herschbach DR

更新日期：1981-12-01 00:00:00

abstract：:Herein, we report the identification of a unique HIV-1 integrase (IN) inhibitor-binding site using photoaffinity labeling and mass spectrometric analysis. We chemically incorporated a photo-activatable benzophenone moiety into a series of coumarin-containing IN inhibitors. A representative of this series was covalentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Al-Mawsawi LQ,Fikkert V,Dayam R,Witvrouw M,Burke TR Jr,Borchers CH,Neamati N

更新日期：2006-06-27 00:00:00

abstract：:Single molecule atomic force microscopy was used to characterize structure, binding strength (unbinding force), and binding kinetics of a classical cadherin, vascular endothelial (VE)-cadherin, secreted by transfected Chinese hamster ovary cells as cis-dimerized full-length external domain fused to Fc-portion of human...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baumgartner W,Hinterdorfer P,Ness W,Raab A,Vestweber D,Schindler H,Drenckhahn D

更新日期：2000-04-11 00:00:00

abstract：:Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer to a rough (R) low-GPL producer is associated with increased virulence in zebrafish, which involves the formation of massive serpentine cords, absc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloum I,Carrère-Kremer S,Blaise M,Viljoen A,Bernut A,Le Moigne V,Vilchèze C,Guérardel Y,Lutfalla G,Herrmann JL,Jacobs WR Jr,Kremer L

更新日期：2016-07-19 00:00:00

abstract：:We have recently shown that p-terphenyl-3,5,3',5'-tetracarboxylic acid adsorbed on graphite self-assembles into a two-dimensional rhombus random tiling. This tiling is close to ideal, displaying long-range correlations punctuated by sparse localized tiling defects. In this article we explore the analogy between dynami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garrahan JP,Stannard A,Blunt MO,Beton PH

更新日期：2009-09-08 00:00:00

abstract：:To understand complex biological systems, such as the development of multicellular organisms, it is important to characterize the gene expression dynamics. However, there is currently no universal technique for targeted insertion of reporter genes and quantitative imaging in multicellular model systems. Recently, geno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochiai H,Sakamoto N,Fujita K,Nishikawa M,Suzuki K,Matsuura S,Miyamoto T,Sakuma T,Shibata T,Yamamoto T

更新日期：2012-07-03 00:00:00

abstract：:The sensitive and accurate quantification of protein biomarkers plays important roles in clinical diagnostics and biomedical research. Sandwich ELISA and its variants accomplish the capture and detection of a target protein via two antibodies that tightly bind at least two distinct epitopes of the same antigen and hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee T,Knappik A,Sandford E,Tewari M,Choi SW,Strong WB,Thrush EP,Oh KJ,Liu N,Walter NG,Johnson-Buck A

更新日期：2020-09-15 00:00:00

abstract：:We constructed a comprehensive cDNA library from HeLa cell mRNA in a vector that directs expression of the cDNA in Saccharomyces cerevisiae. We used this library to clone the human counterpart of the Sa. cerevisiae CCAAT-binding transcription factor, Hap2, by functional complementation of a hap2 mutation. The cDNA enc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker DM,Fikes JD,Guarente L

更新日期：1991-03-01 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-CSF) induces differentiation of M1 murine myeloid leukemia cells into mature granulocytes/macrophages and also causes accumulation of the cells in the G1 phase of the cell cycle. We examined, therefore, whether synchronization of M1 cells in the G1 phase could affect G-CSF-indu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuda H,Neckers LM,Pluznik DH

更新日期：1986-06-01 00:00:00

abstract：:Histone H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively. Here we have reconstituted fully functional yeast Set1/COMPASS and human MLL/COMPASS-like complex in vitro and have iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi YH,Westfield GH,Oleskie AN,Trievel RC,Shilatifard A,Skiniotis G

更新日期：2011-12-20 00:00:00

abstract：:Diisopropyl fluorophosphate (DFP) causes neurotoxicity related to an irreversible inhibition of acetylcholinesterase (AChE). Management of this intoxication includes: (i) pretreatment with reversible blockers of AChE, (ii) blockade of muscarinic receptors with atropine, and (iii) facilitation of GABA(A) receptor signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pibiri F,Kozikowski AP,Pinna G,Auta J,Kadriu B,Costa E,Guidotti A

更新日期：2008-09-16 00:00:00

abstract：:To identify genetic factors that interact with social environments to impact human health, we used a bioinformatic strategy that couples expression array-based detection of environmentally responsive transcription factors with in silico discovery of regulatory polymorphisms to predict genetic loci that modulate transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole SW,Arevalo JM,Takahashi R,Sloan EK,Lutgendorf SK,Sood AK,Sheridan JF,Seeman TE

更新日期：2010-03-23 00:00:00

abstract：:Deep aquifers in South and Southeast Asia are increasingly exploited as presumed sources of pathogen- and arsenic-free water, although little is known of the processes that may compromise their long-term viability. We analyze a large area (>1,000 km(2)) of the Mekong Delta, Vietnam, in which arsenic is found pervasive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Erban LE,Gorelick SM,Zebker HA,Fendorf S

更新日期：2013-08-20 00:00:00

abstract：:Lethal factor, the principal virulence factor of Bacillus anthracis, inhibits mitogen-activated protein kinase (MAPK) signaling by proteolytically cleaving MAPK kinases. Edema factor, another component of anthrax toxin, is an adenylate cyclase, which increases intracellular cAMP. Inhibition of MAPK signaling with eith...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koo HM,VanBrocklin M,McWilliams MJ,Leppla SH,Duesbery NS,Vande Woude GF

更新日期：2002-03-05 00:00:00

abstract：:Cortical blood flow at the level of individual capillaries and the coupling of neuronal activity to flow in capillaries are fundamental aspects of homeostasis in the normal and the diseased brain. To probe the dynamics of blood flow at this level, we used two-photon laser scanning microscopy to image the motion of red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinfeld D,Mitra PP,Helmchen F,Denk W

更新日期：1998-12-22 00:00:00

abstract：:Taz1 is a hybrid signal-transducing membrane receptor between Tar, an aspartate chemoreceptor, and EnvZ, an osmosensor of Escherichia coli that is able to induce ompC expression by phosphorylating OmpR (a transcriptional activator) in response to aspartate. When the Taz1 His-277, the proposed autophosphorylation site ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Inouye M

更新日期：1991-12-15 00:00:00

abstract：:The effect of pressure up to 175 kilobars on the electronic structure of three ferric hydroxamates and on ferrichrome A has been studied by optical absorption and Mössbauer resonance. The ferric ion was reduced to ferrous ion with pressure, as has been previously observed for various compounds. For the hydroxamates, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grenoble DC,Drickamer HG

更新日期：1971-03-01 00:00:00

abstract：:Vertebrate dentitions are extraordinarily diverse in both morphology and regenerative capacity. The teleost order Tetraodontiformes exhibits an exceptional array of novel dental morphologies, epitomized by constrained beak-like dentitions in several families, i.e., porcupinefishes, three-toothed pufferfishes, ocean su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thiery AP,Shono T,Kurokawa D,Britz R,Johanson Z,Fraser GJ

更新日期：2017-05-30 00:00:00