Cellular mechanisms for resolving phase ambiguity in the owl's inferior colliculus.

Abstract:

:Both mammals and birds use the interaural time difference (ITD) for localization of sound in the horizontal plane. They may localize either real or phantom sound sources, when the signal consists of a narrow frequency band. This ambiguity does not occur with broadband signals. A plot of impulse rates or amplitude of excitatory postsynaptic potentials against ITDs (ITD curve) consists of peaks and troughs. In the external nucleus (ICX) of the owl's inferior colliculus, ITD curves show multiple peaks when the signal is narrow-band, such as tones. Of these peaks, one occurs at ITDi, which is independent of frequency, and others at ITDi +/- T, where T is the tonal period. The ITD curve of the same neuron shows a large peak (main peak) at ITDi and no or small peaks (side peaks) at ITDi +/- T, when the signal is broadband. ITD curves for postsynaptic potentials indicate that ICX neurons integrate the results of binaural cross-correlation in different frequency bands. However, the difference between the main and side peaks is small. ICX neurons further enhance this difference in the process of converting membrane potentials to impulse rates. Inhibition also appears to augment the difference between the main and side peaks.

authors

Peña JL,Konishi M

doi

10.1073/pnas.97.22.11787

keywords:

subject

Has Abstract

pub_date

2000-10-24 00:00:00

pages

11787-92

issue

22

eissn

0027-8424

issn

1091-6490

pii

97/22/11787

journal_volume

97

pub_type

杂志文章
  • Homeotic genes and the arthropod head: expression patterns of the labial, proboscipedia, and Deformed genes in crustaceans and insects.

    abstract::cDNA fragments of the homologues of the Drosophila head homeotic genes labial (lab), proboscipedia (pb), and Deformed (Dfd) have been isolated from the crustacean Porcellio scaber. Because the accumulation domains of the head homeotic complex (Hox) genes had not been previously reported for crustaceans, we studied the...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.18.10224

    authors: Abzhanov A,Kaufman TC

    更新日期:1999-08-31 00:00:00

  • Cell surface insertion of exogenous epidermal growth factor receptors into receptor- mutant cells: demonstration of insertion in the absence of added fusogenic agents.

    abstract::We show that epidermal growth factor (EGF) receptor can be transferred in a biologically active orientation from donor hepatic membranes to recipient receptorless fibroblast cells. The recipient cells (NR-6) normally lack EGF receptors and are biologically unresponsive to EGF. The transfer of receptors from donor plas...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.79.6.1893

    authors: Bishayee S,Feinman J,Pittenger M,Michael H,Das M

    更新日期:1982-03-01 00:00:00

  • Non-bee insects are important contributors to global crop pollination.

    abstract::Wild and managed bees are well documented as effective pollinators of global crops of economic importance. However, the contributions by pollinators other than bees have been little explored despite their potential to contribute to crop production and stability in the face of environmental change. Non-bee pollinators ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1517092112

    authors: Rader R,Bartomeus I,Garibaldi LA,Garratt MP,Howlett BG,Winfree R,Cunningham SA,Mayfield MM,Arthur AD,Andersson GK,Bommarco R,Brittain C,Carvalheiro LG,Chacoff NP,Entling MH,Foully B,Freitas BM,Gemmill-Herren B,Ghazoul

    更新日期:2016-01-05 00:00:00

  • Task-related "cortical" bursting depends critically on basal ganglia input and is linked to vocal plasticity.

    abstract::Basal ganglia-thalamocortical circuits are critical for motor control and motor learning. Classically, basal ganglia nuclei are thought to regulate motor behavior by increasing or decreasing cortical firing rates, and basal ganglia diseases are assumed to reflect abnormal overall activity levels. More recent studies s...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1216308110

    authors: Kojima S,Kao MH,Doupe AJ

    更新日期:2013-03-19 00:00:00

  • Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid.

    abstract::Resistance to the antibiotic fusidic acid (FA) in the human pathogen Staphylococcus aureus usually results from expression of FusB-type proteins (FusB or FusC). These proteins bind to elongation factor G (EF-G), the target of FA, and rescue translation from FA-mediated inhibition by an unknown mechanism. Here we show ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1117275109

    authors: Cox G,Thompson GS,Jenkins HT,Peske F,Savelsbergh A,Rodnina MV,Wintermeyer W,Homans SW,Edwards TA,O'Neill AJ

    更新日期:2012-02-07 00:00:00

  • Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin: demonstration of cleavage within clathrin-coated (pro)secretory vesicles.

    abstract::Polyclonal antibodies reactive with a cleavage site in human proinsulin (HPI) (C-peptide-A-chain junction) have been raised (rabbit, guinea pig) using a synthetic peptide antigen coupled with keyhole limpet hemocyanin. These antisera recognize native HPI and des-31,32-HPI equally well but react 20-50 times less well w...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.84.17.6184

    authors: Steiner DF,Michael J,Houghten R,Mathieu M,Gardner PR,Ravazzola M,Orci L

    更新日期:1987-09-01 00:00:00

  • Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.

    abstract::The gene encoding latent-infection membrane protein 1 (LMP1) was specifically mutated in Epstein-Barr virus (EBV) recombinants by inserting a nonsense linker after codon 9 or codon 84 or into an intron 186 bp 3' to the latter insertion site. EBV recombinants with the LMP1 intron mutation were wild type for LMP1 expres...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.19.9150

    authors: Kaye KM,Izumi KM,Kieff E

    更新日期:1993-10-01 00:00:00

  • 3T3 fibroblasts induce cloned interleukin 3-dependent mouse mast cells to resemble connective tissue mast cells in granular constituency.

    abstract::As assessed by ultrastructure, histochemical staining, and T-cell dependency, in vitro-differentiated inter-leukin 3-dependent mouse mast cells are comparable to the mast cells that reside in the gastrointestinal mucosa but not in the skin or the serosal cavity of the mouse. We now demonstrate that when cloned interle...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.2.569

    authors: Dayton ET,Pharr P,Ogawa M,Serafin WE,Austen KF,Levi-Schaffer F,Stevens RL

    更新日期:1988-01-01 00:00:00

  • KaiA-stimulated KaiC phosphorylation in circadian timing loops in cyanobacteria.

    abstract::Cyanobacterial clock proteins KaiA and KaiC are proposed as positive and negative regulators in the autoregulatory circadian kaiBC expression, respectively. Here, we show that activation of kaiBC expression by kaiA requires KaiC, suggesting a positive feedback control in the cyanobacterial clockwork. We found that rob...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.222467299

    authors: Iwasaki H,Nishiwaki T,Kitayama Y,Nakajima M,Kondo T

    更新日期:2002-11-26 00:00:00

  • Nature and evolution of incommensurate charge order in manganites visualized with cryogenic scanning transmission electron microscopy.

    abstract::Incommensurate charge order in hole-doped oxides is intertwined with exotic phenomena such as colossal magnetoresistance, high-temperature superconductivity, and electronic nematicity. Here, we map, at atomic resolution, the nature of incommensurate charge-lattice order in a manganite using scanning transmission elect...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1714901115

    authors: El Baggari I,Savitzky BH,Admasu AS,Kim J,Cheong SW,Hovden R,Kourkoutis LF

    更新日期:2018-02-13 00:00:00

  • Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis.

    abstract::J-domain chaperones are involved in the efficient handover of misfolded/partially folded proteins to Hsp70 but also function independently to protect against cell death. Due to their high flexibility, the mechanism by which they regulate the Hsp70 cycle and how specific substrate recognition is performed remains unkno...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1914999116

    authors: Karamanos TK,Tugarinov V,Clore GM

    更新日期:2019-10-22 00:00:00

  • Chloroplast SRP43 acts as a chaperone for glutamyl-tRNA reductase, the rate-limiting enzyme in tetrapyrrole biosynthesis.

    abstract::Assembly of light-harvesting complexes requires synchronization of chlorophyll (Chl) biosynthesis with biogenesis of light-harvesting Chl a/b-binding proteins (LHCPs). The chloroplast signal recognition particle (cpSRP) pathway is responsible for transport of nucleus-encoded LHCPs in the stroma of the plastid and thei...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1719645115

    authors: Wang P,Liang FC,Wittmann D,Siegel A,Shan SO,Grimm B

    更新日期:2018-04-10 00:00:00

  • Gating currents of the cloned delayed-rectifier K+ channel DRK1.

    abstract::Gating currents of the cloned delayed-rectifier K+ channel DRK1 expressed in Xenopus oocytes were measured with the open-oocyte Vaseline-gap voltage-clamp technique. DRK1 gating charge had the following salient properties: (i) gating-charge amplitude correlated positively with size of the expressed ionic K+ currents; ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.10.4758

    authors: Taglialatela M,Stefani E

    更新日期:1993-05-15 00:00:00

  • Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells.

    abstract::Activating region I of GAL4 protein is a stretch of amino acids, positioned adjacent to the DNA-binding region, that activates transcription in yeast and, as we show here, in mammalian cells. Here we describe mutations located throughout a 65-amino acid region that increase the activation function of region I. Most of...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.6.2127

    authors: Gill G,Sadowski I,Ptashne M

    更新日期:1990-03-01 00:00:00

  • Accurate estimation of influenza epidemics using Google search data via ARGO.

    abstract::Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistic...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1515373112

    authors: Yang S,Santillana M,Kou SC

    更新日期:2015-11-24 00:00:00

  • Crossover from interaction to driven regimes in quantum vortex reconnections.

    abstract::Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1818668116

    authors: Galantucci L,Baggaley AW,Parker NG,Barenghi CF

    更新日期:2019-06-18 00:00:00

  • Committed sea-level rise for the next century from Greenland ice sheet dynamics during the past decade.

    abstract::We use a three-dimensional, higher-order ice flow model and a realistic initial condition to simulate dynamic perturbations to the Greenland ice sheet during the last decade and to assess their contribution to sea level by 2100. Starting from our initial condition, we apply a time series of observationally constrained...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1017313108

    authors: Price SF,Payne AJ,Howat IM,Smith BE

    更新日期:2011-05-31 00:00:00

  • Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex.

    abstract::We previously reported that long-term cyclic estrogen (E) treatment reverses age-related impairment of cognitive function mediated by the dorsolateral prefrontal cortex (dlPFC) in ovariectomized (OVX) female rhesus monkeys, and that E induces a corresponding increase in spine density in layer III dlPFC pyramidal neuro...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0704757104

    authors: Hao J,Rapp PR,Janssen WG,Lou W,Lasley BL,Hof PR,Morrison JH

    更新日期:2007-07-03 00:00:00

  • Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin.

    abstract::Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest in their therapeutic potential, we continue to know very little about how they work in the brain. Here we used psilocybin, a classic psychedelic found in magic mushrooms, and a task-free functional MRI (fMRI) protocol desi...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 临床试验,杂志文章

    doi:10.1073/pnas.1119598109

    authors: Carhart-Harris RL,Erritzoe D,Williams T,Stone JM,Reed LJ,Colasanti A,Tyacke RJ,Leech R,Malizia AL,Murphy K,Hobden P,Evans J,Feilding A,Wise RG,Nutt DJ

    更新日期:2012-02-07 00:00:00

  • Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

    abstract::Antibodies to the insulin receptor were prepared in BALB/c mice by immunization with IM-9 human lymphocytes, a cell type that has a large number of plasma membrane insulin receptors. The spleens of these mice were then removed, and their lymphocytes were fused to a mouse myeloma cell line, FO cells. After screening ov...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.79.23.7312

    authors: Roth RA,Cassell DJ,Wong KY,Maddux BA,Goldfine ID

    更新日期:1982-12-01 00:00:00

  • Target-effector interaction in the natural killer cell system: isolation of target structures.

    abstract::A sensitive target binding assay has recently been shown to detect natural killer (NK) cells in the mouse. Preincubation of NK cells with detergent-solubilized cell-surface proteins of YAC lymphoma cells prevented subsequent binding to intact YAC targets. The NK target structures (NK-TS) consisted of three molecular s...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.3.1405

    authors: Roder JC,Rosén A,Fenyö EM,Troy FA

    更新日期:1979-03-01 00:00:00

  • Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation.

    abstract::DL-1,2-Dioctanoylglycerol (1,2-DiC8) added to human peripheral resting T lymphocytes was rapidly metabolized to produce octanoic acid and further to small molecules, probably by the action of diacylglycerol lipase and/or nonspecific esterase. Only a small portion was converted to the corresponding phosphatidic acid or...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.19.8681

    authors: Asaoka Y,Oka M,Yoshida K,Nishizuka Y

    更新日期:1991-10-01 00:00:00

  • Substrate binding and catalysis by ribonuclease P from cyanobacteria and Escherichia coli are affected differently by the 3' terminal CCA in tRNA precursors.

    abstract::We have studied the effect of the 3' terminal CCA sequence in precursors of tRNAs on catalysis by the RNase P RNA or the holoenzyme from the cyanobacterium Synechocystis sp. PCC 6803 in a completely homologous system. We have found that the absence of the 3' terminal CCA is not detrimental to activity, which is in sha...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.12.6672

    authors: Pascual A,Vioque A

    更新日期:1999-06-08 00:00:00

  • High affinity cross-reacting mAb generated by minimal mimicry: implications for the pathogenesis of anti-nuclear autoantibodies and immunosuppression.

    abstract::The antigen recognition of a profoundly immunosuppressive mAb, mAb 2E1, in vivo was investigated. In addition to the 62-kDa effector cell protease receptor 1, mAb 2E1 bound the 32-kDa T cell adhesion receptor E2 (CD99) and the 86-kDa p80 subunit of the nuclear antigen complex Ku. These molecules share no overall seque...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.7.3816

    authors: Rothermel AL,Altieri DC

    更新日期:1998-03-31 00:00:00

  • The hydrophobic moment detects periodicity in protein hydrophobicity.

    abstract::Periodicities in the polar/apolar character of the amino acid sequence of a protein can be examined by assigning to each residue a numerical hydrophobicity and searching for periodicity in the resulting one-dimensional function. The strength of each periodic component is the quantity that has been termed the hydrophob...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.1.140

    authors: Eisenberg D,Weiss RM,Terwilliger TC

    更新日期:1984-01-01 00:00:00

  • A complex history of rearrangement in an orthologous region of the maize, sorghum, and rice genomes.

    abstract::The sequences of large insert clones containing genomic DNA that is orthologous to the maize adh1 region were obtained for sorghum, rice, and the adh1-homoeologous region of maize, a remnant of the tetraploid history of the Zea lineage. By using all four genomes, it was possible to describe the nature, timing, and lin...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1434476100

    authors: Ilic K,SanMiguel PJ,Bennetzen JL

    更新日期:2003-10-14 00:00:00

  • (Finite) statistical size effects on compressive strength.

    abstract::The larger structures are, the lower their mechanical strength. Already discussed by Leonardo da Vinci and Edmé Mariotte several centuries ago, size effects on strength remain of crucial importance in modern engineering for the elaboration of safety regulations in structural design or the extrapolation of laboratory r...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1403500111

    authors: Weiss J,Girard L,Gimbert F,Amitrano D,Vandembroucq D

    更新日期:2014-04-29 00:00:00

  • PSD-95 binding dynamically regulates NLGN1 trafficking and function.

    abstract::PSD-95 is a scaffolding protein that regulates the synaptic localization of many receptors, channels, and signaling proteins. The NLGN gene family encodes single-pass transmembrane postsynaptic cell adhesion molecules that are important for synapse assembly and function. At excitatory synapses, NLGN1 mediates transsyn...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1821775116

    authors: Jeong J,Pandey S,Li Y,Badger JD 2nd,Lu W,Roche KW

    更新日期:2019-06-11 00:00:00

  • Quantifying the driving factors for language shift in a bilingual region.

    abstract::Many of the world's around 6,000 languages are in danger of disappearing as people give up use of a minority language in favor of the majority language in a process called language shift. Language shift can be monitored on a large scale through the use of mathematical models by way of differential equations, for examp...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 历史文章,杂志文章

    doi:10.1073/pnas.1617252114

    authors: Prochazka K,Vogl G

    更新日期:2017-04-25 00:00:00

  • Formation of neuromuscular junctions in embryonic cell cultures.

    abstract::The formation of nerve-muscle junctions in monolayer cultures of embryonic muscle and spinal cord cells is described. Muscle-forming cells (myoblasts) from leg muscles of 12-day chick embryos were separated with trypsin and cultured on a collagen substrate for two days. Suspensions of ventral spinal cord cells from si...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.62.3.715

    authors: Shimada Y,Fischman DA,Moscona AA

    更新日期:1969-03-01 00:00:00