Search for deep slabs in the Northwest Pacific mantle.

abstract：:Various enzymatic derivatives of the murine myeloma protein IgA(MOPC-315) were subjected to hapten-binding quantitation and circular dichroic analysis in an attempt to ascertain the structural localization and functional definition of the immunoglobulin active site. The extrinsic Cotton effects observed with near satu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merz DC,Litman GW,Good RA

更新日期：1974-05-01 00:00:00

abstract：:The beta plasmid from Streptococcus faecalis strain DS5, which codes for resistance to erythromycin and lincomycin, was introduced into a Lancefield group F streptococcus, strain DR1501, by transformation. This strain, DR1501 (beta), was found to be an excellent donor of the beta plasmid and readily transferred the re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LeBlanc DJ,Hawley RJ,Lee LN,St Martin EJ

更新日期：1978-07-01 00:00:00

abstract：:Recombinant techniques allow one to engineer an antibody molecule and, in this way, manipulate its properties and functions. We engineered a chimeric human/mouse antibody to the tumor-associated antigen ganglioside GD2, with the aim of decreasing its serum half-life, maintaining its full antigen-binding capacity, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mueller BM,Reisfeld RA,Gillies SD

更新日期：1990-08-01 00:00:00

abstract：:A 2.5-fold stimulation of cyclic AMP cellular content is measured 60 sec after addition of 100 nM synthetic ovine corticotropin-releasing factor (C-RF; corticoliberin) to rat anterior pituitary cells in culture. A maximal response of cyclic AMP content at 400% above control is observed between 2 and 30 min after addit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giguère V,Labrie F,Côté J,Coy DH,Sueiras-Diaz J,Schally AV

更新日期：1982-06-01 00:00:00

abstract：:The theory presented here is based on results from in vitro experiments and deals with three proteins in the postsynaptic density/membrane-namely, calmodulin, the Ca2+/calmodulin-dependent protein kinase, and the voltage-dependent Ca2+ channel. It is visualized that, in vivo in the polarized state of the membrane, cal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siekevitz P

更新日期：1991-06-15 00:00:00

abstract：:Efficient and reliable classification of visual stimuli requires that their representations reside a low-dimensional and, therefore, computationally manageable feature space. We investigated the ability of the human visual system to derive such representations from the sensory input-a highly nontrivial task, given the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cutzu F,Edelman S

更新日期：1996-10-15 00:00:00

abstract：:Amoebae of the cellular slime mold Dictyostelium discoideum possess an extensive and dynamic endomembrane system that includes many types of acidic vacuoles. A light membrane fraction from Dictyostelium, rich in vacuolar-type H(+)-ATPase, has been described [Padh, H., Lavasa, M. & Steck, T.L. (1989) J. Cell Biol. 108,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rooney EK,Gross JD

更新日期：1992-09-01 00:00:00

abstract：:A 60,000-dalton polypeptide (p60) has been identified in the feline leukemia virus (FeLV) pseudotype of Moloney sarcoma virus [MSV(FeLV)]. This polypeptide is present in the purified virus complex in concentrations greater than either the murine p30 or the feline p27. Purified p60 crossreacts immunologically with muri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oskarsson MK,Robey WG,Harris CL,Fischinger PJ,Haapala DK,Vande Woude GF

更新日期：1975-06-01 00:00:00

abstract：:Pronounced bright and dark bands are seen at the bright and dark edges of half-shadows and similar distributions of illumination. These are the so-called Mach bands. A pair of vertical Mach bands was generated with a ramp pattern in the central strip of a horizontal tripartite oscilloscope display. This pattern consis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratliff F,Milkman N,Rennert N

更新日期：1983-07-01 00:00:00

abstract：:Animals often use sex pheromones for mate choice and reproduction. As for other signals, the genetic control of the emission and perception of sex pheromones must be tightly coadapted, and yet we still have no worked-out example of how these two aspects interact. Most models suggest that emission and perception rely o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bousquet F,Nojima T,Houot B,Chauvel I,Chaudy S,Dupas S,Yamamoto D,Ferveur JF

更新日期：2012-01-03 00:00:00

abstract：:Controlling topological defects in 3D liquid crystal phases is a crucial element in the development of novel devices, from blue-phase displays to passive biochemical sensors. However, it remains challenging to realize the 3D topological conditions necessary to robustly and arbitrarily direct the formation of defects. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honglawan A,Beller DA,Cavallaro M Jr,Kamien RD,Stebe KJ,Yang S

更新日期：2013-01-02 00:00:00

abstract：:G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes and, therefore, is important for carcinogenesis. Although hypoxia is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casciello F,Al-Ejeh F,Kelly G,Brennan DJ,Ngiow SF,Young A,Stoll T,Windloch K,Hill MM,Smyth MJ,Gannon F,Lee JS

更新日期：2017-07-03 00:00:00

abstract：:Despite nearly four decades of effort, broad inhibition of oncogenic RAS using small-molecule approaches has proven to be a major challenge. Here we describe the development of a pan-RAS biologic inhibitor composed of the RAS-RAP1-specific endopeptidase fused to the protein delivery machinery of diphtheria toxin. We s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vidimar V,Beilhartz GL,Park M,Biancucci M,Kieffer MB,Gius DR,Melnyk RA,Satchell KJF

更新日期：2020-07-21 00:00:00

abstract：:Cleavage of precursor proteins occurs during assembly of numerous viruses. Seven bacteriophage T4 head-related proteins areknown to be cleaved during morphogenesis. Sequences surrounding the cleavage sites in T4 head precursors P23 and IPIII are reported here. We previously determined the sequences of precursor and pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isobe T,Black LW,Tsugita A

更新日期：1976-11-01 00:00:00

abstract：:In spite of the critical role of the process of adaptation in evolution, there are few detailed studies of the genotypic and molecular basis of the process. Drosophila melanogaster flies selected for increased tolerance to ethanol exhibited higher levels of alcohol dehydrogenase (alcohol:NAD+ oxidoreductase; EC 1.1.1....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDonald JF,Chambers GK,David J,Ayala FJ

更新日期：1977-10-01 00:00:00

abstract：:Numerous relatively short regions within intrinsically disordered proteins (IDPs) serve as molecular recognition elements (MoREs). They fold into ordered structures upon binding to their partner molecules. Currently, there is still a lack of in-depth understanding of how coupled binding and folding occurs in MoREs. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Chu X,Longhi S,Roche P,Han W,Wang E,Wang J

更新日期：2013-10-01 00:00:00

abstract：:Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molecular biology to address the major limitations of standard ChIP-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dainese R,Gardeux V,Llimos G,Alpern D,Jiang JY,Meireles-Filho ACA,Deplancke B

更新日期：2020-06-16 00:00:00

abstract：:Recombinant DNA techniques have been combined with somatic cell genetic methods to identify, isolate, and amplify fragments of human DNA localized at specific regions of human chromosome 11 selected as a model system. A library of genomic DNA segments has been constructed, in lambda Charon 4A bacteriophage, from the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gusella JF,Keys C,VarsanyiBreiner A,Kao FT,Jones C,Puck TT,Housman D

更新日期：1980-05-01 00:00:00

abstract：:Peroxisomes play an essential role in a number of different metabolic pathways, including the beta-oxidation of a distinct set of fatty acids and fatty acid derivatives. The importance of the peroxisomal beta-oxidation system in humans is made apparent by the existence of a group of inherited diseases in which peroxis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Grunsven EG,van Berkel E,Ijlst L,Vreken P,de Klerk JB,Adamski J,Lemonde H,Clayton PT,Cuebas DA,Wanders RJ

更新日期：1998-03-03 00:00:00

abstract：:Most genetic regulatory mechanisms involve protein-DNA interactions. In these processes, the classical Watson-Crick DNA structure sometimes is distorted severely, which in turn enables the precise recognition of the specific sites by the protein. Despite its key importance, very little is known about such deformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leger JF,Robert J,Bourdieu L,Chatenay D,Marko JF

更新日期：1998-10-13 00:00:00

abstract：:Millions of individuals routinely remain awake for more than 18 h daily, which causes performance decrements. It is unknown if these functional impairments are the result of that extended wakefulness or from the associated shortened sleep durations. We therefore examined changes in objective reaction time performance ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McHill AW,Hull JT,Wang W,Czeisler CA,Klerman EB

更新日期：2018-06-05 00:00:00

abstract：:The cingulate gyri in 37 subjects with and without early dementia of the Alzheimer type (DAT) were studied by using MRI at 1.0 mm3 isotropic resolution. Groups were segregated into young controls (n = 10), age-matched normal controls (n = 10), very mild DAT (n = 8), and mild DAT (n = 9). By using automated Bayesian se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MI,Hosakere M,Barker AR,Priebe CE,Lee N,Ratnanather JT,Wang L,Gado M,Morris JC,Csernansky JG

更新日期：2003-12-09 00:00:00

abstract：:The degeneracy of the genetic code allows nucleic acids to encode amino acid identity as well as noncoding information for gene regulation and genome maintenance. The rare arginine codons AGA and AGG (AGR) present a case study in codon choice, with AGRs encoding important transcriptional and translational properties d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Napolitano MG,Landon M,Gregg CJ,Lajoie MJ,Govindarajan L,Mosberg JA,Kuznetsov G,Goodman DB,Vargas-Rodriguez O,Isaacs FJ,Söll D,Church GM

更新日期：2016-09-20 00:00:00

abstract：:The RuvC protein of Escherichia coli catalyzes the resolution of recombination intermediates during genetic recombination and the recombinational repair of damaged DNA. Resolution involves specific recognition of the Holliday structure to form a complex that exhibits twofold symmetry with the DNA in an open configurat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett RJ,West SC

更新日期：1996-10-29 00:00:00

abstract：:The expression of CD5 increases progressively as thymocytes mature. We have shown that CD5 expression is controlled by a tissue-specific regulatory promoter located upstream of the CD5 translation start sites. Deletion of this regulatory promoter, which contains three potential transcription factor binding sites (CCAA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Contag CH,Felsher D,Shachaf CM,Cao Y,Herzenberg LA,Herzenberg LA,Tung JW

更新日期：2004-03-16 00:00:00

abstract：:Superoxide dismutase from chicken-liver mitochondria (manganese enzyme) and the two dismutases from Escherichia coli (manganese and iron enzymes) were analyzed through 29 cycles of automated Edman degradations. The high degree of homology among the amino-terminal sequences of these three dismutases corroborates their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinman HM,Hill RL

更新日期：1973-12-01 00:00:00

abstract：:Cholinergic neuromodulation is involved in all aspects of sensory processing and is crucial for processes such as attention, learning and memory, etc. However, despite the known roles of acetylcholine (ACh), we still do not how to disentangle ACh contributions from sensory or task-evoked changes in functional magnetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaldivar D,Rauch A,Logothetis NK,Goense J

更新日期：2018-12-18 00:00:00

abstract：:The phenomenon of selective translation of T4 template RNA by ribosomes from T4-infected cells, or factors derived therefrom, has been extended to studies on the initiation of protein synthesis. A high-salt extract derived from T4-infected ribosomes inhibits the formation of initiation complexes of MS2 and Escherichia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klem EB,Hsu WT,Weiss SB

更新日期：1970-10-01 00:00:00

abstract：:If, because of trade-offs or similar considerations, components of fitness are negatively correlated in equilibrium populations, they may then exhibit no correlation with total fitness. Lack of correlation with fitness is a fundamental characteristic of selective neutrality. Hence, selectively important traits become ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve R,Smith E,Wallace B

更新日期：1990-03-01 00:00:00

abstract：:More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand-receptor interaction, movement of specific transmembrane helices within the receptor opens a crevice at the cytoplasm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Eps N,Altenbach C,Caro LN,Latorraca NR,Hollingsworth SA,Dror RO,Ernst OP,Hubbell WL

更新日期：2018-03-06 00:00:00