Abstract:
:The phenomenon of selective translation of T4 template RNA by ribosomes from T4-infected cells, or factors derived therefrom, has been extended to studies on the initiation of protein synthesis. A high-salt extract derived from T4-infected ribosomes inhibits the formation of initiation complexes of MS2 and Escherichia coli template RNA with uninfected ribosomes while efficiently supporting the formation of initiation complexes with T4 template RNA. T4 factors also permit T5 template RNA to bind to E. coli ribosomes, which indicates that the T4 selective effect is not exclusive for T4 templates. Other evidence indicates that T4 factors do not alter the process of polypeptide chain elongation.
journal_name
Proc Natl Acad Sci U S Aauthors
Klem EB,Hsu WT,Weiss SBdoi
10.1073/pnas.67.2.696subject
Has Abstractpub_date
1970-10-01 00:00:00pages
696-701issue
2eissn
0027-8424issn
1091-6490journal_volume
67pub_type
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