Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex.

abstract：:Awareness that our planet is a self-supporting biosphere with sunlight as its major source of energy for life has resulted in a long-term historical fascination with the workings of self-supporting ecological systems. However, the studies of such systems have never entered the canon of ecological or evolutionary tools...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rillig MC,Antonovics J

更新日期：2019-06-04 00:00:00

abstract：:A majority of the total protein synthesis in host cell cytoplasm is inhibited by cycloheximide. Because leghemoglobin represents a large proportion of total cellular protein in the nodule, this observation suggests that leghemoglobin may be translated on the 80S-type ribosomes. Analysis of the nascent peptides isolate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma DP,Bal AK

更新日期：1976-11-01 00:00:00

abstract：:Adult-born granule cells in the dentate gyrus of the rodent hippocampus are important for memory formation and mood regulation, but the cellular mechanism underlying their polarized development, a process critical for their incorporation into functional circuits, remains unknown. We found that deletion of the serine-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang W,She L,Chang XY,Yang RR,Wang L,Ji HB,Jiao JW,Poo MM

更新日期：2014-01-07 00:00:00

abstract：:Although nanoparticle-protein conjugates have been synthesized for numerous applications, bioconjugation remains a challenge, often resulting in denaturation or loss of protein function. This is partly because the protein-nanoparticle interface is poorly understood, which impedes the use of nanoparticles in nanomedici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aubin-Tam ME,Hwang W,Hamad-Schifferli K

更新日期：2009-03-17 00:00:00

abstract：:BALB/c murine sarcoma Meth A is known to have three missense point mutations in p53. We previously reported that a nonamer peptide containing the codon 234 mutational product (designated 234CM) elicited 234CM-specific cytotoxic T cells and that immunization with 234CM in adjuvant before tumor challenge inhibited Meth ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noguchi Y,Richards EC,Chen YT,Old LJ

更新日期：1995-03-14 00:00:00

abstract：:The 93-residue transmembrane protein CrgA in Mycobacterium tuberculosis is a central component of the divisome, a large macromolecular machine responsible for cell division. Through interactions with multiple other components including FtsZ, FtsQ, FtsI (PBPB), PBPA, and CwsA, CrgA facilitates the recruitment of the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das N,Dai J,Hung I,Rajagopalan MR,Zhou HX,Cross TA

更新日期：2015-01-13 00:00:00

abstract：:Humans walk and run over a wide range of speeds with remarkable efficiency. For steady locomotion, moving at different speeds requires the muscle-tendon units of the leg to modulate the amount of mechanical power the limb absorbs and outputs in each step. How individual muscles adapt their behavior to modulate limb po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farris DJ,Sawicki GS

更新日期：2012-01-17 00:00:00

abstract：:To repurpose compounds for diffuse large B cell lymphoma (DLBCL), we screened a library of drugs and other targeted compounds approved by the US Food and Drug Administration on 9 cell lines and validated the results on a panel of 32 genetically characterized DLBCL cell lines. Dasatinib, a multikinase inhibitor, was ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scuoppo C,Wang J,Persaud M,Mittan SK,Basso K,Pasqualucci L,Rabadan R,Inghirami G,Grandori C,Bosch F,Dalla-Favera R

更新日期：2019-08-20 00:00:00

abstract：:Breakage-fusion-bridge (BFB) is a mechanism of genomic instability characterized by the joining and subsequent tearing apart of sister chromatids. When this process is repeated during multiple rounds of cell division, it leads to patterns of copy number increases of chromosomal segments as well as fold-back inversions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zakov S,Kinsella M,Bafna V

更新日期：2013-04-02 00:00:00

abstract：:Phyllosphere microbial communities were evaluated on leaves of field-grown plant species by culture-dependent and -independent methods. Denaturing gradient gel electrophoresis (DGGE) with 16S rDNA primers generally indicated that microbial community structures were similar on different individuals of the same plant sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang CH,Crowley DE,Borneman J,Keen NT

更新日期：2001-03-27 00:00:00

abstract：:Recent epidemics demonstrate the global threat of Zika virus (ZIKV), a flavivirus transmitted by mosquitoes. Although infection is usually asymptomatic or mild, newborns of infected mothers can display severe symptoms, including neurodevelopmental abnormalities and microcephaly. Given the large-scale spread, symptom s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esswein SR,Gristick HB,Jurado A,Peace A,Keeffe JR,Lee YE,Voll AV,Saeed M,Nussenzweig MC,Rice CM,Robbiani DF,MacDonald MR,Bjorkman PJ

更新日期：2020-05-05 00:00:00

abstract：:The problem of Congressional apportionment is explained together with a brief history of the methods used or considered for its solution. Reasons are given for rejecting the presently used method of equal proportions and for accepting a new method, the quota method, which is the unique method satisfying three essentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balinski ML,Young HP

更新日期：1974-11-01 00:00:00

abstract：:The mechanisms ensuring balanced growth remain a critical question in developmental biology. In plants, this balance relies on spatiotemporal integration of hormonal signaling pathways, but the understanding of the precise contribution of each hormone is just beginning to take form. Brassinosteroid (BR) hormone is sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vragović K,Sela A,Friedlander-Shani L,Fridman Y,Hacham Y,Holland N,Bartom E,Mockler TC,Savaldi-Goldstein S

更新日期：2015-01-20 00:00:00

abstract：:Autocatalytic chemical reactions are widely studied as models of biological processes and to better understand the origins of life on Earth. Minimal self-reproducing amphiphiles have been developed in this context and as an approach to de novo "bottom-up" synthetic protocells. How chemicals come together to produce li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortega-Arroyo J,Bissette AJ,Kukura P,Fletcher SP

更新日期：2016-10-04 00:00:00

abstract：:Abnormal H2O2 levels are closely related to many diseases, including inflammation and cancers. Herein, we simultaneously load HRP and its substrate, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), into liposomal nanoparticles, obtaining a Lipo@HRP&ABTS optical nanoprobe for in vivo H2O2-responsive chrom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Q,Liang C,Sun X,Chen J,Yang Z,Zhao H,Feng L,Liu Z

更新日期：2017-05-23 00:00:00

abstract：:In nonneuronal cells, several plasma membrane proteins such as exofacial enzymes, receptors, and ion channels recycle between their intracellular compartment(s) and the cell surface via an endosomal pathway. In neurons, however, this pathway has not been extensively characterized. In particular, it remains unclear whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thoidis G,Chen P,Pushkin AV,Vallega G,Leeman SE,Fine RE,Kandror KV

更新日期：1998-01-06 00:00:00

abstract：:Lymphatic vessel growth or lymphangiogenesis occurs during embryonic development and wound healing and plays an important role in tumor metastasis and inflammatory diseases. However, the possibility of noninvasive detection and quantification of lymphangiogenesis has been lacking. Here, we present the Vegfr3(EGFPLuc) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martínez-Corral I,Olmeda D,Diéguez-Hurtado R,Tammela T,Alitalo K,Ortega S

更新日期：2012-04-17 00:00:00

abstract：:Olfactory neuroblastoma (ONB) is a malignant tumor of the nasal mucosa whose histogenesis is unclear. A relationship to neuroblastoma (NB), a pediatric tumor of the sympathetic nervous system, is based on morphologic similarities and the expression of similar neural antigens. However, the clinical presentation of ONB ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorensen PH,Wu JK,Berean KW,Lim JF,Donn W,Frierson HF,Reynolds CP,López-Terrada D,Triche TJ

更新日期：1996-02-06 00:00:00

abstract：:The plant Mentzelia pumila (family Loasaceae) has leaves and stems densely covered with tiny hooked trichomes. The structures entrap and kill insects and therefore are most probably protective. But they are also maladaptive in that they incapacitate a coccinellid beetle (Hippodamia convergens) that preys upon an aphid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisner T,Eisner M,Hoebeke ER

更新日期：1998-04-14 00:00:00

abstract：:Mutagenic specificity of 2-acetylaminofluorene (AAF) has been established in mammalian cells and several strains of bacteria by using a shuttle plasmid vector containing a single N-(deoxyguanosin-8-yl)acetylaminofluorene (C8-dG-AAF) adduct. The nucleotide sequence of the gene conferring tetracycline resistance was mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moriya M,Takeshita M,Johnson F,Peden K,Will S,Grollman AP

更新日期：1988-03-01 00:00:00

abstract：:Activator-dependent recruitment of TFIID initiates formation of the transcriptional preinitiation complex. TFIID binds core promoter DNA elements and directs the assembly of other general transcription factors, leading to binding of RNA polymerase II and activation of RNA synthesis. How TATA box-binding protein (TBP) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright KJ,Marr MT 2nd,Tjian R

更新日期：2006-08-15 00:00:00

abstract：:P transposable elements in Drosophila are mobilized via a cut-and-paste mechanism. The broken DNA ends generated during transposition can be repaired via the homology-directed synthesis-dependent strand annealing or by nonhomologous end joining (NHEJ). Genetic studies have demonstrated an interaction between the gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Min B,Weinert BT,Rio DC

更新日期：2004-06-15 00:00:00

abstract：:Parasponia, a woody member of the elm family, is the only nonlegume genus whose members are known to form an effective nitrogen-fixing symbiosis with a Rhizobium species. The bacterial strain RP501 is a slow-growing strain of Rhizobium isolated from Parasponia nodules. Strain RP501 also nodulates the legumes siratro (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marvel DJ,Kuldau G,Hirsch A,Richards E,Torrey JG,Ausubel FM

更新日期：1985-09-01 00:00:00

abstract：:Bacteria commonly grow in densely populated surface-bound communities, termed biofilms, where they gain benefits including superior access to nutrients and resistance to environmental insults. The secretion of extracellular polymeric substances (EPS), which bind bacterial collectives together, is ubiquitously associat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadell CD,Bassler BL

更新日期：2011-08-23 00:00:00

abstract：:Cytotactin is an extracellular matrix protein that is dynamically and transiently expressed in a place-dependent fashion during development by glial cells, fibroblasts, and several other cell types. In the present study, the effects of cytotactin on cell proliferation were examined in fibroblastic cells in culture. NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crossin KL

更新日期：1991-12-15 00:00:00

abstract：:Because the insolubility of the scrapie prion protein (PrP(Sc)) has frustrated structural studies by x-ray crystallography or NMR spectroscopy, we used electron crystallography to characterize the structure of two infectious variants of the prion protein. Isomorphous two-dimensional crystals of the N-terminally trunca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wille H,Michelitsch MD,Guenebaut V,Supattapone S,Serban A,Cohen FE,Agard DA,Prusiner SB

更新日期：2002-03-19 00:00:00

abstract：:Chronic and adult-onset GM2 gangliosidoses are neurological disorders caused by marked deficiency of the A isoenzyme of beta-hexosaminidase; they occur in the Ashkenazi Jewish population, though less frequently than classic (infantile) Tay-Sachs disease. Earlier biosynthetic studies had identified a defective alpha-su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paw BH,Kaback MM,Neufeld EF

更新日期：1989-04-01 00:00:00

abstract：:CooA, the CO-sensing heme protein from Rhodospirillum rubrum, regulates the expression of genes that encode a CO-oxidation system, allowing R. rubrum to use CO as a sole energy source. To better understand the gas-sensing regulation mechanism used by R. rubrum CooA and its homologs in other organisms, we characterized...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark RW,Lanz ND,Lee AJ,Kerby RL,Roberts GP,Burstyn JN

更新日期：2006-01-24 00:00:00

abstract：:New important applications of copper metal, e.g., in the areas of hydrogen production, fuel cell operation, and spent nuclear fuel disposal, require accurate knowledge of the physical and chemical properties of stable and metastable copper compounds. Among the copper(I) compounds with oxygen and hydrogen, cuprous oxid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korzhavyi PA,Soroka IL,Isaev EI,Lilja C,Johansson B

更新日期：2012-01-17 00:00:00

abstract：:A rat model of hereditary renal carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan and named the "Nihon" rat. In heterozygotes, RCs, predominantly the clear cell type, develop from early preneoplastic lesions, which began to appear as early as 3 weeks of age, to adenocarcinomas by the age o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okimoto K,Sakurai J,Kobayashi T,Mitani H,Hirayama Y,Nickerson ML,Warren MB,Zbar B,Schmidt LS,Hino O

更新日期：2004-02-17 00:00:00