Abstract:
:Autocatalytic chemical reactions are widely studied as models of biological processes and to better understand the origins of life on Earth. Minimal self-reproducing amphiphiles have been developed in this context and as an approach to de novo "bottom-up" synthetic protocells. How chemicals come together to produce living systems, however, remains poorly understood, despite much experimentation and speculation. Here, we use ultrasensitive label-free optical microscopy to visualize the spontaneous emergence of an autocatalytic system from an aqueous mixture of two chemicals. Quantitative, in situ nanoscale imaging reveals heterogeneous self-reproducing aggregates and enables the real-time visualization of the synthesis of new aggregates at the reactive interface. The aggregates and reactivity patterns observed vary together with differences in the respective environment. This work demonstrates how imaging of chemistry at the nanoscale can provide direct insight into the dynamic evolution of nonequilibrium systems across molecular to microscopic length scales.
journal_name
Proc Natl Acad Sci U S Aauthors
Ortega-Arroyo J,Bissette AJ,Kukura P,Fletcher SPdoi
10.1073/pnas.1602363113subject
Has Abstractpub_date
2016-10-04 00:00:00pages
11122-11126issue
40eissn
0027-8424issn
1091-6490pii
1602363113journal_volume
113pub_type
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