An axoplasmic myosin with a calmodulin-like light chain.

abstract：:Efficient single nucleotide polymorphism (SNP) genotyping methods are necessary to accomplish many current gene discovery goals. A crucial element in large-scale SNP genotyping is the number of individual biochemical reactions that must be performed. An efficient method that can be used to simultaneously amplify a set...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan B,Charest A,Dowd JF,Blumenstiel JP,Yeh Rf RF,Osman A,Housman DE,Landers JE

更新日期：2002-03-05 00:00:00

abstract：:Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit that forms load-bearing microtubule attachments that drive mitotic chromosome movements. There is intriguing evidence suggesting that central kinetochore components influence kinetochore-microtubule attachment, but the mechanism re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudalkar EM,Scarborough EA,Umbreit NT,Zelter A,Gestaut DR,Riffle M,Johnson RS,MacCoss MJ,Asbury CL,Davis TN

更新日期：2015-10-13 00:00:00

abstract：:The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is dramatically remodeled in an isogenic breast epithelial cell line stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung KK,Wilson GM,Kirkemo LL,Riley NM,Coon JJ,Wells JA

更新日期：2020-04-07 00:00:00

abstract：:A23187 is a carboxylic antibiotic that selectively transfers calcium, magnesium, and other divalent cations across biologic membranes. This ionophore was found to produce morphologic blast transformation, DNA synthesis, and mitosis in human lymphocytes. Several hours of ionophore-cell contact were necessary to produce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luckasen JR,White JG,Kersey JH

更新日期：1974-12-01 00:00:00

abstract：:Two precursors to Chinook salmon (Oncorhynchus tshawytscha) melanin-concentrating hormone, an important factor in teleosts involved in the control of skin pigmentation and stress responsiveness, have been identified from DNA sequence analysis. Both precursors encode proteins of 132 amino acids and they share 107/132 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minth CD,Qiu H,Akil H,Watson SJ,Dixon JE

更新日期：1989-06-01 00:00:00

abstract：:Collectivistic cultures have been characterized as having harmonious, cooperative ingroup relationships. However, we find evidence that people in collectivistic cultures are more vigilant toward ingroup members, mindful of their possible unethical intentions. Study 1 found that Chinese participants were more vigilant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu SS,Morris MW,Talhelm T,Yang Q

更新日期：2019-07-16 00:00:00

abstract：:To study the protein structure-function relationship, we propose a method to efficiently create three-dimensional maps of structure space using a very large dataset of > 30,000 Structural Classification of Proteins (SCOP) domains. In our maps, each domain is represented by a point, and the distance between any two poi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Osadchy M,Kolodny R

更新日期：2011-07-26 00:00:00

abstract：:Gene editing techniques have been extensively used to attempt to model recurrent genomic rearrangements found in tumor cells. These methods involve the induction of double-strand breaks at endogenous loci followed by the identification of breakpoint junctions within a population, which typically arise by nonhomologous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vanoli F,Tomishima M,Feng W,Lamribet K,Babin L,Brunet E,Jasin M

更新日期：2017-04-04 00:00:00

abstract：:A hitherto unknown Neoproterozoic orogenic system, the Saharides, is described in North Africa. It formed during the 900-500-Ma interval. The Saharides involved large subduction accretion complexes occupying almost the entire Arabian Shield and much of Egypt and parts of the small Precambrian inliers in the Sahara inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Şengör AMC,Lom N,Zabcı C,Sunal G,Öner T

更新日期：2020-12-22 00:00:00

abstract：:Measurements of auditory sensitivity in terms of the cochlear potentials were made in young specimens of three species of crocodilians, Caiman crocodilus and Alligator mississipiensis of the subfamily Alligatorinae and Crocodylus acutus of the subfamily Crocodylinae. These species show considerable similarity in their...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wever EG

更新日期：1971-07-01 00:00:00

abstract：:RelB is an NF-κB family transcription factor activated in the noncanonical pathway downstream of NF-κB-inducing kinase (NIK) and TNF receptor family members including lymphotoxin-β receptor (LTβR) and CD40. Early analysis suggested that RelB is required for classical dendritic cell (cDC) development based on a severe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA 3rd,Novack DV,Murphy TL,Murphy KM

更新日期：2017-04-11 00:00:00

abstract：:DNA polymerases replicate DNA by adding nucleotides to a growing primer strand while avoiding frameshift and point mutations. Here we present a series of up to six successive replication events that were obtained by extension of a primed template directly in a crystal of the thermostable Bacillus DNA polymerase I. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson SJ,Taylor JS,Beese LS

更新日期：2003-04-01 00:00:00

abstract：:Transcriptional regulation of gene expression is a major mechanism used by plants to confer phenotypic plasticity, and yet compared with other eukaryotes or bacteria, little is known about the design principles. We generated an extensive catalog of nascent and steady-state transcripts in Arabidopsis thaliana seedlings...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hetzel J,Duttke SH,Benner C,Chory J

更新日期：2016-10-25 00:00:00

abstract：:Characterization and functional annotation of the large number of proteins predicted from genome sequencing projects poses a major scientific challenge. Whereas several proteomics techniques have been developed to quantify the abundance of proteins, these methods provide little information regarding protein function. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okerberg ES,Wu J,Zhang B,Samii B,Blackford K,Winn DT,Shreder KR,Burbaum JJ,Patricelli MP

更新日期：2005-04-05 00:00:00

abstract：:A series of spontaneous suppressors to the temperature-sensitive phenotype of the single-stranded DNA-binding protein mutation ssb-1 were isolated. A genomic library of EcoRI fragments from one of these suppressor strains was prepared by using pBR325 as the cloning vector. A 10.0-kilobase class of inserts was identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruben SM,VanDenBrink-Webb SE,Rein DC,Meyer RR

更新日期：1988-06-01 00:00:00

abstract：:Capsaicin (CP), the pungent component of chili pepper, acts on sensory neurons to convey the sensation of pain. The CP receptor, vanilloid receptor 1 (VR1), has been shown to be highly expressed by nociceptive neurons in dorsal root and trigeminal ganglia. We demonstrate here that the dendritic cell (DC), a key cell t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu S,Srivastava P

更新日期：2005-04-05 00:00:00

abstract：:The inference of the evolutionary history of a set of languages is a complex problem. Although some languages are known to be related through descent from common ancestral languages, for other languages determining whether such a relationship holds is itself a difficult problem. In this paper we report on new methods,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warnow T

更新日期：1997-06-24 00:00:00

abstract：:The Snf1 protein kinase family has been conserved in eukaryotes. In the yeast Saccharomyces cerevisiae, Snf1 is essential for transcription of glucose-repressed genes in response to glucose starvation. The direct interaction between Snf1 and its activating subunit, Snf4, within the kinase complex is regulated by the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludin K,Jiang R,Carlson M

更新日期：1998-05-26 00:00:00

abstract：:Because many survivors of mass extinctions do not participate in postrecovery diversifications, and therefore fall into a pattern that can be termed "Dead Clade Walking" (DCW), the effects of mass extinctions extend beyond the losses observed during the event itself. Analyses at two taxonomic levels provide a first-or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jablonski D

更新日期：2002-06-11 00:00:00

abstract：:Sequences of each of the four framework segments FR1, FR2, FR3, and FR4 of the variable regions (V-regions) of light and heavy chains of immunoglobulins were grouped into sets with identical sequences. Sets contained from 1 to 18 members. When each V-region was traced from one FR to the next, it was seen that members ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kabat EA,Wu TT,Bilofsky H

更新日期：1978-05-01 00:00:00

abstract：:The functional role of residue Tyr-19 of Chromatium vinosum HiPIP has been evaluated by site-directed mutagenesis experiments. The stability of the [Fe4S4] cluster prosthetic center is sensitive to side-chain replacements. Polar residues result in significant instability, while nonpolar residues (especially with aroma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agarwal A,Li D,Cowan JA

更新日期：1995-10-10 00:00:00

abstract：:The cofactor composition and electron-transfer kinetics of the reaction center (RC) from a magnesium chelatase (bchD) mutant of Rhodobacter sphaeroides were characterized. In this RC, the special pair (P) and accessory (B) bacteriochlorophyll (BChl) -binding sites contain Zn-BChl rather than BChl a. Spectroscopic meas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin S,Jaschke PR,Wang H,Paddock M,Tufts A,Allen JP,Rosell FI,Mauk AG,Woodbury NW,Beatty JT

更新日期：2009-05-26 00:00:00

abstract：:Mixed-metal oxides play a very important role in many areas of chemistry, physics, materials science, and geochemistry. Recently, there has been a strong interest in understanding phenomena associated with the deposition of oxide nanoparticles on the surface of a second (host) oxide. Here, scanning tunneling microscop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JB,Graciani J,Evans J,Stacchiola D,Ma S,Liu P,Nambu A,Sanz JF,Hrbek J,Rodriguez JA

更新日期：2009-03-31 00:00:00

abstract：:Cytotoxic lymphocytes eliminate virus-infected and cancerous cells by immune recognition and killing through the perforin-granzyme pathway. Traditional killing assays measure average target cell lysis at fixed times and high effector:target ratios. Such assays obscure kinetic details that might reveal novel physiology...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi PJ,Mitchison TJ

更新日期：2013-04-16 00:00:00

abstract：:The mRNA for organic anion transport protein (oatp) was previously shown to be present in abundance in liver and kidney, and in small amounts in brain. Data obtained from experiments with reverse transcriptase-PCR techniques and in situ hybridization analysis showed that the oatp mRNA is present within the brain, loca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angeletti RH,Novikoff PM,Juvvadi SR,Fritschy JM,Meier PJ,Wolkoff AW

更新日期：1997-01-07 00:00:00

abstract：:The freezing tolerance of protoplasts isolated from nonacclimated rye leaves (Secale cereale L. cv Puma) was significantly altered by using a pH-induced protoplastliposome fusion technique to modify the lipid composition of the plasma membrane. The increase in freezing tolerance was elicited by fusion with liposomes c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steponkus PL,Uemura M,Balsamo RA,Arvinte T,Lynch DV

更新日期：1988-12-01 00:00:00

abstract：:Fragile X syndrome (FXS) results in intellectual disability (ID) most often caused by silencing of the fragile X mental retardation 1 (FMR1) gene. The resulting absence of fragile X mental retardation protein 1 (FMRP) leads to both pre- and postsynaptic defects, yet whether the pre- and postsynaptic functions of FMRP ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Myrick LK,Deng PY,Hashimoto H,Oh YM,Cho Y,Poidevin MJ,Suhl JA,Visootsak J,Cavalli V,Jin P,Cheng X,Warren ST,Klyachko VA

更新日期：2015-01-27 00:00:00

abstract：:Fisheries-induced evolution and its impact on the productivity of exploited fish stocks remains a highly contested research topic in applied fish evolution and fisheries science. Although many quantitative models assume that larger, more fecund fish are preferentially removed by fishing, there is no empirical evidence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutter DA,Suski CD,Philipp DP,Klefoth T,Wahl DH,Kersten P,Cooke SJ,Arlinghaus R

更新日期：2012-12-18 00:00:00

abstract：:c-Jun transcriptional activity is augmented by expression of oncogenic Ras and Raf proteins. This study demonstrates a direct correlation between Ras transforming activity and c-Jun activation, supporting an important role for c-Jun in transformation by Ras. Since we observed that Ras activated c-Jun transcriptional a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westwick JK,Cox AD,Der CJ,Cobb MH,Hibi M,Karin M,Brenner DA

更新日期：1994-06-21 00:00:00

abstract：:We use age distributions of sea otters (Enhydra lutris) found dead on beaches of western Prince William Sound, Alaska, between 1976 and 1998 in conjunction with time-varying demographic models to test for lingering effects from the 1989 Exxon Valdez oil spill. Our results show that sea otters in this area had decrease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monson DH,Doak DF,Ballachey BE,Johnson A,Bodkin JL

更新日期：2000-06-06 00:00:00