Electron transfer in the Rhodobacter sphaeroides reaction center assembled with zinc bacteriochlorophyll.

abstract：:The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acharya AS,Manning JM

更新日期：1983-06-01 00:00:00

abstract：:Saccharomyces cerevisiae has a complex system for switching the mating type of haploid cells, requiring the genome to have three mating-type (MAT)-like loci and a mechanism for silencing two of them. How this system originated is unknown, because the three-locus system is present throughout the family Saccharomycetace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanson SJ,Byrne KP,Wolfe KH

更新日期：2014-11-11 00:00:00

abstract：:In insulin resistant states such as type 2 diabetes, there is a high demand on the β-cell to synthesize and secrete insulin, which challenges the ability of the endoplasmic reticulum (ER) to synthesize and fold nascent proteins. This creates a state of ER stress that triggers a coordinated program referred to as the u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winnay JN,Dirice E,Liew CW,Kulkarni RN,Kahn CR

更新日期：2014-01-21 00:00:00

abstract：:After treatment with nitrite, Japanese soy sauce was strongly mutagenic to Salmonella typhimurium TA100 without S9 mixture. Two precursors of the mutagen were isolated from Japanese soy sauce, and these were identified as (-)-(1S,3S)-1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid [(-)-(1S,3S)-MTCA] and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakabayashi K,Ochiai M,Saitô H,Tsuda M,Suwa Y,Nagao M,Sugimura T

更新日期：1983-05-01 00:00:00

abstract：:The parathyroid hormone 2 (PTH2) receptor's anatomical distribution suggests that, among other functions, it may be involved in modulation of nociception. We localized PTH2 receptor protein to spinal cord lamina II and showed that it is synthesized by subpopulations of primary sensory neurons and intrinsic spinal cord...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dobolyi A,Ueda H,Uchida H,Palkovits M,Usdin TB

更新日期：2002-02-05 00:00:00

abstract：:Ontogenetic changes in the protein phosphorylation/dephosphorylation systems in rat brain were investigated. It was found that the activity level of phospholipid-sensitive Ca2+-dependent protein kinase (PL-Ca-PK) in the particulate fraction of grey and white matter and the soluble fraction of grey matter increased rap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner RS,Raynor RL,Mazzei GJ,Girard PR,Kuo JF

更新日期：1984-05-01 00:00:00

abstract：:Controlling topological defects in 3D liquid crystal phases is a crucial element in the development of novel devices, from blue-phase displays to passive biochemical sensors. However, it remains challenging to realize the 3D topological conditions necessary to robustly and arbitrarily direct the formation of defects. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honglawan A,Beller DA,Cavallaro M Jr,Kamien RD,Stebe KJ,Yang S

更新日期：2013-01-02 00:00:00

abstract：:Banded iron formations (BIFs) record a time of extensive Fe deposition in the Precambrian oceans, but the sources and pathways for metals in BIFs remain controversial. Here, we present Fe- and Nd-isotope data that indicate two sources of Fe for the large BIF units deposited 2.5 billion y ago. High-εNd and -δ(56)Fe sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Beard BL,Johnson CM

更新日期：2015-07-07 00:00:00

abstract：:Mature peripheral T cells respond to foreign but not to self-antigens. During development in the thymus, deletion of high-affinity self-reactive immature thymocytes contributes to tolerance of mature T cells. However, double-positive thymocytes are positively selected to survive if they respond to self-peptide-MHC com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephen TL,Wilson BS,Laufer TM

更新日期：2012-05-08 00:00:00

abstract：:Individual diastereomeric phosphoramidites and mixtures of diastereomeric phosphoramidites were evaluated in the iridium-catalyzed amination of allylic carbonates. The original process was conducted with a phosphoramidite ligand containing a resolved 2,2-dihydroxy-1,1-binaphthyl (BINOL) group and a diastereomerically ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leitner A,Shu C,Hartwig JF

更新日期：2004-04-20 00:00:00

abstract：:The interaction of configurations, including all possible singly excited configurations, is incorporated into the calculation of oscillatory and rotatory intensities of simple nonplanar pi-electronic systems such as skewed butadiene and acrolein. The results are discussed in terms of the reliability of the (self-consi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheong KK,Oshita A,Caldwell DJ,Eyring H

更新日期：1970-12-01 00:00:00

abstract：:Stearoyl-acyl-carrier-protein-desaturase-mediated conversion of stearic acid (18:0) to oleic acid (18:1) is a key step, which regulates levels of unsaturated fatty acids in cells. We previously showed that stearoyl-acyl-carrier-protein-desaturase mutants ssi2/fab2 carrying a loss-of-function mutation in the plastidial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kachroo A,Venugopal SC,Lapchyk L,Falcone D,Hildebrand D,Kachroo P

更新日期：2004-04-06 00:00:00

abstract：:Competing interpretations of human origins and evolution have recently proliferated despite the accelerated pace of fossil discovery. These controversies parallel those involving other vertebrate families and result from the difficulty of studying evolution among closely related species. Recent advances in development...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hlusko LJ

更新日期：2004-03-02 00:00:00

abstract：:The unique specificity of monoclonal antibodies (Ab) was combined with the cell-killing function of the cytolytic alternative pathway of complement. The functionally C3b-like glycoprotein of cobra venom was linked to a murine monoclonal Ab directed to a human melanoma-associated antigen by a disulfide bond, by using a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogel CW,Müller-Eberhard HJ

更新日期：1981-12-01 00:00:00

abstract：:To define the gene content of the HLA class I region, cDNA selection was applied to three overlapping yeast artificial chromosomes (YACs) that spanned 1 megabase (Mb) of this region of the human major histocompatibility complex. These YACs extended from the region centromeric to HLA-E to the region telomeric to HLA-F....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei H,Fan WF,Xu H,Parimoo S,Shukla H,Chaplin DD,Weissman SM

更新日期：1993-12-15 00:00:00

abstract：:Many paleoredox proxies indicate low-level and dynamic incipient oxygenation of Earth's surface environments during the Neoarchean (2.8-2.5 Ga) before the Great Oxidation Event (GOE) at ∼2.4 Ga. The mode, tempo, and scale of these redox changes are poorly understood, because data from various locations and ages sugges...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koehler MC,Buick R,Kipp MA,Stüeken EE,Zaloumis J

更新日期：2018-07-24 00:00:00

abstract：:In this study, we describe the use of nuclease-resistant molecular beacons (MBs) for the real-time detection of coxsackievirus B6 replication in living Buffalo green monkey kidney (BGMK) cells via Tat peptide delivery. A nuclease-resistant MB containing 2'-O-methyl RNA bases with phosphorothioate internucleotide linka...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh HY,Yates MV,Mulchandani A,Chen W

更新日期：2008-11-11 00:00:00

abstract：:Mild oxidation of human serum low-density lipoprotein (LDL) converts the apoprotein from a nearly homogeneous component of high apparent molecular weight to a mixture of apparently lower molecular weight polypeptide components, as characterized by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. This protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuh J,Fairclough GF Jr,Haschemeyer RH

更新日期：1978-07-01 00:00:00

abstract：:A calix[4]arene was designed to reversibly dimerize and form an egg-shaped enclosure. Adhesive interactions in the assembly were provided by four self-associating ureas, which form a cyclic array containing 16 hydrogen bonds. The synthesis was completed in four steps from the previously described O,O',O",O"'-tetrabenz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu KD,Rebek J Jr

更新日期：1995-12-19 00:00:00

abstract：:The ecological niche is a key concept for elucidating patterns of species distributions and developing strategies for conserving biodiversity. However, recent times are seeing a widespread debate whether species niches are conserved across space and time (niche conservatism hypothesis). Biological invasions represent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Wolter C,Xian W,Jeschke JM

更新日期：2020-09-22 00:00:00

abstract：:Recent theoretical and experimental results point to the existence of small barriers to protein folding. These barriers can even be absent altogether, resulting in a continuous folding transition (i.e., downhill folding). With small barriers, the detailed properties of folding ensembles may become accessible to equili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muñoz V,Sanchez-Ruiz JM

更新日期：2004-12-21 00:00:00

abstract：:The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10-15 times higher than that of pediatric ACC worldwide. Because childhood ACC is associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status of 36 Brazilian patients and their families. Remarkably, 35 of 36 patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro RC,Sandrini F,Figueiredo B,Zambetti GP,Michalkiewicz E,Lafferty AR,DeLacerda L,Rabin M,Cadwell C,Sampaio G,Cat I,Stratakis CA,Sandrini R

更新日期：2001-07-31 00:00:00

abstract：:The mechanisms that regulate hematopoietic stem cell (HSC) fate decisions between proliferation and multilineage differentiation are unclear. Members of the Wnt family of ligands that activate the canonical Wnt signaling pathway, which utilizes beta-catenin to relay the signal, have been demonstrated to regulate HSC f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nemeth MJ,Topol L,Anderson SM,Yang Y,Bodine DM

更新日期：2007-09-25 00:00:00

abstract：:Antibody to poly(ADP-ribose) has been covalently coupled to Sepharose and utilized to isolate selectively oligonucleosomes undergoing the poly(ADP-ribosyl)ation reaction from the bulk of chromatin. Approximately 12% of the unfractionated oligonucleosomes were bound to the immunoaffinity column and these represented es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malik N,Miwa M,Sugimura T,Thraves P,Smulson M

更新日期：1983-05-01 00:00:00

abstract：:A major calmodulin-binding protein (CaM-BP) of Mr 240,000 was demonstrated in various rat tissues by using a 125I-labeled CaM gel overlay technique. This protein (designated p240) was detected in the particulate fraction and to a lesser extent in the cytosol of all tissues studied. Binding of CaM to p240 was completel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palfrey HC,Schiebler W,Greengard P

更新日期：1982-06-01 00:00:00

abstract：:The degradation of the plant cell wall by glycoside hydrolases is central to environmentally sustainable industries. The major polysaccharides of the plant cell wall are cellulose and xylan, a highly decorated β-1,4-xylopyranose polymer. Glycoside hydrolases displaying multiple catalytic functions may simplify the enz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKee LS,Peña MJ,Rogowski A,Jackson A,Lewis RJ,York WS,Krogh KB,Viksø-Nielsen A,Skjøt M,Gilbert HJ,Marles-Wright J

更新日期：2012-04-24 00:00:00

abstract：:The activation of plant defensive genes in leaves of tomato plants in response to herbivore damage or mechanical wounding is mediated by a mobile 18-amino acid polypeptide signal called systemin. Systemin is derived from a larger, 200-amino acid precursor called prosystemin, similar to polypeptide hormones and soluble...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bergey DR,Howe GA,Ryan CA

更新日期：1996-10-29 00:00:00

abstract：:PH-30, a sperm surface protein involved in sperm-egg fusion, is composed of two subunits, alpha and beta, which are synthesized as precursors and processed, during sperm development, to yield the mature forms. The mature PH-30 alpha/beta complex resembles certain viral fusion proteins in membrane topology and predicte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolfsberg TG,Bazan JF,Blobel CP,Myles DG,Primakoff P,White JM

更新日期：1993-11-15 00:00:00

abstract：:1-Aminocyclopropane-1-carboxylate (ACC) synthase (EC 4.4.1.14), extracted from tomato pericarp tissue, was purified 6500-fold by conventional and high-performance liquid chromatography. Two-dimensional gel electrophoresis of this preparation indicated that ACC synthase activity was associated with a protein band at 50...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleecker AB,Kenyon WH,Somerville SC,Kende H

更新日期：1986-10-01 00:00:00

abstract：:In December of 2015, the international community pledged to limit global warming to below 2 °C above preindustrial (PI) to prevent dangerous climate change. However, to what extent, and for whom, is danger avoided if this ambitious target is realized? We address these questions by scrutinizing heat stress, because the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matthews TK,Wilby RL,Murphy C

更新日期：2017-04-11 00:00:00