Oleic acid levels regulated by glycerolipid metabolism modulate defense gene expression in Arabidopsis.

abstract：:A randomized double-blind controlled trial was conducted to determine the efficacy of passive immunotherapy in the treatment of symptomatic human immunodeficiency virus (HIV) infection. This trial included 86 symptomatic patients randomized to receive plasma rich in anti-HIV-1 antibody or standard seronegative plasma....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vittecoq D,Chevret S,Morand-Joubert L,Heshmati F,Audat F,Bary M,Dusautoir T,Bismuth A,Viard JP,Barré-Sinoussi F

更新日期：1995-02-14 00:00:00

abstract：:Emotional signals are crucial for sharing important information, with conspecifics, for example, to warn humans of danger. Humans use a range of different cues to communicate to others how they feel, including facial, vocal, and gestural signals. We examined the recognition of nonverbal emotional vocalizations, such a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauter DA,Eisner F,Ekman P,Scott SK

更新日期：2010-02-09 00:00:00

abstract：:The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the signature of species interactions at coarser spatial scales is unclear. We present evidence that species interactions may be a significant factor in mediating the regional assem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gotelli NJ,Graves GR,Rahbek C

更新日期：2010-03-16 00:00:00

abstract：:This study examines the basis of resistance and sensitivity of normal and transformed cells to histone deacetylase inhibitor (HDACi)-induced cell death, specifically the role of caspases and thioredoxin (Trx). An important attribute of HDACis is that they induce cancer cell death at concentrations to which normal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ungerstedt JS,Sowa Y,Xu WS,Shao Y,Dokmanovic M,Perez G,Ngo L,Holmgren A,Jiang X,Marks PA

更新日期：2005-01-18 00:00:00

abstract：:Several polypeptides contained in the coat and the core of adenovirus type 2 particles have been identified as virus gene products. They are synthesized in vitro by a cell-free protein-making system programmed by adenovirus type 2 messenger RNA that has been hybridized with and eluted from virus DNA. Fractionation by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eron L,Westphal H

更新日期：1974-09-01 00:00:00

abstract：:The protooncogene src encodes two proteins, designated pp60c-src+ and pp60c-src.pp60c-src+ is expressed only in neurons, whereas pp60c-src is expressed in neuronal and nonneuronal cells. pp60c-src+ differs from pp60c-src in that it contains an insert of 6 amino acids. To study the evolutionary conservation of the 6-am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang XM,Martinez R,Le Beau J,Wiestler O,Walter G

更新日期：1989-06-01 00:00:00

abstract：:Arteriovenous (AV) malformation (AVM) is a devastating condition characterized by focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. AVMs can form anywhere in the body and can cause debilitating ischemia and life-threatening hemorrhagic stroke. The mechanisms that underlie AVM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy PA,Kim TN,Huang L,Nielsen CM,Lawton MT,Adams RH,Schaffer CB,Wang RA

更新日期：2014-12-16 00:00:00

abstract：:In rodent models of Parkinson disease in which transplants of dissociated rodent and human embryonic mesencephalic tissue, rich in dopamine neurons, have been studied, only 5-20% of the dopamine neurons survive the implantation procedure. We have investigated the effects of inhibiting free radical generation with two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakao N,Frodl EM,Duan WM,Widner H,Brundin P

更新日期：1994-12-20 00:00:00

abstract：:Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-alpha), fibroblast interferon (IFN-beta), or immune interferon (INF-gamma) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-alpha and IFN-beta genes to the sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trent JM,Olson S,Lawn RM

更新日期：1982-12-01 00:00:00

abstract：:Alfalfa mosaic virus (AlMV) coat protein is involved in systemic infection of host plants, and a specific mutation in this gene prevents the virus from moving into the upper uninoculated leaves. The coat protein also is required for different viral functions during early and late infection. To study the role of the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spitsin S,Steplewski K,Fleysh N,Belanger H,Mikheeva T,Shivprasad S,Dawson W,Koprowski H,Yusibov V

更新日期：1999-03-02 00:00:00

abstract：:Defining the virus-host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish NF,Gao F,Li H,Giorgi EE,Barbian HJ,Parrish EH,Zajic L,Iyer SS,Decker JM,Kumar A,Hora B,Berg A,Cai F,Hopper J,Denny TN,Ding H,Ochsenbauer C,Kappes JC,Galimidi RP,West AP Jr,Bjorkman PJ,Wilen CB,Doms RW

更新日期：2013-04-23 00:00:00

abstract：:We describe a physical map of the end of the long arm of the human X chromosome encompassing the region from Xq27.2 to the q telomere, inclusive of the chromosomal band Xq28. This region is of particular interest, since it contains the highest density of genes associated with genetic diseases. The map covers a total o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poustka A,Dietrich A,Langenstein G,Toniolo D,Warren ST,Lehrach H

更新日期：1991-10-01 00:00:00

abstract：:Gaseous HCl generated from a variety of sources is ubiquitous in both outdoor and indoor air. Oxides of nitrogen (NO(y)) are also globally distributed, because NO formed in combustion processes is oxidized to NO(2), HNO(3), N(2)O(5) and a variety of other nitrogen oxides during transport. Deposition of HCl and NO(y) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raff JD,Njegic B,Chang WL,Gordon MS,Dabdub D,Gerber RB,Finlayson-Pitts BJ

更新日期：2009-08-18 00:00:00

abstract：:Tobacco mosaic virus and turnip yellow mosaic virus genome RNAs, which have long (greater than or equal to 69 nucleotides) 5'-terminal leader sequences preceding the AUG initiation codon, can form disome initiation complexes when incubated with a wheat germ extract and sparsomycin. In tobacco mosaic virus RNA, whereas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filipowicz W,Haenni AL

更新日期：1979-07-01 00:00:00

abstract：:Herein, we report the identification of a unique HIV-1 integrase (IN) inhibitor-binding site using photoaffinity labeling and mass spectrometric analysis. We chemically incorporated a photo-activatable benzophenone moiety into a series of coumarin-containing IN inhibitors. A representative of this series was covalentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Al-Mawsawi LQ,Fikkert V,Dayam R,Witvrouw M,Burke TR Jr,Borchers CH,Neamati N

更新日期：2006-06-27 00:00:00

abstract：:Reinforcement learning models now provide principled guides for a wide range of reward learning experiments in animals and humans. One key learning (error) signal in these models is experiential and reports ongoing temporal differences between expected and experienced reward. However, these same abstract learning mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lohrenz T,McCabe K,Camerer CF,Montague PR

更新日期：2007-05-29 00:00:00

abstract：:Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain's striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression of HD are associate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma M,Rajendrarao S,Shahani N,Ramírez-Jarquín UN,Subramaniam S

更新日期：2020-07-07 00:00:00

abstract：:It is well known that two regular tetrahedra can be combined with a single regular octahedron to tile (complete fill) three-dimensional Euclidean space . This structure was called the "octet truss" by Buckminster Fuller. It was believed that such a tiling, which is the Delaunay tessellation of the face-centered cubic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway JH,Jiao Y,Torquato S

更新日期：2011-07-05 00:00:00

abstract：:A biomimetic hydrogel platform was designed to signal encapsulated cells using immobilized cell-cell communication cues, with a focus on enhancing the survival and function of encapsulated pancreatic β-cells to treat type 1 diabetes. When MIN6 cells, a pancreatic β-cell line, were encapsulated in poly(ethylene glycol)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CC,Anseth KS

更新日期：2011-04-19 00:00:00

abstract：:The chromophore of photoactive yellow protein (PYP) (i.e., 4-hydroxycinnamic acid) has been replaced by an analogue with a triple bond, rather than a double bond (by using 4-hydroxyphenylpropiolic acid in the reconstitution, yielding hybrid I) and by a "locked" chromophore (through reconstitution with 7-hydroxycoumari...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cordfunke R,Kort R,Pierik A,Gobets B,Koomen GJ,Verhoeven JW,Hellingwerf KJ

更新日期：1998-06-23 00:00:00

abstract：:Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes in relation to heroin abuse and gene expression in the human striatum and the relevance of genetic dopamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikoshkov A,Drakenberg K,Wang X,Horvath MC,Keller E,Hurd YL

更新日期：2008-01-15 00:00:00

abstract：:The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herlocher ML,Maassab HF,Webster RG

更新日期：1993-07-01 00:00:00

abstract：:We constructed a comprehensive cDNA library from HeLa cell mRNA in a vector that directs expression of the cDNA in Saccharomyces cerevisiae. We used this library to clone the human counterpart of the Sa. cerevisiae CCAAT-binding transcription factor, Hap2, by functional complementation of a hap2 mutation. The cDNA enc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker DM,Fikes JD,Guarente L

更新日期：1991-03-01 00:00:00

abstract：:Mouse blastocyst functions have been shown to be disrupted by in vitro exposure to N-methyl-N-nitrosourea (MeNU). After exposure, the chemically treated blastocysts were transferred to the uteri of pseudopregnant surrogate mothers. Implantation rate and birth rate have been shown previously to decrease in a concentrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bossert NL,Iannaccone PM

更新日期：1985-12-01 00:00:00

abstract：:P201 is a short (eight-residue) nonacidic peptide that comprises a strong transcriptional activating region when tethered to DNA in yeast. Here we identify the mediator protein Gal11 as an essential target of P201. Deletion of Gal11, which modestly decreases activation elicited by the typical acidic yeast activator, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Z,Ansari AZ,Lu X,Ogirala A,Ptashne M

更新日期：2002-06-25 00:00:00

abstract：:Environmental cues modulate a variety of intracellular pathways whose signaling is integrated by the molecular mechanism that constitutes the circadian clock. Although the essential gears of the circadian machinery have been elucidated, very little is known about the signaling systems regulating it. Here, we report th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yujnovsky I,Hirayama J,Doi M,Borrelli E,Sassone-Corsi P

更新日期：2006-04-18 00:00:00

abstract：:The nucleoside triphosphates ATP, GTP, TTP, and CTP induce conformational changes in histone IV at concentrations that are of the same magnitude as the histone concentration. The purine nucleoside triphosphates are much more effective than the pyrimidine nucleoside triphosphates. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickett R,Isenberg I

更新日期：1972-09-01 00:00:00

abstract：:Hair cells of the inner ear, the mechanosensory receptors, convert sound waves into neural signals that are passed to the brain via the auditory nerve. Little is known about the molecular mechanisms that govern the development of hair cell-neuronal connections. We ascertained a family with autosomal recessive deafness...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diaz-Horta O,Abad C,Sennaroglu L,Foster J 2nd,DeSmidt A,Bademci G,Tokgoz-Yilmaz S,Duman D,Cengiz FB,Grati M,Fitoz S,Liu XZ,Farooq A,Imtiaz F,Currall BB,Morton CC,Nishita M,Minami Y,Lu Z,Walz K,Tekin M

更新日期：2016-05-24 00:00:00

abstract：:The existence and neuroanatomical locations of separate extrastriate visual pathways for object recognition and spatial localization were investigated in healthy young men. Regional cerebral blood flow was measured by positron emission tomography and bolus injections of H2(15)O, while subjects performed face matching,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haxby JV,Grady CL,Horwitz B,Ungerleider LG,Mishkin M,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

更新日期：1991-03-01 00:00:00

abstract：:Pressures of 200-1000 atmospheres (20-100 MPa) are found to decrease significantly the amount of phosphate (H32PO4-2)transported into the rabbit erythrocyte under otherwise physiological conditions. Such compression does not cause irreversible morphological changes or result in membrane disruption. The findings are in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy RB,Libby WF

更新日期：1976-08-01 00:00:00