Regulation of the self-renewal probability in Hydra stem cell clones.

abstract：:High molecular weight RNA (35S) isolated from avian myeloblastosis virus directs the cell-free synthesis of two prominent polypeptides of 180,000 and 76,000 molecular weight. The latter polypeptide has previously been identified as the precursor to the group-specific antigens of the virus ("gag" proteins) [Vogt, V. M....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paterson BM,Marciani DJ,Papas TS

更新日期：1977-11-01 00:00:00

abstract：:The rigidity of numerous biological filaments and crafted microrods has been conveniently deduced from the analysis of their thermal fluctuations. However, the difficulty of measuring nanometric displacements with an optical microscope has so far limited such studies to sufficiently flexible rods, of which the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerbal F,Wang Y

更新日期：2017-03-07 00:00:00

abstract：:rev-regulated expression of HIV-1 envelope proteins from a simian virus 40 late replacement vector was found to be dependent on the presence of a 5' splice site in the env mRNA in spite of the fact that this mRNA remains unspliced. When the 5' splice site upstream of the env open reading frame was deleted or mutated, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu XB,Heimer J,Rekosh D,Hammarskjöld ML

更新日期：1990-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer. Mitochondria are an important source of ROS; however, the spatiotemporal ROS events underlying oxidative cellular damage from dysfunctional mitochondria remain unresolved. To this end, we have developed and validated a chemoptogenet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian W,Kumar N,Roginskaya V,Fouquerel E,Opresko PL,Shiva S,Watkins SC,Kolodieznyi D,Bruchez MP,Van Houten B

更新日期：2019-09-10 00:00:00

abstract：:Circadian rhythms describe biological phenomena that oscillate with an approximately 24-hour cycle. These rhythms include blood pressure, body temperature, hormone levels, the number of immune cells in blood, and the sleep-wake cycle. In this paper, we will focus on common genes between species that are responsible fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida N,Kaneko M,Allada R

更新日期：1999-08-03 00:00:00

abstract：:The c-ras family is a set of c-onc genes that are highly conserved in vertebrates. The genes in this family are homologous to the transforming genes of Harvey and Kirsten murine sarcoma viruses (v-Ha-ras and v-Ki-ras, respectively). Using an in situ molecular hybridization method, we detected three sites on the human ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jhanwar SC,Neel BG,Hayward WS,Chaganti RS

更新日期：1983-08-01 00:00:00

abstract：:Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by axonal degeneration. Drosophila mutants for the homolog gene of NTE, swisscheese (sws), indicated a possible involvement of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akassoglou K,Malester B,Xu J,Tessarollo L,Rosenbluth J,Chao MV

更新日期：2004-04-06 00:00:00

abstract：:The human chemokine receptors CCR5 and CXCR4 have emerged as the predominant cofactors, along with CD4, for cellular entry of HIV-1 in vivo whereas the contribution of other chemokine receptors to HIV disease has not been yet determined. CCR5-specific (R5) viruses predominate during primary HIV-1 infection whereas vir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penn ML,Grivel JC,Schramm B,Goldsmith MA,Margolis L

更新日期：1999-01-19 00:00:00

abstract：:We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varela F,Andersson A,Dietrich G,Sundblad A,Holmberg D,Kazatchkine M,Coutinho A

更新日期：1991-07-01 00:00:00

abstract：:A primary method for studying cellular function is to examine cell morphology after a given manipulation. Fluorescent markers attached to proteins/intracellular structures of interest in conjunction with 3D fluorescent microscopy are frequently exploited for functional analysis. Despite the central role of morphology ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duong T,Goud B,Schauer K

更新日期：2012-05-29 00:00:00

abstract：:The phosphorylation of protein I, a specific neuronal protein, has been found to be regulated both by cyclic AMP (cAMP) and by calcium, in intact as well as in lysed synaptosome preparations from rat brain. In order to determine the phosphorylation site(s) of protein I that were regulated by cAMP and calcium, protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huttner WB,Greengard P

更新日期：1979-10-01 00:00:00

abstract：:The zinc finger motif, exemplified by a segment of the Drosophila gap gene Krüppel, is a nucleic acid-binding domain present in many transcription factors. To investigate the gene family encoding this motif in the human genome, a placental genomic library was screened at moderate stringency with a degenerate oligodeox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bray P,Lichter P,Thiesen HJ,Ward DC,Dawid IB

更新日期：1991-11-01 00:00:00

abstract：:Recent evidence indicates there is a role for small membrane vesicles, including exosomes, as vehicles for intercellular communication. Exosomes secreted by most cell types can mediate transfer of proteins, mRNAs, and microRNAs, but their role in the transmission of infectious agents is less established. Recent studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnaiah V,Thumann C,Fofana I,Habersetzer F,Pan Q,de Ruiter PE,Willemsen R,Demmers JA,Stalin Raj V,Jenster G,Kwekkeboom J,Tilanus HW,Haagmans BL,Baumert TF,van der Laan LJ

更新日期：2013-08-06 00:00:00

abstract：:The tissue-specific, cell-aggregating component of embryonic neural retina cells was purified from the retina cell-aggregating factor and characterized as a glycoprotein. Its molecular weight in solution is in the range of 50,000, and it contains 10-15% carbohydrate. The amino-acid and carbohydrate compositions have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hausman RE,Moscona AA

更新日期：1975-03-01 00:00:00

abstract：:We report dynamic glycoprotein recognition of gels prepared by biomolecular imprinting using lectin and antibody molecules as ligands for tumor-specific marker glycoproteins. The glycoprotein-imprinted gels prepared with minute amounts of cross-linkers could dynamically recognize tumor-specific marker glycoproteins by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyata T,Jige M,Nakaminami T,Uragami T

更新日期：2006-01-31 00:00:00

abstract：:A quantitative understanding of nucleic acid hybridization is essential to many aspects of biotechnology, such as DNA microarrays, as well as to the structure and folding kinetics of RNA. However, predictions of nucleic acid secondary structures have long been impeded by the presence of helices interior to loops, so-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isambert H,Siggia ED

更新日期：2000-06-06 00:00:00

abstract：:Starting with assignments of proton nuclear magnetic resonance previously made for oxytocin in deuterated dimethylsulfoxide at 220 MHz, we have assigned resonances for the mammalian antidiuretic hormone, lysine vasopressin. The results demonstrate that spectral assignments of neurohypophyseal hormones and their congen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Glickson JD,Schwartz IL,Havran RT,Meienhofer J,Urry DW

更新日期：1972-07-01 00:00:00

abstract：:Sands from various geographic locations reduce N(2) from the air to NH(3) and traces of N(2)H(4) on exposure to sunlight. This N(2) photofixation occurs under sterile conditions on the surface of finely dispersed titanium minerals such as rutile, utilizing reducing equivalents generated through the photolysis of chemi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schrauzer GN,Strampach N,Hui LN,Palmer MR,Salehi J

更新日期：1983-06-01 00:00:00

abstract：:Rat carbonic anhydrase (CA) IV was purified by affinity chromatography and used to produce a specific antiserum in rabbits for immunolocalization studies in rat kidney. CA IV was localized in apical plasma membranes of the proximal convoluted tubule and the thick ascending limb of Henle. Both of these segments are inv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown D,Zhu XL,Sly WS

更新日期：1990-10-01 00:00:00

abstract：:Ocular cicatricial pemphigoid (OCP) is an autoimmune disease that affects mainly conjunctiva and other squamous epithelia. OCP is histologically characterized by a separation of the epithelium from underlying tissues within the basement membrane zone. Immunopathological studies demonstrate the deposition of anti-basem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tyagi S,Bhol K,Natarajan K,Livir-Rallatos C,Foster CS,Ahmed AR

更新日期：1996-12-10 00:00:00

abstract：:The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apcher S,Daskalogianni C,Lejeune F,Manoury B,Imhoos G,Heslop L,Fåhraeus R

更新日期：2011-07-12 00:00:00

abstract：:CHD7 encodes an ATP-dependent chromatin remodeling factor. Mutation of this gene causes multiple developmental disorders, including CHARGE (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth/development, Genital abnormalities, and Ear anomalies) syndrome, in which conotruncal anomalies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan S,Thienthanasit R,Chen D,Engelen E,Brühl J,Crossman DK,Kesterson R,Wang Q,Bouazoune K,Jiao K

更新日期：2020-11-17 00:00:00

abstract：:Turkey erythrocyte membranes showed specific binding of [(3)H]epinephrine. The concentration of hormone required for half-maximal binding (30 muM) was the same as that required for half-maximal activation of the adenylate cyclase located in the same membrane preparation. The binding reaction at 37 degrees C reached co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schramm M,Feinstein H,Naim E,Lang E,Lasser M

更新日期：1972-02-01 00:00:00

abstract：:Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans. A striking observation in support of this is an apparent monotonic decline in Neandertal ancestry observed in modern humans in Europe over the past 45,000 years. Here, we show that this decline is an a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petr M,Pääbo S,Kelso J,Vernot B

更新日期：2019-01-29 00:00:00

abstract：:By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle rat cell line, in monolayer culture. The mitochondria were found to be arranged along the cytoplasmic microtubules in ea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heggeness MH,Simon M,Singer SJ

更新日期：1978-08-01 00:00:00

abstract：:Depression, the most prevalent mental illness, is underdiagnosed and undertreated, highlighting the need to extend the scope of current screening methods. Here, we use language from Facebook posts of consenting individuals to predict depression recorded in electronic medical records. We accessed the history of Faceboo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eichstaedt JC,Smith RJ,Merchant RM,Ungar LH,Crutchley P,Preoţiuc-Pietro D,Asch DA,Schwartz HA

更新日期：2018-10-30 00:00:00

abstract：:To identify the metabolic pathway that generates choline (Cho) for acetylcholine (AcCho) from its storage pool in membrane phosphatidylcholine (PtdCho), human neuronal cells (LA-N-2) were radioisotopically labeled with 1-O-hexadecyl-2-hydroxy-sn-glycero(3)phospho[14C]choline. The compound was efficiently taken up by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee HC,Fellenz-Maloney MP,Liscovitch M,Blusztajn JK

更新日期：1993-11-01 00:00:00

abstract：:Bicistronic cassettes under control of a single promoter have recently been suggested as useful tools for coordinate expression of two different foreign proteins in mammalian cells. Using the long 5' untranslated region of encephalomyocarditis virus as translational enhancer of the second gene, a bicistronic unit comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aran JM,Gottesman MM,Pastan I

更新日期：1994-04-12 00:00:00

abstract：:Tunas are migratory fishes in offshore habitats and top predators with unique features. Despite their ecological importance and high market values, the open-ocean lifestyle of tuna, in which effective sensing systems such as color vision are required for capture of prey, has been poorly understood. To elucidate the ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Mori K,Saitoh K,Oshima K,Mekuchi M,Sugaya T,Shigenobu Y,Ojima N,Muta S,Fujiwara A,Yasuike M,Oohara I,Hirakawa H,Chowdhury VS,Kobayashi T,Nakajima K,Sano M,Wada T,Tashiro K,Ikeo K,Hattori M,Kuhara S,

更新日期：2013-07-02 00:00:00

abstract：:It is widely accepted that modern humans originated in sub-Saharan Africa approximately 150-200 thousand years ago (ka), but their route of dispersal across the currently hyperarid Sahara remains controversial. Given that the first modern humans north of the Sahara are found in the Levant approximately 120-90 ka, nort...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Osborne AH,Vance D,Rohling EJ,Barton N,Rogerson M,Fello N

更新日期：2008-10-28 00:00:00