Localization of c-ras oncogene family on human germ-line chromosomes.

abstract：:The hereditary hearing-vision loss disease Usher syndrome (USH) is caused by defects in several proteins, most of which form an integrated protein network called Usher interactome. Harmonin/Ush1C is a master scaffold in the assembly of the Usher protein complexes, because harmonin is known to bind to every protein in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pan L,Yan J,Wu L,Zhang M

更新日期：2009-04-07 00:00:00

abstract：:The cycles of carbon and oxygen at the Earth surface are intimately linked, where the burial of organic carbon into sediments represents a source of oxygen to the surface environment. This coupling is typically quantified through the isotope records of organic and inorganic carbon. Yet, the late Neoproterozoic Eon, th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bjerrum CJ,Canfield DE

更新日期：2011-04-05 00:00:00

abstract：:A serumless, chemically defined medium has been developed for the culture of oligodendrocytes isolated from primary neonatal rat cerebral cultures. Combined together, insulin, transferrin, and fibroblast growth factor synergistically induced an essentially homogenous population (95-98%) of cells expressing glycerol-3-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saneto RP,de Vellis J

更新日期：1985-05-01 00:00:00

abstract：:The stress inoculation hypothesis presupposes that brief intermittent stress exposure early in life induces the development of subsequent stress resistance in human and nonhuman primates. Rodent studies, however, suggest a role for maternal care rather than stress exposure per se (i.e., the maternal mediation hypothes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker KJ,Buckmaster CL,Sundlass K,Schatzberg AF,Lyons DM

更新日期：2006-02-21 00:00:00

abstract：:Infection by Plasmodium, the causative agent of malaria, is associated with hemolysis and therefore with release of hemoglobin from RBC. Under inflammatory conditions, cell-free hemoglobin can be oxidized, releasing its heme prosthetic groups and producing deleterious free heme. Here we demonstrate that survival of a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seixas E,Gozzelino R,Chora A,Ferreira A,Silva G,Larsen R,Rebelo S,Penido C,Smith NR,Coutinho A,Soares MP

更新日期：2009-09-15 00:00:00

abstract：:The human aspects of conservation are often overlooked but will be critical for identifying strategies for biological conservation in the face of climate change. We surveyed the behavioral intentions of coastal landowners with respect to various conservation strategies aimed at facilitating ecosystem migration for tid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Field CR,Dayer AA,Elphick CS

更新日期：2017-08-22 00:00:00

abstract：:A decade ago, it seemed rational that our rapidly increasing knowledge of the molecular identities of tumor antigens and a deeper understanding of basic immunology would point the way to an effective therapeutic cancer vaccine. Significant progress has been made, but we do not yet have a cancer vaccine that can reliab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis JJ

更新日期：2004-10-05 00:00:00

abstract：:Normal rat kidney cells were nonproductively infected either with CP27, a mutant of Moloney sarcoma virus that is temperature-sensitive for maintenance of transformation, or with the parental wild-type virus. The nonproducer cells were inoculated into the tails of athymic nude mice that were subsequently incubated at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klarlund JK,Forchhammer J

更新日期：1980-03-01 00:00:00

abstract：:Natural killer (NK) cells provide in vivo control of orthopoxvirus infections in association with their expansion in the draining lymph node (LN), where they are normally very rare. The mechanism of this expansion is unclear. Herein, we determined that NK-cell depletion results in enhanced infection following footpad ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pak-Wittel MA,Yang L,Sojka DK,Rivenbark JG,Yokoyama WM

更新日期：2013-01-02 00:00:00

abstract：:A decade ago it was discovered that mature birds are able to regenerate hair cells, the receptors for auditory perception. This surprising finding generated hope in the field of auditory neuroscience that new hair cells someday may be coaxed to form in another class of warm-blooded vertebrates, mammals. We have made c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stone JS,Rubel EW

更新日期：2000-10-24 00:00:00

abstract：:Chloroplasts have evolved from a cyanobacterial endosymbiont and been retained for more than 1 billion years by coordinated chloroplast division in multiplying eukaryotic cells. Chloroplast division is performed by ring structures at the division site, encompassing both the inside and the outside of the two envelopes....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyagishima SY,Kuwayama H,Urushihara H,Nakanishi H

更新日期：2008-09-30 00:00:00

abstract：:Figs (Ficus spp., Moraceae) and their pollinating wasps (Agaonidae, Chalcidoidea) constitute perhaps the most tightly integrated pollination mutualism that is known. Figs are characterized by extraordinarily high global and local species diversity. It has been proposed that the diversification of this mutualism has oc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machado CA,Robbins N,Gilbert MT,Herre EA

更新日期：2005-05-03 00:00:00

abstract：:Explaining the variation between human languages and the constraints on that variation is a core goal of linguistics. In the last 20 y, it has been claimed that many striking universals of cross-linguistic variation follow from a hypothetical principle that dependency length--the distance between syntactically related...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Futrell R,Mahowald K,Gibson E

更新日期：2015-08-18 00:00:00

abstract：:Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eriksson P,Kallin B,van 't Hooft FM,Båvenholm P,Hamsten A

更新日期：1995-03-14 00:00:00

abstract：:We have isolated a human gastrin gene from a genomic library by employing a human gastrin cDNA clone as a hybridization probe. The total length of the gene is approximately 4.0 kilobase pairs, and the gene is separated into three exons and two introns. A 130-base-pair intron interrupts the coding region and a 3.0-kilo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito R,Sato K,Helmer T,Jay G,Agarwal K

更新日期：1984-08-01 00:00:00

abstract：:Many neurodegenerative diseases are characterized by the accumulation of amyloid fibers in the brain, which can occur when a protein misfolds into an extended beta-sheet conformation. The nucleation of these beta-sheet aggregates is of particular interest, not only because it is the rate-determining step toward fiber ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petty SA,Decatur SM

更新日期：2005-10-04 00:00:00

abstract：:In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arrested breast cancer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung P,Menssen A,Mayr D,Hermeking H

更新日期：2008-09-30 00:00:00

abstract：:We present whole-genome assemblies of four divergent Arabidopsis thaliana strains that complement the 125-Mb reference genome sequence released a decade ago. Using a newly developed reference-guided approach, we assembled large contigs from 9 to 42 Gb of Illumina short-read data from the Landsberg erecta (Ler-1), C24,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneeberger K,Ossowski S,Ott F,Klein JD,Wang X,Lanz C,Smith LM,Cao J,Fitz J,Warthmann N,Henz SR,Huson DH,Weigel D

更新日期：2011-06-21 00:00:00

abstract：:Exocytosis allows the release of secretory products and the delivery of new membrane material to the plasma membrane. So far, little is known about the underlying molecular mechanism and its control in plant cells. We have used the whole-cell patch-clamp technique to monitor changes in membrane capacitance to study ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Homann U,Tester M

更新日期：1997-06-10 00:00:00

abstract：:A TL+ leukemia of a (B6 X A)F1 hybrid mouse (H-2b/H-2a) was previously subjected to immunoselection against H-2a by passage in (B6 X A.SW)F1 mice (H-2b/H-2s). A variant leukemia line was obtained that serologically lacked not only the H-2a phenotype but also the TL phenotype determined by the linked cis Tlaa allele of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen FW,Chaganti RS,Doucette LA,Litman GW,Steinmetz M,Hood L,Boyse EA

更新日期：1984-10-01 00:00:00

abstract：:The fusiform face area (FFA) is a region of human cortex that responds selectively to faces, but whether it supports a more general function relevant for perceptual expertise is debated. Although both faces and objects of expertise engage many brain areas, the FFA remains the focus of the strongest modular claims and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGugin RW,Gatenby JC,Gore JC,Gauthier I

更新日期：2012-10-16 00:00:00

abstract：:Infection is a major complication of implantable medical devices, which provide a scaffold for biofilm formation, thereby reducing susceptibility to antibiotics and complicating treatment. Hematogenous implant-related infections following bacteremia are particularly problematic because they can occur at any time in a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Cheng LI,Helfer DR,Ashbaugh AG,Miller RJ,Tzomides AJ,Thompson JM,Ortines RV,Tsai AS,Liu H,Dillen CA,Archer NK,Cohen TS,Tkaczyk C,Stover CK,Sellman BR,Miller LS

更新日期：2017-06-27 00:00:00

abstract：:Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the solution structure of the cysteine/histidine-rich 1 (CH1) domain of p300 bound to the C-terminal transactivation domain of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freedman SJ,Sun ZY,Poy F,Kung AL,Livingston DM,Wagner G,Eck MJ

更新日期：2002-04-16 00:00:00

abstract：:Seasonal epidemics and periodic worldwide pandemics caused by influenza A viruses are of continuous concern. The viral nonstructural (NS1) protein is a multifunctional virulence factor that antagonizes several host innate immune defenses during infection. NS1 also directly stimulates class IA phosphoinositide 3-kinase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hale BG,Kerry PS,Jackson D,Precious BL,Gray A,Killip MJ,Randall RE,Russell RJ

更新日期：2010-02-02 00:00:00

abstract：:The combustion of fossil fuels has enriched levels of CO(2) in the world's oceans and decreased ocean pH. Although the continuation of these processes may alter the growth, survival, and diversity of marine organisms that synthesize CaCO(3) shells, the effects of ocean acidification since the dawn of the industrial re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Talmage SC,Gobler CJ

更新日期：2010-10-05 00:00:00

abstract：:Direct structural insights on the fundamental mechanisms of permeation, selectivity, and gating remain unavailable for the Na(+) and Ca(2+) channel families. Here, we report the spectroscopic structural characterization of the isolated Voltage-Sensor Domain (VSD) of the prokaryotic Na(+) channel NaChBac in a lipid bil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakrapani S,Sompornpisut P,Intharathep P,Roux B,Perozo E

更新日期：2010-03-23 00:00:00

abstract：:Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development of improved microtubule-directed therapies. Although there is a large body of data on the interactions of different MTAs with pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohan R,Katrukha EA,Doodhi H,Smal I,Meijering E,Kapitein LC,Steinmetz MO,Akhmanova A

更新日期：2013-05-28 00:00:00

abstract：:It is shown that a stereochemical correspondence between two molecular systems can be represented by a commuting diagram of the point groups and permutation groups involved. The effect of the diagrammatic condition on the mappings of the cosets, double cosets, subgroup lattice, and double coset algebra determined for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nourse JG

更新日期：1975-06-01 00:00:00

abstract：:There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, the recognition that growth hormone (GH) cells are arranged in functionally organized networks raises the possibility that the responses...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez-Cardenas C,Fontanaud P,He Z,Lafont C,Meunier AC,Schaeffer M,Carmignac D,Molino F,Coutry N,Bonnefont X,Gouty-Colomer LA,Gavois E,Hodson DJ,Le Tissier P,Robinson IC,Mollard P

更新日期：2010-12-14 00:00:00

abstract：:Although prairie voles (Microtus ochrogaster) are socially monogamous, males vary in both sexual and spatial fidelity. Most males form pairbonds, cohabit with one female, and defend territories. Wandering males, in contrast, have expansive home ranges that overlap many males and females. In the laboratory, pairing is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ophir AG,Wolff JO,Phelps SM

更新日期：2008-01-29 00:00:00