Abstract:
:Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 promoter is associated with higher plasma PAI-1 activity. The prevalence of the 4G allele is significantly higher in patients with myocardial infarction before the age of 45 than in population-based controls (allele frequencies of 0.63 vs. 0.53). Both alleles bind a transcriptional activator, whereas the 5G allele also binds a repressor protein to an overlapping binding site. In the absence of bound repressor, the basal level of PAI-1 transcription is increased.
journal_name
Proc Natl Acad Sci U S Aauthors
Eriksson P,Kallin B,van 't Hooft FM,Båvenholm P,Hamsten Adoi
10.1073/pnas.92.6.1851subject
Has Abstractpub_date
1995-03-14 00:00:00pages
1851-5issue
6eissn
0027-8424issn
1091-6490journal_volume
92pub_type
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