Abstract:
:A way to assess specific CD8+ T-cell activity in a skin test analogous to the conventional delayed-type hypersensitivity (DTH) reaction for CD4+ T cells is presented. Local injection of viral class I binding peptides caused a specific CD8+ T-cell-mediated DTH in footpads of virally infected mice. The DTH was inducible only during the acute phase of the infection. Apparently because of the short half-life of locally available peptide, only activated CD8+ effector T cells could mediate the reaction. This skin test may prove to be particularly interesting for use in humans to evaluate the activation status of CD8+ T cells during acute viral infections and of memory CD8+ T cells, for example, in chronically active immunopathological disease or infection.
journal_name
Proc Natl Acad Sci U S Aauthors
Kündig TM,Althage A,Hengartner H,Zinkernagel RMdoi
10.1073/pnas.89.16.7757keywords:
subject
Has Abstractpub_date
1992-08-15 00:00:00pages
7757-61issue
16eissn
0027-8424issn
1091-6490journal_volume
89pub_type
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