Abstract:
:Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.
journal_name
Proc Natl Acad Sci U S Aauthors
Robinson NE,Robinson ABdoi
10.1073/pnas.221463198keywords:
subject
Has Abstractpub_date
2001-10-23 00:00:00pages
12409-13issue
22eissn
0027-8424issn
1091-6490pii
221463198journal_volume
98pub_type
杂志文章abstract::Inflammatory destruction of insulin-producing beta cells in the pancreatic islets is the hallmark of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese diabetic mice resembling human juvenile (type I) diabetes. Histochemical analysis of diabetic pancreata revealed that mononuclear cells...
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:2010-08-31 00:00:00
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