Plants and animals share functionally common bacterial virulence factors.

abstract：:Most variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lonn E,Koskela E,Mappes T,Mokkonen M,Sims AM,Watts PC

更新日期：2017-04-04 00:00:00

abstract：:The dansyl-conjugated (Dns) peptides Dns-Pro-Gly-Gly-Gln-Gln-Ile-Val and Dns-Ala-Gln-Gln-Ile-Val, patterned on the N-terminal sequence of fibronectin, were synthesized and used for the transglutaminase (protein-glutamine:amine gamma-glutamyltransferase, EC 2.3.2.13)-directed selective blocking of lens proteins that ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorand L,Parameswaran KN,Velasco PT

更新日期：1991-01-01 00:00:00

abstract：:Current evidence suggests that the length of poly(A) tails of bacterial mRNAs result from a competition between poly(A) polymerase and exoribonucleases that attack the 3' ends of RNAs. Here, we show that host factor Hfq is also involved in poly(A) tail metabolism. Inactivation of the hfq gene reduces the length of pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hajnsdorf E,Régnier P

更新日期：2000-02-15 00:00:00

abstract：:Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure 1/28th the area of the starting gel in 24 hr. The rate of the process can be regulated by varying the protein content of the lattice, the cell number, or the concentration of an inhibitor such as Colcemid. Fibroblasts of high population do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bell E,Ivarsson B,Merrill C

更新日期：1979-03-01 00:00:00

abstract：:Mononucleated myogenic cells from 11-day-old chicken embryos were infected with tsLA24 or tsNY68, temperature-sensitive transformation mutants of Rous sarcoma virus. The infected mononucleated myogenic cells were incubated at the nonpermissive temperature (41 degrees C) and allowed to develop into multinucleated myotu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi N,Kaji A

更新日期：1978-11-01 00:00:00

abstract：:The Bam complex assembles β-barrel proteins into the outer membrane (OM) of Gram-negative bacteria. These proteins comprise cylindrical β-sheets with long extracellular loops and create pores to allow passage of nutrients and waste products across the membrane. Despite their functional importance, several questions re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wzorek JS,Lee J,Tomasek D,Hagan CL,Kahne DE

更新日期：2017-03-07 00:00:00

abstract：:To identify the binding domain for dihydropyridine Ca2+ antagonists, skeletal muscle Ca2+ channels were photolabeled with [3H](+)-PN200-110 and [3H]azidopine. Regions of alpha 1 photolabeled by these ligands were then identified by antibody mapping of proteolytic fragments. Approximately 50% of the specific labeling b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Striessnig J,Murphy BJ,Catterall WA

更新日期：1991-12-01 00:00:00

abstract：:A general approach to high-throughput screening of enantiomeric excess (ee) and concentration was developed by using indicator displacement assays (IDAs), and the protocol was then applied to the vicinal diol hydrobenzoin. The method involves the sequential utilization of what we define herein as screening, training, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shabbir SH,Regan CJ,Anslyn EV

更新日期：2009-06-30 00:00:00

abstract：:Reversible ligands were attached covalently to membrane-bound acetylcholine receptor from Torpedo marmorata by a method which is generally applicable and does not require the synthesis of specially designed molecules. UV irradiation of the receptor in the presence of [3H]trimethisoquin, [3H]phencyclidine, or [3H]perhy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oswald R,Changeux JP

更新日期：1981-06-01 00:00:00

abstract：:The lentiviruses are associated with a wide range of chronic diseases in mammals. These include immunodeficiencies (such as HIV/AIDS in humans), malignancies, and lymphatic and neurological disorders in primates, felids, and a variety of wild and domesticated ungulates. Evolutionary analyses of the genomic sequences o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katzourakis A,Tristem M,Pybus OG,Gifford RJ

更新日期：2007-04-10 00:00:00

abstract：:The oscillator of the circadian clock of cyanobacteria is composed of three proteins, KaiA, KaiB, and KaiC, which together generate a self-sustained ∼24-h rhythm of phosphorylation of KaiC. The mechanism propelling this oscillator has remained elusive, however. We show that stacking interactions between the CI and CII...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang YG,Tseng R,Kuo NW,LiWang A

更新日期：2012-10-16 00:00:00

abstract：:Pain is a major health concern even though numerous analgesic agents are available. Side effects and lack of wide-spectrum efficacy of current drugs justify efforts to better understand pain mechanisms. Stabilization of natural epoxy-fatty acids (EFAs) through inhibition of the soluble epoxide hydrolase (sEH) reduces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inceoglu B,Wagner K,Schebb NH,Morisseau C,Jinks SL,Ulu A,Hegedus C,Rose T,Brosnan R,Hammock BD

更新日期：2011-03-22 00:00:00

abstract：:The transcription and processing of mitochondrial 21S rRNA in a petite strain of Saccharomyces cerevisiae has been examined by electron microscopic analysis of R-loop hybrids and by hybridization of labeled mitochondrial DNA probes to RNA transferred to diazobenzyloxymethyl paper. We have shown the presence of a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merten S,Synenki RM,Locker J,Christianson T,Rabinowitz M

更新日期：1980-03-01 00:00:00

abstract：:We recently found that many residues in enzyme active sites can be computationally predicted by the optimization of scoring functions based on substrate binding affinity, subject to constraints on the geometry of catalytic residues and protein stability. Here, we explore the generality of this surprising observation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakrabarti R,Klibanov AM,Friesner RA

更新日期：2005-08-23 00:00:00

abstract：:Nonhuman primates possess a highly developed capacity for face recognition, which resembles the human capacity both cognitively and neurologically. Face recognition is typically tested by having subjects compare facial images, whereas there has been virtually no attention to how they connect these images to reality. C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pokorny JJ,de Waal FB

更新日期：2009-12-22 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) infection induces transcription of the chloramphenicol acetyltransferase (CAT) gene directed by the long terminal repeat (LTR) of human immunodeficiency virus (HIV) in both transiently and permanently transfected cells containing the HIV-LTR/CAT hybrid gene. To define the mechanism by wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosca JD,Bednarik DP,Raj NB,Rosen CA,Sodroski JG,Haseltine WA,Hayward GS,Pitha PM

更新日期：1987-11-01 00:00:00

abstract：:Recommended Daily Allowances (US RDA) of the Food and Drug Administration for ascorbic acid are higher than Recommended Dietary Allowances (set by the Food and Nutrition Board) for adults. There is a 6-fold margin between the requirement to prevent scurvy and the US RDA. The high requirement reported for the rhesus mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jukes TH

更新日期：1975-10-01 00:00:00

abstract：:How granzymes gain entry into the cytosol of target cells during killer cell attack has been the subject of several studies in the past, but the effective delivery mechanism during target cell encounter has not been clarified. Here we show that granzyme B (GzmB) mutants lacking binding to negatively charged, essential...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurschus FC,Fellows E,Stegmann E,Jenne DE

更新日期：2008-09-16 00:00:00

abstract：:This paper presents some calculated results on the vibrational structuring of the magnetic circular dichroism of the benzene (1)A(1g)"(1)B(2u) transition. The good agreement between the experimental and calculated relative intensities of the B-bands (positive magnetic circular dichroism bands) indicates that these ban...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shieh DJ,Lin SH,Eyring H

更新日期：1972-08-01 00:00:00

abstract：:A specific antibody against proinsulin has been obtained by adsorbing the original anti-proinsulin guinea pig serum with a solid immunosorbent of Sephadex-insulin. The specificity of the antibody against antigenic determinants of proinsulin was established by radioimmunoassay and by passive cutaneous anaphylaxis (PCA)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yip CC,Logothetopoulos J

更新日期：1969-02-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) represents a serious threat to the health of hospitalized patients. Attempts to reduce the spread of MRSA have largely depended on hospital hygiene and patient isolation. These measures have met with mixed success: although some countries have almost eliminated MRSA o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper BS,Medley GF,Stone SP,Kibbler CC,Cookson BD,Roberts JA,Duckworth G,Lai R,Ebrahim S

更新日期：2004-07-06 00:00:00

abstract：:The unique specificity of monoclonal antibodies (Ab) was combined with the cell-killing function of the cytolytic alternative pathway of complement. The functionally C3b-like glycoprotein of cobra venom was linked to a murine monoclonal Ab directed to a human melanoma-associated antigen by a disulfide bond, by using a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogel CW,Müller-Eberhard HJ

更新日期：1981-12-01 00:00:00

abstract：:The size of virus-specific RNA synthesized in cultured mouse kidney cells infected with polyoma virus was estimated by electrophoresis and sedimentation analysis of RNA extracts from whole cells. Newly synthesized "late" polyoma-specific RNA appears as "giant" molecules of heterogeneous size, up to several times large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheson NH,Buetti E,Scherrer K,Weil R

更新日期：1971-09-01 00:00:00

abstract：:Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davidoff AM,Iglehart JD,Marks JR

更新日期：1992-04-15 00:00:00

abstract：:The persistent tetrodotoxin (TTX)-sensitive sodium current, detected in neurons of many regions of mammalian brains, is associated with many essential neuronal activities, including boosting of excitatory synaptic inputs, acceleration of firing rates, and promotion of oscillatory neuronal activities. However, the orig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Song W,Dong K

更新日期：2004-08-10 00:00:00

abstract：:Mechanisms for controlling symbiont populations are critical for maintaining the associations that exist between a host and its microbial partners. We describe here the transcriptional, metabolic, and ultrastructural characteristics of a diel rhythm that occurs in the symbiosis between the squid Euprymna scolopes and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wier AM,Nyholm SV,Mandel MJ,Massengo-Tiassé RP,Schaefer AL,Koroleva I,Splinter-Bondurant S,Brown B,Manzella L,Snir E,Almabrazi H,Scheetz TE,Bonaldo Mde F,Casavant TL,Soares MB,Cronan JE,Reed JL,Ruby EG,McFall-Ngai MJ

更新日期：2010-02-02 00:00:00

abstract：:Anxiety disorders are the most prevalent mental disorders in developed societies. Although roles for the prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus in anxiety disorders are well documented, molecular mechanisms contributing to the functions of these structures are poorly understood. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tekinay AB,Nong Y,Miwa JM,Lieberam I,Ibanez-Tallon I,Greengard P,Heintz N

更新日期：2009-03-17 00:00:00

abstract：:Combined intracellular and microfluorometric recording techniques were used to evaluate whether the inhibition by cholinergic or adrenergic transmitters of the Ca2(+)-activated potassium current (IAHP) in hippocampal CA3 pyramidal cells was mediated by an alteration of depolarization-induced change in cytosolic free C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knöpfel T,Vranesic I,Gähwiler BH,Brown DA

更新日期：1990-06-01 00:00:00

abstract：:Although it is known that the c-myc oncogene is rearranged in a head-to-head fashion with the immunoglobulin heavy chain locus in mouse plasmacytomas, it has not been clear whether the c-myc oncogene is translocated to the heavy chain locus on mouse chromosome 12 or whether the heavy chain locus is translocated to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Erikson J,Miller DA,Miller OJ,Abcarian PW,Skurla RM,Mushinski JF,Croce CM

更新日期：1985-06-01 00:00:00

abstract：:Protocell models are used to investigate how cells might have first assembled on Earth. Some, like oil-in-water droplets, can be seemingly simple models, while able to exhibit complex and unpredictable behaviors. How such simple oil-in-water systems can come together to yield complex and life-like behaviors remains a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Points LJ,Taylor JW,Grizou J,Donkers K,Cronin L

更新日期：2018-01-30 00:00:00