Transcription of the polyoma virus genome: synthesis and cleavage of giant late polyoma-specific RNA.

abstract：:Radiation dose rates were evaluated in three areas neighboring a restricted area within a 20- to 50-km radius of the Fukushima Daiichi Nuclear Power Plant in August-September 2012 and projected to 2022 and 2062. Study participants wore personal dosimeters measuring external dose equivalents, almost entirely from depos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada KH,Niisoe T,Imanaka M,Takahashi T,Amako K,Fujii Y,Kanameishi M,Ohse K,Nakai Y,Nishikawa T,Saito Y,Sakamoto H,Ueyama K,Hisaki K,Ohara E,Inoue T,Yamamoto K,Matsuoka Y,Ohata H,Toshima K,Okada A,Sato H,Kuwa

更新日期：2014-03-11 00:00:00

abstract：:Cell-to-cell communication is essential for the development and patterning of multicellular organisms. In plants, plasmodesmata (PD) provide direct routes for intercellular signaling. However, the role that PD-mediated signaling plays in plant development has not been fully investigated. To gain a comprehensive view o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu S,O'Lexy R,Xu M,Sang Y,Chen X,Yu Q,Gallagher KL

更新日期：2016-10-11 00:00:00

abstract：:Toll-like receptor 3 (TLR3) is a key effector of the innate immune system against viruses. Activation of TLR3 exerts an antitumoral effect through a mechanism of action still poorly understood. Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of microRNA-29b, -29c, -148b, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galli R,Paone A,Fabbri M,Zanesi N,Calore F,Cascione L,Acunzo M,Stoppacciaro A,Tubaro A,Lovat F,Gasparini P,Fadda P,Alder H,Volinia S,Filippini A,Ziparo E,Riccioli A,Croce CM

更新日期：2013-06-11 00:00:00

abstract：:Neonicotinoid insecticides control crop pests based on their action as agonists at the insect nicotinic acetylcholine receptor, which accepts chloropyridinyl- and chlorothiazolyl-analogs almost equally well. In some cases, these compounds have also been reported to enhance plant vigor and (a)biotic stress tolerance, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ford KA,Casida JE,Chandran D,Gulevich AG,Okrent RA,Durkin KA,Sarpong R,Bunnelle EM,Wildermuth MC

更新日期：2010-10-12 00:00:00

abstract：:In herpes simplex virus 1 (HSV-1) DNA, a small sequence, designated the a sequence, flanks the reiterated sequences at the ends of both the L and S components. The a sequence is the only sequence shared by the termini of all isomeric arrangements of HSV-1 DNA that arise from inversions of the covalently linked L and S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knipe DM,Ruyechan WT,Honess RW,Roizman B

更新日期：1979-09-01 00:00:00

abstract：:The crystal structures of Escherichia coli thymidylate kinase (TmpK) in complex with P1-(5'-adenosyl)-P5-(5'-thymidyl)pentaphosphate and P1-(5'-adenosyl)P5-[5'-(3'-azido-3'-deoxythymidine)] pentaphosphate have been solved to 2.0-A and 2.2-A resolution, respectively. The overall structure of the bacterial TmpK is very ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavie A,Ostermann N,Brundiers R,Goody RS,Reinstein J,Konrad M,Schlichting I

更新日期：1998-11-24 00:00:00

abstract：:DNA hybridization was used to compare representatives of the major groups of marsupials and a eutherian outgroup. Because of the large genetic distances separating marsupial families, trees were calculated from normalized percentages of hybridization; thermal-melting statistics, however, gave identical topologies for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirsch JA,Dickerman AW,Reig OA,Springer MS

更新日期：1991-12-01 00:00:00

abstract：:The protein encoded by the neu protooncogene (human gene symbol NGL for neuro/glioblastoma-derived) is a member of the surface receptor/tyrosine kinase family. Though its structure suggests that it can transduce a transmembrane signal, neither its extracellular ligand nor its critical intracellular substrates are know...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flanagan JG,Leder P

更新日期：1988-11-01 00:00:00

abstract：:A full-length cDNA clone encoding a glutamate receptor was isolated from a human brain cDNA library, and the gene product was characterized after expression in Xenopus oocytes. Degenerate PCR primers to conserved regions of published rat brain glutamate receptor sequences amplified a 1-kilobase fragment from a human b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun W,Ferrer-Montiel AV,Schinder AF,McPherson JP,Evans GA,Montal M

更新日期：1992-02-15 00:00:00

abstract：:The processes of isolated rat sympathetic neurons growing in culture were marked with glass or carmine particles and observed with timelapse microphotography. Particles on the processes moved with the cell in relation to the dish and underwent continual small jerky movements. They did not, however, show any over-all d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bray D

更新日期：1970-04-01 00:00:00

abstract：:Hydrogen bond networks are key elements of protein structure and function but have been challenging to study within the complex protein environment. We have carried out in-depth interrogations of the proton transfer equilibrium within a hydrogen bond network formed to bound phenols in the active site of ketosteroid is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sigala PA,Fafarman AT,Schwans JP,Fried SD,Fenn TD,Caaveiro JM,Pybus B,Ringe D,Petsko GA,Boxer SG,Herschlag D

更新日期：2013-07-09 00:00:00

abstract：:Partial, unilateral nigrostriatal lesions of varying severity were produced in rats by injecting graded doses of 6-hydroxydopamine into the substantia nigra. Formation of the dopamine metabolites dihydroxyphenylacetic acid and homovanillic acid in each surviving nigrostriatal neuron (estimated by the ratios of dihydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melamed E,Hefti F,Wurtman RJ

更新日期：1980-07-01 00:00:00

abstract：:Adrenocortical carcinomas (ACCs) are rare and highly malignant cancers associated with poor survival of patients. Currently, mitotane, a nonspecific derivative of the pesticide DDT (1,1-(dichlorobiphenyl)-2,2-dichloroethane), is used as the standard treatment, but its mechanism of action in ACCs remains elusive. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belavgeni A,Bornstein SR,von Mässenhausen A,Tonnus W,Stumpf J,Meyer C,Othmar E,Latk M,Kanczkowski W,Kroiss M,Hantel C,Hugo C,Fassnacht M,Ziegler CG,Schally AV,Krone NP,Linkermann A

更新日期：2019-10-29 00:00:00

abstract：:Infective stages of the protozoan parasite Leishmania spp. accumulate a class of beta-1,2-mannan oligosaccharides as their major carbohydrate reserve material. Here, we describe the biosynthesis of Leishmania mannan. Mannan precursors were identified by metabolic labeling of Leishmania mexicana promastigotes with [(3)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sernee MF,Ralton JE,Dinev Z,Khairallah GN,O'Hair RA,Williams SJ,McConville MJ

更新日期：2006-06-20 00:00:00

abstract：:Oxygen free radicals are highly reactive species generated by many cellular oxidation-reduction processes. These radicals damage cellular constituents and have been causally implicated in the pathogenesis of many human diseases. We report here that oxygen free radicals generated by Fe2+ in aqueous solution are mutagen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loeb LA,James EA,Waltersdorph AM,Klebanoff SJ

更新日期：1988-06-01 00:00:00

abstract：:We investigated whether genes escape X chromosome inactivation by positioning outside of the territory defined by XIST RNA. Results reveal an unanticipated higher order organization of genes and noncoding sequences. All 15 X-linked genes, regardless of activity, position on the border of the XIST RNA territory, which ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clemson CM,Hall LL,Byron M,McNeil J,Lawrence JB

更新日期：2006-05-16 00:00:00

abstract：:For almost a century, alcohols have been thought to produce their effects by actions on the membrane lipids of central nervous system neurons--the well known "lipid theory" of alcohol action. The rationale for this theory is the correlation of potency with oil/water or membrane/buffer partition coefficient. Although a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Peoples RW,Weight FF

更新日期：1994-08-16 00:00:00

abstract：:The BvgAS phosphorelay regulates ∼10% of the annotated genomes of Bordetella pertussis and Bordetella bronchiseptica and controls their infectious cycles. The hierarchical organization of the regulatory network allows the integration of contextual signals to control all or specific subsets of BvgAS-regulated genes. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahuja U,Shokeen B,Cheng N,Cho Y,Blum C,Coppola G,Miller JF

更新日期：2016-03-01 00:00:00

abstract：:Herpesvirus saimiri (HVS) is the prototype member of a distinctive subset of lymphotropic herpesviruses (the gamma 2 subgroup) with A+T-rich coding sequences. In this paper, we show that cells productively infected with HVS contain high concentrations of a virus-specified thymidylate synthase (5,10-methylenetetrahydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honess RW,Bodemer W,Cameron KR,Niller HH,Fleckenstein B,Randall RE

更新日期：1986-06-01 00:00:00

abstract：:Tail-anchored (TA) membrane proteins are involved in a variety of important cellular functions, including membrane fusion, protein translocation, and apoptosis. The ATPase Get3 (Asna1, TRC40) was identified recently as the endoplasmic reticulum targeting factor of TA proteins. Get3 consists of an ATPase and alpha-heli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bozkurt G,Stjepanovic G,Vilardi F,Amlacher S,Wild K,Bange G,Favaloro V,Rippe K,Hurt E,Dobberstein B,Sinning I

更新日期：2009-12-15 00:00:00

abstract：:Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zoltowski BD,Chelliah Y,Wickramaratne A,Jarocha L,Karki N,Xu W,Mouritsen H,Hore PJ,Hibbs RE,Green CB,Takahashi JS

更新日期：2019-09-24 00:00:00

abstract：:The immunocytochemical demonstration of (pro)insulin on intracellular membrane compartments of the pancreatic B cell reveals that the immunolabeling detected by the protein A/gold method is associated, at the level of the Golgi apparatus, with the inner aspect of the cisternal membranes; on the secretory granules, by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orci L,Ravazzola M,Perrelet A

更新日期：1984-11-01 00:00:00

abstract：:Twelve zeolitic imidazolate frameworks (ZIFs; termed ZIF-1 to -12) have been synthesized as crystals by copolymerization of either Zn(II) (ZIF-1 to -4, -6 to -8, and -10 to -11) or Co(II) (ZIF-9 and -12) with imidazolate-type links. The ZIF crystal structures are based on the nets of seven distinct aluminosilicate zeo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KS,Ni Z,Côté AP,Choi JY,Huang R,Uribe-Romo FJ,Chae HK,O'Keeffe M,Yaghi OM

更新日期：2006-07-05 00:00:00

abstract：:The T-box transcription factor TBX5 plays essential roles in cardiac and limb development. Various mutations in the TBX5 gene have been identified in patients with Holt-Oram syndrome, which is characterized by congenital defects in the heart and upper extremities. In this study, we identified a WW-domain-containing tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami M,Nakagawa M,Olson EN,Nakagawa O

更新日期：2005-12-13 00:00:00

abstract：:Many current treatments for the reclamation of contaminated water sources are chemical-intensive, energy-intensive, and/or require posttreatment due to unwanted by-product formation. We demonstrate that through the integration of nanostructured materials, enzymatic catalysis, and iron-catalyzed free radical reactions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis SR,Datta S,Gui M,Coker EL,Huggins FE,Daunert S,Bachas L,Bhattacharyya D

更新日期：2011-05-24 00:00:00

abstract：:The basic assumptions of van der Waals theory are contained in two well-known concepts: excluded volume (repulsive forces) and a homogeneous, isotropic field potential (attractive forces). We have superimposed on these, one more well-known concept: the existence of dimers, trimers, etc., at chemical equilibrium. With ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heidemann RA,Prausnitz JM

更新日期：1976-06-01 00:00:00

abstract：:Integrated hepadnaviral DNA in livers and tumors of chronic hepatitis B patients has been reported for many years. In this study, we investigated whether hepatitis B virus DNA integration occurs preferentially at sites of cell DNA damage. A single I-SceI homing endonuclease recognition site was introduced into the DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bill CA,Summers J

更新日期：2004-07-27 00:00:00

abstract：:The largest known DNA viruses infect Acanthamoeba and belong to two markedly different families. The Megaviridae exhibit pseudo-icosahedral virions up to 0.7 μm in diameter and adenine-thymine (AT)-rich genomes of up to 1.25 Mb encoding a thousand proteins. Like their Mimivirus prototype discovered 10 y ago, they enti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legendre M,Bartoli J,Shmakova L,Jeudy S,Labadie K,Adrait A,Lescot M,Poirot O,Bertaux L,Bruley C,Couté Y,Rivkina E,Abergel C,Claverie JM

更新日期：2014-03-18 00:00:00

abstract：:Relatively little is known about the biochemical mechanisms through which the Epstein-Barr virus latent infection integral membrane protein 1 (LMP1) transmembrane domains cause constitutive LMP1 aggregation and continuous cytoplasmic C terminus-mediated signal transduction. We now evaluate the role of the three consec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasui T,Luftig M,Soni V,Kieff E

更新日期：2004-01-06 00:00:00

abstract：:Transposition of the genetically related insertion elements gamma delta and Tn3 is thought to involve two steps. In the case of transposition from one replicon to another, the first step is fusion of the parent and target replicons with the element appearing in direct orientation at the two junctions. In a subsequent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed RR

更新日期：1981-06-01 00:00:00