Abstract:
:The diabetogenic agent alloxan exerts a preferential cytotoxic effect on the pancreatic B cell. The determinants of such a tissue specificity were investigated. Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle. The activity of glutathione peroxidase and the resistance to exogenous peroxide were approximately 20 times higher in liver and kidney than in islets, intermediate values being found in exocrine pancreas and muscle. These findings suggest that the selective cytotoxicity of alloxan to the pancreatic B cell is attributable to the conjunction of two features: a rapid cellular uptake of the drug and an exquisite sensitivity of the B cell to peroxide.
journal_name
Proc Natl Acad Sci U S Aauthors
Malaisse WJ,Malaisse-Lagae F,Sener A,Pipeleers DGdoi
10.1073/pnas.79.3.927subject
Has Abstractpub_date
1982-02-01 00:00:00pages
927-30issue
3eissn
0027-8424issn
1091-6490journal_volume
79pub_type
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