A complete Holocene record of trematode-bivalve infection and implications for the response of parasitism to climate change.

abstract：:Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered at the fitness-1 (fit1) locus in mouse chromosome 7 cause hematopoietic abnormalities, growth retardation, and shortened life span, with varying severity of the defects in different alleles. Abnormal iron distribution and metabolism and frequent scolios...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klebig ML,Wall MD,Potter MD,Rowe EL,Carpenter DA,Rinchik EM

更新日期：2003-07-08 00:00:00

abstract：:A 978-base-pair gene that encodes thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) from Lactobacillus casei has been synthesized and inserted into Escherichia coli expression vectors. The DNA sequence contains 35 unique restriction sites that are located an average of 28 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Climie S,Santi DV

更新日期：1990-01-01 00:00:00

abstract：:This paper's findings suggest that an arbitrary Chinese policy that greatly increases total suspended particulates (TSPs) air pollution is causing the 500 million residents of Northern China to lose more than 2.5 billion life years of life expectancy. The quasi-experimental empirical approach is based on China's Huai ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Ebenstein A,Greenstone M,Li H

更新日期：2013-08-06 00:00:00

abstract：:CSB/ERCC6 belongs to an orphan subfamily of SWI2/SNF2-related chromatin remodelers and plays crucial roles in gene expression, DNA damage repair, and the maintenance of genome integrity. The molecular basis of chromatin remodeling by Cockayne syndrome B protein (CSB) is not well understood. Here we investigate the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Xu J,Limbo O,Fei J,Kassavetis GA,Chong J,Kadonaga JT,Russell P,Li B,Wang D

更新日期：2019-03-26 00:00:00

abstract：:The specificity with which the genetic code is read in protein synthesis, and with which other highly specific biosynthetic reactions take place, can be increased above the level available from free energy differences in intermediates or kinetic barriers by a process defined here as kinetic proofreading. A simple kine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopfield JJ

更新日期：1974-10-01 00:00:00

abstract：:Mechanisms by which macrophages discriminate between "mature-self" and "senescent-self" were investigated using the human red blood cell (RBC) system as a model. Conditions simulating those encountered in situ were adhered to as closely as possible by using short term culture techniques and incubating with autologous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM

更新日期：1975-09-01 00:00:00

abstract：:Resting-state functional connectivity is used throughout neuroscience to study brain organization and to generate biomarkers of development, disease, and cognition. The processes that give rise to correlated activity are, however, poorly understood. Here we decompose resting-state functional connectivity using a tempo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamani Esfahlani F,Jo Y,Faskowitz J,Byrge L,Kennedy DP,Sporns O,Betzel RF

更新日期：2020-11-10 00:00:00

abstract：:Humans have altered natural patterns of fire for millennia, but the impact of human-set fires is thought to have been slight in wet closed-canopy forests. In the South Island of New Zealand, Polynesians (Māori), who arrived 700-800 calibrated years (cal y) ago, and then Europeans, who settled ∼150 cal y ago, used fire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McWethy DB,Whitlock C,Wilmshurst JM,McGlone MS,Fromont M,Li X,Dieffenbacher-Krall A,Hobbs WO,Fritz SC,Cook ER

更新日期：2010-12-14 00:00:00

abstract：:Endometriosis is a highly prevalent gynecological disease with severe negative impacts on life quality and financial burden. Unfortunately, there is no cure for this disease, which highlights the need for further investigation about the pathophysiology of this disease to provide clues for developing novel therapeutic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li WN,Hsiao KY,Wang CA,Chang N,Hsu PL,Sun CH,Wu SR,Wu MH,Tsai SJ

更新日期：2020-10-13 00:00:00

abstract：:Lignocellulosic plant biomass is an attractive feedstock for the production of sustainable biofuels, but the commercialization of such products is hampered by the high costs of processing this material into fermentable sugars (saccharification). One approach to lowering these costs is to produce crops with cell walls ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marriott PE,Sibout R,Lapierre C,Fangel JU,Willats WG,Hofte H,Gómez LD,McQueen-Mason SJ

更新日期：2014-10-07 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b(+)Gr1(+) myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/MEK/ERK pathway reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phan VT,Wu X,Cheng JH,Sheng RX,Chung AS,Zhuang G,Tran C,Song Q,Kowanetz M,Sambrone A,Tan M,Meng YG,Jackson EL,Peale FV,Junttila MR,Ferrara N

更新日期：2013-04-09 00:00:00

abstract：:The multifunctional Ca2+/calmodulin-dependent protein kinase purified from rat brain cytosol undergoes an intramolecular self-phosphorylation or autophosphorylation. Autophosphorylation produces two strikingly different effects on kinase activity that are dependent on the level of ATP used in the reaction. At low but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lou LL,Lloyd SJ,Schulman H

更新日期：1986-12-01 00:00:00

abstract：:The protein products of T4 bacteriophage genes 41, 43, 45, 44, and 62 have been purified to near homogeneity using an assay which measures their stimulation of DNA synthesis in a crude lysate of Escherichia coli cells in fected by an appropriate mutant phage. When all of these proteins and T4 gene 32 protein are incub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morris CF,Sinha NK,Alberts BM

更新日期：1975-12-01 00:00:00

abstract：:A unified structure theory of icosahedral quasicrystals, combining the twinned-cubic-crystal theory and the Penrose-tiling-six-dimensional-projection theory, is described. Values of the primitive-cubic lattice constant for several quasicrystals are evaluated from x-ray and neutron diffraction data. The fact that the l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1988-11-01 00:00:00

abstract：:An improved mammalian two-hybrid system designed for interaction trap screening is described in this paper. CV-1/EBNA-1 monkey kidney epithelial cells expressing Epstein-Barr virus nuclear antigen 1 (EBNA-1) were stably transfected with a reporter plasmid for GAL4-dependent expression of the green fluorescent protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shioda T,Andriole S,Yahata T,Isselbacher KJ

更新日期：2000-05-09 00:00:00

abstract：:IL-17 is a T cell-derived, proinflammatory cytokine that is suspected to be involved in the development of various inflammatory diseases. Although there are elevated levels of IL-17 in synovial fluid of patients with rheumatoid arthritis, the pathogenic role of IL-17 in the development of rheumatoid arthritis remains ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakae S,Saijo S,Horai R,Sudo K,Mori S,Iwakura Y

更新日期：2003-05-13 00:00:00

abstract：:Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hyporheic zone sediment. To assess the fate of As during discharge, surface (0-5 cm) and subsurface (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Mailloux B,Jung HB,Hoque MA,Stute M,Ahmed KM,Zheng Y

更新日期：2009-10-06 00:00:00

abstract：:The Tol2 element of the medaka fish Oryzias latipes belongs to the hAT family of transposons (hobo/Ac/Tam3). We report here identification of a functional transposase of Tol2 that is capable of catalyzing its transposition in the germ line of zebrafish Danio rerio. A transcript produced from Tol2 encodes a putative tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami K,Shima A,Kawakami N

更新日期：2000-10-10 00:00:00

abstract：:A ribosomal RNA-encoding DNA (rDNA) cloned sequence, consisting of a 0.8-kilobase fragment from the 26S/nontranscribed spacer region, was used to identify diagnostic restriction enzyme fragments that distinguish the Moreton and Torresian subspecies of the grasshopper Caledia captiva. These restriction fragments were t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold ML,Shaw DD,Contreras N

更新日期：1987-06-01 00:00:00

abstract：:Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of misfolded proteins in the hear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Satz JS,Vo MN,Nangle LA,Schimmel P,Ackerman SL

更新日期：2014-12-09 00:00:00

abstract：:From 1980 to 1992, a series of influential papers reported on the discovery, genetics, and evolution of a periodic cycling of the interval between Drosophila male courtship song pulses. The molecular mechanisms underlying this periodicity were never described. To reinitiate investigation of this phenomenon, we previou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern DL,Clemens J,Coen P,Calhoun AJ,Hogenesch JB,Arthur BJ,Murthy M

更新日期：2017-09-12 00:00:00

abstract：:We have obtained long-term cultures of differentiated proliferating follicular cells from normal adult human thyroid glands. In vitro growth of such human cells has been sustained by a modified F-12 medium, supplemented with bovine hypothalamus and pituitary extracts and no added thyrotropin. Cultures have been expand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curcio F,Ambesi-Impiombato FS,Perrella G,Coon HG

更新日期：1994-09-13 00:00:00

abstract：:The ever-increasing industrial demand for nylon-6 (polycaprolactam) necessitates the development of environmentally benign methods of producing its precursor, epsilon-caprolactam, from cyclohexanone. It is currently manufactured in two popular double-step processes, each of which uses highly aggressive reagents, and e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas JM,Raja R

更新日期：2005-09-27 00:00:00

abstract：:Compartmentalization of biomolecules within lipid membranes is a fundamental requirement of living systems and an essential feature of many pharmaceutical therapies. However, applications of membrane-enclosed solutions of proteins, DNA, and other biologically active compounds have been limited by the difficulty of for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stachowiak JC,Richmond DL,Li TH,Liu AP,Parekh SH,Fletcher DA

更新日期：2008-03-25 00:00:00

abstract：:Adrenal chromaffin granules contain at least 10 peptides, ranging in size from 3 to 5 kilodaltons, that yield, upon digestion with trypsin, peptides that show specific binding to opiate receptors. All are distinctly different from beta-endorphin. Two of these peptides have been purified to homogeneity and subjected to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura S,Lewis RV,Stern AS,Rossier J,Stein S,Udenfriend S

更新日期：1980-03-01 00:00:00

abstract：:Commercial hydrogen production by electrocatalytic water splitting will benefit from the realization of more efficient and less expensive catalysts compared with noble metal catalysts, especially for the oxygen evolution reaction, which requires a current density of 500 mA/cm2 at an overpotential below 300 mV with lon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou H,Yu F,Sun J,He R,Chen S,Chu CW,Ren Z

更新日期：2017-05-30 00:00:00

abstract：:The goal of this study was to characterize and classify pulmonary neuroendocrine tumors based on array comparative genomic hybridization (aCGH). Using aCGH, we performed karyotype analysis of 33 small cell lung cancer (SCLC) tumors, 13 SCLC cell lines, 19 bronchial carcinoids, and 9 gastrointestinal carcinoids. In con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voortman J,Lee JH,Killian JK,Suuriniemi M,Wang Y,Lucchi M,Smith WI Jr,Meltzer P,Wang Y,Giaccone G

更新日期：2010-07-20 00:00:00

abstract：:Group II intron RNAs self-splice in vitro but only at high salt and/or Mg2+ concentrations and have been thought to require proteins to stabilize their active structure for efficient splicing in vivo. Here, we show that a DEAD-box protein, CYT-19, can by itself promote the splicing and reverse splicing of the yeast aI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohr S,Matsuura M,Perlman PS,Lambowitz AM

更新日期：2006-03-07 00:00:00

abstract：:In the last decade, a number of quantitative epidemiological studies of specific diseases have been done in developing countries that for the first time allow estimation of the total burden of disease (mortality and morbidity) attributable to use of solid fuels in adult women and young children, who jointly receive th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith KR

更新日期：2000-11-21 00:00:00

abstract：:The v-jun oncogene encodes a nuclear DNA binding protein that functions as a transcription factor and is part of the activator protein 1 complex. Oncogenic transformation by v-jun is thought to be mediated by the aberrant expression of specific target genes. To identify such Jun-regulated genes and to explore the mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kruse U,Iacovoni JS,Goller ME,Vogt PK

更新日期：1997-11-11 00:00:00