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Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes.

Abstract：

:Y chromosomes control essential male functions in many species, including sex determination and fertility. However, because of obstacles posed by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model organisms, constraining our understanding of Y biology across the tree of life. Here, we leverage long single-molecule sequencing to determine the content and structure of the nonrecombining Y chromosome of the primary African malaria mosquito, Anopheles gambiae We find that the An. gambiae Y consists almost entirely of a few massively amplified, tandemly arrayed repeats, some of which can recombine with similar repeats on the X chromosome. Sex-specific genome resequencing in a recent species radiation, the An. gambiae complex, revealed rapid sequence turnover within An. gambiae and among species. Exploiting 52 sex-specific An. gambiae RNA-Seq datasets representing all developmental stages, we identified a small repertoire of Y-linked genes that lack X gametologs and are not Y-linked in any other species except An. gambiae, with the notable exception of YG2, a candidate male-determining gene. YG2 is the only gene conserved and exclusive to the Y in all species examined, yet sequence similarity to YG2 is not detectable in the genome of a more distant mosquito relative, suggesting rapid evolution of Y chromosome genes in this highly dynamic genus of malaria vectors. The extensive characterization of the An. gambiae Y provides a long-awaited foundation for studying male mosquito biology, and will inform novel mosquito control strategies based on the manipulation of Y chromosomes.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Hall AB,Papathanos PA,Sharma A,Cheng C,Akbari OS,Assour L,Bergman NH,Cagnetti A,Crisanti A,Dottorini T,Fiorentini E,Galizi R,Hnath J,Jiang X,Koren S,Nolan T,Radune D,Sharakhova MV,Steele A,Timoshevskiy VA,Windbich

doi

10.1073/pnas.1525164113

subject

Has Abstract

pub_date

2016-04-12 00:00:00

pages

E2114-23

issue

15

eissn

0027-8424

issn

1091-6490

pii

1525164113

journal_volume

113

pub_type

杂志文章

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