Constituents and functional implications of the rat default mode network.

abstract：:Macrophage migration inhibition factor (MIF) is one of a class of lymphocyte-derived mediator substances (lymphokines) which plays a role in the mechanism of cellular immunity. A variety of other soluble factors produced by non-lymphoid cells have been shown to have effects on macrophage mobility similar to that of MI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshida T,Bigazzi P,Cohen S

更新日期：1975-04-01 00:00:00

abstract：:The Cdc6 protein is essential for the assembly of pre-replicative complexes (pre-RCs) at origins of DNA replication in the budding yeast Saccharomyces cerevisiae. This reaction is blocked in vivo by the cyclin-dependent kinase Cdc28p, together with its regulatory subunits, the B type cyclins that are present throughou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donovan S,Harwood J,Drury LS,Diffley JF

更新日期：1997-05-27 00:00:00

abstract：:Understanding the detailed mechanism of the activation of voltage-gated ion channels has been a problem of great current interest. Reliable molecular simulations of voltage effects present a major challenge because meaningful converging microscopic simulations are not yet available and macroscopic treatments involve m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dryga A,Chakrabarty S,Vicatos S,Warshel A

更新日期：2012-02-28 00:00:00

abstract：:Cell-free extracts of nifF and nifJ mutants of Klebsiella pneumoniae are unable to couple acetylene reduction (N2 fixation) by nitrogenase to the oxidation of organic metabolites. However, nifF and nifJ mutants can complement each other in vitro to establish the coupling. This indicates that the products of the nifF a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nieva-Gómez D,Roberts GP,Klevickis S,Brill WJ

更新日期：1980-05-01 00:00:00

abstract：:Resequencing or reference-based assemblies reveal large parts of the small-scale sequence variation. However, they typically fail to separate such local variation into colinear and rearranged variation, because they usually do not recover the complement of large-scale rearrangements, including transpositions and inver...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zapata L,Ding J,Willing EM,Hartwig B,Bezdan D,Jiao WB,Patel V,Velikkakam James G,Koornneef M,Ossowski S,Schneeberger K

更新日期：2016-07-12 00:00:00

abstract：:Phytosulfokine-alpha [PSK-alpha, Tyr(SO(3)H)-Ile-Tyr(SO(3)H)-Thr-Gln], a sulfated mitogenic peptide found in plants, strongly promotes proliferation of plant cells in culture at very low concentrations. Oryza sativa PSK (OsPSK) cDNA encoding a PSK-alpha precursor has been isolated. The cDNA is 725 base pairs long, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang H,Matsubayashi Y,Nakamura K,Sakagami Y

更新日期：1999-11-09 00:00:00

abstract：:The second critical endpoint in the basalt-H(2)O system was directly determined by a high-pressure and high-temperature X-ray radiography technique. We found that the second critical endpoint occurs at around 3.4 GPa and 770 °C (corresponding to a depth of approximately 100 km in a subducting slab), which is much shal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mibe K,Kawamoto T,Matsukage KN,Fei Y,Ono S

更新日期：2011-05-17 00:00:00

abstract：:RelB is an NF-κB family transcription factor activated in the noncanonical pathway downstream of NF-κB-inducing kinase (NIK) and TNF receptor family members including lymphotoxin-β receptor (LTβR) and CD40. Early analysis suggested that RelB is required for classical dendritic cell (cDC) development based on a severe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA 3rd,Novack DV,Murphy TL,Murphy KM

更新日期：2017-04-11 00:00:00

abstract：:Ride-sharing services are transforming urban mobility by providing timely and convenient transportation to anybody, anywhere, and anytime. These services present enormous potential for positive societal impacts with respect to pollution, energy consumption, congestion, etc. Current mathematical models, however, do not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alonso-Mora J,Samaranayake S,Wallar A,Frazzoli E,Rus D

更新日期：2017-01-17 00:00:00

abstract：:Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The popul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trivedi U,Madsen JS,Everett J,Fell C,Russel J,Haaber J,Crosby HA,Horswill AR,Burmølle M,Rumbaugh KP,Sørensen SJ

更新日期：2018-12-11 00:00:00

abstract：:Ras proteins are small GTP binding proteins that serve as critical relays in a variety of signal transduction pathways in eukaryotic cells. Like most metazoan Ras proteins, yeast Ras is post-translationally modified by addition of a farnesyl and a palmitoyl moiety, and these modifications are required for targeting th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharya S,Chen L,Broach JR,Powers S

更新日期：1995-03-28 00:00:00

abstract：:Mind wandering represents the human capacity for internally focused thought and relies upon the brain's default network and its interactions with attentional networks. Studies have characterized mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical population...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Callaghan C,Shine JM,Hodges JR,Andrews-Hanna JR,Irish M

更新日期：2019-02-19 00:00:00

abstract：:Cellular telomere length is linked to replicative life span. Telomere repeats are lost in peripheral blood cells in vivo by age, and women show less telomere attrition than men. Previous reports have indicated that telomere length and chromosome-specific telomere-length patterns partly are inherited. The mode of hered...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nordfjäll K,Larefalk A,Lindgren P,Holmberg D,Roos G

更新日期：2005-11-08 00:00:00

abstract：:Previous studies have identified nuclear matrix attachment regions (MARs) that are closely associated with transcriptional enhancers in the IgH, Igkappa, and T cell receptor (TCR) beta loci, but have yielded conflicting information regarding their functional significance. In this report, a combination of in vitro and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong XP,Carabaña J,Krangel MS

更新日期：1999-10-12 00:00:00

abstract：:The leukemic fusion gene AML1-MDS1-EVI1 (AME) encodes a chimeric transcription factor that results from the t(3,21)(q26;q22) translocation seen in patients with acute myeloid leukemia, with therapy-related myelodysplastic syndrome, or with chronic myeloid leukemia in blast crisis. The myeloid transcription factor CEBP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helbling D,Mueller BU,Timchenko NA,Hagemeijer A,Jotterand M,Meyer-Monard S,Lister A,Rowley JD,Huegli B,Fey MF,Pabst T

更新日期：2004-09-07 00:00:00

abstract：:Fast-atom bombardment mass spectrometry was used to follow the time course of disulfide bond formation during in vitro refolding of recombinant human macrophage-colony-stimulating factor. The content of iodoacetamide-alkylated half-cystines in proteolytic peptides of trapped refolding intermediates collected at 0, 6, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glocker MO,Arbogast B,Milley R,Cowgill C,Deinzer ML

更新日期：1994-06-21 00:00:00

abstract：:The mouse p19Arf (human p14ARF) tumor suppressor protein, encoded in part from an alternative reading frame of the Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53. Arf is not expressed in most normal tissues of young mice but is induced by high thresholds of aberrant hyperproliferative signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Oosterwijk JG,Li C,Yang X,Opferman JT,Sherr CJ

更新日期：2017-07-11 00:00:00

abstract：:Natural killer (NK) cells play a critical role in controlling malignancies. Susceptibility or resistance to lung cancer, for example, specifically depends on NK cell function. Nevertheless, intrinsic factors that control NK cell-mediated clearance of lung cancer are unknown. Here we report that NK cells exposed to exo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi L,Li K,Guo Y,Banerjee A,Wang Q,Lorenz UM,Parlak M,Sullivan LC,Onyema OO,Arefanian S,Stelow EB,Brautigan DL,Bullock TNJ,Brown MG,Krupnick AS

更新日期：2018-11-13 00:00:00

abstract：:In characterizing mice with targeted disruption of the SerpinB2 gene, we observed animals that were small at birth with delayed growth and decreased life expectancy. Although this phenotype cosegregated with homozygosity for the inactive SerpinB2 allele, analysis of homozygous SerpinB2-deficient mice derived from two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westrick RJ,Mohlke KL,Korepta LM,Yang AY,Zhu G,Manning SL,Winn ME,Dougherty KM,Ginsburg D

更新日期：2010-09-28 00:00:00

abstract：:2-[4-(3,4-Dichlorophenylureido)phenoxy]-2-methylpropionic acid, LR16, combines with two symmetrically related sites in the central cavity of deoxyhemoglobin, 20 A away from the binding site of 2,3-bisphosphoglycerate, and acts as an allosteric effector synergistic with 2,3-bisphosphoglycerate. LR16 (1 mM) raises P50, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalezari I,Rahbar S,Lalezari P,Fermi G,Perutz MF

更新日期：1988-08-01 00:00:00

abstract：:Stem cells have been identified as essential for maintaining multiple organ systems, including the hematopoietic system. The distinct cell fates of self-renewal and differentiation of hematopoietic stem cells (HSCs) depend on cell division. Recently, several negative regulators of the cell cycle, such as the cyclin-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walkley CR,Orkin SH

更新日期：2006-06-13 00:00:00

abstract：:Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff J,Jones AB

更新日期：1970-02-01 00:00:00

abstract：:Cell cycle checkpoints appear to contribute to an increase in cell survival and a decrease in abnormal heritable genetic changes following exposure to DNA damaging agents. Though several radiation-sensitive yeast mutants have been identified, little is known about the genes that control these responses in mammalian ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuerbitz SJ,Plunkett BS,Walsh WV,Kastan MB

更新日期：1992-08-15 00:00:00

abstract：:The redox siblings nitroxyl (HNO) and nitric oxide (NO) have often been assumed to undergo casual redox reactions in biological systems. However, several recent studies have demonstrated distinct pharmacological effects for donors of these two species. Here, infusion of the HNO donor Angeli's salt into normal dogs res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miranda KM,Paolocci N,Katori T,Thomas DD,Ford E,Bartberger MD,Espey MG,Kass DA,Feelisch M,Fukuto JM,Wink DA

更新日期：2003-08-05 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:The drought of progress in clinical brain tumor therapy provides an impetus for developing new treatments as well as methods for testing therapeutics in animal models. The inability of traditional assays to simultaneously measure tumor size, location, growth kinetics, and cell kill achieved by a treatment complicates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross BD,Zhao YJ,Neal ER,Stegman LD,Ercolani M,Ben-Yoseph O,Chenevert TL

更新日期：1998-06-09 00:00:00

abstract：:Most proteins are in equilibrium with partially and globally unfolded conformations. In contrast, kinetically stable proteins (KSPs) are trapped by an energy barrier in a specific state, unable to transiently sample other conformations. Among many potential roles, it appears that kinetic stability (KS) is a feature us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia K,Manning M,Hesham H,Lin Q,Bystroff C,Colón W

更新日期：2007-10-30 00:00:00

abstract：:DNA vaccines, comprised of plasmid DNA encoding proteins from pathogens, allergens, and tumors, are being evaluated as prophylactic vaccines and therapeutic treatments for infectious diseases, allergies, and cancer; plasmids encoding normal human proteins are likewise being tested as vaccines and treatments for autoim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Acres B,Balloul JM,Bizouarne N,Paul S,Slos P,Squiban P

更新日期：2004-10-05 00:00:00

abstract：:Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signatur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volinia S,Calin GA,Liu CG,Ambs S,Cimmino A,Petrocca F,Visone R,Iorio M,Roldo C,Ferracin M,Prueitt RL,Yanaihara N,Lanza G,Scarpa A,Vecchione A,Negrini M,Harris CC,Croce CM

更新日期：2006-02-14 00:00:00

abstract：:Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell LE,Lin JC,Bowling DR,Pataki DE,Strong C,Schauer AJ,Bares R,Bush SE,Stephens BB,Mendoza D,Mallia D,Holland L,Gurney KR,Ehleringer JR

更新日期：2018-03-20 00:00:00