Ras membrane targeting is essential for glucose signaling but not for viability in yeast.

abstract：:Phytohormones have essential roles in coordinately regulating a large array of developmental processes. Studies have revealed that brassinosteroids (BRs) and abscisic acid (ABA) interact to regulate hundreds of expression in genes, governing many biological processes. However, whether their interaction is through modi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang S,Cai Z,Wang X

更新日期：2009-03-17 00:00:00

abstract：:Neuroglobin (Ngb), a vertebrate globin expressed primarily in neurons, is induced by and protects against neuronal hypoxia and cerebral ischemia. To investigate the spectrum and mechanism of Ngb's neuroprotective action, we studied the effect of transgenic overexpression of Ngb on NMDA and beta-amyloid (Abeta) toxicit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan AA,Mao XO,Banwait S,Jin K,Greenberg DA

更新日期：2007-11-27 00:00:00

abstract：:In this paper we solve several boundary value problems for the Helmholtz equation on polygonal domains. We observe that when the problems are formulated as the boundary integral equations of potential theory, the solutions are representable by series of appropriately chosen Bessel functions. In addition to being analy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serkh K,Rokhlin V

更新日期：2016-08-16 00:00:00

abstract：:Dihydropteridine reductase (EC 1.6.99.7) is a member of the recently identified family of proteins known as short-chain dehydrogenases. When the x-ray structure of dihydropteridine reductase is correlated with conserved amino acid sequences characteristic of this enzyme class, two important common structural regions c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varughese KI,Xuong NH,Kiefer PM,Matthews DA,Whiteley JM

更新日期：1994-06-07 00:00:00

abstract：:Human thioredoxin reductase (TR) contains selenocysteine (Secys) in a redox center [cysteine (Cys)-497,Secys-498] near the C-terminus. The essential role of Secys in TR isolated from HeLa cells was demonstrated by the alkylation studies. Reaction of native NADPH reduced enzyme with bromoacetate at pH 6.5 inhibited enz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorlatov SN,Stadtman TC

更新日期：1998-07-21 00:00:00

abstract：:The interactions between products of the 15-lipoxygenase cascade and human natural killer (NK) cell activity have been studied. Addition of human leukocyte-derived (14R,15S)-14,15-dihydroxy-5Z,8Z,10E,12E-ic osatetraenoic acid (14,15-DiHETE) to the NK cytotoxicity assay against K562 target cells resulted in inhibition ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramstedt U,Serhan CN,Lundberg U,Wigzell H,Samuelsson B

更新日期：1984-11-01 00:00:00

abstract：:We have studied the effects of food restriction (FR) and substitution of fish oil (FO; omega 3) for corn oil (CO; omega 6) on breast tumor incidence and survival in mouse mammary tumor virus/v-Ha-ras transgenic (Onco) mice. The diets were as follows: group 1, 5% (wt/wt) CO fed ad libitum (AL); group 2, 5% CO, restrict...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandes G,Chandrasekar B,Troyer DA,Venkatraman JT,Good RA

更新日期：1995-07-03 00:00:00

abstract：:The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tyson JJ

更新日期：1991-08-15 00:00:00

abstract：:The thymus lacks self-renewing hematopoietic cells, and thymopoiesis fails rapidly when the migration of progenitor cells to the thymus ceases. Hence, the process of thymus homing is an essential step for T-cell development and cellular immunity. Despite decades of research, the molecular details of thymus homing have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calderón L,Boehm T

更新日期：2011-05-03 00:00:00

abstract：:Examples from various plant and animal groups indicate that there has been a general increase in potential versatility of form, determined by the number and range of independently varying morphogenetic parameters, among taxa appearing at successively younger stages in the fossil record. Taxa or body plans with higher ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeij GJ

更新日期：1973-07-01 00:00:00

abstract：:The marine cyanobacterium Trichodesmium is ubiquitous in tropical and subtropical seas and is an important contributor to global N and C cycling. We sought to characterize metabolic uptake patterns in individual Trichodesmium IMS-101 cells by quantitatively imaging (13)C and (15)N uptake with high-resolution secondary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finzi-Hart JA,Pett-Ridge J,Weber PK,Popa R,Fallon SJ,Gunderson T,Hutcheon ID,Nealson KH,Capone DG

更新日期：2009-04-14 00:00:00

abstract：:The Drosophila clock genes period (per) and timeless (tim) have been studied behaviorally and biochemically, but to date there has been no viable culture system for studying the cell biology of the Drosophila clock. We have cultured pupal ring glands attached to the central nervous system and observed rhythms of perio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emery IF,Noveral JM,Jamison CF,Siwicki KK

更新日期：1997-04-15 00:00:00

abstract：:Nicotiana tabacum cv. Turkish Samsun NN plants were transformed with a modified and truncated replicase gene encoded by RNA-2 of cucumber mosaic virus strain Fny. The replicase gene had been modified by deleting a 94-base-pair region spanning nucleotides 1857-1950; the deletion also caused a shift in the open reading ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson JM,Palukaitis P,Zaitlin M

更新日期：1992-09-15 00:00:00

abstract：:Vibrio cholerae O1 exists as two major serotypes, Inaba and Ogawa, which are associated with the O antigen of the lipopolysaccharide and are capable of unequal reciprocal interconversion. The 20-kilobase rfb regions encoding O-antigen biosynthesis in strains 569B (Inaba) and O17 (Ogawa) have been cloned in Escherichia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stroeher UH,Karageorgos LE,Morona R,Manning PA

更新日期：1992-04-01 00:00:00

abstract：:The phenotype of several erythromycin-resistant mutants of Chlamydomonas reinhardi was further characterized in terms of the electrophoretic properties of their chloroplast ribosomal proteins. In mutant ery-M2d a single protein of the large (52 S) subunit has altered properties, which probably result from a change in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mets L,Bogorad L

更新日期：1972-12-01 00:00:00

abstract：:Rat superior cervical sympathetic ganglion was used to begin studying the regulation of molecular components of the synapse. Ganglionic postsynaptic densities (PSDs)exhibited a thin, disc-shaped profile electron microscopically, comparable to that described for brain. Moreover, the presumptive ganglionic PSD protein (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu K,Black IB

更新日期：1987-12-01 00:00:00

abstract：:Coimmunoprecipitation of members of the phytochrome red/farred photoreceptor family from plant extracts has been used to analyze their heteromeric binding interactions. Phytochrome (phy)B or phyD apoproteins with six myc epitopes fused to their N termini are biologically active when expressed in Arabidopsis. Immunopre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharrock RA,Clack T

更新日期：2004-08-03 00:00:00

abstract：:Dihydrofolate reductase (EC 1.5.1.3; 5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase) from antifolate-resistant Lactobacillus casei has been isolated in pure form and examined in solution by high resolution proton magnetic resonance spectroscopy. The 220 MHz proton magnetic resonance spectrum of this small enzyme (abo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pastore EJ,Kisliuk RL,Plante LT,Wright JM,Kaplan NO

更新日期：1974-10-01 00:00:00

abstract：:Heterogeneous nucleation is vital to a wide range of areas as diverse as ice nucleation on atmospheric aerosols and the fabrication of high-performance thin films. There is excellent evidence that surface topography is a key factor in directing crystallization in real systems; however, the mechanisms by which nanoscal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell JM,Meldrum FC,Christenson HK

更新日期：2017-01-31 00:00:00

abstract：:FtsZ, the ancestral homolog of eukaryotic tubulins, is a GTPase that assembles into a cytokinetic ring structure essential for cell division in prokaryotic cells. Similar to tubulin, purified FtsZ polymerizes into dynamic protofilaments in the presence of GTP; polymer assembly is accompanied by GTP hydrolysis. We used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Margalit DN,Romberg L,Mets RB,Hebert AM,Mitchison TJ,Kirschner MW,RayChaudhuri D

更新日期：2004-08-10 00:00:00

abstract：:Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for exter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosmans F,Milescu M,Swartz KJ

更新日期：2011-12-13 00:00:00

abstract：:Plant mortality and birth rates are critical components of plant life history affecting the stability of plant populations and the ecosystems they form. Although allometric theory predicts that both plant birth and mortality rates should be size-dependent, this prediction has not yet been tested across plants ranging ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marbà N,Duarte CM,Agustí S

更新日期：2007-10-02 00:00:00

abstract：:Is there a sense of chance shared by all individuals, regardless of their schooling or culture? To test whether the ability to make correct probabilistic evaluations depends on educational and cultural guidance, we investigated probabilistic cognition in preliterate and prenumerate Kaqchikel and K'iche', two indigenou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontanari L,Gonzalez M,Vallortigara G,Girotto V

更新日期：2014-12-02 00:00:00

abstract：:In a primitive chordate model of natural chimerism, one chimeric partner is often eliminated in a process of allogeneic resorption. Here, we identify the cellular framework underlying loss of tolerance to one partner within a natural Botryllus schlosseri chimera. We show that the principal cell type mediating chimeric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corey DM,Rosental B,Kowarsky M,Sinha R,Ishizuka KJ,Palmeri KJ,Quake SR,Voskoboynik A,Weissman IL

更新日期：2016-06-07 00:00:00

abstract：:Low phosphate (Pi) availability constrains plant development and seed production in both natural and agricultural ecosystems. When Pi is scarce, modifications of root system architecture (RSA) enhance the soil exploration ability of the plant and lead to an increase in Pi uptake. In Arabidopsis, an iron-dependent mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mora-Macías J,Ojeda-Rivera JO,Gutiérrez-Alanís D,Yong-Villalobos L,Oropeza-Aburto A,Raya-González J,Jiménez-Domínguez G,Chávez-Calvillo G,Rellán-Álvarez R,Herrera-Estrella L

更新日期：2017-04-25 00:00:00

abstract：:Calcium, a universal second messenger, regulates diverse cellular processes in eukaryotes. Ca2+ and Ca2+/calmodulin-regulated protein phosphorylation play a pivotal role in amplifying and diversifying the action of Ca(2+)-binding domain was cloned and characterized from lily. The cDNA clone contains an open reading fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patil S,Takezawa D,Poovaiah BW

更新日期：1995-05-23 00:00:00

abstract：:Ovarian cancer remains the most lethal gynecologic malignancy. We analyzed the mutational landscape of 64 primary, 41 metastatic, and 17 recurrent fresh-frozen tumors from 77 patients along with matched normal DNA, by whole-exome sequencing (WES). We also sequenced 13 pairs of synchronous bilateral ovarian cancer (SBO...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Bonazzoli E,Bellone S,Choi J,Dong W,Menderes G,Altwerger G,Han C,Manzano A,Bianchi A,Pettinella F,Manara P,Lopez S,Yadav G,Riccio F,Zammataro L,Zeybek B,Yang-Hartwich Y,Buza N,Hui P,Wong S,Ravaggi A,Bigno

更新日期：2019-01-08 00:00:00

abstract：:Paired oxygen-isotopic analyses of abiotic carbonate and benthic-ostracode shells from lake sediments provide a continuous quantitative record of growing-season temperature for the past 2000 years in the northwestern foothills of the Alaska Range. This record reveals three time intervals of comparable warmth: anno Dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu FS,Ito E,Brown TA,Curry BB,Engstrom DR

更新日期：2001-09-11 00:00:00

abstract：:We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egerton M,Scollay R,Shortman K

更新日期：1990-04-01 00:00:00

abstract：:The neu gene is distantly related to the erbB gene and encodes a cell surface protein that appears to function as a growth factor receptor. To study the mechanisms that caused the conversion of the normal neu gene to an oncogenic allele, we have isolated molecular clones of the neu oncogene as well as a clone of the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hung MC,Schechter AL,Chevray PY,Stern DF,Weinberg RA

更新日期：1986-01-01 00:00:00